Strain Name:
C57BL/6J-MtgxR1367Btlr/Mmmh
Stock Number:
039432-MU
Citation ID:
RRID:MMRRC_039432-MU
Other Names:
R1367 (G1), C57BL/6J-MtgxR1367Btlr
Major Collection:

Gene Information

Glrb
Name: glycine receptor, beta subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14658
HGNC: HGNC:4329
Homologene: 20224
Rictor
Name: RPTOR independent companion of MTOR, complex 2
Synonyms: 6030405M08Rik, D530039E11Rik, 4921505C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 78757
VEGA: 15
Homologene: 34317
Tns3
Name: tensin 3
Synonyms: TEM6, F830010I22Rik, Tens1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 319939
Homologene: 49713
Arhgef10
Name: Rho guanine nucleotide exchange factor (GEF) 10
Synonyms: 6430549H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234094
Homologene: 22827
Slc44a2
Name: solute carrier family 44, member 2
Synonyms: 1110028E10Rik, CTL2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 68682
VEGA: 9
Homologene: 10711
Tkfc
Name: triokinase, FMN cyclase
Synonyms: Dak
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 225913
VEGA: 19
Homologene: 56710
Usp48
Name: ubiquitin specific peptidase 48
Synonyms: D330022K21Rik, 2810449C13Rik, Usp31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 170707
Homologene: 12988
Exoc2
Name: exocyst complex component 2
Synonyms: Sec5, 2410030I24Rik, Sec5l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 66482
Homologene: 10122
Cep170
Name: centrosomal protein 170
Synonyms: 4933426L22Rik, A330004A13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 545389
Homologene: 22844
Lgr4
Name: leucine-rich repeat-containing G protein-coupled receptor 4
Synonyms: A930009A08Rik, Gpr48, A330106J01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 107515
Homologene: 10226
Rbm28
Name: RNA binding motif protein 28
Synonyms: 2810480G15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 68272
Homologene: 135952
Acvr1b
Name: activin A receptor, type 1B
Synonyms: ActR-IB, Acvrlk4, SKR2, ActRIB, Alk4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 11479
HGNC: HGNC:172
Homologene: 20906
Pms2
Name: PMS1 homolog2, mismatch repair system component
Synonyms: mismatch repair, DNA mismatch repair
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18861
HGNC: HGNC:9122
Homologene: 133560
Pxk
Name: PX domain containing serine/threonine kinase
Synonyms: C230080L11Rik, D14Ertd813e, MONaKA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218699
VEGA: 14
Homologene: 9828
Adamts12
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239337
VEGA: 15
Homologene: 12808
Gga2
Name: golgi associated, gamma adaptin ear containing, ARF binding protein 2
Synonyms: 1200007E24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74105
Homologene: 22860
Hectd3
Name: HECT domain E3 ubiquitin protein ligase 3
Synonyms: 1700064K09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 76608
Homologene: 18426
Ank1
Name: ankyrin 1, erythroid
Synonyms: Ank-1, pale
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11733
HGNC: HGNC:492
Homologene: 55427
Nek3
Name: NIMA (never in mitosis gene a)-related expressed kinase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 23954
HGNC: HGNC:7746
Homologene: 1869
Nuak1
Name: NUAK family, SNF1-like kinase, 1
Synonyms: B230104P22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 77976
Homologene: 8896
Kif17
Name: kinesin family member 17
Synonyms: N-4 kinesin, 5930435E01Rik, Kif17b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 16559
Homologene: 5883
F3
Name: coagulation factor III
Synonyms: tissue factor, TF, Cf-3, CD142, Cf3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14066
HGNC: HGNC:3541
Homologene: 1511
Vmn2r115
Name: vomeronasal 2, receptor 115
Synonyms: EG638102, V2Rp4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 638102
Homologene: 86604
Nlrp14
Name: NLR family, pyrin domain containing 14
Synonyms: 4921520L01Rik, Nalp14, GC-LRR, Nalp-iota
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76858
Homologene: 18531
Ly75
Name: lymphocyte antigen 75
Synonyms: DEC-205, CD205
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17076
HGNC: HGNC:6729
Homologene: 31085
Mfsd13a
Name: major facilitator superfamily domain containing 13a
Synonyms: 4930449A08Rik, 4930538D17Rik, Tmem180
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 75146
Homologene: 12592
Ugt2b38
Name: UDP glucuronosyltransferase 2 family, polypeptide B38
Synonyms: 9430041C03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100559
Homologene: 137225
Gid8
Name: GID complex subunit 8
Synonyms: 2310003C23Rik, 4833420G11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76425
Homologene: 41207
Fanca
Name: Fanconi anemia, complementation group A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14087
HGNC: HGNC:3582
Homologene: 108
Cd209e
Name: CD209e antigen
Synonyms: SIGNR4, mSIGNR4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 170780
HGNC: HGNC:1641
Homologene: 128353
Cebpz
Name: CCAAT/enhancer binding protein zeta
Synonyms: Cbf, CBF2, Cebpa-rs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12607
VEGA: 17
Homologene: 4210
Nin
Name: ninein
Synonyms: 3110068G20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 18080
Homologene: 40632
Tll2
Name: tolloid-like 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 24087
VEGA: 19
Homologene: 56545
Kif26b
Name: kinesin family member 26B
Synonyms: N-11 kinesin, D230039L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 269152
Homologene: 18623
Zdhhc23
Name: zinc finger, DHHC domain containing 23
Synonyms: LOC332175, LOC385651
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 332175
VEGA: 16
Homologene: 17840
H2-M1
Name: histocompatibility 2, M region locus 1
Synonyms: H-2M1, Mb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224756
Homologene: 110792
Olfr191
Name: olfactory receptor 191
Synonyms: GA_x54KRFPKG5P-55314632-55313703, MOR183-5P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 258035
Homologene: 128162
Slc41a1
Name: solute carrier family 41, member 1
Synonyms: B230315F01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98396
Homologene: 14871
Abcc1
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Synonyms: MRP, Mdrap, Mrp1, Abcc1b, Abcc1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 17250
HGNC: HGNC:51
Homologene: 133779
Rasl10b
Name: RAS-like, family 10, member B
Synonyms: VTS58635, B230331P10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 276952
Homologene: 14108
Prl3b1
Name: prolactin family 3, subfamily b, member 1
Synonyms: Pl-2, Pl2, mplII, PL, prolactin-like, Csh2, mPL-II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18776
Homologene: 7476
Slpi
Name: secretory leukocyte peptidase inhibitor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20568
Homologene: 2305
Insyn1
Name: inhibitory synaptic factor 1
Synonyms: 6030419C18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 319477
VEGA: 9
Homologene: 18538
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 131,844,008 bp
  • A to G, chromosome 1 at 176,735,724 bp
  • A to G, chromosome 1 at 178,916,463 bp
  • A to G, chromosome 2 at 60,293,758 bp
  • C to G, chromosome 2 at 109,991,135 bp
  • A to G, chromosome 2 at 164,354,867 bp
  • A to G, chromosome 2 at 180,713,232 bp
  • A to G, chromosome 3 at 80,862,004 bp
  • A to G, chromosome 3 at 121,729,374 bp
  • G to T, chromosome 4 at 116,997,170 bp
  • T to A, chromosome 4 at 137,639,295 bp
  • T to A, chromosome 4 at 137,644,463 bp
  • C to A, chromosome 4 at 138,277,994 bp
  • A to T, chromosome 5 at 87,424,114 bp
  • G to A, chromosome 5 at 143,925,913 bp
  • A to T, chromosome 6 at 29,137,640 bp
  • A to G, chromosome 7 at 107,182,811 bp
  • G to A, chromosome 7 at 121,998,915 bp
  • T to C, chromosome 8 at 3,849,084 bp
  • T to A, chromosome 8 at 14,940,225 bp
  • T to C, chromosome 8 at 22,160,361 bp
  • T to A, chromosome 8 at 23,111,803 bp
  • G to A, chromosome 8 at 123,304,281 bp
  • T to C, chromosome 9 at 21,343,026 bp
  • G to T, chromosome 9 at 58,498,980 bp
  • C to T, chromosome 10 at 84,392,328 bp
  • T to C, chromosome 11 at 8,448,704 bp
  • G to A, chromosome 11 at 83,417,839 bp
  • A to T, chromosome 12 at 70,043,929 bp
  • G to A, chromosome 13 at 27,243,865 bp
  • A to T, chromosome 13 at 30,882,273 bp
  • T to G, chromosome 14 at 8,150,915 bp
  • T to C, chromosome 15 at 6,790,638 bp
  • T to G, chromosome 15 at 11,256,894 bp
  • T to C, chromosome 15 at 101,193,938 bp
  • T to C, chromosome 16 at 14,443,386 bp
  • A to G, chromosome 16 at 43,974,150 bp
  • T to A, chromosome 16 at 59,086,343 bp
  • ATCTTCT to ATCT, chromosome 17 at 23,359,988 bp
  • A to G, chromosome 17 at 36,671,167 bp
  • A to G, chromosome 17 at 78,923,313 bp
  • A to G, chromosome 19 at 10,593,474 bp
  • G to A, chromosome 19 at 41,120,228 bp
  • C to T, chromosome 19 at 46,366,504 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1367 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039432-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.