Strain Name:
C57BL/6J-MtgxR2349Btlr/Mmmh
Stock Number:
040331-MU
Citation ID:
RRID:MMRRC_040331-MU
Other Names:
R2349 (G1), C57BL/6J-MtgxR2349Btlr
Major Collection:

Gene Information

Dst
Name: dystonin
Synonyms: A830042E19Rik, Bpag1, Macf2, athetoid, bullous pemphigoid antigen 1, 2310001O04Rik, BPAG1-n, BPAG1, nmf339, bullous pemphigoid antigen 1, ah, Bpag, nmf203
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Jmjd1c
Name: jumonji domain containing 1C
Synonyms: TRIP8, D630035I23Rik, 5430433L24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 108829
Homologene: 3129
Arfgef2
Name: ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
Synonyms: BIG2, E230011G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 99371
Homologene: 111880
Vps13c
Name: vacuolar protein sorting 13C
Synonyms: C230055H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 320528
VEGA: 9
Homologene: 41188
Wwp1
Name: WW domain containing E3 ubiquitin protein ligase 1
Synonyms: SDRP1, AIP5, Tiul1, 8030445B08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 107568
Homologene: 21385
Rock2
Name: Rho-associated coiled-coil containing protein kinase 2
Synonyms: Rock2m, Rho-kinase, B230113H15Rik, Rock-II, ROKalpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 19878
VEGA: 12
Homologene: 21010
Sfswap
Name: splicing factor SWAP
Synonyms: 1190005N23Rik, 6330437E22Rik, Sfrs8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231769
Homologene: 134548
Xpo6
Name: exportin 6
Synonyms: C230091E20Rik, Ranbp20, 2610005L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 74204
Homologene: 12544
Trip4
Name: thyroid hormone receptor interactor 4
Synonyms: 4930558E03Rik, ASC-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 56404
Homologene: 9426
Usp10
Name: ubiquitin specific peptidase 10
Synonyms: 2610014N07Rik, Uchrp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 22224
Homologene: 31294
Vars
Name: valyl-tRNA synthetase
Synonyms: Vars2, G7a, Bat-6, Bat6, D17H6S56E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 22321
Homologene: 4587
Ap1ar
Name: adaptor-related protein complex 1 associated regulatory protein
Synonyms: Gadkin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 211556
Homologene: 10236
Crebbp
Name: CREB binding protein
Synonyms: CBP, KAT3A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 12914
HGNC: HGNC:2348
Homologene: 68393
Esam
Name: endothelial cell-specific adhesion molecule
Synonyms: 2310008D05Rik, W117m
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 69524
Homologene: 12316
Igf2r
Name: insulin-like growth factor 2 receptor
Synonyms: M6P/IGF2R, CD222, CI-MPR, IGF-II/CI-MPR, mannose-6-phosphate receptor, cation independent, Mpr300
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 16004
HGNC: HGNC:5467
Homologene: 676
Cntrl
Name: centriolin
Synonyms: Ma2a8, Cep110, Cep1, IB3/5, 6720467O09Rik, b2b1468Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 26920
HGNC: HGNC:1858
Homologene: 38260
Pkd1l1
Name: polycystic kidney disease 1 like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 171395
Homologene: 51376
Rac2
Name: Rac family small GTPase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 19354
VEGA: 15
HGNC: HGNC:9802
Homologene: 55699
Got1l1
Name: glutamic-oxaloacetic transaminase 1-like 1
Synonyms: 1700083M11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 76615
Homologene: 65045
Man1a
Name: mannosidase 1, alpha
Synonyms: PCR1, mannosyl-oligosaccharide alpha-1,2-mannosidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 17155
HGNC: HGNC:6821
Homologene: 4316
Adam34
Name: a disintegrin and metallopeptidase domain 34
Synonyms: testase 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 252866
Homologene: 78104
C1s1
Name: complement component 1, s subcomponent 1
Synonyms: C1s
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 50908
HGNC: HGNC:1247
Homologene: 1314
Col15a1
Name: collagen, type XV, alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 12819
HGNC: HGNC:2192
Homologene: 1396
Galnt1
Name: polypeptide N-acetylgalactosaminyltransferase 1
Synonyms: ppGaNTase-T1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 14423
HGNC: HGNC:4123
Homologene: 8469
Thsd4
Name: thrombospondin, type I, domain containing 4
Synonyms: B230114P05Rik, ADAMTSL6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 207596
Homologene: 49796
Cdh15
Name: cadherin 15
Synonyms: M cadherin, Cdh14, Mcad
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 12555
HGNC: HGNC:1754
Homologene: 3622
Atg16l2
Name: autophagy related 16-like 2 (S. cerevisiae)
Synonyms: 2410118P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 73683
Homologene: 18981
Gpr182
Name: G protein-coupled receptor 182
Synonyms: Admr, AM-R, G10-D, NOW, Gpcr22, Gpcr17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 11536
Homologene: 5255
Pex13
Name: peroxisomal biogenesis factor 13
Synonyms: 2610008O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 72129
HGNC: HGNC:8855
Homologene: 1967
Papss1
Name: 3'-phosphoadenosine 5'-phosphosulfate synthase 1
Synonyms: Asapk, SK1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 23971
HGNC: HGNC:8603
Homologene: 81740
Krt222
Name: keratin 222
Synonyms: 6330509G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 268481
Homologene: 17556
Dbx2
Name: developing brain homeobox 2
Synonyms: LOC383001, 9430056A22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 223843
Homologene: 54981
Ifi209
Name: interferon activated gene 209
Synonyms: Ifix, Pyhin1, Pyhin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 236312
HGNC: HGNC:5395
Homologene: 115929
Slco5a1
Name: solute carrier organic anion transporter family, member 5A1
Synonyms: A630033C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 240726
Homologene: 57135
Nkx2-9
Name: NK2 homeobox 9
Synonyms: tinman, Nkx-2.9, Nkx2.9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 18094
Homologene: 7444
Gm17415
Name: predicted gene, 17415
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 108167670
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 12,921,152 bp
  • C to T, chromosome 1 at 34,256,662 bp
  • A to G, chromosome 1 at 93,422,234 bp
  • G to A, chromosome 1 at 173,642,556 bp
  • A to G, chromosome 2 at 35,176,251 bp
  • T to A, chromosome 2 at 166,852,028 bp
  • A to G, chromosome 3 at 127,808,759 bp
  • A to G, chromosome 3 at 131,599,866 bp
  • A to T, chromosome 4 at 19,638,644 bp
  • G to A, chromosome 4 at 47,306,742 bp
  • C to T, chromosome 5 at 129,569,738 bp
  • C to A, chromosome 6 at 124,541,473 bp
  • T to C, chromosome 7 at 101,296,539 bp
  • A to T, chromosome 7 at 126,113,703 bp
  • T to C, chromosome 8 at 27,197,931 bp
  • T to C, chromosome 8 at 43,652,378 bp
  • T to C, chromosome 8 at 119,956,709 bp
  • G to A, chromosome 8 at 122,856,635 bp
  • A to C, chromosome 9 at 37,528,231 bp
  • A to G, chromosome 9 at 59,972,515 bp
  • T to C, chromosome 9 at 65,866,562 bp
  • A to G, chromosome 9 at 67,957,526 bp
  • T to A, chromosome 10 at 53,919,341 bp
  • T to C, chromosome 10 at 67,255,500 bp
  • T to A, chromosome 10 at 127,750,937 bp
  • A to T, chromosome 11 at 8,826,819 bp
  • A to G, chromosome 11 at 23,655,789 bp
  • A to G, chromosome 11 at 99,238,765 bp
  • A to G, chromosome 12 at 16,977,615 bp
  • A to G, chromosome 12 at 56,612,222 bp
  • A to G, chromosome 15 at 78,565,475 bp
  • A to G, chromosome 15 at 95,624,959 bp
  • G to A, chromosome 16 at 4,138,910 bp
  • A to T, chromosome 17 at 12,722,311 bp
  • A to G, chromosome 17 at 35,015,752 bp
  • A to G, chromosome 18 at 24,280,028 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2349 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040331-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.