Strain Name:
C57BL/6J-MtgxR1590Btlr/Mmmh
Stock Number:
039627-MU
Citation ID:
RRID:MMRRC_039627-MU
Other Names:
R1590 (G1), C57BL/6J-MtgxR1590Btlr
Major Collection:

Gene Information

Nfat5
Name: nuclear factor of activated T cells 5
Synonyms: nfatz, TonEBP, B130038B15Rik, OREBP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 54446
HGNC: HGNC:7774
Homologene: 4811
Pygb
Name: brain glycogen phosphorylase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 110078
HGNC: HGNC:9723
Homologene: 100930
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: Megalin, Gp330, D230004K18Rik, b2b1625.2Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Cdc42ep4
Name: CDC42 effector protein (Rho GTPase binding) 4
Synonyms: CEP4, Borg4, 1500041M20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 56699
Homologene: 8110
Ulk1
Name: unc-51 like kinase 1
Synonyms: Unc51.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22241
Homologene: 2640
Prtg
Name: protogenin
Synonyms: A230098A12Rik, Igdcc5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235472
Homologene: 54453
Ipo11
Name: importin 11
Synonyms: E330021B14Rik, 1700081H05Rik, 2510001A17Rik, Ranbp11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 76582
Homologene: 7089
Eprs
Name: glutamyl-prolyl-tRNA synthetase
Synonyms: 2410081F06Rik, 3010002K18Rik, Qprs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 107508
HGNC: HGNC:3418
Homologene: 5870
Septin7
Name: septin 7
Synonyms: Cdc10, Sept7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235072
VEGA: 9
HGNC: HGNC:1717
Homologene: 1354
Sbno1
Name: strawberry notch 1
Synonyms: sno, 9330180L10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 243272
Homologene: 10055
Gtf3c1
Name: general transcription factor III C 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233863
HGNC: HGNC:4664
Homologene: 31040
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: D130015N03Rik, 2810449H11Rik, tbl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Ipo8
Name: importin 8
Synonyms: OM-1, 6230418K12Rik, Om1, C130009K11Rik, Ranbp8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 320727
HGNC: HGNC:9853
Homologene: 48430
Dact1
Name: dishevelled-binding antagonist of beta-catenin 1
Synonyms: THYEX3, Frd1, Frodo, Frodo1, Dapper1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 59036
Homologene: 9613
Sh3d19
Name: SH3 domain protein D19
Synonyms: Kryn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 27059
Homologene: 19064
Mcm3ap
Name: minichromosome maintenance complex component 3 associated protein
Synonyms: GANP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 54387
VEGA: 10
HGNC: HGNC:6946
Homologene: 2902
Ckmt1
Name: creatine kinase, mitochondrial 1, ubiquitous
Synonyms: Mt-CK, mi-CK, UbCKmit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12716
Homologene: 69058
Lamc1
Name: laminin, gamma 1
Synonyms: Lamb2, laminin B2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226519
HGNC: HGNC:6492
Homologene: 1724
Slf2
Name: SMC5-SMC6 complex localization factor 2
Synonyms: 6030443O07Rik, Fam178a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226151
VEGA: 19
Homologene: 23077
Aamp
Name: angio-associated migratory protein
Synonyms: Aamp-rs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227290
HGNC: HGNC:18
Homologene: 846
Atp1b3
Name: ATPase, Na+/K+ transporting, beta 3 polypeptide
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 11933
HGNC: HGNC:806
Homologene: 37510
Atp12a
Name: ATPase, H+/K+ transporting, nongastric, alpha polypeptide
Synonyms: HKalpha2, cHKA, Atp1al1, ATPase H+K+-transporting, alpha 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 192113
VEGA: 14
Homologene: 68197
Abcb4
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 4
Synonyms: mdr-2, Mdr2, Pgy-2, Pgy2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18670
HGNC: HGNC:45
Homologene: 136368
Dnah2
Name: dynein, axonemal, heavy chain 2
Synonyms: D330014H01Rik, 2900022L05Rik, Dnhd3, Dnahc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 327954
HGNC: HGNC:2948
Homologene: 72110
Klhl1
Name: kelch-like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 93688
HGNC: HGNC:6352
Homologene: 56903
Vmn2r103
Name: vomeronasal 2, receptor 103
Synonyms: EG627636
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 627636
Homologene: 115024
Tpgs2
Name: tubulin polyglutamylase complex subunit 2
Synonyms: 5730437P09Rik, 5730494M16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 66648
Homologene: 9161
Mag
Name: myelin-associated glycoprotein
Synonyms: Gma, siglec-4a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17136
HGNC: HGNC:6783
Homologene: 1771
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241516
Homologene: 110349
Gm6614
Name: predicted gene 6614
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 625716
Homologene: 87075
Vwa8
Name: von Willebrand factor A domain containing 8
Synonyms: 4932416F07Rik, 1300010F03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219189
VEGA: 14
Homologene: 44881
Vmn2r84
Name: vomeronasal 2, receptor 84
Synonyms: EG625068
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 625068
Homologene: 129606
Mrps2
Name: mitochondrial ribosomal protein S2
Synonyms: 1500019M10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 118451
Homologene: 99837
Parp2
Name: poly (ADP-ribose) polymerase family, member 2
Synonyms: PARP-2, C78626, Adprt2, Aspartl2, Adprtl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 11546
VEGA: 14
HGNC: HGNC:272
Homologene: 4004
Samd9l
Name: sterile alpha motif domain containing 9-like
Synonyms: ESTM25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 209086
HGNC: HGNC:1349
Homologene: 7707
Brme1
Name: break repair meiotic recombinase recruitment factor 1
Synonyms: Meiok21, 4930432K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74666
Homologene: 11525
Nnt
Name: nicotinamide nucleotide transhydrogenase
Synonyms: 4930423F13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18115
HGNC: HGNC:7863
Efcab14
Name: EF-hand calcium binding domain 14
Synonyms: 4732418C07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230648
Homologene: 8858
Cabs1
Name: calcium binding protein, spermatid specific 1
Synonyms: 4931407G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 70977
Homologene: 13225
Itga10
Name: integrin, alpha 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 213119
HGNC: HGNC:6135
Homologene: 2697
Hip1r
Name: huntingtin interacting protein 1 related
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 29816
Homologene: 78348
Prdm9
Name: PR domain containing 9
Synonyms: Meisetz, G1-419-29, repro7, Dsbc1, Rcr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 213389
Homologene: 104139
Mpl
Name: myeloproliferative leukemia virus oncogene
Synonyms: c-mpl, thrombopoietin receptor, TPO-R, CD110, c-mpl-II, c-mpl-I, hlb219
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 17480
HGNC: HGNC:7217
Homologene: 7845
Tmbim7
Name: transmembrane BAX inhibitor motif containing 7
Synonyms: 4930403J02Rik, 4930500J03Rik, 4930511M11Rik, Lfg5, Tmbim1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 75010
Homologene: 81927
Myo18b
Name: myosin XVIIIb
Synonyms: 4932408L24Rik, 4933411E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 74376
Homologene: 53435
Vmn2r112
Name: vomeronasal 2, receptor 112
Synonyms: EG628185
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 628185
Homologene: 86604
Mcmdc2
Name: minichromosome maintenance domain containing 2
Synonyms: 6030422M02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240697
Homologene: 18309
Ankmy1
Name: ankyrin repeat and MYND domain containing 1
Synonyms: 4930483I10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241158
Homologene: 9561
B3galt4
Name: UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
Synonyms: Gal-T2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 54218
HGNC: HGNC:919
Homologene: 2805
Ecm1
Name: extracellular matrix protein 1
Synonyms: p85
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 13601
HGNC: HGNC:3153
Homologene: 3260
Ccdc68
Name: coiled-coil domain containing 68
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 381175
Homologene: 11880
Vmn1r237
Name: vomeronasal 1 receptor 237
Synonyms: V1rf3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 171234
Homologene: 64475
Btnl2
Name: butyrophilin-like 2
Synonyms: butyrophylin-like MHC class II associated, BTL-II, NG9, BTLN2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 547431
HGNC: HGNC:1142
Homologene: 10482
Olfr146
Name: olfactory receptor 146
Synonyms: M15, MOR171-10, GA_x6K02T2PVTD-32715386-32714466
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258742
VEGA: 9
Uba1y
Name: ubiquitin-activating enzyme, Chr Y
Synonyms: Sby, Ube-2, A1s9Y-1, Ube1y-1, Ube1y1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
NCBI: 22202
Homologene: 129435
Olfr437
Name: olfactory receptor 437
Synonyms: GA_x6K02T2P3E9-4391088-4390156, MOR261-11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 258293
Homologene: 122778
Esp36
Name: exocrine gland secreted peptide 36
Synonyms: Gm20408
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 100126765
Fpr-rs7
Name: formyl peptide receptor, related sequence 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 321021
Gimap7
Name: GTPase, IMAP family member 7
Synonyms: IAN7, Ian3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 231932
Homologene: 134307
Slc25a44
Name: solute carrier family 25, member 44
Synonyms: B430110G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229517
Homologene: 14000
Semg1
Name: semenogelin 1
Synonyms: semenoclotin, SVS II, Svs2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 53878
Homologene: 49325
Olfr12
Name: olfactory receptor 12
Synonyms: MOR208-5, GA_x6K02T2R7CC-81134096-81133095
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 257890
Homologene: 114777
Pick1
Name: protein interacting with C kinase 1
Synonyms: Prkcabp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18693
HGNC: HGNC:9394
Homologene: 7470
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 9,916,555 bp
  • A to G, chromosome 1 at 74,283,211 bp
  • G to A, chromosome 1 at 92,620,745 bp
  • T to C, chromosome 1 at 92,888,675 bp
  • A to C, chromosome 1 at 153,226,557 bp
  • A to G, chromosome 1 at 185,401,510 bp
  • C to T, chromosome 2 at 28,469,488 bp
  • A to G, chromosome 2 at 69,466,763 bp
  • A to T, chromosome 2 at 82,982,787 bp
  • G to A, chromosome 2 at 121,363,522 bp
  • A to G, chromosome 2 at 150,817,663 bp
  • A to G, chromosome 2 at 164,237,658 bp
  • A to G, chromosome 3 at 86,123,794 bp
  • A to G, chromosome 3 at 88,416,007 bp
  • G to A, chromosome 3 at 95,735,963 bp
  • C to T, chromosome 3 at 96,651,738 bp
  • A to G, chromosome 4 at 115,756,549 bp
  • A to C, chromosome 4 at 118,444,024 bp
  • G to T, chromosome 5 at 3,665,338 bp
  • G to T, chromosome 5 at 8,941,124 bp
  • A to T, chromosome 5 at 87,979,631 bp
  • A to G, chromosome 5 at 110,795,766 bp
  • G to A, chromosome 5 at 112,875,266 bp
  • A to G, chromosome 5 at 124,002,140 bp
  • A to C, chromosome 5 at 124,384,504 bp
  • C to A, chromosome 6 at 3,375,761 bp
  • A to G, chromosome 6 at 43,167,912 bp
  • G to A, chromosome 6 at 48,724,019 bp
  • C to T, chromosome 6 at 141,980,872 bp
  • T to C, chromosome 6 at 148,810,665 bp
  • T to C, chromosome 7 at 30,901,852 bp
  • T to C, chromosome 7 at 125,676,661 bp
  • A to T, chromosome 8 at 84,167,086 bp
  • A to G, chromosome 8 at 107,293,890 bp
  • C to T, chromosome 9 at 25,277,604 bp
  • T to C, chromosome 9 at 39,018,957 bp
  • T to A, chromosome 9 at 66,491,953 bp
  • T to A, chromosome 9 at 72,842,807 bp
  • T to C, chromosome 9 at 96,343,349 bp
  • T to A, chromosome 10 at 76,496,541 bp
  • T to C, chromosome 10 at 130,391,480 bp
  • A to G, chromosome 11 at 69,422,754 bp
  • T to C, chromosome 11 at 69,521,198 bp
  • T to C, chromosome 11 at 113,728,566 bp
  • G to T, chromosome 12 at 71,317,575 bp
  • T to C, chromosome 13 at 106,886,717 bp
  • T to A, chromosome 13 at 119,386,661 bp
  • C to T, chromosome 14 at 50,810,544 bp
  • T to C, chromosome 14 at 56,380,055 bp
  • C to T, chromosome 14 at 78,908,230 bp
  • A to T, chromosome 14 at 96,368,636 bp
  • C to T, chromosome 15 at 79,245,301 bp
  • A to G, chromosome 17 at 15,554,767 bp
  • G to T, chromosome 17 at 19,794,234 bp
  • T to C, chromosome 17 at 20,113,416 bp
  • T to A, chromosome 17 at 21,314,039 bp
  • T to C, chromosome 17 at 22,615,008 bp
  • G to A, chromosome 17 at 33,950,839 bp
  • A to T, chromosome 17 at 34,361,140 bp
  • T to A, chromosome 17 at 38,417,311 bp
  • T to C, chromosome 18 at 25,140,573 bp
  • T to A, chromosome 18 at 69,940,180 bp
  • G to T, chromosome 19 at 44,942,073 bp
  • T to A, chromosome Y at 826,893 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1590 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039627-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.