Strain Name:
C57BL/6J-MtgxR2921Btlr/Mmmh
Stock Number:
040506-MU
Citation ID:
RRID:MMRRC_040506-MU
Other Names:
R2921 (G1), C57BL/6J-MtgxR2921Btlr
Major Collection:

Gene Information

Adipor1
Name: adiponectin receptor 1
Synonyms: 2810031L11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 72674
Homologene: 69199
Cemip2
Name: cell migration inducing hyaluronidase 2
Synonyms: Tmem2, 3110012M15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 83921
VEGA: 19
Homologene: 75008
Nup155
Name: nucleoporin 155
Synonyms: D930027M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 170762
VEGA: 15
HGNC: HGNC:8063
Homologene: 43155
Rpl22
Name: ribosomal protein L22
Synonyms: 2700038K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 19934
Homologene: 37378
Golga4
Name: golgi autoantigen, golgin subfamily a, 4
Synonyms: Olp-1, golgin-245
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 54214
HGNC: HGNC:4427
Homologene: 68224
Setx
Name: senataxin
Synonyms: A930037J23Rik, Als4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 269254
HGNC: HGNC:445
Homologene: 41003
Baz2a
Name: bromodomain adjacent to zinc finger domain, 2A
Synonyms: C030005G16Rik, Walp3, Tip5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 116848
VEGA: 10
HGNC: HGNC:962
Homologene: 8393
Gapvd1
Name: GTPase activating protein and VPS9 domains 1
Synonyms: 2010005B09Rik, 4432404J10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66691
Homologene: 32637
Ncor2
Name: nuclear receptor co-repressor 2
Synonyms: SMRT, SMRTe
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20602
HGNC: HGNC:7673
Homologene: 31370
Safb2
Name: scaffold attachment factor B2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224902
Homologene: 35210
Tmx1
Name: thioredoxin-related transmembrane protein 1
Synonyms: 2810425A04Rik, Txndc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 72736
Homologene: 12482
Grm7
Name: glutamate receptor, metabotropic 7
Synonyms: SMN2, Tg(SMN2)89Ahmb, E130018M02Rik, Gpr1g, 6330570A01Rik, mGluR7, mGlu7a receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 108073
HGNC: HGNC:4599
Homologene: 20233
Akt2
Name: thymoma viral proto-oncogene 2
Synonyms: 2410016A19Rik, PKB, PKBbeta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11652
HGNC: HGNC:392
Homologene: 48773
Zdhhc18
Name: zinc finger, DHHC domain containing 18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 503610
Homologene: 110918
Hdc
Name: histidine decarboxylase
Synonyms: Hdc-c, Hdc-e, Hdc-a, L-histidine decarboxylase, Hdc-s
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 15186
HGNC: HGNC:4855
Homologene: 20490
Zfp507
Name: zinc finger protein 507
Synonyms: 1810022O10Rik, A230056M16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 668501
Homologene: 8942
Nipal3
Name: NIPA-like domain containing 3
Synonyms: Npal3, 9130020G22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74552
Homologene: 10722
Agap3
Name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
Synonyms: MRIP-1, Crag, Centg3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 213990
Homologene: 23742
Eif5b
Name: eukaryotic translation initiation factor 5B
Synonyms: IF2, A030003E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226982
Homologene: 134613
Rfx7
Name: regulatory factor X, 7
Synonyms: 9930116O05Rik, Rfxdc2, 2510005N23Rik, D130086K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 319758
Homologene: 11275
Kalrn
Name: kalirin, RhoGEF kinase
Synonyms: LOC224126, Hapip, E530005C20Rik, 2210407G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 545156
HGNC: HGNC:4814
Homologene: 57160
Trpc6
Name: transient receptor potential cation channel, subfamily C, member 6
Synonyms: mtrp6, Trrp6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22068
VEGA: 9
Homologene: 37944
Mlkl
Name: mixed lineage kinase domain-like
Synonyms: 9130019I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74568
Homologene: 77416
Hivep2
Name: human immunodeficiency virus type I enhancer binding protein 2
Synonyms: Gm20114, Schnurri-2, Shn-2, MIBP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 15273
HGNC: HGNC:4921
Homologene: 4900
Ralgps1
Name: Ral GEF with PH domain and SH3 binding motif 1
Synonyms: RALGPS1A, 5830418G11Rik, RALGEF2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241308
Homologene: 65163
Ccdc116
Name: coiled-coil domain containing 116
Synonyms: 4930432J16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 76872
Homologene: 51873
Slc24a2
Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
Synonyms: 6330417K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 76376
Homologene: 10669
Slc26a2
Name: solute carrier family 26 (sulfate transporter), member 2
Synonyms: Dtd, ST-OB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13521
Homologene: 73876
Tuba8
Name: tubulin, alpha 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 53857
Homologene: 56766
Adamts3
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3
Synonyms: 1100001H14Rik, 6330442E02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 330119
HGNC: HGNC:219
Homologene: 8596
Tspan15
Name: tetraspanin 15
Synonyms: Tm4sf15, 2700063A19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 70423
VEGA: 10
Homologene: 22716
Pde4dip
Name: phosphodiesterase 4D interacting protein (myomegalin)
Synonyms: D130016K21Rik, Usmg4, D3Bwg1078e, 9430063L05Rik, 4732458A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 83679
Homologene: 66961
Cmah
Name: cytidine monophospho-N-acetylneuraminic acid hydroxylase
Synonyms: CMP-NeuAc hydroxylase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 12763
HGNC: HGNC:2098
Homologene: 7269
Gbp7
Name: guanylate binding protein 7
Synonyms: 9830147J24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229900
Homologene: 138296
Atp6v0a2
Name: ATPase, H+ transporting, lysosomal V0 subunit A2
Synonyms: ATP6a2, TJ6s, Atp6n2, V-ATPase a2, Tj6, 8430408C20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 21871
Homologene: 56523
Slc6a15
Name: solute carrier family 6 (neurotransmitter transporter), member 15
Synonyms: v7-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 103098
VEGA: 10
Homologene: 18163
Vmn2r60
Name: vomeronasal 2, receptor 60
Synonyms: Casr-rs3, EG637898, Gprc2a-rs3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 637898
Homologene: 129683
Ccn5
Name: cellular communication network factor 5
Synonyms: CCN5, rCop1, Wisp2, Crgr4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22403
Homologene: 2882
Fndc1
Name: fibronectin type III domain containing 1
Synonyms: 1110027O12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 68655
Hgd
Name: homogentisate 1, 2-dioxygenase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 15233
HGNC: HGNC:4892
Homologene: 156
Olfr1218
Name: olfactory receptor 1218
Synonyms: MOR233-12, GA_x6K02T2Q125-50536041-50535106
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258815
Homologene: 73986
Ccdc144b
Name: coiled-coil domain containing 144B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 241943
Homologene: 87263
Slfn3
Name: schlafen 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20557
Homologene: 133236
Spatc1
Name: spermatogenesis and centriole associated 1
Synonyms: 1700084J23Rik, speriolin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 74281
VEGA: 15
Homologene: 129861
Rdm1
Name: RAD52 motif 1
Synonyms: 2410008M22Rik, Rad52b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 66599
Homologene: 11992
Rnf151
Name: ring finger protein 151
Synonyms: 1700010O16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 67504
VEGA: 17
Homologene: 12146
Rassf4
Name: Ras association (RalGDS/AF-6) domain family member 4
Synonyms: 3830411C14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 213391
Homologene: 12926
Nr1h4
Name: nuclear receptor subfamily 1, group H, member 4
Synonyms: FXR, RIP14, HRR1, Rxrip14, Fxr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 20186
HGNC: HGNC:7967
Homologene: 3760
Fhl3
Name: four and a half LIM domains 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 14201
HGNC: HGNC:3704
Homologene: 37928
Arhgap4
Name: Rho GTPase activating protein 4
Synonyms: Rgc1, A530015A20Rik, A130009C12Rik, c1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 171207
HGNC: HGNC:674
Homologene: 20403
Rptn
Name: repetin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20129
Homologene: 84780
Mboat2
Name: membrane bound O-acyltransferase domain containing 2
Synonyms: 2810049G06Rik, Oact2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 67216
VEGA: 12
Homologene: 6971
Crygs
Name: crystallin, gamma S
Synonyms: Opj
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 12970
VEGA: 16
HGNC: HGNC:2417
Homologene: 40695
Hoxb1
Name: homeobox B1
Synonyms: Hox-2.9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 15407
HGNC: HGNC:5111
Homologene: 1615
Atg4a
Name: autophagy related 4A, cysteine peptidase
Synonyms: Autl2, Apg4a, autophagin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 666468
Homologene: 70873
Dpm3
Name: dolichyl-phosphate mannosyltransferase polypeptide 3
Synonyms: 1110001H19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 68563
HGNC: HGNC:3007
Homologene: 17810
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 38,018,019 bp
  • T to C, chromosome 1 at 134,425,993 bp
  • TGTGG to TG, chromosome 2 at 29,154,060 bp
  • GTGGCT to GT, chromosome 2 at 29,154,061 bp
  • A to T, chromosome 2 at 33,143,070 bp
  • A to T, chromosome 2 at 34,688,863 bp
  • A to G, chromosome 2 at 89,054,499 bp
  • G to A, chromosome 2 at 126,593,990 bp
  • G to A, chromosome 2 at 163,832,346 bp
  • T to C, chromosome 3 at 36,025,928 bp
  • C to T, chromosome 3 at 89,266,755 bp
  • A to G, chromosome 3 at 93,398,708 bp
  • T to C, chromosome 3 at 97,719,569 bp
  • A to T, chromosome 3 at 142,534,572 bp
  • A to G, chromosome 4 at 86,991,354 bp
  • T to C, chromosome 4 at 124,705,670 bp
  • G to T, chromosome 4 at 133,633,144 bp
  • A to T, chromosome 4 at 135,477,465 bp
  • C to A, chromosome 4 at 152,327,545 bp
  • C to T, chromosome 5 at 24,499,906 bp
  • T to C, chromosome 5 at 89,861,534 bp
  • C to T, chromosome 5 at 124,717,917 bp
  • A to G, chromosome 5 at 125,055,791 bp
  • T to A, chromosome 6 at 111,495,905 bp
  • T to C, chromosome 6 at 116,661,833 bp
  • G to T, chromosome 6 at 121,220,369 bp
  • A to G, chromosome 7 at 27,628,986 bp
  • T to C, chromosome 7 at 35,794,799 bp
  • T to A, chromosome 7 at 42,141,035 bp
  • T to C, chromosome 8 at 111,316,447 bp
  • A to T, chromosome 9 at 8,653,033 bp
  • G to A, chromosome 9 at 72,617,664 bp
  • T to A, chromosome 9 at 118,559,343 bp
  • C to A, chromosome 10 at 14,128,969 bp
  • GTTTT to GTTTTT, chromosome 10 at 62,189,797 bp
  • A to T, chromosome 10 at 89,498,361 bp
  • A to G, chromosome 10 at 103,418,387 bp
  • AGCGGCGGTACTTGCGGG to AG, chromosome 10 at 128,125,077 bp
  • A to G, chromosome 11 at 83,215,045 bp
  • T to C, chromosome 11 at 96,366,293 bp
  • T to A, chromosome 11 at 101,630,890 bp
  • T to A, chromosome 12 at 24,954,240 bp
  • T to A, chromosome 12 at 70,466,121 bp
  • T to A, chromosome 13 at 24,460,334 bp
  • A to C, chromosome 15 at 8,153,641 bp
  • T to C, chromosome 15 at 76,283,925 bp
  • T to C, chromosome 16 at 17,142,443 bp
  • C to T, chromosome 16 at 22,805,551 bp
  • A to T, chromosome 16 at 34,314,368 bp
  • T to C, chromosome 16 at 37,618,968 bp
  • A to G, chromosome 17 at 7,804,875 bp
  • C to T, chromosome 17 at 24,716,261 bp
  • A to G, chromosome 17 at 56,568,906 bp
  • T to A, chromosome 18 at 61,201,935 bp
  • A to G, chromosome 19 at 21,817,939 bp
  • T to C, chromosome X at 73,897,962 bp
  • T to C, chromosome X at 141,158,772 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2921 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040506-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.