Strain Name:
C57BL/6J-MtgxR1417Btlr/Mmmh
Stock Number:
039473-MU
Citation ID:
RRID:MMRRC_039473-MU
Other Names:
R1417 (G1), C57BL/6J-MtgxR1417Btlr
Major Collection:

Gene Information

Mtmr3
Name: myotubularin related protein 3
Synonyms: 1700092A20Rik, ZFYVE10, FYVE-DSP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 74302
HGNC: HGNC:7451
Homologene: 23662
Zfp423
Name: zinc finger protein 423
Synonyms: Zfp104, Roaz, Ebfaz, ataxia1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 94187
Homologene: 9010
Lrp5
Name: low density lipoprotein receptor-related protein 5
Synonyms: LR3, LRP7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 16973
HGNC: HGNC:6697
Homologene: 1746
Stx12
Name: syntaxin 12
Synonyms: syntaxin 13, Stx13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100226
Homologene: 128192
Ipo8
Name: importin 8
Synonyms: C130009K11Rik, Ranbp8, Om1, OM-1, 6230418K12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 320727
HGNC: HGNC:9853
Homologene: 48430
Atp6v1b1
Name: ATPase, H+ transporting, lysosomal V1 subunit B1
Synonyms: D630039P21Rik, D630030L16Rik, Atp6b1, Vpp-3, lysosomal 56/58kDa, Vpp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 110935
HGNC: HGNC:853
Homologene: 68198
Atp13a5
Name: ATPase type 13A5
Synonyms: C630015F21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 268878
Homologene: 77451
Car9
Name: carbonic anhydrase 9
Synonyms: MN/CA9, CAIX
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230099
HGNC: HGNC:1383
Homologene: 20325
Hspg2
Name: perlecan (heparan sulfate proteoglycan 2)
Synonyms: Plc, perlecan, per, Pcn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 15530
HGNC: HGNC:5273
Homologene: 68473
Pfkp
Name: phosphofructokinase, platelet
Synonyms: 9330125N24Rik, PFK-C, 1200015H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 56421
HGNC: HGNC:8878
Homologene: 20579
Edc4
Name: enhancer of mRNA decapping 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234699
Homologene: 40937
Pcdhb16
Name: protocadherin beta 16
Synonyms: PcdhbP, Pcdhb8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93887
HGNC: HGNC:8693
Homologene: 99843
Ift172
Name: intraflagellar transport 172
Synonyms: avc1, 4930553F24Rik, wim
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 67661
Homologene: 15202
Clu
Name: clusterin
Synonyms: Sgp-2, Sugp-2, D14Ucla3, Sgp2, ApoJ, Cli, testosterone repressed prostate message-2, SP-40, complement lysis inhibitor, Apolipoprotein J
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12759
HGNC: HGNC:2095
Homologene: 1382
Usf3
Name: upstream transcription factor family member 3
Synonyms: 5530400K22Rik, Gm608, LOC207806, LOC385650
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 207806
Homologene: 19504
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: diminished cone electroretinogram, D12Ertd777e, Nesp2g, 6820443O06Rik, Cpfl8, dice, nesprin-2, syne-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 319565
Homologene: 56700
Galns
Name: galactosamine (N-acetyl)-6-sulfate sulfatase
Synonyms: N-acetylgalactosamine-6-sulfate sulfatase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 50917
HGNC: HGNC:4122
Homologene: 55468
G6pc2
Name: glucose-6-phosphatase, catalytic, 2
Synonyms: IGRP, islet specific glucose-6-phosphatase, G6pc-rs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14378
Homologene: 41423
Myh8
Name: myosin, heavy polypeptide 8, skeletal muscle, perinatal
Synonyms: Myhs-p, MyHC-pn, Myhsp, 4832426G23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17885
HGNC: HGNC:7578
Homologene: 68256
Dnah9
Name: dynein, axonemal, heavy chain 9
Synonyms: Dnahc9, D11Ertd686e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237806
HGNC: HGNC:2953
Homologene: 20357
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Syt11
Name: synaptotagmin XI
Synonyms: 6530420C11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229521
Homologene: 23120
Ttc21a
Name: tetratricopeptide repeat domain 21A
Synonyms: 4921538N17Rik, Thm2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74052
Homologene: 14728
Slc8a1
Name: solute carrier family 8 (sodium/calcium exchanger), member 1
Synonyms: D930008O12Rik, Ncx1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20541
VEGA: 17
Homologene: 69090
Kmt2d
Name: lysine (K)-specific methyltransferase 2D
Synonyms: Mll2, C430014K11Rik, Mll4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 381022
HGNC: HGNC:7133
Homologene: 86893
Phlpp2
Name: PH domain and leucine rich repeat protein phosphatase 2
Synonyms: Phlppl, C130044A18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244650
Homologene: 71015
Lrrtm2
Name: leucine rich repeat transmembrane neuronal 2
Synonyms: C630011A14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 107065
VEGA: 18
Homologene: 65342
Zkscan16
Name: zinc finger with KRAB and SCAN domains 16
Synonyms: Zfp483
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100041581
Homologene: 26419
Cnnm1
Name: cyclin M1
Synonyms: Acdp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 83674
VEGA: 19
HGNC: HGNC:102
Homologene: 10673
Xylb
Name: xylulokinase homolog (H. influenzae)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 102448
VEGA: 9
Homologene: 3746
Gm12185
Name: predicted gene 12185
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 620913
Homologene: 83188
Klhl11
Name: kelch-like 11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217194
Homologene: 10030
Prss23
Name: protease, serine 23
Synonyms: 2310046G15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76453
Homologene: 5191
Ces1a
Name: carboxylesterase 1A
Synonyms: Gm4976
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244595
HGNC: HGNC:1863
Homologene: 134142
Gm6994
Name: predicted gene 6994
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 629678
Olfr722
Name: olfactory receptor 722
Synonyms: GA_x6K02T2PMLR-5566715-5565789, MOR241-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258487
Homologene: 17270
Hbq1a
Name: hemoglobin, theta 1A
Synonyms: LOC380691, A230090E05Rik, Hbq1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216635
HGNC: HGNC:4833
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 2 at 41,004,641 bp
  • T to C, chromosome 2 at 69,222,968 bp
  • A to T, chromosome 3 at 88,761,982 bp
  • G to T, chromosome 4 at 43,512,439 bp
  • T to C, chromosome 4 at 58,952,377 bp
  • A to G, chromosome 4 at 132,860,542 bp
  • A to G, chromosome 4 at 137,517,636 bp
  • T to C, chromosome 5 at 31,256,649 bp
  • T to C, chromosome 6 at 83,753,880 bp
  • C to T, chromosome 6 at 148,818,052 bp
  • T to A, chromosome 7 at 89,510,184 bp
  • T to C, chromosome 8 at 87,773,656 bp
  • C to T, chromosome 8 at 93,022,416 bp
  • G to A, chromosome 8 at 105,887,855 bp
  • G to T, chromosome 8 at 109,940,681 bp
  • T to C, chromosome 8 at 122,584,913 bp
  • A to G, chromosome 9 at 119,364,540 bp
  • A to G, chromosome 9 at 119,954,261 bp
  • C to A, chromosome 11 at 4,487,923 bp
  • A to G, chromosome 11 at 32,300,722 bp
  • A to C, chromosome 11 at 48,907,842 bp
  • T to C, chromosome 11 at 65,955,747 bp
  • A to G, chromosome 11 at 67,306,185 bp
  • T to C, chromosome 11 at 100,472,289 bp
  • A to G, chromosome 12 at 76,029,795 bp
  • T to C, chromosome 13 at 6,605,719 bp
  • T to A, chromosome 14 at 49,895,563 bp
  • T to A, chromosome 14 at 65,974,971 bp
  • C to T, chromosome 14 at 77,486,005 bp
  • A to T, chromosome 15 at 98,866,430 bp
  • A to G, chromosome 16 at 29,298,235 bp
  • A to G, chromosome 16 at 44,217,449 bp
  • T to G, chromosome 17 at 81,408,280 bp
  • A to T, chromosome 18 at 35,213,958 bp
  • A to G, chromosome 18 at 37,478,127 bp
  • A to G, chromosome 19 at 3,586,425 bp
  • A to G, chromosome 19 at 43,469,723 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1417 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039473-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.