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Strain Name:
C57BL/6J-MtgxR1605Btlr/Mmmh
Stock Number:
039642-MU
Citation ID:
RRID:MMRRC_039642-MU
Other Names:
R1605 (G1), C57BL/6J-MtgxR1605Btlr
Major Collection:

Strain Information

Pkd1
Name: polycystin 1, transient receptor potential channel interacting
Synonyms: polycystin-1, PC1, PC-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18763
VEGA: 17
HGNC: HGNC:9008
Homologene: 250
Chd7
Name: chromodomain helicase DNA binding protein 7
Synonyms: GENA 60, GENA 47, Gena 52, Cyn, A730019I05Rik, WBE1, Whi, Todo, Obt, Mt, Lda, Flo, Edy, Dz, Cycn
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320790
Homologene: 19067
St3gal5
Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 5
Synonyms: ST3Gal V, mST3Gal V, GM3-specific sialytransferase, GM3 synthase, [a]2, 3S-T, Siat9
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20454
Homologene: 2893
Ptpn14
Name: protein tyrosine phosphatase, non-receptor type 14
Synonyms: PTP36, C130080N23Rik, OTTMUSG00000022087
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19250
HGNC: HGNC:9647
Homologene: 3941
Gli2
Name: GLI-Kruppel family member GLI2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14633
HGNC: HGNC:4318
Homologene: 12725
Acot7
Name: acyl-CoA thioesterase 7
Synonyms: 2410041A17Rik, Bach, AU014716
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 70025
Homologene: 15780
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 26,684,430 bp
  • A to G, chromosome 1 at 39,391,125 bp
  • A to G, chromosome 1 at 54,828,622 bp
  • G to T, chromosome 1 at 74,493,004 bp
  • G to A, chromosome 1 at 118,854,560 bp
  • A to G, chromosome 1 at 189,865,512 bp
  • A to G, chromosome 2 at 104,255,570 bp
  • G to C, chromosome 2 at 164,507,499 bp
  • G to A, chromosome 3 at 114,131,641 bp
  • G to A, chromosome 4 at 8,844,675 bp
  • A to T, chromosome 4 at 92,144,740 bp
  • T to A, chromosome 4 at 94,928,350 bp
  • C to A, chromosome 4 at 107,368,096 bp
  • A to G, chromosome 4 at 126,612,311 bp
  • A to G, chromosome 4 at 152,206,828 bp
  • A to C, chromosome 5 at 30,166,656 bp
  • G to A, chromosome 5 at 34,674,557 bp
  • A to C, chromosome 5 at 112,475,049 bp
  • A to T, chromosome 5 at 137,985,164 bp
  • A to G, chromosome 5 at 139,761,456 bp
  • A to G, chromosome 5 at 147,189,928 bp
  • T to G, chromosome 6 at 66,636,948 bp
  • T to C, chromosome 6 at 72,142,288 bp
  • T to C, chromosome 6 at 84,106,941 bp
  • A to G, chromosome 6 at 96,164,812 bp
  • T to C, chromosome 6 at 108,349,659 bp
  • T to A, chromosome 7 at 4,151,396 bp
  • T to A, chromosome 7 at 19,000,993 bp
  • T to A, chromosome 7 at 24,104,624 bp
  • C to T, chromosome 7 at 26,686,418 bp
  • C to A, chromosome 7 at 79,771,509 bp
  • T to C, chromosome 7 at 103,716,651 bp
  • G to T, chromosome 7 at 127,880,187 bp
  • G to T, chromosome 7 at 142,211,866 bp
  • A to T, chromosome 8 at 13,393,489 bp
  • T to A, chromosome 8 at 45,241,580 bp
  • T to A, chromosome 8 at 63,328,849 bp
  • T to C, chromosome 9 at 6,266,012 bp
  • T to C, chromosome 9 at 52,063,591 bp
  • A to T, chromosome 9 at 58,151,883 bp
  • T to C, chromosome 9 at 72,611,789 bp
  • G to A, chromosome 9 at 81,927,586 bp
  • T to A, chromosome 9 at 95,936,463 bp
  • C to T, chromosome 10 at 81,499,391 bp
  • G to A, chromosome 10 at 108,274,200 bp
  • T to C, chromosome 11 at 67,301,671 bp
  • T to A, chromosome 11 at 75,633,481 bp
  • A to T, chromosome 11 at 78,508,326 bp
  • A to C, chromosome 11 at 79,440,923 bp
  • A to G, chromosome 11 at 88,076,299 bp
  • G to A, chromosome 11 at 94,048,539 bp
  • A to T, chromosome 11 at 98,666,493 bp
  • C to A, chromosome 13 at 21,366,643 bp
  • T to C, chromosome 13 at 33,038,129 bp
  • T to A, chromosome 13 at 33,093,663 bp
  • T to C, chromosome 13 at 49,060,894 bp
  • C to A, chromosome 13 at 50,469,919 bp
  • T to C, chromosome 13 at 92,300,275 bp
  • T to C, chromosome 13 at 114,824,584 bp
  • G to A, chromosome 13 at 119,768,780 bp
  • G to T, chromosome 14 at 56,493,365 bp
  • C to T, chromosome 14 at 75,337,483 bp
  • T to G, chromosome 15 at 3,298,121 bp
  • G to A, chromosome 15 at 4,945,090 bp
  • A to G, chromosome 15 at 58,872,915 bp
  • A to G, chromosome 15 at 58,921,190 bp
  • A to G, chromosome 16 at 9,663,330 bp
  • A to G, chromosome 16 at 37,208,111 bp
  • A to G, chromosome 16 at 45,770,779 bp
  • T to C, chromosome 16 at 91,657,664 bp
  • T to C, chromosome 16 at 97,839,306 bp
  • T to C, chromosome 17 at 24,577,526 bp
  • A to G, chromosome 17 at 78,492,108 bp
  • T to A, chromosome 19 at 6,850,469 bp
  • A to G, chromosome 19 at 13,585,630 bp
  • C to A, chromosome 19 at 38,141,492 bp
  • G to T, chromosome X at 161,231,446 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1605 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039642-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.