Strain Name:
C57BL/6J-MtgxR1351Btlr/Mmmh
Stock Number:
039416-MU
Citation ID:
RRID:MMRRC_039416-MU
Other Names:
R1351 (G1), C57BL/6J-MtgxR1351Btlr
Major Collection:

Gene Information

Dicer1
Name: dicer 1, ribonuclease type III
Synonyms: Dicer1, D12Ertd7e, 1110006F08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 192119
VEGA: 12
Homologene: 13251
Sema3c
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
Synonyms: 1110036B02Rik, Semae
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20348
Homologene: 36201
Cacna1h
Name: calcium channel, voltage-dependent, T type, alpha 1H subunit
Synonyms: T-type Cav3.2, alpha13.2, Cav3.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 58226
HGNC: HGNC:1395
Homologene: 56913
Orc1
Name: origin recognition complex, subunit 1
Synonyms: MmORC1, Orc1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18392
HGNC: HGNC:8487
Homologene: 31221
Mbtps1
Name: membrane-bound transcription factor peptidase, site 1
Synonyms: 0610038M03Rik, site-1 protease, SKI-1, S1P, subtilisin/kexin isozyme-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 56453
Homologene: 2808
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: DOXNPH, DNAPDcs, DNA-PK, slip, dxnph, XRCC7, DNA-PKcs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Zmym6
Name: zinc finger, MYM-type 6
Synonyms: D4Wsu24e, Zfp258, 9330177P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100177
Homologene: 5186
Eif4g2
Name: eukaryotic translation initiation factor 4, gamma 2
Synonyms: Natm1, Nat1, DAP-5, E130105L11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13690
HGNC: HGNC:3297
Homologene: 37477
Tacc2
Name: transforming, acidic coiled-coil containing protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57752
Homologene: 5087
Hif1a
Name: hypoxia inducible factor 1, alpha subunit
Synonyms: bHLHe78, HIF-1alpha, MOP1, HIF1alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 15251
HGNC: HGNC:4910
Homologene: 1171
Prrc2a
Name: proline-rich coiled-coil 2A
Synonyms: Bat2, Wbp12, G2, Bat-2, 3110039B05Rik, D17H6S51E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 53761
Homologene: 10567
Xdh
Name: xanthine dehydrogenase
Synonyms: Xox-1, xanthine oxidase, XO, Xox1, Xor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22436
VEGA: 17
Homologene: 324
Rif1
Name: replication timing regulatory factor 1
Synonyms: 6530403D07Rik, D2Ertd145e, 5730435J01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 51869
Homologene: 41231
Nuf2
Name: NUF2, NDC80 kinetochore complex component
Synonyms: Nuf2R, Cdca1, 2410003C07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 66977
Homologene: 40205
Rrp1b
Name: ribosomal RNA processing 1 homolog B (S. cerevisiae)
Synonyms: 2600005C20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 72462
Homologene: 57086
Hapln3
Name: hyaluronan and proteoglycan link protein 3
Synonyms: 4930554N11Rik, Lpr3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67666
Homologene: 18654
Car9
Name: carbonic anhydrase 9
Synonyms: MN/CA9, CAIX
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230099
HGNC: HGNC:1383
Homologene: 20325
Tent4b
Name: terminal nucleotidyltransferase 4B
Synonyms: Papd5, 5730445M16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 214627
Homologene: 64245
Fgf3
Name: fibroblast growth factor 3
Synonyms: Fgf-3, Int-P, Int-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14174
HGNC: HGNC:3681
Homologene: 3841
Pgk2
Name: phosphoglycerate kinase 2
Synonyms: Pgk-2, Tcp-2, Tcp-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18663
VEGA: 17
HGNC: HGNC:8898
Homologene: 57138
Pde4d
Name: phosphodiesterase 4D, cAMP specific
Synonyms: Dpde3, dunce, 9630011N22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238871
HGNC: HGNC:8783
Astl
Name: astacin-like metalloendopeptidase (M12 family)
Synonyms: C87576, Sas1b, Ovastacin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 215095
Homologene: 128191
Gprc5d
Name: G protein-coupled receptor, family C, group 5, member D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 93746
Homologene: 10250
Zfyve28
Name: zinc finger, FYVE domain containing 28
Synonyms: 9630058O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231125
Homologene: 15119
Mocos
Name: molybdenum cofactor sulfurase
Synonyms: 1110018O12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 68591
VEGA: 18
Homologene: 9931
Plekhh2
Name: pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 213556
VEGA: 17
Homologene: 35317
Olfr639
Name: olfactory receptor 639
Synonyms: MOR12-1, GA_x6K02T2PBJ9-6747143-6746193
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259088
Homologene: 17497
Zfp608
Name: zinc finger protein 608
Synonyms: 4932417D18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 269023
VEGA: 18
Homologene: 18485
Zfp646
Name: zinc finger protein 646
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233905
Homologene: 8802
Ermap
Name: erythroblast membrane-associated protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 27028
Homologene: 22782
Vmn2r70
Name: vomeronasal 2, receptor 70
Synonyms: EG620835
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 670940
Homologene: 115466
Rbm11
Name: RNA binding motif protein 11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224344
HGNC: HGNC:9897
Homologene: 16988
Cep126
Name: centrosomal protein 126
Synonyms: AK129341
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 234915
VEGA: 9
Homologene: 28313
Pcdhb22
Name: protocadherin beta 22
Synonyms: PcdhbV, Pcdhb15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93893
HGNC: HGNC:8686
Homologene: 113752
Defb26
Name: defensin beta 26
Synonyms: EG654457
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 654457
Homologene: 86850
Sacs
Name: sacsin
Synonyms: E130115J16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 50720
Arhgef26
Name: Rho guanine nucleotide exchange factor (GEF) 26
Synonyms: 8430436L14Rik, 4631416L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 622434
Homologene: 9204
Pou3f2
Name: POU domain, class 3, transcription factor 2
Synonyms: Brn-2, 9430075J19Rik, Otf7, Brn2, A230098E07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18992
HGNC: HGNC:9215
Homologene: 4095
Irf2bpl
Name: interferon regulatory factor 2 binding protein-like
Synonyms: 6430527G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238330
VEGA: 12
Homologene: 11555
Lrrc39
Name: leucine rich repeat containing 39
Synonyms: Myomasp, 2010005E21Rik, 9430028I06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 109245
Homologene: 13668
Spata2l
Name: spermatogenesis associated 2-like
Synonyms: 2610039E05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 78779
Homologene: 32729
Mios
Name: meiosis regulator for oocyte development
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 252875
Homologene: 10371
Trpc4
Name: transient receptor potential cation channel, subfamily C, member 4
Synonyms: Trp4, CCE1, Trrp4, STRPC4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 22066
Homologene: 22955
Cyp2j13
Name: cytochrome P450, family 2, subfamily j, polypeptide 13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230459
Homologene: 138297
Rad18
Name: RAD18 E3 ubiquitin protein ligase
Synonyms: 2810024C04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 58186
Homologene: 48572
Bicdl2
Name: BICD family like cargo adaptor 2
Synonyms: Ccdc64b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 212733
VEGA: 17
Homologene: 17815
Gpr162
Name: G protein-coupled receptor 162
Synonyms: A-2, Grca
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14788
Homologene: 8400
Fcamr
Name: Fc receptor, IgA, IgM, high affinity
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 64435
Homologene: 12929
AW146154
Name: expressed sequence AW146154
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101835
Homologene: 134516
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 130,813,020 bp
  • T to C, chromosome 1 at 169,510,549 bp
  • T to G, chromosome 2 at 52,111,555 bp
  • G to A, chromosome 2 at 127,347,185 bp
  • A to T, chromosome 2 at 152,507,817 bp
  • A to G, chromosome 3 at 54,195,002 bp
  • A to G, chromosome 3 at 62,380,841 bp
  • G to T, chromosome 3 at 116,565,820 bp
  • A to T, chromosome 4 at 22,487,162 bp
  • G to T, chromosome 4 at 43,512,439 bp
  • T to C, chromosome 4 at 96,056,918 bp
  • T to A, chromosome 4 at 108,595,367 bp
  • C to T, chromosome 4 at 119,181,361 bp
  • G to A, chromosome 4 at 127,123,005 bp
  • A to G, chromosome 5 at 17,678,336 bp
  • T to G, chromosome 5 at 34,232,205 bp
  • T to A, chromosome 6 at 8,228,120 bp
  • T to C, chromosome 6 at 112,620,902 bp
  • T to C, chromosome 6 at 124,861,198 bp
  • T to C, chromosome 6 at 135,116,232 bp
  • A to T, chromosome 7 at 41,480,454 bp
  • A to C, chromosome 7 at 79,121,960 bp
  • A to G, chromosome 7 at 85,565,054 bp
  • A to G, chromosome 7 at 104,012,316 bp
  • A to G, chromosome 7 at 111,074,080 bp
  • T to A, chromosome 7 at 127,883,511 bp
  • C to T, chromosome 7 at 130,663,003 bp
  • T to C, chromosome 7 at 144,840,780 bp
  • C to A, chromosome 8 at 88,200,374 bp
  • A to G, chromosome 8 at 119,518,162 bp
  • G to A, chromosome 8 at 123,233,333 bp
  • C to T, chromosome 9 at 8,100,086 bp
  • T to C, chromosome 12 at 73,940,461 bp
  • A to G, chromosome 12 at 86,882,624 bp
  • G to A, chromosome 12 at 104,729,142 bp
  • G to T, chromosome 13 at 109,951,275 bp
  • T to C, chromosome 14 at 61,202,761 bp
  • C to T, chromosome 16 at 15,667,700 bp
  • T to C, chromosome 16 at 75,596,643 bp
  • G to A, chromosome 17 at 23,667,545 bp
  • G to T, chromosome 17 at 25,391,951 bp
  • A to G, chromosome 17 at 32,056,637 bp
  • T to C, chromosome 17 at 35,157,887 bp
  • T to C, chromosome 17 at 40,207,800 bp
  • A to G, chromosome 17 at 73,923,078 bp
  • A to T, chromosome 17 at 84,577,146 bp
  • T to C, chromosome 18 at 24,660,050 bp
  • T to C, chromosome 18 at 37,518,574 bp
  • T to C, chromosome 18 at 54,898,391 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1351 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039416-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.