Strain Name:
C57BL/6J-MtgxR3052Btlr/Mmmh
Stock Number:
040561-MU
Citation ID:
RRID:MMRRC_040561-MU
Other Names:
R3052 (G1), C57BL/6J-MtgxR3052Btlr
Major Collection:

Gene Information

Ubxn2a
Name: UBX domain protein 2A
Synonyms: 6330407P03Rik, Ubxd4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217379
Homologene: 17076
Tacc2
Name: transforming, acidic coiled-coil containing protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57752
Homologene: 5087
Banp
Name: BTG3 associated nuclear protein
Synonyms: SMAR1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 53325
Homologene: 9635
Unk
Name: unkempt family zinc finger
Synonyms: Zc3h5, B230379M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217331
Homologene: 18194
Xpo6
Name: exportin 6
Synonyms: Ranbp20, 2610005L19Rik, C230091E20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74204
Homologene: 12544
Skp2
Name: S-phase kinase-associated protein 2
Synonyms: FBXL1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 27401
Homologene: 55942
Rttn
Name: rotatin
Synonyms: 4921538A15Rik, C530033I08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 246102
VEGA: 18
Homologene: 65275
Trp53bp2
Name: transformation related protein 53 binding protein 2
Synonyms: ASPP2, 53BP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 209456
Homologene: 3959
Sc5d
Name: sterol-C5-desaturase
Synonyms: A830073K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235293
VEGA: 9
Homologene: 5044
Nbeal2
Name: neurobeachin-like 2
Synonyms: 1110014F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235627
Homologene: 86422
Cldn8
Name: claudin 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 54420
HGNC: HGNC:2050
Homologene: 8117
Mfsd2a
Name: major facilitator superfamily domain containing 2A
Synonyms: Mfsd2, 1700018O18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 76574
Homologene: 19229
Rsu1
Name: Ras suppressor protein 1
Synonyms: RsuI, rsp-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20163
Homologene: 7521
Ppp3ca
Name: protein phosphatase 3, catalytic subunit, alpha isoform
Synonyms: 2900074D19Rik, Caln, Calna, CN, PP2BA alpha, PP2B alpha 1, CnA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 19055
HGNC: HGNC:9314
Homologene: 55497
Phf13
Name: PHD finger protein 13
Synonyms: SPOC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230936
Homologene: 17822
Atp8b1
Name: ATPase, class I, type 8B, member 1
Synonyms: Ic, FIC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 54670
VEGA: 18
HGNC: HGNC:3706
Homologene: 21151
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: Ryr, skrr, calcium release channel isoform 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20190
Homologene: 68069
Il13ra1
Name: interleukin 13 receptor, alpha 1
Synonyms: CD213a1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 16164
HGNC: HGNC:5974
Homologene: 1198
Nav3
Name: neuron navigator 3
Synonyms: 9630020C08Rik, Pomfil1p, POMFIL1, 4732483H20Rik, steerin 3, unc53H3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 260315
Homologene: 56688
Acsl1
Name: acyl-CoA synthetase long-chain family member 1
Synonyms: Acas1, Facl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14081
HGNC: HGNC:3569
Homologene: 37561
Col6a3
Name: collagen, type VI, alpha 3
Synonyms: Col6a-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12835
HGNC: HGNC:2213
Homologene: 37917
Zc3h12c
Name: zinc finger CCCH type containing 12C
Synonyms: C230027N18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244871
VEGA: 9
Homologene: 35462
A2m
Name: alpha-2-macroglobulin
Synonyms: A2mp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232345
HGNC: HGNC:7
Homologene: 37248
Adcy5
Name: adenylate cyclase 5
Synonyms: AC5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224129
VEGA: 16
HGNC: HGNC:236
Homologene: 11213
Capn2
Name: calpain 2
Synonyms: m-calpain, Capa2, Capa-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12334
HGNC: HGNC:1479
Homologene: 1326
Gm973
Name: predicted gene 973
Synonyms: LOC381260
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 381260
Homologene: 124277
Vmn2r94
Name: vomeronasal 2, receptor 94
Synonyms: EG665227
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 665227
Homologene: 129751
Axdnd1
Name: axonemal dynein light chain domain containing 1
Synonyms: 9430070O13Rik, LOC381304
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 77352
Homologene: 52328
Olfr1126
Name: olfactory receptor 1126
Synonyms: MOR264-5, GA_x6K02T2Q125-48959068-48960012
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258834
Homologene: 133659
Gm12500
Name: predicted gene 12500
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 791415
Vcam1
Name: vascular cell adhesion molecule 1
Synonyms: Vcam-1, CD106
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 22329
Homologene: 838
Ces1g
Name: carboxylesterase 1G
Synonyms: Ces1, Ces-1, Ses-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12623
HGNC: HGNC:1863
Homologene: 137354
Cep250
Name: centrosomal protein 250
Synonyms: B230210E21Rik, Inmp, Cep2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16328
HGNC: HGNC:1859
Homologene: 38286
Ift88
Name: intraflagellar transport 88
Synonyms: Ttc10, orpk, Tg737, IFT88, TgN737Rpw, polaris, Tg737Rpw, fxo, Oak Ridge polycystic kidneys
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 21821
Homologene: 4761
Ugt3a2
Name: UDP glycosyltransferases 3 family, polypeptide A2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223337
Homologene: 122787
Asb18
Name: ankyrin repeat and SOCS box-containing 18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 208372
Homologene: 16382
Qars
Name: glutaminyl-tRNA synthetase
Synonyms: 1200016L19Rik, 1110018N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 97541
HGNC: HGNC:9751
Homologene: 133975
Ccpg1
Name: cell cycle progression 1
Synonyms: 1700030B06Rik, D9Ertd392e, 9430028F23Rik, 1810073J13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 72278
Homologene: 3487
Tbc1d21
Name: TBC1 domain family, member 21
Synonyms: 1700095K08Rik, MgcRabGAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74286
VEGA: 9
Homologene: 14033
Cyp2a5
Name: cytochrome P450, family 2, subfamily a, polypeptide 5
Synonyms: Coh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13087
Homologene: 85917
Podnl1
Name: podocan-like 1
Synonyms: 5832418A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244550
Homologene: 41590
B430306N03Rik
Name: RIKEN cDNA B430306N03 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 320148
Homologene: 138443
Gm10384
Name: predicted gene 10384
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 100038735
VEGA: 15
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 59,633,140 bp
  • T to A, chromosome 1 at 89,992,985 bp
  • T to A, chromosome 1 at 90,802,130 bp
  • T to C, chromosome 1 at 156,341,870 bp
  • T to C, chromosome 1 at 182,453,782 bp
  • G to A, chromosome 1 at 182,487,772 bp
  • A to G, chromosome 2 at 13,170,135 bp
  • C to A, chromosome 2 at 87,457,903 bp
  • G to T, chromosome 2 at 155,991,048 bp
  • C to T, chromosome 3 at 108,086,487 bp
  • A to C, chromosome 3 at 116,124,430 bp
  • T to G, chromosome 3 at 136,797,844 bp
  • A to G, chromosome 4 at 122,951,842 bp
  • T to C, chromosome 4 at 151,992,363 bp
  • G to A, chromosome 6 at 121,675,109 bp
  • A to G, chromosome 7 at 26,842,985 bp
  • A to T, chromosome 7 at 29,053,090 bp
  • T to C, chromosome 7 at 126,104,721 bp
  • G to A, chromosome 7 at 130,625,496 bp
  • G to A, chromosome 8 at 46,521,337 bp
  • T to C, chromosome 8 at 84,127,674 bp
  • C to A, chromosome 8 at 93,335,048 bp
  • G to A, chromosome 8 at 122,005,687 bp
  • G to T, chromosome 9 at 42,255,570 bp
  • A to T, chromosome 9 at 52,144,056 bp
  • T to A, chromosome 9 at 58,363,069 bp
  • A to T, chromosome 9 at 73,005,868 bp
  • T to C, chromosome 9 at 108,509,428 bp
  • T to C, chromosome 9 at 110,633,085 bp
  • T to A, chromosome 10 at 109,903,752 bp
  • T to C, chromosome 11 at 116,050,123 bp
  • T to A, chromosome 12 at 4,891,322 bp
  • C to T, chromosome 14 at 57,430,568 bp
  • A to G, chromosome 15 at 9,113,878 bp
  • G to T, chromosome 15 at 9,365,288 bp
  • A to G, chromosome 15 at 36,871,752 bp
  • T to C, chromosome 16 at 35,303,716 bp
  • A to C, chromosome 16 at 88,562,731 bp
  • T to C, chromosome 17 at 18,244,506 bp
  • T to C, chromosome 17 at 48,316,910 bp
  • T to C, chromosome 18 at 64,553,108 bp
  • T to C, chromosome 18 at 89,015,246 bp
  • A to C, chromosome X at 36,155,534 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3052 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040561-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.