Strain Name:
C57BL/6J-MtgxR2089Btlr/Mmmh
Stock Number:
040094-MU
Citation ID:
RRID:MMRRC_040094-MU
Other Names:
R2089 (G1), C57BL/6J-MtgxR2089Btlr
Major Collection:

Gene Information

Rest
Name: RE1-silencing transcription factor
Synonyms: 2610008J04Rik, NRSF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19712
HGNC: HGNC:9966
Homologene: 4099
Ntrk2
Name: neurotrophic tyrosine kinase, receptor, type 2
Synonyms: trkB, C030027L06Rik, Tkrb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18212
VEGA: 13
HGNC: HGNC:8032
Homologene: 4504
Gpr37
Name: G protein-coupled receptor 37
Synonyms: Pael-R, parkin-associated endothelin B-like receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14763
HGNC: HGNC:4494
Homologene: 3875
Pik3cd
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
Synonyms: p110delta, 2410099E07Rik, 2610208K16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18707
HGNC: HGNC:8977
Homologene: 3686
Suclg1
Name: succinate-CoA ligase, GDP-forming, alpha subunit
Synonyms: Sucla1, 1500000I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 56451
Homologene: 55785
Tnrc6a
Name: trinucleotide repeat containing 6a
Synonyms: CAGH26, 3110054G10Rik, D130023A07Rik, 2010321I05Rik, Tnrc6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233833
Homologene: 41399
Dido1
Name: death inducer-obliterator 1
Synonyms: DIO-1, 6720461J16Rik, D130048F08Rik, Datf1, dido, C130092D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 23856
HGNC: HGNC:2680
Homologene: 34139
Atg14
Name: autophagy related 14
Synonyms: D14Ertd114e, D14Ertd436e, Barkor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 100504663
VEGA: 14
Homologene: 45423
Ccdc93
Name: coiled-coil domain containing 93
Synonyms: 9230102M16Rik, 4633402D15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 70829
Homologene: 10393
Nfx1
Name: nuclear transcription factor, X-box binding 1
Synonyms: TEG-42, 3000003M19Rik, 1300017N15Rik, Tex42
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74164
HGNC: HGNC:7803
Homologene: 1875
Hat1
Name: histone aminotransferase 1
Synonyms: 2410071B14Rik, KAT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 107435
HGNC: HGNC:4821
Homologene: 2701
4932438A13Rik
Name: RIKEN cDNA 4932438A13 gene
Synonyms: Tweek, FSA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229227
Homologene: 52105
Prom1
Name: prominin 1
Synonyms: AC133, CD133, Prom, 4932416E19Rik, Prom-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19126
HGNC: HGNC:9454
Homologene: 4390
Mars1
Name: methionine-tRNA synthetase 1
Synonyms: MetRS, methionine tRNA ligase, methionyl-tRNA synthetase, Mars
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216443
HGNC: HGNC:6898
Homologene: 90878
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Adgrl1
Name: adhesion G protein-coupled receptor L1
Synonyms: Lec2, lectomedin-2, 2900070I05Rik, Lphn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 330814
Homologene: 8951
Dab1
Name: disabled 1
Synonyms: C630028C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 13131
HGNC: HGNC:2661
Homologene: 32084
Micu3
Name: mitochondrial calcium uptake family, member 3
Synonyms: 2900075B16Rik, Efha2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 78506
Homologene: 15058
Nrros
Name: negative regulator of reactive oxygen species
Synonyms: E430025L02Rik, Lrrc33
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224109
Homologene: 17134
Lrrc4
Name: leucine rich repeat containing 4
Synonyms: Nag14, NGL-2, NGL2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 192198
Homologene: 36403
Trap1
Name: TNF receptor-associated protein 1
Synonyms: HSP75, 2410002K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 68015
Homologene: 9457
Pcdhb18
Name: protocadherin beta 18
Synonyms: Pcdhb9, PcdhbR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93889
Homologene: 137649
Nbas
Name: neuroblastoma amplified sequence
Synonyms: 4933425L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 71169
VEGA: 12
Homologene: 41073
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: calcium release channel isoform 1, Ryr, skrr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20190
Homologene: 68069
Bicdl1
Name: BICD family like cargo adaptor 1
Synonyms: 2210403N09Rik, BICDR-1, Ccdc64
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 75665
Homologene: 18013
Agbl1
Name: ATP/GTP binding protein-like 1
Synonyms: Nna1-l1, EG244071, Ccp4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244071
Homologene: 17552
Unc80
Name: unc-80, NALCN activator
Synonyms: C230061B10Rik, C030018G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329178
Homologene: 122243
Sntg1
Name: syntrophin, gamma 1
Synonyms: G1SYN, SYN4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71096
Homologene: 56834
Angpt4
Name: angiopoietin 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11602
HGNC: HGNC:487
Homologene: 36302
Serpina3g
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3G
Synonyms: Spi2-1, Spi2/eb.1, 2A2, alpha-1 antiproteinase,, alpha-1 antiproteinase, Spi2A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20715
HGNC: HGNC:16
Homologene: 115927
Umodl1
Name: uromodulin-like 1
Synonyms: D17Ertd488e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 52020
VEGA: 17
Homologene: 45466
Skint6
Name: selection and upkeep of intraepithelial T cells 6
Synonyms: OTTMUSG00000008519
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230622
Homologene: 135888
Trpm8
Name: transient receptor potential cation channel, subfamily M, member 8
Synonyms: CMR1, TRPP8, Trp-p8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 171382
Homologene: 23433
4930402F06Rik
Name: RIKEN cDNA 4930402F06 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74854
Homologene: 78017
Gbp7
Name: guanylate binding protein 7
Synonyms: 9830147J24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229900
Homologene: 138296
Cyp2g1
Name: cytochrome P450, family 2, subfamily g, polypeptide 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13108
HGNC: HGNC:2633
Homologene: 75020
Adam9
Name: a disintegrin and metallopeptidase domain 9 (meltrin gamma)
Synonyms: MDC9, Mltng, MDC9, Mltng
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11502
HGNC: HGNC:216
Homologene: 20824
Tnrc18
Name: trinucleotide repeat containing 18
Synonyms: EG381742, Zfp469
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231861
Homologene: 45603
Dsc2
Name: desmocollin 2
Synonyms: Dsc2b, Dsc2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13506
HGNC: HGNC:3036
Homologene: 8397
Myrf
Name: myelin regulatory factor
Synonyms: LOC225908, LOC386531, Gm98
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 225908
HGNC: HGNC:1181
Homologene: 32167
Ptger4
Name: prostaglandin E receptor 4 (subtype EP4)
Synonyms: Ptgerep4, EP4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 19219
HGNC: HGNC:9596
Homologene: 20261
Hook3
Name: hook microtubule tethering protein 3
Synonyms: E330005F07Rik, 5830454D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 320191
Homologene: 13022
Apba2
Name: amyloid beta (A4) precursor protein-binding, family A, member 2
Synonyms: X11-like, X11L, Mint 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11784
HGNC: HGNC:579
Homologene: 4021
Mterf1b
Name: mitochondrial transcription termination factor 1b
Synonyms: Gm9897
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 208595
Homologene: 5073
4921504E06Rik
Name: RIKEN cDNA 4921504E06 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70909
Homologene: 87049
Zfp174
Name: zinc finger protein 174
Synonyms: LOC385674
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 385674
Homologene: 55755
Plaat3
Name: phospholipase A and acyltransferase 3
Synonyms: Hrasls3, Pla2g16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 225845
Homologene: 5136
Pigm
Name: phosphatidylinositol glycan anchor biosynthesis, class M
Synonyms: 4933437L05Rik, C920011G20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67556
Homologene: 6274
Etnk2
Name: ethanolamine kinase 2
Synonyms: 4933417N20Rik, Eki2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 214253
Homologene: 10072
AC124724.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Olfr979
Name: olfactory receptor 979
Synonyms: GA_x6K02T2PVTD-33699706-33698771, MOR223-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 259112
VEGA: 9
Homologene: 81556
Polh
Name: polymerase (DNA directed), eta (RAD 30 related)
Synonyms: RAD30A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 80905
VEGA: 17
HGNC: HGNC:9181
Homologene: 38189
Rasl11a
Name: RAS-like, family 11, member A
Synonyms: 1110065D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 68895
Homologene: 45783
Tti2
Name: TELO2 interacting protein 2
Synonyms: BC019943
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234138
Homologene: 11836
Grxcr1
Name: glutaredoxin, cysteine rich 1
Synonyms: tde, pi
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 433899
Homologene: 42423
Ssbp1
Name: single-stranded DNA binding protein 1
Synonyms: 2810480P10Rik, mtDBP, G630031O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 381760
Homologene: 74462
Igkv8-30
Name: immunoglobulin kappa chain variable 8-30
Synonyms: ENSMUSG00000073025, Gm10883
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 384419
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 8,595,539 bp
  • T to A, chromosome 1 at 66,671,715 bp
  • T to C, chromosome 1 at 88,343,326 bp
  • T to A, chromosome 1 at 121,483,342 bp
  • T to G, chromosome 1 at 133,377,053 bp
  • T to C, chromosome 1 at 172,377,533 bp
  • G to C, chromosome 2 at 19,517,546 bp
  • T to C, chromosome 2 at 35,376,067 bp
  • T to C, chromosome 2 at 71,434,034 bp
  • A to T, chromosome 2 at 151,936,783 bp
  • A to T, chromosome 2 at 180,661,884 bp
  • C to T, chromosome 3 at 36,988,256 bp
  • A to T, chromosome 3 at 142,534,622 bp
  • A to T, chromosome 3 at 142,545,555 bp
  • T to C, chromosome 4 at 40,977,004 bp
  • C to T, chromosome 4 at 104,731,751 bp
  • T to C, chromosome 4 at 112,846,684 bp
  • A to G, chromosome 4 at 149,652,699 bp
  • A to T, chromosome 5 at 4,197,057 bp
  • T to C, chromosome 5 at 44,014,086 bp
  • T to C, chromosome 5 at 68,110,412 bp
  • A to G, chromosome 5 at 77,281,279 bp
  • A to G, chromosome 5 at 115,724,579 bp
  • A to C, chromosome 5 at 142,773,641 bp
  • T to A, chromosome 5 at 146,847,117 bp
  • A to G, chromosome 6 at 25,689,063 bp
  • T to G, chromosome 6 at 28,830,587 bp
  • A to G, chromosome 6 at 40,476,499 bp
  • A to C, chromosome 6 at 70,117,086 bp
  • A to G, chromosome 6 at 73,264,276 bp
  • A to G, chromosome 7 at 26,808,917 bp
  • A to G, chromosome 7 at 29,086,049 bp
  • T to A, chromosome 7 at 64,695,593 bp
  • G to A, chromosome 7 at 76,589,500 bp
  • T to C, chromosome 7 at 123,172,120 bp
  • A to T, chromosome 8 at 24,995,184 bp
  • A to T, chromosome 8 at 26,059,394 bp
  • T to C, chromosome 8 at 31,154,266 bp
  • G to A, chromosome 8 at 40,308,372 bp
  • T to C, chromosome 8 at 83,934,464 bp
  • T to C, chromosome 9 at 40,001,204 bp
  • A to G, chromosome 10 at 127,299,285 bp
  • G to A, chromosome 12 at 13,361,045 bp
  • A to T, chromosome 12 at 104,239,158 bp
  • G to T, chromosome 13 at 11,945,977 bp
  • A to G, chromosome 13 at 58,859,301 bp
  • A to T, chromosome 14 at 47,542,895 bp
  • T to A, chromosome 15 at 5,242,845 bp
  • A to G, chromosome 16 at 3,854,642 bp
  • A to C, chromosome 16 at 4,046,039 bp
  • C to T, chromosome 16 at 32,144,157 bp
  • A to G, chromosome 17 at 30,971,919 bp
  • A to T, chromosome 17 at 46,181,454 bp
  • G to A, chromosome 18 at 20,033,294 bp
  • T to C, chromosome 18 at 37,490,600 bp
  • A to G, chromosome 19 at 7,579,109 bp
  • A to T, chromosome 19 at 10,224,600 bp
  • T to A, chromosome 19 at 47,151,991 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2089 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040094-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.