Strain Name:
C57BL/6J-MtgxR1146Btlr/Mmmh
Stock Number:
039219-MU
Citation ID:
RRID:MMRRC_039219-MU
Other Names:
R1146 (G1), C57BL/6J-MtgxR1146Btlr
Major Collection:

Gene Information

Gaa
Name: glucosidase, alpha, acid
Synonyms: E430018M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14387
HGNC: HGNC:4065
Homologene: 37268
Arrdc4
Name: arrestin domain containing 4
Synonyms: 2410003C09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 66412
Homologene: 41636
Rexo1
Name: REX1, RNA exonuclease 1
Synonyms: 1700021P10Rik, 2610511M11Rik, Tceb3bp1, Rex1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 66932
Homologene: 41391
Nsf
Name: N-ethylmaleimide sensitive fusion protein
Synonyms: SKD2, N-ethylmaleimide sensitive factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18195
HGNC: HGNC:8016
Homologene: 4502
Wwox
Name: WW domain-containing oxidoreductase
Synonyms: WOX1, 9030416C10Rik, 5330426P09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 80707
Homologene: 56334
Msh2
Name: mutS homolog 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 17685
HGNC: HGNC:7325
Homologene: 210
Herc2
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2
Synonyms: D7H15F32S1, D15F32S1h, D7H15F37S1, rjs, jdf2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 15204
HGNC: HGNC:4868
Homologene: 3430
Phc1
Name: polyhomeotic 1
Synonyms: Rae-28, Mph1, rae28, Edr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 13619
HGNC: HGNC:3182
Homologene: 107079
Kpna1
Name: karyopherin (importin) alpha 1
Synonyms: mSRP1, m-importin-alpha-S1, Rch2, NPI1, importin alpha 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 16646
HGNC: HGNC:6394
Homologene: 55642
Prss16
Name: protease, serine 16 (thymus)
Synonyms: TSSP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 54373
HGNC: HGNC:9480
Homologene: 38106
Frg1
Name: FSHD region gene 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14300
HGNC: HGNC:3954
Homologene: 3295
Piwil1
Name: piwi-like RNA-mediated gene silencing 1
Synonyms: MIWI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 57749
HGNC: HGNC:9007
Homologene: 37963
Fabp3
Name: fatty acid binding protein 3, muscle and heart
Synonyms: H-FABP, Fabph-4, Fabph-1, Fabph4, Fabph1, Mdgi, Fabp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 14077
HGNC: HGNC:3557
Homologene: 68379
Asb4
Name: ankyrin repeat and SOCS box-containing 4
Synonyms: 8430401O13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 65255
Homologene: 9392
Zfp335
Name: zinc finger protein 335
Synonyms: 1810045J01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329559
Homologene: 11129
Gfral
Name: GDNF family receptor alpha like
Synonyms: GRAL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 404194
Homologene: 45748
Ifnk
Name: interferon kappa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 387510
Homologene: 36384
Dync1i2
Name: dynein cytoplasmic 1 intermediate chain 2
Synonyms: 3110079H08Rik, Dncic2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13427
HGNC: HGNC:2964
Homologene: 37921
Sec31a
Name: Sec31 homolog A (S. cerevisiae)
Synonyms: 1810024J13Rik, Sec31l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 69162
Homologene: 42056
Fzd2
Name: frizzled class receptor 2
Synonyms: Mfz10a, Mfz10, Fz10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 57265
HGNC: HGNC:4040
Homologene: 20377
Olfr980
Name: olfactory receptor 980
Synonyms: GA_x6K02T2PVTD-33705428-33704496, MOR223-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 259110
VEGA: 9
Homologene: 81557
Ptpro
Name: protein tyrosine phosphatase, receptor type, O
Synonyms: D28, PTPROt, PTP-phi, PTP-BK, PTP-U2, GLEPP1, PTP-oc, Ptpn15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19277
HGNC: HGNC:9678
Homologene: 21564
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: VLGR1, Mass1, Mgr1, Gpr98
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 110789
Homologene: 19815
Zfp652
Name: zinc finger protein 652
Synonyms: 9530033F24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268469
Homologene: 54768
Vmn2r115
Name: vomeronasal 2, receptor 115
Synonyms: EG638102, V2Rp4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 638102
Homologene: 86604
Mogat1
Name: monoacylglycerol O-acyltransferase 1
Synonyms: 0610030A14Rik, mDC2, MGAT1, 1110064N14Rik, Dgat2l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68393
Homologene: 105237
Ccdc150
Name: coiled-coil domain containing 150
Synonyms: 4930511H11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 78016
Homologene: 15814
Sel1l3
Name: sel-1 suppressor of lin-12-like 3 (C. elegans)
Synonyms: 2310045A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231238
Homologene: 9054
Otogl
Name: otogelin-like
Synonyms: Gm6924
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 628870
Homologene: 46008
Pfkfb4
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270198
HGNC: HGNC:8875
Homologene: 48288
Alpk3
Name: alpha-kinase 3
Synonyms: Midori
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 116904
Homologene: 10813
Ctsj
Name: cathepsin J
Synonyms: rat gene/Cathepsin L-related protein, CatRLP, CATP, Cat P, Ctsp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 26898
VEGA: 13
Homologene: 137246
Gucy1a2
Name: guanylate cyclase 1, soluble, alpha 2
Synonyms: 6330407I18Rik, A230060L24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 234889
HGNC: HGNC:4684
Homologene: 47953
Masp1
Name: mannan-binding lectin serine peptidase 1
Synonyms: Crarf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 17174
VEGA: 16
HGNC: HGNC:6901
Homologene: 88793
Pappa2
Name: pappalysin 2
Synonyms: placenta-specific 3, pregnancy-associated plasma preproprotein-A2, pregnancy-associated plasma protein-E, PAPP-A2, PLAC3, Pappe
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 23850
Homologene: 10661
Zfp110
Name: zinc finger protein 110
Synonyms: NRIF, 2900024E01Rik, Nrif1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 65020
Homologene: 129707
Tmcc2
Name: transmembrane and coiled-coil domains 2
Synonyms: 1110063G11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68875
Homologene: 8905
Tor1aip2
Name: torsin A interacting protein 2
Synonyms: 15kDa, 1110020D10Rik, LULL1, Ifrg15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240832
Homologene: 17028
Rbsn
Name: rabenosyn, RAB effector
Synonyms: 5330426D11Rik, Rabenosyn-5, Zfyve20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 78287
Homologene: 41477
Unc45b
Name: unc-45 myosin chaperone B
Synonyms: UNC45, D230041A13Rik, Cmya4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217012
Homologene: 14666
Ppfia3
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
Synonyms: 2410127E16Rik, Liprin-alpha3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76787
HGNC: HGNC:9247
Homologene: 37833
Eme1
Name: essential meiotic structure-specific endonuclease 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268465
Homologene: 16123
Olfr1449
Name: olfactory receptor 1449
Synonyms: GA_x6K02T2RE5P-3264213-3265157, MOR202-34
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258300
Homologene: 17184
Iqub
Name: IQ motif and ubiquitin domain containing
Synonyms: 4932408B21Rik, Trs4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 214704
Homologene: 44790
Usp16
Name: ubiquitin specific peptidase 16
Synonyms: 2810483I07Rik, UBP-M, 1200004E02Rik, 6330514E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 74112
Homologene: 38183
Pax5
Name: paired box 5
Synonyms: Pax-5, EBB-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18507
HGNC: HGNC:8619
Homologene: 56419
Sema4c
Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
Synonyms: M-Sema F, Semaf, Semacl1, Semai, Semacl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20353
Homologene: 23047
Olfr1257
Name: olfactory receptor 1257
Synonyms: GA_x6K02T2Q125-51319458-51320387, MOR232-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258984
Homologene: 115501
Mpi
Name: mannose phosphate isomerase
Synonyms: Mpi-1, 1110002E17Rik, Mpi1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 110119
HGNC: HGNC:7216
Homologene: 1825
AC242409.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Sf3b5
Name: splicing factor 3b, subunit 5
Synonyms: 10kDa, 1110005L13Rik, Sf3b10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 66125
Homologene: 41825
Olfr1416
Name: olfactory receptor 1416
Synonyms: GA_x6K02T2R7CC-81277975-81278913, MOR103-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 259040
Homologene: 17472
Gm10774
Name: predicted pseudogene 10774
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 100043714
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 36,550,565 bp
  • A to T, chromosome 1 at 54,364,971 bp
  • A to G, chromosome 1 at 78,523,613 bp
  • G to A, chromosome 1 at 92,479,890 bp
  • TTGCTGCTGCTGCTGCTGC to TTGCTGCTGCTGCTGC, chromosome 1 at 132,357,755 bp
  • T to C, chromosome 1 at 156,064,737 bp
  • T to C, chromosome 1 at 158,854,982 bp
  • C to T, chromosome 2 at 71,227,820 bp
  • C to T, chromosome 2 at 89,881,206 bp
  • T to C, chromosome 2 at 126,709,472 bp
  • G to A, chromosome 2 at 164,896,123 bp
  • T to C, chromosome 4 at 35,152,231 bp
  • G to T, chromosome 4 at 44,697,512 bp
  • C to T, chromosome 4 at 130,312,387 bp
  • A to T, chromosome 5 at 53,117,103 bp
  • T to C, chromosome 5 at 100,362,173 bp
  • T to C, chromosome 5 at 128,747,893 bp
  • A to G, chromosome 6 at 5,423,591 bp
  • G to A, chromosome 6 at 24,505,628 bp
  • A to G, chromosome 6 at 92,201,730 bp
  • T to C, chromosome 6 at 122,323,457 bp
  • T to A, chromosome 6 at 137,443,594 bp
  • A to G, chromosome 7 at 12,846,794 bp
  • A to C, chromosome 7 at 45,352,215 bp
  • T to C, chromosome 7 at 56,146,696 bp
  • T to A, chromosome 7 at 68,740,008 bp
  • A to G, chromosome 7 at 81,077,595 bp
  • A to G, chromosome 8 at 41,411,217 bp
  • T to C, chromosome 8 at 114,712,036 bp
  • T to A, chromosome 9 at 3,759,830 bp
  • A to T, chromosome 9 at 40,006,094 bp
  • A to G, chromosome 9 at 57,545,189 bp
  • A to G, chromosome 9 at 76,167,059 bp
  • A to G, chromosome 9 at 109,007,726 bp
  • A to G, chromosome 10 at 13,008,831 bp
  • C to T, chromosome 10 at 80,544,405 bp
  • T to A, chromosome 10 at 107,886,513 bp
  • A to G, chromosome 11 at 82,922,907 bp
  • A to G, chromosome 11 at 94,645,451 bp
  • G to A, chromosome 11 at 95,749,782 bp
  • A to T, chromosome 11 at 102,605,380 bp
  • G to A, chromosome 11 at 103,828,538 bp
  • G to T, chromosome 11 at 119,274,904 bp
  • A to G, chromosome 13 at 22,006,968 bp
  • G to A, chromosome 13 at 61,002,498 bp
  • A to T, chromosome 13 at 81,531,676 bp
  • T to C, chromosome 14 at 19,415,963 bp
  • T to C, chromosome 16 at 23,492,115 bp
  • C to T, chromosome 16 at 36,033,379 bp
  • C to T, chromosome 16 at 87,474,648 bp
  • ATCTTCT to ATCT, chromosome 17 at 23,359,988 bp
  • C to A, chromosome 17 at 87,680,060 bp
  • T to A, chromosome 19 at 12,934,965 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1146 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039219-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.