Strain Name:
C57BL/6J-MtgxR2397Btlr/Mmmh
Stock Number:
040364-MU
Citation ID:
RRID:MMRRC_040364-MU
Other Names:
R2397 (G1), C57BL/6J-MtgxR2397Btlr
Major Collection:

Gene Information

Ptdss2
Name: phosphatidylserine synthase 2
Synonyms: PSS2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 27388
Homologene: 8462
Actn4
Name: actinin alpha 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 60595
HGNC: HGNC:166
Homologene: 55857
Gria4
Name: glutamate receptor, ionotropic, AMPA4 (alpha 4)
Synonyms: Glur-4, Glur4, spkw1, Gluralpha4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 14802
HGNC: HGNC:4574
Homologene: 20227
Parn
Name: poly(A)-specific ribonuclease (deadenylation nuclease)
Synonyms: DAN, 1200003I18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 74108
VEGA: 16
HGNC: HGNC:8609
Homologene: 31098
Ruvbl1
Name: RuvB-like protein 1
Synonyms: Pontin52, 2510009G06Rik, Tip49a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 56505
Homologene: 37839
Slf1
Name: SMC5-SMC6 complex localization factor 1
Synonyms: C730024G01Rik, 2700017A04Rik, Brctx, Brctd1, Ankrd32
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105377
Homologene: 13000
Golga3
Name: golgi autoantigen, golgin subfamily a, 3
Synonyms: Mea-2, Mea2, 5430416E01Rik, G1-499-14, repro27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 269682
HGNC: HGNC:4426
Homologene: 4308
Gm7964
Name: predicted gene 7964
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 666170
Ncr1
Name: natural cytotoxicity triggering receptor 1
Synonyms: NKp46, MAR1 (mouse activating receptor 1), Ly94
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17086
HGNC: HGNC:6731
Homologene: 3551
Adamtsl1
Name: ADAMTS-like 1
Synonyms: punctin-1, 6720426B09Rik, 5930437A14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 77739
Homologene: 64642
Fibcd1
Name: fibrinogen C domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 98970
Homologene: 122246
Cars
Name: cysteinyl-tRNA synthetase
Synonyms: CA3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 27267
HGNC: HGNC:1493
Homologene: 1328
Agtpbp1
Name: ATP/GTP binding protein 1
Synonyms: Nna1, 2900054O13Rik, 4930445M19Rik, 1700020N17Rik, 5730402G09Rik, 2310001G17Rik, Ccp1, atms
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 67269
Homologene: 9067
Capn11
Name: calpain 11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268958
HGNC: HGNC:1478
Homologene: 21392
Fstl5
Name: follistatin-like 5
Synonyms: 9130207J01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 213262
Homologene: 10584
Foxn4
Name: forkhead box N4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 116810
Homologene: 17526
Dhx36
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 36
Synonyms: Ddx36, 2810407E23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 72162
Homologene: 6356
Slc15a3
Name: solute carrier family 15, member 3
Synonyms: cI-1, Ci1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 65221
Homologene: 69222
Jakmip1
Name: janus kinase and microtubule interacting protein 1
Synonyms: Marlin-1, 5830437M04Rik, C330021K24Rik, Gababrbp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 76071
Homologene: 90789
Col14a1
Name: collagen, type XIV, alpha 1
Synonyms: 5730412L22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12818
HGNC: HGNC:2191
Homologene: 18741
Heg1
Name: heart development protein with EGF-like domains 1
Synonyms: LOC268884, 5530401I02Rik, 9530025L16Rik, 4632417D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 77446
Homologene: 35276
Ift140
Name: intraflagellar transport 140
Synonyms: Wdtc2, Tce5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 106633
Homologene: 40979
Krt84
Name: keratin 84
Synonyms: HRb-1, Krt2-3, Krt2-16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16680
VEGA: 15
HGNC: HGNC:6461
Homologene: 22473
Cyp2d26
Name: cytochrome P450, family 2, subfamily d, polypeptide 26
Synonyms: 1300006E06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 76279
VEGA: 15
Homologene: 130660
Ifi205
Name: interferon activated gene 205
Synonyms: D3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226695
HGNC: HGNC:5395
Homologene: 115929
Vmn2r54
Name: vomeronasal 2, receptor 54
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 666085
Homologene: 104040
Pacs2
Name: phosphofurin acidic cluster sorting protein 2
Synonyms: 6720425G15Rik, Pacs1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217893
VEGA: 12
Homologene: 15016
Mc2r
Name: melanocortin 2 receptor
Synonyms: adrenocorticotropic hormone receptor, Acthr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 17200
VEGA: 18
HGNC: HGNC:6930
Homologene: 444
Fscn2
Name: fascin actin-bundling protein 2
Synonyms: C630046B20Rik, ahl8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 238021
HGNC: HGNC:3960
Homologene: 22722
Adam29
Name: a disintegrin and metallopeptidase domain 29
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244486
HGNC: HGNC:207
Homologene: 8607
Nr1h3
Name: nuclear receptor subfamily 1, group H, member 3
Synonyms: LXR alpha, Unr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22259
HGNC: HGNC:7966
Homologene: 21165
Fam228a
Name: family with sequence similarity 228, member A
Synonyms: 4930417G10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 74855
VEGA: 12
Homologene: 54902
CT573017.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Vmn2r124
Name: vomeronasal 2, receptor 124
Synonyms: Gm7196, Vmn2r-ps113
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 637021
Homologene: 115024
Ehf
Name: ets homologous factor
Synonyms: 9030625L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13661
HGNC: HGNC:3246
Homologene: 7301
Atp13a2
Name: ATPase type 13A2
Synonyms: 1110012E06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74772
Homologene: 56940
Xrcc2
Name: X-ray repair complementing defective repair in Chinese hamster cells 2
Synonyms: RecA, 8030409M04Rik, 4921524O04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 57434
Homologene: 3964
4932442E05Rik
Name: RIKEN cDNA 4932442E05 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Socs5
Name: suppressor of cytokine signaling 5
Synonyms: Cish5, SOCS-5, 1810018L08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 56468
VEGA: 17
Homologene: 10495
Cers1
Name: ceramide synthase 1
Synonyms: Uog-1, to, CerS1, Lass1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 93898
Homologene: 128762
Obox2
Name: oocyte specific homeobox 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 246792
Homologene: 44937
Esrra
Name: estrogen related receptor, alpha
Synonyms: Estrra, Err1, ERRalpha, Nr3b1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 26379
HGNC: HGNC:3471
Homologene: 20941
Echs1
Name: enoyl Coenzyme A hydratase, short chain, 1, mitochondrial
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 93747
HGNC: HGNC:3151
Homologene: 3018
Scgb1b30
Name: secretoglobin, family 1B, member 30
Synonyms: Gm12776, Abpa30
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100043868
Homologene: 114479
Gm8582
Name: predicted gene 8582
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 667341
Tcp10c
Name: t-complex protein 10c
Synonyms: T66C-a, D17Leh66ca, D17Leh66C, Tcp-10c, Gm9880
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 100041352
VEGA: 17
Homologene: 83254
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 174,017,575 bp
  • A to T, chromosome 2 at 31,834,423 bp
  • G to A, chromosome 2 at 91,191,857 bp
  • T to A, chromosome 2 at 103,276,819 bp
  • A to T, chromosome 3 at 62,498,097 bp
  • G to A, chromosome 3 at 76,661,745 bp
  • C to T, chromosome 4 at 86,199,357 bp
  • A to G, chromosome 4 at 141,003,155 bp
  • T to C, chromosome 5 at 25,705,710 bp
  • T to A, chromosome 5 at 37,100,743 bp
  • T to C, chromosome 5 at 110,205,877 bp
  • A to G, chromosome 5 at 114,255,495 bp
  • A to C, chromosome 6 at 88,465,552 bp
  • T to A, chromosome 7 at 4,338,261 bp
  • T to G, chromosome 7 at 12,615,651 bp
  • C to T, chromosome 7 at 15,397,046 bp
  • G to A, chromosome 7 at 28,898,266 bp
  • T to A, chromosome 7 at 34,100,672 bp
  • T to G, chromosome 7 at 83,757,113 bp
  • T to C, chromosome 7 at 140,112,477 bp
  • T to A, chromosome 7 at 141,147,092 bp
  • T to C, chromosome 7 at 143,592,507 bp
  • T to A, chromosome 8 at 55,872,898 bp
  • A to T, chromosome 8 at 70,321,536 bp
  • A to G, chromosome 9 at 4,537,717 bp
  • T to A, chromosome 10 at 118,861,368 bp
  • T to C, chromosome 11 at 120,362,169 bp
  • A to T, chromosome 12 at 4,718,718 bp
  • G to A, chromosome 12 at 113,063,367 bp
  • C to T, chromosome 13 at 59,474,569 bp
  • G to T, chromosome 13 at 77,103,583 bp
  • T to C, chromosome 14 at 19,131,940 bp
  • T to C, chromosome 15 at 55,338,439 bp
  • C to T, chromosome 15 at 82,794,035 bp
  • A to G, chromosome 15 at 101,530,254 bp
  • A to G, chromosome 16 at 13,566,654 bp
  • T to A, chromosome 16 at 33,742,479 bp
  • C to A, chromosome 17 at 13,370,211 bp
  • T to A, chromosome 17 at 18,049,597 bp
  • T to G, chromosome 17 at 25,020,736 bp
  • T to A, chromosome 17 at 45,653,221 bp
  • T to C, chromosome 17 at 68,840,947 bp
  • T to C, chromosome 17 at 87,134,949 bp
  • T to A, chromosome 18 at 68,408,153 bp
  • A to G, chromosome 19 at 6,920,176 bp
  • A to G, chromosome 19 at 10,843,043 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2397 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040364-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.