Strain Name:
C57BL/6J-MtgxR3723Btlr/Mmmh
Stock Number:
040714-MU
Citation ID:
RRID:MMRRC_040714-MU
Other Names:
R3723 (G1), C57BL/6J-MtgxR3723Btlr
Major Collection:

Gene Information

Myo10
Name: myosin X
Synonyms: myosin-X, D15Ertd600e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 17909
HGNC: HGNC:7593
Homologene: 36328
Sptbn1
Name: spectrin beta, non-erythrocytic 1
Synonyms: elf3, Spnb-2, beta fodrin, Spnb2, 9930031C03Rik, non-erythrocytic, brain spectrin, spectrin G, elf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 20742
Homologene: 2354
Npl
Name: N-acetylneuraminate pyruvate lyase
Synonyms: 0610033B02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 74091
Homologene: 12533
Api5
Name: apoptosis inhibitor 5
Synonyms: AAC-11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 11800
HGNC: HGNC:594
Homologene: 4809
Rere
Name: arginine glutamic acid dipeptide (RE) repeats
Synonyms: atrophin-2, eyes3, Atr2, eyem03Jus, 1110033A15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 68703
HGNC: HGNC:9965
Homologene: 8101
Zfp30
Name: zinc finger protein 30
Synonyms: 2610306P15Rik, Zfp-30
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 22693
Homologene: 84799
Pan3
Name: PAN3 poly(A) specific ribonuclease subunit
Synonyms: A430027N15Rik, 2700050F09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 72587
Homologene: 6372
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: LOC381341, Dnahc7, Dnahc7a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 627872
Homologene: 41287
Scube2
Name: signal peptide, CUB domain, EGF-like 2
Synonyms: 4932442O19Rik, ICRFP703N2430Q5.1, Cegf1, ICRFP703B1614Q5.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 56788
Homologene: 36383
Apob
Name: apolipoprotein B
Synonyms: apob-100, apob-48
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Uba6
Name: ubiquitin-like modifier activating enzyme 6
Synonyms: Ube1l2, 5730469D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231380
Homologene: 10080
Srsf4
Name: serine and arginine-rich splicing factor 4
Synonyms: MNCb-2616, SRp75, Sfrs4, 5730499P16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 57317
Homologene: 25624
Tpm1
Name: tropomyosin 1, alpha
Synonyms: TM2, Tm3, Tpm-1, alpha-TM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 22003
Homologene: 128637
Dync2h1
Name: dynein cytoplasmic 2 heavy chain 1
Synonyms: m407Asp, DHC1b, b2b414Clo, Dnchc2, 4432416O06Rik, D030010H02Rik, D330044F14Rik, m152Asp, DHC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 110350
HGNC: HGNC:2962
Homologene: 14468
Prdm4
Name: PR domain containing 4
Synonyms: 2810470D21Rik, SC-1, 1700031E19Rik, SC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 72843
VEGA: 10
HGNC: HGNC:9348
Homologene: 8235
Supt3
Name: SPT3, SAGA and STAGA complex component
Synonyms: 2310066G22Rik, Supt3h, SPT3, SPT3L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 109115
Homologene: 121570
Kif18b
Name: kinesin family member 18B
Synonyms: N-8 kinesin, 3000004C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 70218
Homologene: 15214
Tnfsf13b
Name: tumor necrosis factor (ligand) superfamily, member 13b
Synonyms: BLyS, BAFF, zTNF4, TALL-1, D8Ertd387e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 24099
Homologene: 48443
Ckap4
Name: cytoskeleton-associated protein 4
Synonyms: CLIMP-63, 5630400A09Rik, P63
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 216197
VEGA: 10
Homologene: 4970
Mipol1
Name: mirror-image polydactyly 1
Synonyms: D12Ertd19e, 1700081O04Rik, 6030439O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 73490
Homologene: 16340
Naip5
Name: NLR family, apoptosis inhibitory protein 5
Synonyms: Birc1e, Lgn1, Naip-rs3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 17951
HGNC: HGNC:7634
Homologene: 113589
Cfap53
Name: cilia and flagella associated protein 53
Synonyms: Ccdc11, 4933415I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 74453
Homologene: 27056
Celsr2
Name: cadherin, EGF LAG seven-pass G-type receptor 2
Synonyms: EGFL2, flamingo, mfmi1, Adgrc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 53883
HGNC: HGNC:3231
Homologene: 1078
Ahnak
Name: AHNAK nucleoprotein (desmoyokin)
Synonyms: 2310047C17Rik, 1110004P15Rik, DY6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Glis3
Name: GLIS family zinc finger 3
Synonyms: E330013K21Rik, 4833409N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 226075
Homologene: 34989
Plbd2
Name: phospholipase B domain containing 2
Synonyms: 1300012G16Rik, p76, 66.3 kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 71772
Homologene: 41528
Tns1
Name: tensin 1
Synonyms: Tns, E030037J05Rik, 1110018I21Rik, E030018G17Rik, 1200014E20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 21961
Homologene: 11219
Kctd16
Name: potassium channel tetramerisation domain containing 16
Synonyms: 4930434H12Rik, 2900055J20Rik, LOC383347
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 73001
VEGA: 18
Homologene: 44779
Mefv
Name: Mediterranean fever
Synonyms: marenostrin, TRIM20, FMF, pyrin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 54483
VEGA: 16
HGNC: HGNC:6998
Homologene: 32441
Vmn2r91
Name: vomeronasal 2, receptor 91
Synonyms: EG665210
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 665210
Homologene: 115024
Fam171a1
Name: family with sequence similarity 171, member A1
Synonyms: 9630050M13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 269233
Homologene: 19521
Gm8603
Name: predicted gene 8603
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 667384
Gm13101
Name: predicted gene 13101
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 626922
Ano5
Name: anoctamin 5
Synonyms: Gdd1, Tmem16e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233246
Homologene: 100071
C9
Name: complement component 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 12279
HGNC: HGNC:1358
Homologene: 74406
Arsk
Name: arylsulfatase K
Synonyms: 2810429K17Rik, 4833414G15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 77041
Homologene: 12670
Gm14221
Name: predicted gene 14221
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 105244348
Vmn1r117
Name: vomeronasal 1 receptor 117
Synonyms: Gm8544
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 667262
Homologene: 104166
AC147549.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
Alteration at locus: Chemically Induced
Gm9767
Name: predicted gene 9767
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 100040851
VEGA: 10
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 53,447,346 bp
  • T to C, chromosome 1 at 73,924,940 bp
  • A to G, chromosome 1 at 153,515,464 bp
  • A to G, chromosome 2 at 3,220,375 bp
  • C to T, chromosome 2 at 94,425,613 bp
  • C to G, chromosome 2 at 160,568,427 bp
  • A to G, chromosome 3 at 108,397,415 bp
  • C to T, chromosome 4 at 131,900,102 bp
  • T to C, chromosome 4 at 143,966,681 bp
  • A to G, chromosome 4 at 150,468,795 bp
  • T to C, chromosome 5 at 86,135,047 bp
  • A to G, chromosome 5 at 120,487,776 bp
  • T to A, chromosome 5 at 147,503,208 bp
  • T to A, chromosome 7 at 20,883,455 bp
  • A to G, chromosome 7 at 29,793,353 bp
  • A to G, chromosome 7 at 51,576,528 bp
  • T to C, chromosome 7 at 109,808,406 bp
  • A to G, chromosome 8 at 10,031,545 bp
  • A to T, chromosome 9 at 7,041,658 bp
  • G to A, chromosome 9 at 67,031,945 bp
  • G to T, chromosome 10 at 26,078,571 bp
  • A to G, chromosome 10 at 84,528,392 bp
  • A to G, chromosome 10 at 85,899,281 bp
  • A to G, chromosome 11 at 30,137,335 bp
  • A to G, chromosome 11 at 102,916,276 bp
  • A to T, chromosome 12 at 8,006,327 bp
  • A to G, chromosome 12 at 8,011,763 bp
  • C to A, chromosome 12 at 57,457,092 bp
  • T to A, chromosome 13 at 76,066,653 bp
  • G to T, chromosome 13 at 100,223,014 bp
  • G to A, chromosome 15 at 6,483,080 bp
  • T to C, chromosome 15 at 25,803,288 bp
  • A to G, chromosome 16 at 3,708,194 bp
  • A to C, chromosome 17 at 13,516,813 bp
  • G to A, chromosome 17 at 18,085,278 bp
  • A to G, chromosome 17 at 44,994,387 bp
  • A to G, chromosome 18 at 40,258,859 bp
  • A to G, chromosome 18 at 74,359,569 bp
  • T to C, chromosome 19 at 9,016,853 bp
  • A to T, chromosome 19 at 28,262,591 bp
  • G to A, chromosome Y at 10,641,814 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3723 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040714-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.