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Strain Name:
C57BL/6J-MtgxR1103Btlr/Mmmh
Stock Number:
039176-MU
Citation ID:
RRID:MMRRC_039176-MU
Other Names:
R1103 (G1), C57BL/6J-MtgxR1103Btlr
Major Collection:

Strain Information

Ltbp3
Name: latent transforming growth factor beta binding protein 3
Synonyms: Ltbp2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16998
VEGA: 19
HGNC: HGNC:6716
Homologene: 7405
Pnmt
Name: phenylethanolamine-N-methyltransferase
Synonyms: Pent
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18948
HGNC: HGNC:9160
Homologene: 55673
Map1b
Name: microtubule-associated protein 1B
Synonyms: MAP5, Mtap-5, Mtap5, LC1, Mtap1b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17755
VEGA: 13
HGNC: HGNC:6836
Homologene: 38111
Map3k4
Name: mitogen-activated protein kinase kinase kinase 4
Synonyms: MTK1, MAPKKK4, D17Rp17, RP17, D17Rp17e, Mekk4, T-associated sex reversal, Tas
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 26407
VEGA: 17
HGNC: HGNC:6856
Homologene: 31346
Luzp1
Name: leucine zipper protein 1
Synonyms: Luzp, 2700072H04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269593
Homologene: 11545
Erbin
Name: Erbb2 interacting protein
Synonyms: 1700028E05Rik, Erbin, Erbb2ip
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 59079
Homologene: 41282
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 116,580,669 bp
  • T to C, chromosome 1 at 132,607,057 bp
  • T to C, chromosome 1 at 174,136,891 bp
  • C to T, chromosome 1 at 184,033,505 bp
  • T to A, chromosome 2 at 6,026,175 bp
  • A to G, chromosome 2 at 32,781,398 bp
  • A to G, chromosome 2 at 82,257,500 bp
  • T to C, chromosome 2 at 126,154,723 bp
  • A to G, chromosome 3 at 19,981,985 bp
  • A to T, chromosome 3 at 36,996,523 bp
  • G to T, chromosome 3 at 103,310,885 bp
  • T to C, chromosome 3 at 122,276,422 bp
  • C to T, chromosome 3 at 158,148,706 bp
  • G to A, chromosome 4 at 19,309,658 bp
  • T to A, chromosome 4 at 124,838,468 bp
  • T to A, chromosome 4 at 136,540,730 bp
  • A to C, chromosome 4 at 143,655,372 bp
  • T to C, chromosome 5 at 20,611,103 bp
  • G to A, chromosome 5 at 99,979,121 bp
  • T to C, chromosome 5 at 135,061,139 bp
  • G to A, chromosome 6 at 47,517,177 bp
  • G to A, chromosome 6 at 129,868,843 bp
  • T to A, chromosome 7 at 6,570,112 bp
  • G to T, chromosome 7 at 28,154,520 bp
  • C to A, chromosome 7 at 44,904,169 bp
  • T to C, chromosome 7 at 108,754,883 bp
  • A to T, chromosome 7 at 132,610,755 bp
  • A to G, chromosome 8 at 15,110,827 bp
  • G to A, chromosome 8 at 24,576,223 bp
  • T to A, chromosome 8 at 24,714,271 bp
  • A to T, chromosome 8 at 25,767,863 bp
  • C to A, chromosome 8 at 45,276,146 bp
  • T to A, chromosome 8 at 70,748,417 bp
  • A to G, chromosome 9 at 59,313,796 bp
  • A to G, chromosome 9 at 65,880,906 bp
  • T to C, chromosome 10 at 18,140,526 bp
  • C to A, chromosome 10 at 20,023,676 bp
  • G to T, chromosome 10 at 41,902,593 bp
  • A to T, chromosome 11 at 20,726,547 bp
  • A to G, chromosome 11 at 26,549,325 bp
  • C to T, chromosome 11 at 49,636,339 bp
  • A to T, chromosome 11 at 59,021,483 bp
  • T to C, chromosome 11 at 60,403,950 bp
  • C to A, chromosome 11 at 61,671,718 bp
  • T to A, chromosome 11 at 77,823,330 bp
  • T to C, chromosome 11 at 78,225,473 bp
  • G to T, chromosome 11 at 98,387,676 bp
  • A to G, chromosome 12 at 74,266,898 bp
  • G to A, chromosome 12 at 76,109,835 bp
  • G to T, chromosome 13 at 76,055,593 bp
  • A to T, chromosome 13 at 99,427,466 bp
  • G to T, chromosome 13 at 103,886,202 bp
  • A to T, chromosome 15 at 47,948,006 bp
  • A to T, chromosome 15 at 66,719,655 bp
  • A to G, chromosome 16 at 4,084,061 bp
  • G to T, chromosome 16 at 93,585,194 bp
  • A to T, chromosome 17 at 12,237,063 bp
  • T to C, chromosome 17 at 67,790,947 bp
  • A to G, chromosome 18 at 21,026,102 bp
  • T to C, chromosome 19 at 4,613,271 bp
  • A to T, chromosome 19 at 5,747,411 bp
  • G to C, chromosome 19 at 5,747,412 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1103 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039176-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.