Strain Name:
C57BL/6J-MtgxR1305Btlr/Mmmh
Stock Number:
039371-MU
Citation ID:
RRID:MMRRC_039371-MU
Other Names:
R1305 (G1), C57BL/6J-MtgxR1305Btlr
Major Collection:

Strain Information

Enc1
Name: ectodermal-neural cortex 1
Synonyms: PIG10, Nrpb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 13803
VEGA: 13
HGNC: HGNC:3345
Homologene: 2694
Ppm1a
Name: protein phosphatase 1A, magnesium dependent, alpha isoform
Synonyms: Mpp alpha, 2900017D14Rik, MMPa-2, MPPa-1, 2310003C21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 19042
VEGA: 12
HGNC: HGNC:9275
Homologene: 56428
Pard3
Name: par-3 family cell polarity regulator
Synonyms: ASIP, D8Ertd580e, PAR-3, Par3, Pard3a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 93742
Homologene: 10489
Atxn2
Name: ataxin 2
Synonyms: ATX2, 9630045M23Rik, Sca2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20239
Homologene: 2234
Mark3
Name: MAP/microtubule affinity regulating kinase 3
Synonyms: ETK-1, 1600015G02Rik, A430080F22Rik, C-TAK1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 17169
VEGA: 12
HGNC: HGNC:6897
Homologene: 55653
Mex3c
Name: mex3 RNA binding family member C
Synonyms: BM-013, A130001D14Rik, Rkhd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240396
Homologene: 9601
Snrnp40
Name: small nuclear ribonucleoprotein 40 (U5)
Synonyms: 0610009C03Rik, Wdr57
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66585
Homologene: 3538
Map2
Name: microtubule-associated protein 2
Synonyms: MAP-2, G1-397-34, Mtap2, repro4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17756
HGNC: HGNC:6839
Homologene: 1779
Nid2
Name: nidogen 2
Synonyms: entactin-2, entactin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 18074
VEGA: 14
Homologene: 40575
Bicra
Name: BRD4 interacting chromatin remodeling complex associated protein
Synonyms: Gltscr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243842
HGNC: HGNC:4332
Homologene: 9250
Slc11a2
Name: solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
Synonyms: DMT1, DCT1, van, Nramp2, microcytic anemia, viable anaemia
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18174
Homologene: 55471
Map4k1
Name: mitogen-activated protein kinase kinase kinase kinase 1
Synonyms: Hpk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 26411
HGNC: HGNC:6863
Homologene: 5199
Ifngr1
Name: interferon gamma receptor 1
Synonyms: CD119, Nktar, Ifgr, Ifngr, IFN-gamma R, IFN-gammaR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 15979
HGNC: HGNC:5439
Homologene: 359
Vmn1r124
Name: vomeronasal 1 receptor 124
Synonyms: Gm9500
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 670764
Homologene: 104166
Nwd2
Name: NACHT and WD repeat domain containing 2
Synonyms: B830017A01Rik, 3110047P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 319807
Homologene: 14974
Nme8
Name: NME/NM23 family member 8
Synonyms: 1700056P15Rik, Sptrx-2, Txndc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 73412
Homologene: 9593
Or4p21
Name: olfactory receptor family 4 subfamily P member 21
Synonyms: MOR225-8P, GA_x6K02T2Q125-49934557-49933640, MOR225-8P, MOR225-7P, MOR225-16_p, Olfr1536-ps1, Olfr1182, Gm13757
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258167
Homologene: 86666
Msln
Name: mesothelin
Synonyms: megakaryocyte potentiating factor, MPF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 56047
VEGA: 17
HGNC: HGNC:7371
Homologene: 4249
Or7a37
Name: olfactory receptor family 7 subfamily A member 37
Synonyms: GA_x6K02T2QGN0-2842591-2841662, MOR139-2, Olfr1353
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 259044
HGNC: HGNC:8356
Homologene: 131345
Msl3l2
Name: MSL3 like 2
Synonyms: 1700060H10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 73390
VEGA: 10
Homologene: 128448
Gm9869
Name: predicted gene 9869
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Zfp945
Name: zinc finger protein 945
Synonyms: C730040L01Rik, A630033E08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240041
Homologene: 133214
Zfp827
Name: zinc finger protein 827
Synonyms: 2810449M09Rik, D630040G17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 622675
Homologene: 45622
Rcor3
Name: REST corepressor 3
Synonyms: E130101E15Rik, 4921514E24Rik, C730034D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 214742
Homologene: 135671
Rgs20
Name: regulator of G-protein signaling 20
Synonyms: Rgsz1, 2900073E09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 58175
Homologene: 2745
Ifna2
Name: interferon alpha 2
Synonyms: Ifa2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 15965
Homologene: 68536
Kcnj4
Name: potassium inwardly-rectifying channel, subfamily J, member 4
Synonyms: IRK3, Kir 2.3, MB-IRK3, Kcnf2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16520
VEGA: 15
HGNC: HGNC:6265
Homologene: 3653
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 5,021,039 bp
  • T to A, chromosome 1 at 66,425,395 bp
  • C to T, chromosome 1 at 192,116,346 bp
  • A to T, chromosome 2 at 88,446,302 bp
  • T to C, chromosome 4 at 88,683,377 bp
  • C to G, chromosome 4 at 130,378,043 bp
  • G to T, chromosome 5 at 63,745,197 bp
  • G to A, chromosome 5 at 121,749,184 bp
  • G to T, chromosome 7 at 15,996,395 bp
  • C to A, chromosome 7 at 21,260,263 bp
  • A to T, chromosome 7 at 28,995,465 bp
  • A to G, chromosome 8 at 79,060,894 bp
  • T to A, chromosome 8 at 127,306,410 bp
  • T to C, chromosome 9 at 60,821,886 bp
  • C to T, chromosome 10 at 19,606,253 bp
  • T to C, chromosome 10 at 56,115,535 bp
  • T to C, chromosome 10 at 78,970,099 bp
  • C to A, chromosome 12 at 72,783,720 bp
  • T to A, chromosome 12 at 111,615,446 bp
  • T to A, chromosome 13 at 19,696,907 bp
  • T to C, chromosome 13 at 97,246,700 bp
  • T to C, chromosome 14 at 19,768,862 bp
  • A to T, chromosome 15 at 79,484,819 bp
  • C to A, chromosome 15 at 100,410,082 bp
  • T to C, chromosome 17 at 22,852,386 bp
  • T to C, chromosome 17 at 25,753,027 bp
  • T to A, chromosome 18 at 73,590,235 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1305 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039371-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.