Strain Name:
C57BL/6J-MtgxR3508Btlr/Mmmh
Stock Number:
040664-MU
Citation ID:
RRID:MMRRC_040664-MU
Other Names:
R3508 (G1), C57BL/6J-MtgxR3508Btlr
Major Collection:

Gene Information

Upf1
Name: UPF1 regulator of nonsense transcripts homolog (yeast)
Synonyms: PNORF-1, B430202H16Rik, Rent1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 19704
HGNC: HGNC:9962
Homologene: 2185
Rtel1
Name: regulator of telomere elongation helicase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 269400
Homologene: 13168
Ppp1r13b
Name: protein phosphatase 1, regulatory subunit 13B
Synonyms: ASPP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 21981
VEGA: 12
Homologene: 9090
Adgrl3
Name: adhesion G protein-coupled receptor L3
Synonyms: lectomedin 3, LEC3, D130075K09Rik, 5430402I23Rik, Lphn3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 319387
Homologene: 22878
Vpreb3
Name: pre-B lymphocyte gene 3
Synonyms: Vpreb-3, 8HS-20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 22364
Homologene: 7598
Pck1
Name: phosphoenolpyruvate carboxykinase 1, cytosolic
Synonyms: Pck-1, PEPCK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18534
HGNC: HGNC:8724
Homologene: 1944
Ncaph
Name: non-SMC condensin I complex, subunit H
Synonyms: HCAP-H, A730011O11Rik, Brrn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 215387
HGNC: HGNC:1112
Homologene: 133986
Zc3h13
Name: zinc finger CCCH type containing 13
Synonyms: C87618, 4930570G11Rik, 2600010B19Rik, 3110050K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 67302
VEGA: 14
Sec16a
Name: SEC16 homolog A, endoplasmic reticulum export factor
Synonyms: C230052J16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227648
Homologene: 10533
Ubap1
Name: ubiquitin-associated protein 1
Synonyms: 2700092A01Rik, NAG20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67123
Homologene: 9554
Ipo5
Name: importin 5
Synonyms: RanBP5, 5730478E03Rik, 1110011C18Rik, Kpnb3, IMB3, importin beta 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 70572
VEGA: 14
HGNC: HGNC:6402
Homologene: 1710
Fanci
Name: Fanconi anemia, complementation group I
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 208836
Homologene: 49530
Tonsl
Name: tonsoku-like, DNA repair protein
Synonyms: 2810439M11Rik, Nfkbil2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 72749
HGNC: HGNC:7801
Homologene: 22754
Tk2
Name: thymidine kinase 2, mitochondrial
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 57813
Homologene: 3392
Nbn
Name: nibrin
Synonyms: Nbs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 27354
HGNC: HGNC:7652
Homologene: 1858
Slc18a2
Name: solute carrier family 18 (vesicular monoamine), member 2
Synonyms: Vmat2, 1110037L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 214084
VEGA: 19
Homologene: 2298
Mms22l
Name: MMS22-like, DNA repair protein
Synonyms: F730047E07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 212377
Homologene: 18874
Ppp2r5a
Name: protein phosphatase 2, regulatory subunit B', alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226849
HGNC: HGNC:9309
Homologene: 55961
Napb
Name: N-ethylmaleimide sensitive fusion protein attachment protein beta
Synonyms: SNARE, b-SNAP, I47, E161, Brp14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17957
Homologene: 5332
Homer3
Name: homer scaffolding protein 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 26558
Homologene: 37972
Stimate
Name: STIM activating enhancer
Synonyms: 1810038N08Rik, 2310014H19Rik, Tmem110
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 69179
Homologene: 7082
Atad2b
Name: ATPase family, AAA domain containing 2B
Synonyms: 1110014E10Rik, D530031C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 320817
VEGA: 12
Homologene: 86351
Pnkd
Name: paroxysmal nonkinesiogenic dyskinesia
Synonyms: 2210013N15Rik, 2810403H05Rik, Brp17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 56695
HGNC: HGNC:9153
Homologene: 75045
Sox17
Name: SRY (sex determining region Y)-box 17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20671
Homologene: 7948
Fbn1
Name: fibrillin 1
Synonyms: Fib-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14118
HGNC: HGNC:3603
Homologene: 30958
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Kif27
Name: kinesin family member 27
Synonyms: 4930517I18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 75050
VEGA: 13
Homologene: 69235
Sorcs1
Name: sortilin-related VPS10 domain containing receptor 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 58178
Homologene: 10967
Olfr1251
Name: olfactory receptor 1251
Synonyms: GA_x6K02T2Q125-51109312-51108356, MOR231-24_p, MOR231-15P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 259145
Homologene: 74065
Gm872
Name: predicted gene 872
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Sybu
Name: syntabulin (syntaxin-interacting)
Synonyms: A830027B17Rik, Golsyn/Syntabulin, 5730410E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 319613
VEGA: 15
Homologene: 9838
Pycrl
Name: pyrroline-5-carboxylate reductase-like
Synonyms: 1110058B13Rik, 2700073G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 66194
VEGA: 15
Homologene: 56130
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239420
Homologene: 65982
Gjd4
Name: gap junction protein, delta 4
Synonyms: connexin 39, Cx39, 9430022F06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225152
VEGA: 18
Homologene: 17692
Pcdhb13
Name: protocadherin beta 13
Synonyms: PcdhbM, Pcdbh6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93884
HGNC: HGNC:8691
Homologene: 10338
F12
Name: coagulation factor XII (Hageman factor)
Synonyms: FXII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 58992
HGNC: HGNC:3530
Homologene: 425
Cep162
Name: centrosomal protein 162
Synonyms: 4922501C03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 382090
Homologene: 8930
Abca8a
Name: ATP-binding cassette, sub-family A (ABC1), member 8a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217258
HGNC: HGNC:38
Homologene: 131160
Tmc5
Name: transmembrane channel-like gene family 5
Synonyms: 4932443L08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74424
Homologene: 11713
Vmn2r84
Name: vomeronasal 2, receptor 84
Synonyms: EG625068
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 625068
Homologene: 129606
Micall1
Name: microtubule associated monooxygenase, calponin and LIM domain containing -like 1
Synonyms: Mus EST 820961, D15N2e, D15Mit260
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 27008
VEGA: 15
Homologene: 24911
Pld5
Name: phospholipase D family, member 5
Synonyms: B230365F16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 319455
Homologene: 16081
Klhdc7b
Name: kelch domain containing 7B
Synonyms: EG546648
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 546648
Homologene: 34707
Arhgap15
Name: Rho GTPase activating protein 15
Synonyms: 5830480G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76117
Homologene: 41271
Slc26a7
Name: solute carrier family 26, member 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 208890
Homologene: 13770
Cdc20b
Name: cell division cycle 20B
Synonyms: EG238896, EG622422
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238896
Homologene: 65056
Ppm1l
Name: protein phosphatase 1 (formerly 2C)-like
Synonyms: PP2C-epsilon, Pp2ce, 5930404J21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242083
Homologene: 33158
Fndc1
Name: fibronectin type III domain containing 1
Synonyms: 1110027O12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 68655
Inpp1
Name: inositol polyphosphate-1-phosphatase
Synonyms: 2300002C06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16329
HGNC: HGNC:6071
Homologene: 1655
Krt83
Name: keratin 83
Synonyms: 5430421N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 100126226
HGNC: HGNC:6460
Homologene: 68248
Flt4
Name: FMS-like tyrosine kinase 4
Synonyms: VEGFR3, VEGFR-3, Flt-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14257
HGNC: HGNC:3767
Homologene: 7321
Elmo1
Name: engulfment and cell motility 1
Synonyms: CED-12, C230095H21Rik, 6330578D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 140580
Homologene: 56685
Plekha8
Name: pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8
Synonyms: FAPP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 231999
Homologene: 32284
Musk
Name: muscle, skeletal, receptor tyrosine kinase
Synonyms: MDK4, Nsk2, Nsk3, Nsk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18198
HGNC: HGNC:7525
Homologene: 4084
Ttll12
Name: tubulin tyrosine ligase-like family, member 12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223723
Homologene: 9036
Sgcg
Name: sarcoglycan, gamma (dystrophin-associated glycoprotein)
Synonyms: gamma-SG, 5430420E18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 24053
Homologene: 194
Hspa14
Name: heat shock protein 14
Synonyms: NST-1, 70kDa, HSP70L1, Hsp70-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 50497
Homologene: 74307
Apol8
Name: apolipoprotein L 8
Synonyms: 9830006J20Rik, Apol2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239552
VEGA: 15
HGNC: HGNC:619
Homologene: 12785
1700014D04Rik
Name: RIKEN cDNA 1700014D04 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 102638268
Homologene: 140986
Rxfp4
Name: relaxin family peptide receptor 4
Synonyms: Gpr100, Rln3r2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242093
Homologene: 18775
Ppm1k
Name: protein phosphatase 1K (PP2C domain containing)
Synonyms: 2900063A19Rik, A930026L03Rik, PP2Cm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243382
Homologene: 36819
Mfsd4b1
Name: major facilitator superfamily domain containing 4B1
Synonyms: AI317395
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215929
Homologene: 77426
H2-M10.1
Name: histocompatibility 2, M region locus 10.1
Synonyms: 9.5H
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14985
Homologene: 117973
Crtac1
Name: cartilage acidic protein 1
Synonyms: 2810454P21Rik, Crtac1B, Lotus
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 72832
VEGA: 19
Homologene: 23070
Scp2d1
Name: SCP2 sterol-binding domain containing 1
Synonyms: 1700010M22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66328
Homologene: 11947
Cnpy1
Name: canopy FGF signaling regulator 1
Synonyms: 9630008K15Rik, 1500012D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 269637
Homologene: 89678
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 4,492,155 bp
  • A to T, chromosome 1 at 52,799,391 bp
  • A to G, chromosome 1 at 74,350,634 bp
  • C to T, chromosome 1 at 175,994,037 bp
  • A to T, chromosome 1 at 191,353,983 bp
  • A to G, chromosome 2 at 3,491,008 bp
  • G to T, chromosome 2 at 26,425,850 bp
  • G to A, chromosome 2 at 44,142,242 bp
  • A to G, chromosome 2 at 76,753,757 bp
  • A to G, chromosome 2 at 89,667,472 bp
  • T to C, chromosome 2 at 125,306,327 bp
  • T to C, chromosome 2 at 127,127,193 bp
  • A to G, chromosome 2 at 144,823,998 bp
  • T to C, chromosome 2 at 148,698,960 bp
  • T to C, chromosome 2 at 173,158,384 bp
  • T to C, chromosome 2 at 181,322,409 bp
  • G to T, chromosome 3 at 69,549,480 bp
  • T to C, chromosome 3 at 88,652,592 bp
  • C to T, chromosome 4 at 14,552,523 bp
  • T to A, chromosome 4 at 15,962,387 bp
  • T to G, chromosome 4 at 24,586,224 bp
  • C to A, chromosome 4 at 41,379,163 bp
  • A to G, chromosome 4 at 58,327,347 bp
  • T to C, chromosome 5 at 28,207,367 bp
  • C to A, chromosome 5 at 81,724,256 bp
  • T to C, chromosome 6 at 54,613,194 bp
  • T to C, chromosome 6 at 57,514,990 bp
  • A to G, chromosome 7 at 79,433,472 bp
  • G to A, chromosome 7 at 118,645,395 bp
  • T to A, chromosome 8 at 70,291,355 bp
  • C to T, chromosome 8 at 70,338,460 bp
  • C to T, chromosome 8 at 104,231,193 bp
  • A to G, chromosome 9 at 87,231,977 bp
  • A to G, chromosome 10 at 40,002,719 bp
  • A to C, chromosome 10 at 75,949,203 bp
  • T to A, chromosome 10 at 92,885,424 bp
  • T to C, chromosome 10 at 130,390,908 bp
  • T to C, chromosome 11 at 49,634,114 bp
  • A to T, chromosome 11 at 110,063,165 bp
  • G to A, chromosome 12 at 4,950,595 bp
  • T to C, chromosome 12 at 111,872,367 bp
  • T to C, chromosome 13 at 20,605,232 bp
  • T to C, chromosome 13 at 55,421,059 bp
  • T to C, chromosome 13 at 58,313,212 bp
  • A to T, chromosome 13 at 59,742,505 bp
  • T to C, chromosome 13 at 113,081,042 bp
  • C to T, chromosome 14 at 30,872,580 bp
  • T to A, chromosome 14 at 61,221,746 bp
  • T to A, chromosome 14 at 75,308,940 bp
  • T to A, chromosome 14 at 120,939,544 bp
  • T to A, chromosome 15 at 44,673,082 bp
  • CCTTTGCGCTT to CCTT, chromosome 15 at 47,741,236 bp
  • A to G, chromosome 15 at 75,918,241 bp
  • T to C, chromosome 15 at 76,639,756 bp
  • T to C, chromosome 15 at 77,749,443 bp
  • A to G, chromosome 15 at 79,122,765 bp
  • A to G, chromosome 15 at 83,580,630 bp
  • T to A, chromosome 15 at 89,386,892 bp
  • A to G, chromosome 15 at 101,488,158 bp
  • G to A, chromosome 17 at 7,765,108 bp
  • T to G, chromosome 17 at 36,325,614 bp
  • G to T, chromosome 18 at 9,280,811 bp
  • T to A, chromosome 18 at 37,443,151 bp
  • C to T, chromosome 19 at 42,304,741 bp
  • G to A, chromosome 19 at 50,225,175 bp
  • A to G, chromosome 19 at 59,273,557 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3508 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040664-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.