Strain Name:
C57BL/6J-MtgxR3729Btlr/Mmmh
Stock Number:
040719-MU
Citation ID:
RRID:MMRRC_040719-MU
Other Names:
R3729 (G1), C57BL/6J-MtgxR3729Btlr
Major Collection:

Strain Information

Prrx1
Name: paired related homeobox 1
Synonyms: K-2, Prx1, mHox, Pmx1, mHox, A230024N07Rik, MHox1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18933
HGNC: HGNC:9142
Homologene: 7896
Arpp21
Name: cyclic AMP-regulated phosphoprotein, 21
Synonyms: ARPP-21, Tarpp, D9Bwg1012e, 0710001E13Rik, R3hdm3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74100
Homologene: 32306
Slc4a7
Name: solute carrier family 4, sodium bicarbonate cotransporter, member 7
Synonyms: E430014N10Rik, NBC3, NBCn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218756
VEGA: 14
Homologene: 2680
Manba
Name: mannosidase, beta A, lysosomal
Synonyms: Bmn, 2410030O07Rik, B930014J03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 110173
HGNC: HGNC:6831
Homologene: 4317
Cdk8
Name: cyclin-dependent kinase 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 264064
HGNC: HGNC:1779
Homologene: 55565
Shroom3
Name: shroom family member 3
Synonyms: D5Ertd287e, Shrm, Shrm3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 27428
Homologene: 9263
Gcn1
Name: GCN1 activator of EIF2AK4
Synonyms: GCN1L, G431004K08Rik, Gcn1l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231659
HGNC: HGNC:4199
Homologene: 5887
Nol10
Name: nucleolar protein 10
Synonyms: LOC217431
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217431
VEGA: 12
Homologene: 5998
Trip4
Name: thyroid hormone receptor interactor 4
Synonyms: ASC-1, 4930558E03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 56404
Homologene: 9426
Taf12
Name: TATA-box binding protein associated factor 12
Synonyms: Taf2J, 2810422D08Rik, 20kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66464
Homologene: 68477
Kctd5
Name: potassium channel tetramerisation domain containing 5
Synonyms: 2610030N08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 69259
Homologene: 10363
Mier2
Name: MIER family member 2
Synonyms: 2700087H15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 70427
Homologene: 18941
Zfp960
Name: zinc finger protein 960
Synonyms: BC018101
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 449000
Homologene: 133884
Vegfa
Name: vascular endothelial growth factor A
Synonyms: VPF, VEGF-A, VEGF120, Vegf, VEGF188, VEGF164
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22339
Homologene: 2534
Acvr1
Name: activin A receptor, type 1
Synonyms: ActR-I, ALK2, Acvr, Acvrlk2, ActRIA, SKR1, Tsk7L, D330013D15Rik, Alk8, Alk-2, Acvr1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11477
HGNC: HGNC:171
Homologene: 7
Map2
Name: microtubule-associated protein 2
Synonyms: MAP-2, G1-397-34, Mtap2, repro4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17756
HGNC: HGNC:6839
Homologene: 1779
Hspbp1
Name: HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
Synonyms: 1500019G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 66245
Homologene: 40827
Sec24b
Name: Sec24 related gene family, member B (S. cerevisiae)
Synonyms: SEC24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99683
Homologene: 55968
Cachd1
Name: cache domain containing 1
Synonyms: 1190007F10Rik, Vwcd1, B430218L07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 320508
Homologene: 10854
Dhx33
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 33
Synonyms: 9430096J02Rik, 3110057P17Rik, Ddx33
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216877
Homologene: 56235
Lemd3
Name: LEM domain containing 3
Synonyms: Man1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 380664
Homologene: 8633
Zfp280b
Name: zinc finger protein 280B
Synonyms: D10Jhu82e, Suhw2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 64453
VEGA: 10
Homologene: 62794
Mslnl
Name: mesothelin-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 328783
VEGA: 17
Homologene: 18633
Txnip
Name: thioredoxin interacting protein
Synonyms: THIF, VDUP1, mVDUP1, Hyplip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56338
Homologene: 38186
Acacb
Name: acetyl-Coenzyme A carboxylase beta
Synonyms: Accb, Acc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100705
HGNC: HGNC:85
Homologene: 74382
Fat3
Name: FAT atypical cadherin 3
Synonyms: LOC234973, LOC382129, D430038H04Rik, 9430076A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Dnah12
Name: dynein, axonemal, heavy chain 12
Synonyms: Hdhc3, HL-19, DLP12, HL19, DHC3, LOC380889, 4921531P07Rik, Dnahc7l, Dnahc12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 110083
HGNC: HGNC:2943
Homologene: 56821
Fmnl3
Name: formin-like 3
Synonyms: 2700073B04Rik, Wbp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 22379
Homologene: 69101
Tnn
Name: tenascin N
Synonyms: Tnw, tenascin-W
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329278
Homologene: 18634
Slc16a10
Name: solute carrier family 16 (monocarboxylic acid transporters), member 10
Synonyms: PRO0813, TAT1, 2610103N14Rik, Mct10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 72472
VEGA: 10
Homologene: 75089
Or5p62
Name: olfactory receptor family 5 subfamily P member 62
Synonyms: GA_x6K02T2PBJ9-10501920-10500976, MOR204-19, Olfr486
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258489
Homologene: 110483
Wdr83
Name: WD repeat domain containing 83
Synonyms: 1500041N16Rik, Morg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 67836
Homologene: 12194
Aldoart2
Name: aldolase 1 A, retrogene 2
Synonyms: Aldo1-ps1, 4933425L11Rik, Aldoa-ps1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 79459
HGNC: HGNC:414
Homologene: 134148
Trim46
Name: tripartite motif-containing 46
Synonyms: TRIFIC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 360213
Homologene: 11815
Phtf1
Name: putative homeodomain transcription factor 1
Synonyms: Phft
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18685
HGNC: HGNC:8939
Homologene: 4817
Rbsn
Name: rabenosyn, RAB effector
Synonyms: 5330426D11Rik, Rabenosyn-5, Zfyve20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 78287
Homologene: 41477
Card14
Name: caspase recruitment domain family, member 14
Synonyms: CARMA2, Bimp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 170720
Homologene: 11469
Vmn2r14
Name: vomeronasal 2, receptor 14
Synonyms: EG231591
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231591
Homologene: 129606
Kif4-ps
Name: kinesin family member 4, pseudogene
Synonyms: Kif4b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 74947
Or8d2b
Name: olfactory receptor family 8 subfamily D member 2D
Synonyms: GA_x6K02T2PVTD-32573036-32573962, MOR171-8, Olfr926
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258811
VEGA: 9
HGNC: HGNC:8482
Homologene: 128215
Ehf
Name: ets homologous factor
Synonyms: 9030625L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13661
HGNC: HGNC:3246
Homologene: 7301
Best3
Name: bestrophin 3
Synonyms: mBest4, Vmd2l3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 382427
VEGA: 10
Homologene: 33850
Frmpd4
Name: FERM and PDZ domain containing 4
Synonyms: LOC237234, Pdzk10, Pdzd10, PKAP1, Preso1, Preso
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 333605
Homologene: 45843
Mfsd1
Name: major facilitator superfamily domain containing 1
Synonyms: 1200003O06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66868
Homologene: 11228
Tssk5
Name: testis-specific serine kinase 5
Synonyms: 1700091F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 73542
VEGA: 15
Homologene: 18832
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 66,412,446 bp
  • A to G, chromosome 1 at 160,146,240 bp
  • A to G, chromosome 1 at 163,261,877 bp
  • T to C, chromosome 2 at 58,462,913 bp
  • G to T, chromosome 2 at 103,266,953 bp
  • T to C, chromosome 3 at 67,582,965 bp
  • T to A, chromosome 3 at 89,234,949 bp
  • C to G, chromosome 3 at 96,559,447 bp
  • A to G, chromosome 3 at 103,985,779 bp
  • T to C, chromosome 3 at 130,033,833 bp
  • G to A, chromosome 3 at 135,554,850 bp
  • C to A, chromosome 4 at 100,974,880 bp
  • C to A, chromosome 4 at 132,282,954 bp
  • G to T, chromosome 5 at 92,943,086 bp
  • T to C, chromosome 5 at 109,216,229 bp
  • A to G, chromosome 5 at 114,207,348 bp
  • A to T, chromosome 5 at 115,583,394 bp
  • T to C, chromosome 5 at 146,298,913 bp
  • T to C, chromosome 6 at 92,191,335 bp
  • G to T, chromosome 7 at 4,677,809 bp
  • A to T, chromosome 7 at 108,172,309 bp
  • G to T, chromosome 8 at 85,080,339 bp
  • A to G, chromosome 9 at 16,247,041 bp
  • T to C, chromosome 9 at 38,877,251 bp
  • T to C, chromosome 9 at 65,880,942 bp
  • T to A, chromosome 9 at 112,065,979 bp
  • G to C, chromosome 10 at 40,056,624 bp
  • A to G, chromosome 10 at 76,039,102 bp
  • T to C, chromosome 10 at 79,545,042 bp
  • T to C, chromosome 10 at 116,993,053 bp
  • T to C, chromosome 10 at 120,928,015 bp
  • T to C, chromosome 11 at 70,989,152 bp
  • T to C, chromosome 11 at 119,333,932 bp
  • A to T, chromosome 12 at 17,424,673 bp
  • A to G, chromosome 12 at 55,566,319 bp
  • A to G, chromosome 12 at 101,146,110 bp
  • A to T, chromosome 14 at 14,729,276 bp
  • T to A, chromosome 14 at 26,706,065 bp
  • C to T, chromosome 15 at 76,372,896 bp
  • A to G, chromosome 15 at 99,321,864 bp
  • T to A, chromosome 17 at 17,088,371 bp
  • T to C, chromosome 17 at 24,059,238 bp
  • G to A, chromosome 17 at 25,742,934 bp
  • T to C, chromosome 17 at 46,024,520 bp
  • G to A, chromosome X at 167,486,807 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3729 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040719-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.