Strain Name:
C57BL/6J-MtgxR0783Btlr/Mmmh
Stock Number:
038963-MU
Citation ID:
RRID:MMRRC_038963-MU
Other Names:
R0783 (G1), C57BL/6J-MtgxR0783Btlr
Major Collection:

Strain Information

Tnf
Name: tumor necrosis factor
Synonyms: TNFalpha, DIF, TNF alpha, Tnfsf1a, Tnfa, TNF-alpha, tumor necrosis factor-alpha
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21926
Homologene: 496
Hdac1
Name: histone deacetylase 1
Synonyms: HD1, RPD3, MommeD5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 433759
HGNC: HGNC:4852
Homologene: 68426
Serinc3
Name: serine incorporator 3
Synonyms: DIFF33, Tde1, TMS-1, AIGP1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26943
Homologene: 38230
Eprs1
Name: glutamyl-prolyl-tRNA synthetase 1
Synonyms: 3010002K18Rik, Qprs, 2410081F06Rik, Eprs
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 107508
HGNC: HGNC:3418
Homologene: 5870
Mllt6
Name: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6
Synonyms: Af17
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 246198
HGNC: HGNC:7138
Homologene: 31347
Zfr
Name: zinc finger RNA binding protein
Synonyms: C920030H05Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22763
Homologene: 8009
Urb1
Name: URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
Synonyms: 5730405K23Rik, 4921511H13Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 207932
Homologene: 45941
Pcsk9
Name: proprotein convertase subtilisin/kexin type 9
Synonyms: Narc1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100102
Homologene: 17790
Eif3b
Name: eukaryotic translation initiation factor 3, subunit B
Synonyms: D5Wsu45e, Eif3s9, EIF3-P116
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 27979
HGNC: HGNC:3280
Homologene: 2780
Iars2
Name: isoleucine-tRNA synthetase 2, mitochondrial
Synonyms: 2010002H18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381314
Homologene: 7118
Sez6l2
Name: seizure related 6 homolog like 2
Synonyms: Psk1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233878
Homologene: 8237
Pfas
Name: phosphoribosylformylglycinamidine synthase (FGAR amidotransferase)
Synonyms: 4432409B16Rik, Sofa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237823
HGNC: HGNC:8863
Homologene: 5970
Bbs9
Name: Bardet-Biedl syndrome 9
Synonyms: EST 3159894, E130103I17Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319845
Homologene: 44480
Gigyf2
Name: GRB10 interacting GYF protein 2
Synonyms: 2610016F01Rik, Tnrc15, A830080H02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227331
Homologene: 41048
Klk8
Name: kallikrein related-peptidase 8
Synonyms: Prss19, BSP1, Nrpn
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259277
HGNC: HGNC:6369
Homologene: 21410
Nhlrc3
Name: NHL repeat containing 3
Synonyms: 8030451K01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 212114
Homologene: 35239
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Tmprss7
Name: transmembrane serine protease 7
Synonyms: matriptase-3, B230219I23Rik, LOC385645
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 208171
Homologene: 18178
Loxhd1
Name: lipoxygenase homology domains 1
Synonyms: 1700096C21Rik, sba
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240411
Pcnx4
Name: pecanex homolog 4
Synonyms: Pcnxl4, 1810048J11Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 67708
VEGA: 12
Homologene: 23366
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20192
Homologene: 68151
Camk2g
Name: calcium/calmodulin-dependent protein kinase II gamma
Synonyms: Camkg, CaMK II, Ca2+/calmodulin-dependent protein kinase II, 5930429P18Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12325
VEGA: 14
HGNC: HGNC:1463
Homologene: 15596
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: E130113P14Rik, bl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231470
Homologene: 23516
Klhl5
Name: kelch-like 5
Synonyms: 1300013C10Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71778
HGNC: HGNC:6356
Homologene: 56736
Or4c119
Name: olfactory receptor family 4 subfamily C member 119
Synonyms: Olfr1224, GA_x6K02T2Q125-50635980-50635046, MOR233-15
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258026
Abca14
Name: ATP-binding cassette, sub-family A member 14
Synonyms: 1700110B15Rik, 4930539G24Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67928
Homologene: 86128
Mylk
Name: myosin, light polypeptide kinase
Synonyms: MLCK210, 9530072E15Rik, nmMlck, telokin, Mlck, MLCK108, A930019C19Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 107589
HGNC: HGNC:7590
Homologene: 14202
Or10q1
Name: olfactory receptor family 10 subfamily Q member 1
Synonyms: Olfr1494, GA_x6K02T2RE5P-4082427-4083374, MOR266-1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258992
Homologene: 64855
Or52s1
Name: olfactory receptor family 52 subfamily S member 1
Synonyms: Olfr593, MOR24-2, GA_x6K02T2PBJ9-5927412-5928362
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258378
Homologene: 27147
Or8h9
Name: olfactory receptor family 8 subfamily H member 9
Synonyms: Olfr1099, GA_x6K02T2Q125-48446067-48445129, MOR206-3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258764
Homologene: 107003
Ttbk2
Name: tau tubulin kinase 2
Synonyms: 2610507N02Rik, B930008N24Rik, TTK
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 140810
Homologene: 62795
Itih4
Name: inter alpha-trypsin inhibitor, heavy chain 4
Synonyms: Itih-4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16427
HGNC: HGNC:6169
Homologene: 1670
Abi3bp
Name: ABI family member 3 binding protein
Synonyms: TARSH, eratin, D930038M13Rik, 5033411B22Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 320712
VEGA: 16
Homologene: 134172
Acsm2
Name: acyl-CoA synthetase medium-chain family member 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233799
Homologene: 70404
Akp3
Name: alkaline phosphatase 3, intestine, not Mn requiring
Synonyms: Akp-3, IAP
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11648
Homologene: 134333
Or5h25
Name: olfactory receptor family 5 subfamily H member 25
Synonyms: Olfr1540-ps1, MOR113-7P, MOR183-7P, Olfr193, MOR113-7P, GA_x54KRFPKG5P-55338697-55337768
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 257972
Homologene: 128162
Plk5
Name: polo like kinase 5
Synonyms: 6330514A18Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216166
Homologene: 28072
Irx2
Name: Iroquois homeobox 2
Synonyms: IRX6
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 16372
Homologene: 56490
Eif3i
Name: eukaryotic translation initiation factor 3, subunit I
Synonyms: D4Ertd632e, Eif3s2, TRIP-1, 36kDa
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 54709
HGNC: HGNC:3272
Homologene: 2786
Gm13256
Name: predicted gene 13256
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Fam110d
Name: family with sequence similarity 110, member D
Synonyms: 2810043G13Rik, Grrp1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72690
Homologene: 67184
Zfp128
Name: zinc finger protein 128
Synonyms: mZnf8, 9630016P15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243833
Homologene: 10889
Or52b3
Name: olfactory receptor family 52 subfamily B member 3
Synonyms: MOR31-3, GA_x6K02T2PBJ9-5274337-5275287, Olfr549
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259105
Homologene: 86245
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 87,127,871 bp
  • T to A, chromosome 1 at 87,407,161 bp
  • C to T, chromosome 1 at 150,650,073 bp
  • T to C, chromosome 1 at 185,320,874 bp
  • T to C, chromosome 1 at 185,398,458 bp
  • T to A, chromosome 2 at 9,877,446 bp
  • G to A, chromosome 2 at 76,743,530 bp
  • A to G, chromosome 2 at 86,958,562 bp
  • A to T, chromosome 2 at 89,156,891 bp
  • A to G, chromosome 2 at 112,756,327 bp
  • A to T, chromosome 2 at 120,739,977 bp
  • A to G, chromosome 2 at 163,637,003 bp
  • A to T, chromosome 3 at 53,462,449 bp
  • T to C, chromosome 4 at 106,450,117 bp
  • T to C, chromosome 4 at 129,518,109 bp
  • A to C, chromosome 4 at 129,592,076 bp
  • G to A, chromosome 4 at 134,252,057 bp
  • T to A, chromosome 5 at 65,156,253 bp
  • C to T, chromosome 5 at 96,768,430 bp
  • T to C, chromosome 5 at 140,419,837 bp
  • C to T, chromosome 7 at 12,890,272 bp
  • G to A, chromosome 7 at 43,802,197 bp
  • A to G, chromosome 7 at 102,554,439 bp
  • T to C, chromosome 7 at 103,212,670 bp
  • G to A, chromosome 7 at 119,573,117 bp
  • G to A, chromosome 7 at 120,294,157 bp
  • A to G, chromosome 7 at 126,967,145 bp
  • T to C, chromosome 9 at 22,567,714 bp
  • T to A, chromosome 10 at 80,361,130 bp
  • A to G, chromosome 11 at 69,000,521 bp
  • T to C, chromosome 11 at 97,665,745 bp
  • T to C, chromosome 12 at 72,575,478 bp
  • T to C, chromosome 13 at 72,632,650 bp
  • T to A, chromosome 14 at 20,744,636 bp
  • G to A, chromosome 14 at 30,895,423 bp
  • T to C, chromosome 15 at 12,162,182 bp
  • G to C, chromosome 16 at 34,879,475 bp
  • G to A, chromosome 16 at 45,667,606 bp
  • A to G, chromosome 16 at 56,595,238 bp
  • A to T, chromosome 16 at 59,110,169 bp
  • G to A, chromosome 16 at 90,810,297 bp
  • A to G, chromosome 17 at 35,201,674 bp
  • T to C, chromosome 18 at 77,429,984 bp
  • T to C, chromosome 19 at 13,749,676 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0783 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038963-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.