Strain Name:
C57BL/6J-MtgxR2160Btlr/Mmmh
Stock Number:
040163-MU
Citation ID:
RRID:MMRRC_040163-MU
Other Names:
R2160 (G1), C57BL/6J-MtgxR2160Btlr
Major Collection:

Gene Information

Pzp
Name: PZP, alpha-2-macroglobulin like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 11287
Homologene: 104112
Lrig3
Name: leucine-rich repeats and immunoglobulin-like domains 3
Synonyms: 9430095K15Rik, 9130004I02Rik, 9030421L11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 320398
VEGA: 10
Homologene: 62452
Slc2a3
Name: solute carrier family 2 (facilitated glucose transporter), member 3
Synonyms: Glut3, Glut-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20527
Homologene: 74302
Mark2
Name: MAP/microtubule affinity regulating kinase 2
Synonyms: Emk, Par-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 13728
HGNC: HGNC:3332
Homologene: 69013
Carmil1
Name: capping protein regulator and myosin 1 linker 1
Synonyms: Lrrc16a, Lrrc16, Carmil, 1110037D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 68732
Homologene: 9757
Fbxw8
Name: F-box and WD-40 domain protein 8
Synonyms: FBW8, Fbx29, FBXO29, 4930438M06Rik, FBW6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231672
Homologene: 17731
Braf
Name: Braf transforming gene
Synonyms: D6Ertd631e, Braf-2, Braf2, 9930012E13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 109880
HGNC: HGNC:1097
Homologene: 3197
Rab11fip3
Name: RAB11 family interacting protein 3 (class II)
Synonyms: D030060O14Rik, Rab11-FIP3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 215445
Homologene: 49396
Herc2
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2
Synonyms: jdf2, D7H15F37S1, rjs, D7H15F32S1, D15F32S1h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 15204
HGNC: HGNC:4868
Homologene: 3430
Mon2
Name: MON2 homolog, regulator of endosome to Golgi trafficking
Synonyms: 2610528O22Rik, SF21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 67074
VEGA: 10
Homologene: 44309
Itpr1
Name: inositol 1,4,5-trisphosphate receptor 1
Synonyms: P400, InsP3R type I, wblo, IP3R1, Ip3r, Pcp1, Itpr-1, Pcp-1, opt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16438
HGNC: HGNC:6180
Homologene: 1673
Prpf3
Name: pre-mRNA processing factor 3
Synonyms: 3632413F13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 70767
Homologene: 3447
Sprn
Name: shadow of prion protein
Synonyms: shadoo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 212518
Homologene: 84643
Lrrk2
Name: leucine-rich repeat kinase 2
Synonyms: 9330188B09Rik, 4921513O20Rik, LOC381026, D630001M17Rik, cI-46
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 66725
Homologene: 18982
Jph3
Name: junctophilin 3
Synonyms: JP-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 57340
Homologene: 10762
Ipmk
Name: inositol polyphosphate multikinase
Synonyms: 2410017C19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 69718
Homologene: 76214
Lctl
Name: lactase-like
Synonyms: E130104I05Rik, KLPH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235435
Homologene: 70710
Ppp3ca
Name: protein phosphatase 3, catalytic subunit, alpha isoform
Synonyms: 2900074D19Rik, Caln, Calna, PP2B alpha 1, PP2BA alpha, CN, CnA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 19055
HGNC: HGNC:9314
Homologene: 55497
Nupl1
Name: nucleoporin like 1
Synonyms: 1700017F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 71844
VEGA: 14
Homologene: 40924
Pla2g4e
Name: phospholipase A2, group IVE
Synonyms: Pla2epsilon, 2310026J01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329502
Homologene: 65339
Ercc5
Name: excision repair cross-complementing rodent repair deficiency, complementation group 5
Synonyms: Xpg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22592
HGNC: HGNC:3437
Homologene: 133551
Ipcef1
Name: interaction protein for cytohesin exchange factors 1
Synonyms: A130090K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 320495
Homologene: 32271
Evc2
Name: EvC ciliary complex subunit 2
Synonyms: Ellis van Creveld syndrome 2, Lbn, limbin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 68525
Homologene: 17117
Dnah9
Name: dynein, axonemal, heavy chain 9
Synonyms: D11Ertd686e, Dnahc9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237806
HGNC: HGNC:2953
Homologene: 20357
Pak7
Name: p21 (RAC1) activated kinase 7
Synonyms: Pak5, 2900083L08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241656
Homologene: 22211
Cntnap4
Name: contactin associated protein-like 4
Synonyms: E130114F09Rik, Caspr4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 170571
Homologene: 24912
Ppfia4
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
Synonyms: Liprin-alpha4, LOC100042382, 1110008G13Rik, Gm3812
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68507
HGNC: HGNC:9248
Homologene: 66200
Gprc6a
Name: G protein-coupled receptor, family C, group 6, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 210198
VEGA: 10
Homologene: 17529
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239420
Homologene: 65982
Ccdc150
Name: coiled-coil domain containing 150
Synonyms: 4930511H11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 78016
Homologene: 15814
Vmn2r56
Name: vomeronasal 2, receptor 56
Synonyms: EG629079
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 629079
Homologene: 104040
Inpp4b
Name: inositol polyphosphate-4-phosphatase, type II
Synonyms: E130107I17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234515
HGNC: HGNC:6075
Homologene: 20832
Folh1
Name: folate hydrolase 1
Synonyms: glutamate carboxypeptidase II, mopsm, GCP2, prostate-specific membrane antigen
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 53320
HGNC: HGNC:3788
Homologene: 55826
Thap12
Name: THAP domain containing 12
Synonyms: 2900052B10Rik, Prkrir, Dap4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 72981
HGNC: HGNC:9440
Homologene: 37952
Krt76
Name: keratin 76
Synonyms: 2310001L23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 77055
Homologene: 22931
Kctd16
Name: potassium channel tetramerisation domain containing 16
Synonyms: 2900055J20Rik, 4930434H12Rik, LOC383347
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 73001
VEGA: 18
Homologene: 44779
Ppfibp1
Name: PTPRF interacting protein, binding protein 1 (liprin beta 1)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 67533
HGNC: HGNC:9249
Homologene: 2685
Tectb
Name: tectorin beta
Synonyms: Tctnb, [b]-tectorin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 21684
Homologene: 7568
Wdhd1
Name: WD repeat and HMG-box DNA binding protein 1
Synonyms: D630024B06Rik, AND-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218973
Homologene: 56019
Zfp976
Name: zinc finger protein 976
Synonyms: 9830147E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 208111
Homologene: 134004
Vmn2r54
Name: vomeronasal 2, receptor 54
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 666085
Homologene: 104040
Bpifb9b
Name: BPI fold containing family B, member 9B
Synonyms: OTTMUSG00000015915, 5430413K10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 433492
Homologene: 128535
Klk14
Name: kallikrein related-peptidase 14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 317653
HGNC: HGNC:6362
Homologene: 69348
Vmn1r7
Name: vomeronasal 1 receptor 7
Synonyms: Gm5568, V1rc31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 434016
Homologene: 83427
Carmil2
Name: capping protein regulator and myosin 1 linker 2
Synonyms: D130029J02Rik, Rltpr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234695
Homologene: 128439
Gcm1
Name: glial cells missing homolog 1
Synonyms: Gcm a, glide, GCMa, Gcm1-rs1, Gcm 1, glial cell deficient
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 14531
VEGA: 9
HGNC: HGNC:4197
Homologene: 2702
Gm4868
Name: predicted gene 4868
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231736
Homologene: 138658
Dupd1
Name: dual specificity phosphatase and pro isomerase domain containing 1
Synonyms: EG435391
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 435391
VEGA: 14
Homologene: 51120
4930544M13Rik
Name: RIKEN cDNA 4930544M13 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 75161
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 44,178,170 bp
  • C to T, chromosome 1 at 54,354,792 bp
  • A to T, chromosome 1 at 134,313,723 bp
  • T to C, chromosome 2 at 120,185,206 bp
  • T to C, chromosome 2 at 136,098,382 bp
  • A to G, chromosome 2 at 154,319,675 bp
  • T to C, chromosome 3 at 95,845,230 bp
  • G to A, chromosome 3 at 136,877,630 bp
  • A to G, chromosome 5 at 37,380,518 bp
  • G to A, chromosome 5 at 118,124,988 bp
  • A to T, chromosome 5 at 125,848,549 bp
  • C to T, chromosome 6 at 39,662,073 bp
  • A to G, chromosome 6 at 57,024,894 bp
  • T to C, chromosome 6 at 108,417,877 bp
  • T to A, chromosome 6 at 122,797,795 bp
  • A to G, chromosome 6 at 128,525,276 bp
  • A to G, chromosome 6 at 147,027,453 bp
  • C to T, chromosome 7 at 12,615,493 bp
  • A to G, chromosome 7 at 12,694,219 bp
  • C to T, chromosome 7 at 42,613,930 bp
  • G to A, chromosome 7 at 43,692,077 bp
  • A to G, chromosome 7 at 56,212,922 bp
  • T to A, chromosome 7 at 86,731,721 bp
  • A to G, chromosome 7 at 98,710,126 bp
  • C to A, chromosome 7 at 140,153,506 bp
  • T to A, chromosome 8 at 82,121,375 bp
  • A to G, chromosome 8 at 105,697,048 bp
  • G to T, chromosome 8 at 112,757,571 bp
  • G to T, chromosome 8 at 121,753,231 bp
  • A to G, chromosome 9 at 64,117,767 bp
  • A to G, chromosome 9 at 78,061,380 bp
  • A to T, chromosome 10 at 6,890,650 bp
  • CAAA to CA, chromosome 10 at 51,615,680 bp
  • A to G, chromosome 10 at 71,381,426 bp
  • T to A, chromosome 10 at 123,075,929 bp
  • T to C, chromosome 10 at 125,997,696 bp
  • C to T, chromosome 11 at 66,117,483 bp
  • A to G, chromosome 13 at 24,154,667 bp
  • T to C, chromosome 13 at 114,607,628 bp
  • G to A, chromosome 14 at 21,677,172 bp
  • A to T, chromosome 14 at 47,274,070 bp
  • A to G, chromosome 14 at 60,239,508 bp
  • CCTTTGCGCTT to CCTT, chromosome 15 at 47,741,236 bp
  • C to T, chromosome 15 at 91,796,060 bp
  • A to G, chromosome 15 at 101,888,385 bp
  • G to A, chromosome 17 at 26,069,054 bp
  • A to G, chromosome 18 at 40,259,085 bp
  • G to C, chromosome 19 at 7,282,747 bp
  • C to G, chromosome 19 at 55,180,999 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2160 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040163-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.