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Strain Name:
C57BL/6J-MtgxR1688Btlr/Mmmh
Stock Number:
039721-MU
Citation ID:
RRID:MMRRC_039721-MU
Other Names:
R1688 (G1), C57BL/6J-MtgxR1688Btlr
Major Collection:

Strain Information

Aggf1
Name: angiogenic factor with G patch and FHA domains 1
Synonyms: 2310029P06Rik, VG5Q, 2010009L17Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66549
Homologene: 41220
Igfbp2
Name: insulin-like growth factor binding protein 2
Synonyms: IGFBP-2, Igfbp-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16008
HGNC: HGNC:5471
Homologene: 499
Cacna1g
Name: calcium channel, voltage-dependent, T type, alpha 1G subunit
Synonyms: a1G, Cav3.1d
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12291
HGNC: HGNC:1394
Homologene: 22544
Scn3a
Name: sodium channel, voltage-gated, type III, alpha
Synonyms: LOC381367, Nav1.3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20269
Homologene: 56005
Prrc1
Name: proline-rich coiled-coil 1
Synonyms: 2310058D16Rik, 9430085A19Rik, 3110038B19Rik, 1190002C06Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 73137
VEGA: 18
Homologene: 12491
Ewsr1
Name: Ewing sarcoma breakpoint region 1
Synonyms: Ews
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14030
HGNC: HGNC:3508
Homologene: 134632
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 10,083,487 bp
  • T to C, chromosome 1 at 69,542,280 bp
  • T to C, chromosome 1 at 72,824,966 bp
  • A to G, chromosome 1 at 91,423,829 bp
  • C to T, chromosome 1 at 153,804,676 bp
  • C to T, chromosome 1 at 156,293,392 bp
  • T to C, chromosome 1 at 185,384,896 bp
  • T to C, chromosome 2 at 35,795,379 bp
  • A to G, chromosome 2 at 65,529,489 bp
  • A to G, chromosome 2 at 87,002,386 bp
  • C to T, chromosome 2 at 181,087,033 bp
  • A to G, chromosome 3 at 88,640,300 bp
  • T to C, chromosome 3 at 103,060,373 bp
  • A to T, chromosome 3 at 135,301,638 bp
  • G to T, chromosome 4 at 75,982,684 bp
  • T to A, chromosome 4 at 118,569,646 bp
  • T to C, chromosome 4 at 131,787,345 bp
  • T to C, chromosome 5 at 14,788,493 bp
  • T to A, chromosome 5 at 110,129,041 bp
  • A to T, chromosome 6 at 71,857,011 bp
  • A to G, chromosome 6 at 128,357,934 bp
  • T to A, chromosome 7 at 43,945,805 bp
  • T to C, chromosome 7 at 48,803,071 bp
  • T to A, chromosome 7 at 100,938,384 bp
  • A to G, chromosome 8 at 33,615,452 bp
  • T to C, chromosome 8 at 53,601,034 bp
  • G to A, chromosome 8 at 70,819,402 bp
  • A to G, chromosome 8 at 109,623,818 bp
  • A to T, chromosome 8 at 110,632,631 bp
  • T to A, chromosome 9 at 3,382,765 bp
  • T to C, chromosome 9 at 52,060,911 bp
  • T to A, chromosome 9 at 78,705,091 bp
  • T to C, chromosome 9 at 82,871,657 bp
  • T to C, chromosome 9 at 104,003,124 bp
  • T to C, chromosome 9 at 106,461,334 bp
  • G to A, chromosome 10 at 10,350,317 bp
  • A to T, chromosome 10 at 23,123,861 bp
  • A to T, chromosome 10 at 43,973,798 bp
  • A to G, chromosome 10 at 80,029,095 bp
  • G to T, chromosome 11 at 5,072,870 bp
  • T to C, chromosome 11 at 46,479,364 bp
  • T to C, chromosome 11 at 69,189,906 bp
  • T to C, chromosome 11 at 84,084,759 bp
  • T to G, chromosome 11 at 84,238,896 bp
  • T to A, chromosome 11 at 94,425,953 bp
  • A to G, chromosome 11 at 120,442,782 bp
  • A to C, chromosome 12 at 24,251,919 bp
  • A to T, chromosome 12 at 71,947,046 bp
  • A to T, chromosome 12 at 104,118,643 bp
  • A to G, chromosome 12 at 112,920,218 bp
  • A to T, chromosome 13 at 21,520,154 bp
  • A to G, chromosome 13 at 41,046,341 bp
  • T to C, chromosome 13 at 48,586,224 bp
  • T to A, chromosome 13 at 59,715,460 bp
  • T to C, chromosome 13 at 60,854,881 bp
  • T to C, chromosome 13 at 95,364,767 bp
  • A to G, chromosome 14 at 49,080,834 bp
  • A to T, chromosome 14 at 50,643,248 bp
  • A to G, chromosome 14 at 79,201,103 bp
  • T to C, chromosome 15 at 8,228,609 bp
  • A to G, chromosome 15 at 27,557,234 bp
  • C to T, chromosome 15 at 32,669,424 bp
  • T to C, chromosome 15 at 95,431,613 bp
  • T to C, chromosome 16 at 65,551,036 bp
  • A to T, chromosome 17 at 12,433,807 bp
  • C to T, chromosome 17 at 26,118,908 bp
  • T to A, chromosome 17 at 56,109,363 bp
  • T to A, chromosome 18 at 19,966,227 bp
  • T to C, chromosome 18 at 32,419,935 bp
  • G to A, chromosome 18 at 32,424,972 bp
  • A to T, chromosome 18 at 57,363,064 bp
  • T to A, chromosome 18 at 68,408,019 bp
  • T to G, chromosome 19 at 39,994,443 bp
  • G to A, chromosome X at 101,655,690 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1688 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039721-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.