Strain Name:
C57BL/6J-MtgxR1217Btlr/Mmmh
Stock Number:
039286-MU
Citation ID:
RRID:MMRRC_039286-MU
Other Names:
R1217 (G1), C57BL/6J-MtgxR1217Btlr
Major Collection:

Gene Information

Fgb
Name: fibrinogen beta chain
Synonyms: 2510049G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 110135
HGNC: HGNC:3662
Homologene: 3772
Adora2a
Name: adenosine A2a receptor
Synonyms: ARA2A, A2a, Rs, AA2AR, A2aR, A2AAR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 11540
VEGA: 10
HGNC: HGNC:263
Homologene: 20166
Slco1a5
Name: solute carrier organic anion transporter family, member 1a5
Synonyms: Oatp3, Slc21a7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 108096
Homologene: 56603
Ash2l
Name: ASH2 like histone lysine methyltransferase complex subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 23808
HGNC: HGNC:744
Homologene: 3436
Dhx9
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 9
Synonyms: RHA, NDHII, Ddx9, leukophysin, nuclear DNA helicase II, RNA helicase, NDH II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13211
HGNC: HGNC:2750
Homologene: 1039
Agpat4
Name: 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
Synonyms: 1500003P24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 68262
Homologene: 69293
Metap1
Name: methionyl aminopeptidase 1
Synonyms: 1700029C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 75624
Homologene: 6488
Mcm5
Name: minichromosome maintenance complex component 5
Synonyms: Cdc46, Mcmd5, mCD46
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17218
HGNC: HGNC:6948
Homologene: 4904
Ccp110
Name: centriolar coiled coil protein 110
Synonyms: CP110, 6330503K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101565
Homologene: 8810
Siva1
Name: SIVA1, apoptosis-inducing factor
Synonyms: CD27bp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 30954
VEGA: 12
Homologene: 4692
Cep170b
Name: centrosomal protein 170B
Synonyms: AW555464
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217882
VEGA: 12
Homologene: 46165
Zswim4
Name: zinc finger SWIM-type containing 4
Synonyms: E130119J17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 212168
Homologene: 18183
Col4a4
Name: collagen, type IV, alpha 4
Synonyms: E130010M05Rik, [a]4(IV)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12829
HGNC: HGNC:2206
Homologene: 20071
Esyt3
Name: extended synaptotagmin-like protein 3
Synonyms: Fam62c, D9Ertd280e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 272636
Homologene: 18626
Trpc6
Name: transient receptor potential cation channel, subfamily C, member 6
Synonyms: Trrp6, mtrp6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22068
VEGA: 9
Homologene: 37944
Aldh1a2
Name: aldehyde dehydrogenase family 1, subfamily A2
Synonyms: Raldh2, Aldh1a7, retinaldehyde dehydrogenase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 19378
Homologene: 68368
Naip2
Name: NLR family, apoptosis inhibitory protein 2
Synonyms: Naip2, Naip-rs6, Birc1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17948
HGNC: HGNC:7634
Homologene: 136092
Cul9
Name: cullin 9
Synonyms: 1810035I07Rik, Parc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 78309
Homologene: 56696
Zfp629
Name: zinc finger protein 629
Synonyms: 9330199A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 320683
Homologene: 65318
Gm8251
Name: predicted gene 8251
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 102636082
VEGA: 1
Homologene: 141149
Vmn2r70
Name: vomeronasal 2, receptor 70
Synonyms: EG620835
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 670940
Homologene: 115466
Capn3
Name: calpain 3
Synonyms: p94, Lp82, Capa3, Capa-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12335
HGNC: HGNC:1480
Homologene: 52
Cdh17
Name: cadherin 17
Synonyms: BILL-cadherin, LI-cadherin, HPT-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 12557
HGNC: HGNC:1756
Homologene: 56859
Myo3b
Name: myosin IIIB
Synonyms: A430065P19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329421
Homologene: 51393
Cmklr1
Name: chemokine-like receptor 1
Synonyms: Gpcr27, ChemR23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 14747
HGNC: HGNC:2121
Homologene: 129967
Edar
Name: ectodysplasin-A receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 13608
HGNC: HGNC:2895
Homologene: 7699
Nlrp4d
Name: NLR family, pyrin domain containing 4D
Synonyms: Nalp-beta, Nalp4d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 384752
Cfap57
Name: cilia and flagella associated protein 57
Synonyms: C130004B06Rik, LOC384050, 1110020C03Rik, Wdr65
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68625
Homologene: 51350
Cyp2d26
Name: cytochrome P450, family 2, subfamily d, polypeptide 26
Synonyms: 1300006E06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 76279
VEGA: 15
Homologene: 130660
Slc22a27
Name: solute carrier family 22, member 27
Synonyms: AB056442, mOAT6 related protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 171405
Homologene: 77136
Kif21b
Name: kinesin family member 21B
Synonyms: 2610511N21Rik, N-5 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16565
Homologene: 56868
Rimbp2
Name: RIMS binding protein 2
Synonyms: A930033C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231760
Homologene: 14672
Asrgl1
Name: asparaginase like 1
Synonyms: ALP1, 2410004D18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 66514
Homologene: 11825
Ipo4
Name: importin 4
Synonyms: 8430408O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 75751
Homologene: 5835
Lmx1a
Name: LIM homeobox transcription factor 1 alpha
Synonyms: Lmx1.1, shaker short-tail
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 110648
HGNC: HGNC:6653
Homologene: 24921
St8sia4
Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
Synonyms: PST-1, PST, ST8SiaIV, Siat8d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20452
Homologene: 4147
Mrgpra4
Name: MAS-related GPR, member A4
Synonyms: MrgA4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 235854
Homologene: 131159
Rec114
Name: REC114 meiotic recombination protein
Synonyms: 4930527A11Rik, 2410076I21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 73673
Homologene: 83546
Foxc1
Name: forkhead box C1
Synonyms: fkh1, Mf4, Mf1, FREAC3, fkh-1, Fkh1, frkhda
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17300
HGNC: HGNC:3800
Homologene: 20373
Cyth3
Name: cytohesin 3
Synonyms: Pscd3, cytohesin 3, Grp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19159
HGNC: HGNC:9504
Homologene: 3116
Tprg
Name: transformation related protein 63 regulated
Synonyms: 5430420C16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 71338
Homologene: 18415
Krt1
Name: keratin 1
Synonyms: Krt-2.1, Krt2-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16678
VEGA: 15
HGNC: HGNC:6412
Homologene: 38146
Mylip
Name: myosin regulatory light chain interacting protein
Synonyms: Idol, Mir, 9430057C20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218203
VEGA: 13
Homologene: 8309
Grid1
Name: glutamate receptor, ionotropic, delta 1
Synonyms: GluRdelta1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 14803
HGNC: HGNC:4575
Homologene: 69017
Ccdc114
Name: coiled-coil domain containing 114
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 211535
Homologene: 128610
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 44,057,179 bp
  • A to T, chromosome 1 at 82,489,009 bp
  • G to A, chromosome 1 at 95,653,739 bp
  • A to G, chromosome 1 at 136,152,376 bp
  • G to A, chromosome 1 at 153,458,363 bp
  • G to A, chromosome 1 at 167,791,399 bp
  • A to C, chromosome 2 at 70,330,880 bp
  • C to A, chromosome 2 at 120,486,421 bp
  • T to C, chromosome 3 at 83,043,257 bp
  • A to T, chromosome 3 at 138,475,030 bp
  • T to C, chromosome 4 at 11,799,676 bp
  • A to G, chromosome 4 at 118,606,652 bp
  • A to T, chromosome 5 at 113,614,046 bp
  • C to T, chromosome 5 at 128,788,287 bp
  • T to C, chromosome 5 at 143,702,820 bp
  • T to A, chromosome 6 at 142,254,374 bp
  • T to C, chromosome 7 at 10,364,267 bp
  • C to T, chromosome 7 at 45,942,758 bp
  • A to G, chromosome 7 at 47,981,337 bp
  • C to T, chromosome 7 at 85,559,061 bp
  • T to C, chromosome 7 at 118,729,944 bp
  • C to T, chromosome 7 at 127,612,744 bp
  • T to C, chromosome 8 at 25,822,885 bp
  • A to G, chromosome 8 at 75,126,291 bp
  • A to G, chromosome 8 at 84,219,972 bp
  • A to G, chromosome 9 at 8,658,286 bp
  • A to T, chromosome 9 at 58,665,820 bp
  • A to G, chromosome 9 at 71,281,682 bp
  • C to T, chromosome 9 at 99,318,044 bp
  • T to C, chromosome 10 at 58,628,631 bp
  • A to T, chromosome 10 at 75,333,215 bp
  • C to T, chromosome 12 at 112,646,921 bp
  • T to C, chromosome 12 at 112,740,905 bp
  • C to A, chromosome 13 at 31,808,685 bp
  • G to A, chromosome 13 at 45,406,702 bp
  • T to C, chromosome 13 at 100,161,854 bp
  • C to T, chromosome 13 at 100,161,860 bp
  • T to C, chromosome 14 at 34,820,229 bp
  • T to C, chromosome 14 at 55,634,359 bp
  • A to G, chromosome 15 at 82,792,867 bp
  • T to C, chromosome 15 at 101,848,981 bp
  • T to C, chromosome 16 at 25,412,843 bp
  • C to T, chromosome 17 at 12,210,316 bp
  • C to G, chromosome 17 at 46,522,175 bp
  • T to A, chromosome 19 at 7,926,668 bp
  • A to T, chromosome 19 at 9,116,500 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1217 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039286-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.