Strain Name:
C57BL/6J-MtgxR4072Btlr/Mmmh
Stock Number:
040854-MU
Citation ID:
RRID:MMRRC_040854-MU
Other Names:
R4072 (G1), C57BL/6J-MtgxR4072Btlr
Major Collection:

Gene Information

Pde7a
Name: phosphodiesterase 7A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18583
HGNC: HGNC:8791
Homologene: 1956
Slc30a7
Name: solute carrier family 30 (zinc transporter), member 7
Synonyms: ZnT-7, 4833428C12Rik, 1810059J10Rik, 2610034N15Rik, ZnT7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66500
Homologene: 11332
Tox
Name: thymocyte selection-associated high mobility group box
Synonyms: 1700007F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 252838
Homologene: 8822
Abcc5
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 5
Synonyms: Abcc5a, Abcc5b, Mrp5, 2900011L11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 27416
HGNC: HGNC:56
Homologene: 21164
Eps15l1
Name: epidermal growth factor receptor pathway substrate 15-like 1
Synonyms: 9830147J04Rik, Eps15R, Eps15-rs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 13859
Homologene: 31881
Fcho1
Name: FCH domain only 1
Synonyms: 3322402E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74015
Homologene: 22869
Arfgap3
Name: ADP-ribosylation factor GTPase activating protein 3
Synonyms: 1810035F16Rik, 0610009H19Rik, 9130416J18Rik, 1810004P07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 66251
VEGA: 15
HGNC: HGNC:661
Homologene: 134103
Pms2
Name: PMS1 homolog2, mismatch repair system component
Synonyms: mismatch repair, DNA mismatch repair
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18861
HGNC: HGNC:9122
Homologene: 133560
Vwc2
Name: von Willebrand factor C domain containing 2
Synonyms: A930041G11Rik, Brorin, cradin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 319922
Homologene: 18542
Eva1c
Name: eva-1 homolog C (C. elegans)
Synonyms: 4931408A02Rik, 1700092M14Rik, Fam176c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 70967
Homologene: 14383
Baz1a
Name: bromodomain adjacent to zinc finger domain 1A
Synonyms: Wcrf180, Acf1, Gtl5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217578
HGNC: HGNC:960
Homologene: 45654
Pot1a
Name: protection of telomeres 1A
Synonyms: 1500031H18Rik, Pot1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 101185
Homologene: 32263
Baz2b
Name: bromodomain adjacent to zinc finger domain, 2B
Synonyms: D2Ertd794e, 5830435C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 407823
HGNC: HGNC:963
Homologene: 8394
Zbtb11
Name: zinc finger and BTB domain containing 11
Synonyms: ZNF-U69274, 9230110G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 271377
Homologene: 8678
Atp4a
Name: ATPase, H+/K+ exchanging, gastric, alpha polypeptide
Synonyms: H+/K+-ATPase alpha, H+K+-transporting alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11944
HGNC: HGNC:819
Homologene: 68081
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: hy-3, 4930545D19Rik, 1700034M11Rik, hyrh, hy3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244653
Homologene: 52118
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: b2b1537Clo, b2b1565Clo, b2b1154Clo, b2b1134Clo, b2b3491Clo, Mdnah5, Dnahc5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Dnah11
Name: dynein, axonemal, heavy chain 11
Synonyms: b2b1279Clo, Dnahc11, b2b598Clo, lrd, b2b1727Clo, b2b1203Clo, b2b1289Clo, avc4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 13411
HGNC: HGNC:2942
Homologene: 2801
Srp72
Name: signal recognition particle 72
Synonyms: 5730576P14Rik, 72kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 66661
Homologene: 38254
Dnah9
Name: dynein, axonemal, heavy chain 9
Synonyms: D11Ertd686e, Dnahc9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237806
HGNC: HGNC:2953
Homologene: 20357
Acss3
Name: acyl-CoA synthetase short-chain family member 3
Synonyms: LOC380660, 8430416H19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 380660
Homologene: 11587
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: OTTMUSG00000005786, LOC380698
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380698
Homologene: 70869
Ankar
Name: ankyrin and armadillo repeat containing
Synonyms: 4932422E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 319695
Homologene: 85163
Olfr670
Name: olfactory receptor 670
Synonyms: GA_x6K02T2PBJ9-7589577-7588639, MOR32-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 384703
Homologene: 105163
Adam34l
Name: a disintegrin and metallopeptidase domain 34 like
Synonyms: Gm5346
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 384813
Homologene: 78104
Galntl5
Name: UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5
Synonyms: 1700021B12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 67909
Homologene: 12210
Rp1l1
Name: retinitis pigmentosa 1 homolog like 1
Synonyms: Rp1hl1, Dcdc4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 271209
VEGA: 14
Homologene: 105870
Scnn1a
Name: sodium channel, nonvoltage-gated 1 alpha
Synonyms: mENaC, Scnn1, ENaC alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20276
Homologene: 811
Eqtn
Name: equatorin, sperm acrosome associated
Synonyms: 1700028B15Rik, 4930579C15Rik, Afaf, equatorin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67753
HGNC: HGNC:1359
Homologene: 75250
Chaf1b
Name: chromatin assembly factor 1, subunit B (p60)
Synonyms: CAF1, 2600017H24Rik, CAF-1 subunit B, CAF-I 60 kDa subunit, MPHOSPH7, CAF1A, CAF-IP60, CAF1P60
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 110749
HGNC: HGNC:1911
Homologene: 48346
Tm2d3
Name: TM2 domain containing 3
Synonyms: 1110025I09Rik, 5930422O05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 68634
Homologene: 12275
Obox3
Name: oocyte specific homeobox 3
Synonyms: Ohx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 246791
Homologene: 44937
Axl
Name: AXL receptor tyrosine kinase
Synonyms: Ufo, Ark, Tyro7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 26362
HGNC: HGNC:905
Homologene: 7583
Zbbx
Name: zinc finger, B-box domain containing
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 213234
Homologene: 11661
Ercc4
Name: excision repair cross-complementing rodent repair deficiency, complementation group 4
Synonyms: Xpf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 50505
HGNC: HGNC:3436
Homologene: 3836
Lamp3
Name: lysosomal-associated membrane protein 3
Synonyms: TSC403, 1200002D17Rik, Cd208, DC-LAMP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 239739
VEGA: 16
Homologene: 8670
Pidd1
Name: p53 induced death domain protein 1
Synonyms: 1200011D09Rik, Lrdd, Pidd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57913
Homologene: 11220
Usp31
Name: ubiquitin specific peptidase 31
Synonyms: 6330567E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76179
Homologene: 44504
Nlrp4c
Name: NLR family, pyrin domain containing 4C
Synonyms: Nalp4c, Rnh2, Nalp-alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 83564
Homologene: 75315
Ttc4
Name: tetratricopeptide repeat domain 4
Synonyms: L62, 2810002P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 72354
Homologene: 31249
Slco2a1
Name: solute carrier organic anion transporter family, member 2a1
Synonyms: 2310021C19Rik, mPgt, Slc21a2, Pgt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 24059
Homologene: 38077
Olfr52
Name: olfactory receptor 52
Synonyms: IE6, MOR185-6, GA_x6K02T2Q125-47650922-47649963
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18352
Homologene: 105200
4930590J08Rik
Name: RIKEN cDNA 4930590J08 gene
Synonyms: LOC381798
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 381798
Homologene: 49985
Tmprss11e
Name: transmembrane protease, serine 11e
Synonyms: DESC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 243084
Homologene: 8543
Olfr1469
Name: olfactory receptor 1469
Synonyms: MOR202-11, GA_x6K02T2RE5P-3743369-3744289
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258690
HGNC: HGNC:8324
Homologene: 133675
Zfp128
Name: zinc finger protein 128
Synonyms: mZnf8, 9630016P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243833
Homologene: 10889
Acsm4
Name: acyl-CoA synthetase medium-chain family member 4
Synonyms: O-MACS, OMACS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233801
Homologene: 72281
Krtap31-1
Name: keratin associated protein 31-1
Synonyms: 4733401H21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 70831
Homologene: 134336
Crtac1
Name: cartilage acidic protein 1
Synonyms: Crtac1B, 2810454P21Rik, Lotus
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 72832
VEGA: 19
Homologene: 23070
C2cd4d
Name: C2 calcium-dependent domain containing 4D
Synonyms: LOC271944, Gm659
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 271944
Homologene: 86310
Gm19965
Name: predicted gene, 19965
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Pramel33
Name: PRAME like 33
Synonyms: Gm16427
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100040885
Homologene: 133100
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 72,688,592 bp
  • A to G, chromosome 1 at 116,821,071 bp
  • A to T, chromosome 2 at 59,912,573 bp
  • T to A, chromosome 2 at 86,181,647 bp
  • G to A, chromosome 3 at 19,256,853 bp
  • C to T, chromosome 3 at 75,105,671 bp
  • C to A, chromosome 3 at 94,363,878 bp
  • T to C, chromosome 3 at 115,946,680 bp
  • T to C, chromosome 4 at 6,842,396 bp
  • A to G, chromosome 4 at 94,919,962 bp
  • T to C, chromosome 4 at 106,670,485 bp
  • A to T, chromosome 5 at 25,198,480 bp
  • C to A, chromosome 5 at 76,998,251 bp
  • T to C, chromosome 5 at 86,715,643 bp
  • A to T, chromosome 5 at 93,485,198 bp
  • T to C, chromosome 5 at 143,929,001 bp
  • T to C, chromosome 6 at 25,752,357 bp
  • A to G, chromosome 6 at 91,945,361 bp
  • A to G, chromosome 6 at 125,338,907 bp
  • A to G, chromosome 7 at 6,072,710 bp
  • A to G, chromosome 7 at 12,891,221 bp
  • G to T, chromosome 7 at 15,625,799 bp
  • A to G, chromosome 7 at 25,763,911 bp
  • T to C, chromosome 7 at 30,715,332 bp
  • T to A, chromosome 7 at 65,697,750 bp
  • A to T, chromosome 7 at 104,960,716 bp
  • T to A, chromosome 7 at 119,698,758 bp
  • A to G, chromosome 7 at 121,667,782 bp
  • A to G, chromosome 7 at 141,440,826 bp
  • A to T, chromosome 8 at 43,626,350 bp
  • T to C, chromosome 8 at 71,710,369 bp
  • A to G, chromosome 8 at 72,380,284 bp
  • G to A, chromosome 8 at 110,505,256 bp
  • T to A, chromosome 9 at 103,068,002 bp
  • C to T, chromosome 10 at 107,123,585 bp
  • T to A, chromosome 11 at 11,116,446 bp
  • A to G, chromosome 11 at 58,997,183 bp
  • T to C, chromosome 11 at 66,084,904 bp
  • T to C, chromosome 11 at 99,908,232 bp
  • A to G, chromosome 12 at 54,941,560 bp
  • T to C, chromosome 12 at 118,106,492 bp
  • A to T, chromosome 14 at 64,028,132 bp
  • A to T, chromosome 15 at 28,340,298 bp
  • C to T, chromosome 15 at 83,303,129 bp
  • G to A, chromosome 16 at 13,130,685 bp
  • A to G, chromosome 16 at 19,700,716 bp
  • A to G, chromosome 16 at 20,333,695 bp
  • C to T, chromosome 16 at 55,998,064 bp
  • T to A, chromosome 16 at 90,904,131 bp
  • A to G, chromosome 16 at 93,894,804 bp
  • G to A, chromosome 19 at 13,410,935 bp
  • T to C, chromosome 19 at 42,304,707 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4072 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040854-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.