Strain Name:
C57BL/6J-MtgxR3739Btlr/Mmmh
Stock Number:
040725-MU
Citation ID:
RRID:MMRRC_040725-MU
Other Names:
R3739 (G1), C57BL/6J-MtgxR3739Btlr
Major Collection:

Strain Information

Myh9
Name: myosin, heavy polypeptide 9, non-muscle
Synonyms: D0Jmb2, E030044M24Rik, NMHC II-A, Myhn-1, Myhn1, myosin IIA, Fltn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 17886
HGNC: HGNC:7579
Homologene: 129835
Apoa5
Name: apolipoprotein A-V
Synonyms: RAP3, Apoav, 1300007O05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 66113
Homologene: 14197
Trpc2
Name: transient receptor potential cation channel, subfamily C, member 2
Synonyms: TRPC2b, TRPC2a, mTrp2, trp2, Trrp2, 3010009O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22064
Homologene: 135989
Ifi203
Name: interferon activated gene 203
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 15950
Homologene: 115929
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Zfp423
Name: zinc finger protein 423
Synonyms: Roaz, ataxia1, Zfp104, Ebfaz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 94187
Homologene: 9010
Trpm7
Name: transient receptor potential cation channel, subfamily M, member 7
Synonyms: 5033407O22Rik, 4833414K03Rik, CHAK1, CHAK, TRP-PLIK, Ltpr7, 2310022G15Rik, LTRPC7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 58800
Homologene: 9774
Lig3
Name: ligase III, DNA, ATP-dependent
Synonyms: D11Wsu78e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16882
HGNC: HGNC:6600
Homologene: 32109
Taf3
Name: TATA-box binding protein associated factor 3
Synonyms: mTAFII140, 4933439M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 209361
Homologene: 35415
Ankrd11
Name: ankyrin repeat domain 11
Synonyms: 2410104C19Rik, 9530048I21Rik, 3010027A04Rik, Yod
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 77087
Homologene: 69134
Myo18a
Name: myosin XVIIIA
Synonyms: MyoPDZ
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 360013
Homologene: 7977
Abcb8
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 8
Synonyms: 4833412N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 74610
HGNC: HGNC:49
Homologene: 5203
Osbpl2
Name: oxysterol binding protein-like 2
Synonyms: ORP-2, C130070J12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228983
Homologene: 77324
Otud6b
Name: OTU domain containing 6B
Synonyms: 2600013N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 72201
Homologene: 6064
Mybbp1a
Name: MYB binding protein (P160) 1a
Synonyms: p67MBP, p160MBP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18432
HGNC: HGNC:7546
Homologene: 40954
Srsf4
Name: serine and arginine-rich splicing factor 4
Synonyms: MNCb-2616, 5730499P16Rik, SRp75, Sfrs4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 57317
Homologene: 25624
Nsun2
Name: NOL1/NOP2/Sun domain family member 2
Synonyms: Misu
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 28114
Homologene: 9817
Ntng1
Name: netrin G1
Synonyms: Lmnt1, A930010C08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80883
Homologene: 8949
Tubb6
Name: tubulin, beta 6 class V
Synonyms: 2310057H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 67951
VEGA: 18
Homologene: 69414
Itpkc
Name: inositol 1,4,5-trisphosphate 3-kinase C
Synonyms: 9130023N17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233011
Homologene: 11868
Lcorl
Name: ligand dependent nuclear receptor corepressor-like
Synonyms: Mlr1, A830039H10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 209707
Homologene: 82325
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 665700
Homologene: 90772
Alox12e
Name: arachidonate lipoxygenase, epidermal
Synonyms: 8-LOX, e-LOX1, Alox12-ps1, Aloxe, Alox12-ps2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11685
Homologene: 105868
Cacna1c
Name: calcium channel, voltage-dependent, L type, alpha 1C subunit
Synonyms: (alpha)1 subunit, Cchl1a1, Cav1.2, L-type Cav1.2, D930026N18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12288
HGNC: HGNC:1390
Homologene: 55484
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Acz, Pico
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 26875
Homologene: 69111
Tnr
Name: tenascin R
Synonyms: janusin, restrictin, TN-R, J1-tenascin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 21960
Homologene: 124416
Trappc11
Name: trafficking protein particle complex 11
Synonyms: D030016E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 320714
Homologene: 11076
Taf5l
Name: TATA-box binding protein associated factor 5 like
Synonyms: 1110005N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 102162
Homologene: 8676
Arnt2
Name: aryl hydrocarbon receptor nuclear translocator 2
Synonyms: bHLHe1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11864
Homologene: 7230
Mroh2b
Name: maestro heat-like repeat family member 2B
Synonyms: 4930455B06Rik, Heatr7b2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223825
VEGA: 15
Homologene: 128807
Serpinb6d
Name: serine (or cysteine) peptidase inhibitor, clade B, member 6d
Synonyms: SPI3D, Gm11390
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238568
HGNC: HGNC:8950
Ltbp2
Name: latent transforming growth factor beta binding protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 16997
HGNC: HGNC:6715
Homologene: 369
Prg4
Name: proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
Synonyms: MSF, DOL54, lubricin, SZP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 96875
HGNC: HGNC:9364
Homologene: 137352
Pnma8b
Name: PNMA family member 8B
Synonyms: EG434128, Pnmal2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434128
Homologene: 35491
Fbll1
Name: fibrillarin-like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237730
Homologene: 28185
St18
Name: suppression of tumorigenicity 18
Synonyms: Nzf3, Myt3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240690
Homologene: 8792
AC132131.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Klra17
Name: killer cell lectin-like receptor, subfamily A, member 17
Synonyms: Ly49q1, Ly-49Q, Ly49Q
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 170733
Eml6
Name: echinoderm microtubule associated protein like 6
Synonyms: 2900083P10Rik, C230094A16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237711
Homologene: 104282
Itgbl1
Name: integrin, beta-like 1
Synonyms: with EGF-like repeat domains, B930011D01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 223272
HGNC: HGNC:6164
Homologene: 3519
Mfsd2b
Name: major facilitator superfamily domain containing 2B
Synonyms: Gm1964
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 432628
Homologene: 47753
Pcgf6
Name: polycomb group ring finger 6
Synonyms: Mel18 and Bmi1-like RING finger protein, MBLR, 4933407A11Rik, Rnf134
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 71041
VEGA: 19
Homologene: 12378
Galnt1
Name: polypeptide N-acetylgalactosaminyltransferase 1
Synonyms: ppGaNTase-T1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 14423
HGNC: HGNC:4123
Homologene: 8469
Pcsk7
Name: proprotein convertase subtilisin/kexin type 7
Synonyms: SPC7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 18554
VEGA: 9
HGNC: HGNC:8748
Homologene: 37955
Gbp10
Name: guanylate-binding protein 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 626578
Homologene: 128731
Gfm1
Name: G elongation factor, mitochondrial 1
Synonyms: D3Wsu133e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 28030
Homologene: 6449
Or2y1
Name: olfactory receptor family 2 subfamily Y member 1
Synonyms: GA_x6K02T2QP88-5941817-5940888, MOR256-42P, MOR256-42P, MOR256-41P, Olfr1549-ps1, Olfr1385
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258027
Homologene: 86692
Vmn1r197
Name: vomeronasal 1 receptor 197
Synonyms: V1rh21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 171278
Homologene: 110880
Vmn2r97
Name: vomeronasal 2, receptor 97
Synonyms: EG627367
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 627367
Homologene: 115024
AC148991.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Zfp362
Name: zinc finger protein 362
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230761
Homologene: 77409
9930111J21Rik2
Name: RIKEN cDNA 9930111J21 gene 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 245240
Saa4
Name: serum amyloid A 4
Synonyms: Saa-5, Saa-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20211
Homologene: 4750
Pex11a
Name: peroxisomal biogenesis factor 11 alpha
Synonyms: PEX11alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18631
HGNC: HGNC:8852
Homologene: 20829
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 6,855,473 bp
  • C to T, chromosome 1 at 34,268,894 bp
  • T to A, chromosome 1 at 150,452,213 bp
  • T to C, chromosome 1 at 159,923,413 bp
  • T to A, chromosome 1 at 173,929,474 bp
  • T to C, chromosome 2 at 9,951,658 bp
  • A to T, chromosome 2 at 31,336,612 bp
  • A to G, chromosome 2 at 126,851,521 bp
  • G to A, chromosome 2 at 180,161,560 bp
  • T to C, chromosome 3 at 67,456,700 bp
  • A to T, chromosome 3 at 109,934,691 bp
  • A to G, chromosome 4 at 14,815,678 bp
  • C to G, chromosome 4 at 128,786,889 bp
  • C to T, chromosome 4 at 131,900,102 bp
  • A to C, chromosome 5 at 14,680,899 bp
  • A to G, chromosome 5 at 24,400,621 bp
  • A to T, chromosome 5 at 45,734,041 bp
  • T to A, chromosome 5 at 105,224,458 bp
  • T to C, chromosome 6 at 118,741,952 bp
  • T to A, chromosome 6 at 129,873,365 bp
  • C to T, chromosome 7 at 16,946,596 bp
  • T to A, chromosome 7 at 27,227,604 bp
  • T to A, chromosome 7 at 46,729,629 bp
  • C to T, chromosome 7 at 79,740,170 bp
  • T to C, chromosome 7 at 84,343,801 bp
  • G to A, chromosome 7 at 102,084,504 bp
  • T to C, chromosome 8 at 47,514,103 bp
  • A to G, chromosome 8 at 87,781,344 bp
  • A to G, chromosome 8 at 122,896,715 bp
  • T to C, chromosome 8 at 124,009,675 bp
  • A to G, chromosome 9 at 45,926,759 bp
  • G to C, chromosome 9 at 46,269,117 bp
  • T to A, chromosome 10 at 90,033,216 bp
  • C to A, chromosome 11 at 29,803,137 bp
  • G to A, chromosome 11 at 35,797,678 bp
  • A to T, chromosome 11 at 49,019,281 bp
  • A to G, chromosome 11 at 49,495,460 bp
  • A to G, chromosome 11 at 70,319,842 bp
  • A to G, chromosome 11 at 72,448,737 bp
  • A to G, chromosome 11 at 77,845,615 bp
  • T to C, chromosome 11 at 82,798,241 bp
  • A to G, chromosome 12 at 4,870,578 bp
  • A to T, chromosome 12 at 84,804,474 bp
  • C to A, chromosome 13 at 22,328,576 bp
  • T to A, chromosome 13 at 33,667,680 bp
  • T to C, chromosome 13 at 69,629,638 bp
  • T to C, chromosome 14 at 123,966,678 bp
  • T to C, chromosome 15 at 4,945,148 bp
  • G to A, chromosome 15 at 77,766,812 bp
  • T to C, chromosome 17 at 18,928,151 bp
  • A to G, chromosome 18 at 24,271,655 bp
  • A to G, chromosome 18 at 67,402,051 bp
  • A to T, chromosome 19 at 11,011,499 bp
  • G to A, chromosome 19 at 47,050,440 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3739 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040725-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.