Strain Name:
C57BL/6J-MtgxR3105Btlr/Mmmh
Stock Number:
040579-MU
Citation ID:
RRID:MMRRC_040579-MU
Other Names:
R3105 (G1), C57BL/6J-MtgxR3105Btlr
Major Collection:

Gene Information

Grm1
Name: glutamate receptor, metabotropic 1
Synonyms: rcw, nmf373, mGluR1, Grm1, Gprc1a, 4930455H15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 14816
HGNC: HGNC:4593
Homologene: 649
Tkfc
Name: triokinase, FMN cyclase
Synonyms: Dak
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 225913
VEGA: 19
Homologene: 56710
Ccdc163
Name: coiled-coil domain containing 163
Synonyms: 0610037D15Rik, 4933430J04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 68394
Homologene: 12265
Adam23
Name: a disintegrin and metallopeptidase domain 23
Synonyms: MDC3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 23792
HGNC: HGNC:202
Homologene: 2826
Dip2b
Name: disco interacting protein 2 homolog B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 239667
Homologene: 72227
Baz2a
Name: bromodomain adjacent to zinc finger domain, 2A
Synonyms: Walp3, Tip5, C030005G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 116848
VEGA: 10
HGNC: HGNC:962
Homologene: 8393
Sec16a
Name: SEC16 homolog A, endoplasmic reticulum export factor
Synonyms: C230052J16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 227648
Homologene: 10533
Urb1
Name: URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
Synonyms: 4921511H13Rik, 5730405K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 207932
Homologene: 45941
Ccdc191
Name: coiled-coil domain containing 191
Synonyms: 2610015P09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 212153
Homologene: 19484
Dnaja2
Name: DnaJ heat shock protein family (Hsp40) member A2
Synonyms: 2010206B19Rik, HIRIP4, PRO3015, 1500017M13Rik, DNJ3, mDj3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 56445
Homologene: 21193
Ezh1
Name: enhancer of zeste 1 polycomb repressive complex 2 subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 14055
HGNC: HGNC:3526
Homologene: 20458
Sars
Name: seryl-aminoacyl-tRNA synthetase
Synonyms: Strs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 20226
Homologene: 4751
Otof
Name: otoferlin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 83762
HGNC: HGNC:8515
Homologene: 12892
Pgr
Name: progesterone receptor
Synonyms: ENSMUSG00000074510, 9930019P03Rik, PR-B, NR3C3, PR-A, PR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 18667
HGNC: HGNC:8910
Homologene: 713
Ermard
Name: ER membrane associated RNA degradation
Synonyms: 2410011O22Rik, 2210404J11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 381062
Homologene: 19936
Gfpt1
Name: glutamine fructose-6-phosphate transaminase 1
Synonyms: 2810423A18Rik, GFAT, GFA, GFAT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 14583
HGNC: HGNC:4241
Homologene: 68220
Prune2
Name: prune homolog 2
Synonyms: 6330414G02Rik, A230083H22Rik, A330102H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 353211
VEGA: 19
Homologene: 18939
Clca4b
Name: chloride channel accessory 4B
Synonyms: AI747448
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 99709
HGNC: HGNC:2018
Homologene: 40808
Map2
Name: microtubule-associated protein 2
Synonyms: repro4, Mtap2, G1-397-34, MAP-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 17756
HGNC: HGNC:6839
Homologene: 1779
Magi3
Name: membrane associated guanylate kinase, WW and PDZ domain containing 3
Synonyms: 4732496O19Rik, 6530407C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 99470
Homologene: 26431
Taf6l
Name: TATA-box binding protein associated factor 6 like
Synonyms: 2810417N14Rik, PAF65A, C530024J06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 225895
Homologene: 4728
Abcb6
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 6
Synonyms: 1200005B17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 74104
HGNC: HGNC:47
Homologene: 11375
Stradb
Name: STE20-related kinase adaptor beta
Synonyms: Als2cr2, PRO1038, D1Ucla2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 227154
Homologene: 10237
Olfr1251
Name: olfactory receptor 1251
Synonyms: MOR231-15P, MOR231-24_p, GA_x6K02T2Q125-51109312-51108356
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 259145
Homologene: 74065
Dgkg
Name: diacylglycerol kinase, gamma
Synonyms: Dagk3, E430001K23Rik, 2900055E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 110197
HGNC: HGNC:2853
Homologene: 1029
Slc22a29
Name: solute carrier family 22. member 29
Synonyms: D630002G06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 236293
Homologene: 77136
Col6a3
Name: collagen, type VI, alpha 3
Synonyms: Col6a-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 12835
HGNC: HGNC:2213
Homologene: 37917
Lrp4
Name: low density lipoprotein receptor-related protein 4
Synonyms: 6430526J12Rik, mdig, Megf7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228357
HGNC: HGNC:6696
Homologene: 17964
Sfmbt1
Name: Scm-like with four mbt domains 1
Synonyms: 9330180L21Rik, 4930442N21Rik, Smr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 54650
Homologene: 9472
Lrrd1
Name: leucine rich repeats and death domain containing 1
Synonyms: 4932412H11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 242838
Homologene: 18247
Rnpepl1
Name: arginyl aminopeptidase (aminopeptidase B)-like 1
Synonyms: 1110014H17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 108657
Homologene: 36367
Alpk2
Name: alpha-kinase 2
Synonyms: Hak
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 225638
Homologene: 50475
Hnf4g
Name: hepatocyte nuclear factor 4, gamma
Synonyms: NR2A2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 30942
HGNC: HGNC:5026
Homologene: 37886
F11
Name: coagulation factor XI
Synonyms: plasma thromboplastin antecedent, Cf11, 1600027G01Rik, FXI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 109821
HGNC: HGNC:3529
Homologene: 86654
Abhd13
Name: abhydrolase domain containing 13
Synonyms: 1110065L07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 68904
Homologene: 6716
Il1rap
Name: interleukin 1 receptor accessory protein
Synonyms: IL-1R AcP, IL-1RAcP, 6430709H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 16180
HGNC: HGNC:5995
Homologene: 1643
Tmigd1
Name: transmembrane and immunoglobulin domain containing 1
Synonyms: 2010002A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 66601
Homologene: 41641
Tsga10
Name: testis specific 10
Synonyms: Mtsga10, 4933432N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 211484
Homologene: 23531
Spaca1
Name: sperm acrosome associated 1
Synonyms: 1700124L11Rik, 4930540L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 67652
Homologene: 12170
Tm4sf4
Name: transmembrane 4 superfamily member 4
Synonyms: il-TMP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229302
Homologene: 3393
Vmn1r205
Name: vomeronasal 1 receptor 205
Synonyms: V1rh8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 171251
Homologene: 110880
Pomk
Name: protein-O-mannose kinase
Synonyms: Sgk196, 4930444A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 74653
Homologene: 12580
Tmem212
Name: transmembrane protein 212
Synonyms: E030011K20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 208613
Homologene: 28471
Sbspon
Name: somatomedin B and thrombospondin, type 1 domain containing
Synonyms: LOC226866, Gm106
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226866
Homologene: 45950
Osgep
Name: O-sialoglycoprotein endopeptidase
Synonyms: PRSMG1, GCPL-1, 1500019L24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 66246
Homologene: 6395
Gm8730
Name: predicted pseudogene 8730
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 667618
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 15,892,582 bp
  • G to A, chromosome 1 at 37,801,791 bp
  • C to A, chromosome 1 at 58,992,291 bp
  • T to C, chromosome 1 at 63,549,807 bp
  • T to C, chromosome 1 at 66,433,597 bp
  • T to C, chromosome 1 at 75,175,043 bp
  • T to C, chromosome 1 at 90,816,302 bp
  • C to T, chromosome 1 at 92,916,380 bp
  • G to A, chromosome 2 at 26,438,421 bp
  • T to C, chromosome 2 at 89,666,958 bp
  • T to C, chromosome 2 at 91,501,049 bp
  • T to G, chromosome 3 at 3,652,856 bp
  • T to C, chromosome 3 at 27,884,870 bp
  • C to T, chromosome 3 at 57,437,622 bp
  • A to G, chromosome 3 at 104,051,320 bp
  • C to T, chromosome 3 at 108,429,305 bp
  • A to T, chromosome 3 at 144,916,671 bp
  • G to A, chromosome 4 at 34,028,468 bp
  • C to A, chromosome 4 at 116,709,500 bp
  • A to G, chromosome 5 at 3,858,839 bp
  • A to G, chromosome 5 at 30,381,801 bp
  • A to G, chromosome 6 at 87,057,646 bp
  • T to C, chromosome 8 at 9,987,931 bp
  • A to C, chromosome 8 at 25,982,914 bp
  • T to A, chromosome 8 at 45,245,717 bp
  • G to A, chromosome 8 at 85,555,228 bp
  • T to C, chromosome 8 at 102,865,263 bp
  • T to A, chromosome 9 at 8,958,396 bp
  • A to G, chromosome 10 at 11,079,857 bp
  • AGCGGCGGTACTTGCGGG to AG, chromosome 10 at 128,125,077 bp
  • A to G, chromosome 11 at 76,910,298 bp
  • A to C, chromosome 11 at 101,195,642 bp
  • T to C, chromosome 13 at 22,592,939 bp
  • G to A, chromosome 14 at 30,817,796 bp
  • T to C, chromosome 14 at 50,916,829 bp
  • C to A, chromosome 15 at 100,142,137 bp
  • T to A, chromosome 16 at 22,575,341 bp
  • A to G, chromosome 16 at 26,722,752 bp
  • T to C, chromosome 16 at 43,931,210 bp
  • C to T, chromosome 16 at 90,795,443 bp
  • C to T, chromosome 17 at 15,061,191 bp
  • A to T, chromosome 18 at 65,350,210 bp
  • T to C, chromosome 19 at 8,169,973 bp
  • C to T, chromosome 19 at 8,778,855 bp
  • G to T, chromosome 19 at 10,596,993 bp
  • T to A, chromosome 19 at 17,119,156 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3105 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040579-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.