Strain Name:
C57BL/6J-MtgxR3885Btlr/Mmmh
Stock Number:
040905-MU
Citation ID:
RRID:MMRRC_040905-MU
Other Names:
R3885 (G1), C57BL/6J-MtgxR3885Btlr
Major Collection:

Gene Information

Rictor
Name: RPTOR independent companion of MTOR, complex 2
Synonyms: 6030405M08Rik, D530039E11Rik, 4921505C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 78757
VEGA: 15
Homologene: 34317
Lcor
Name: ligand dependent nuclear receptor corepressor
Synonyms: 3110023F06Rik, Mlr2, A630025C20Rik, LOC381224, Gm340
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 212391
VEGA: 19
Homologene: 18153
Gck
Name: glucokinase
Synonyms: hexokinase 4, MODY2, HK4, Gls006, Hlb62
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103988
HGNC: HGNC:4195
Homologene: 55440
Lrch2
Name: leucine-rich repeats and calponin homology (CH) domain containing 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 210297
Homologene: 32491
Senp7
Name: SUMO1/sentrin specific peptidase 7
Synonyms: 6030449K19Rik, 2900036C23Rik, 2410152H17Rik, 2810413I22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 66315
Homologene: 10778
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Bptf
Name: bromodomain PHD finger transcription factor
Synonyms: 9430093H17Rik, Falz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 207165
HGNC: HGNC:3581
Homologene: 114397
Ank3
Name: ankyrin 3, epithelial
Synonyms: Ank-3, Ankyrin-3, AnkG, 2900054D09Rik, Ankyrin-G
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 11735
HGNC: HGNC:494
Homologene: 56908
Slitrk5
Name: SLIT and NTRK-like family, member 5
Synonyms: 2610019D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 75409
VEGA: 14
Homologene: 9193
Eif2ak1
Name: eukaryotic translation initiation factor 2 alpha kinase 1
Synonyms: Hri
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 15467
Homologene: 8290
Rreb1
Name: ras responsive element binding protein 1
Synonyms: 1110037N09Rik, B930013M22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 68750
Homologene: 2218
Boc
Name: biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 117606
Homologene: 32819
Eif2s1
Name: eukaryotic translation initiation factor 2, subunit 1 alpha
Synonyms: 2410026C18Rik, eIF2alpha, Eif2a, 0910001O23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 13665
HGNC: HGNC:3265
Homologene: 3020
Pnpla6
Name: patatin-like phospholipase domain containing 6
Synonyms: Swiss-cheese, MSws, Nte
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 50767
Homologene: 21333
Mgst3
Name: microsomal glutathione S-transferase 3
Synonyms: GST-III, 2010306B17Rik, 2010012L10Rik, 2700004G04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 66447
HGNC: HGNC:7064
Homologene: 3327
Itga2
Name: integrin alpha 2
Synonyms: VLA-2 receptor, alpha 2 subunit, CD49B, DX5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 16398
VEGA: 13
HGNC: HGNC:6137
Homologene: 1662
Ephb2
Name: Eph receptor B2
Synonyms: eteck, Erk, Tyro5, Prkm5, Nuk, Drt, Hek5, Sek3, Qek5, Cek5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 13844
HGNC: HGNC:3393
Homologene: 37925
Ptpro
Name: protein tyrosine phosphatase, receptor type, O
Synonyms: D28, PTPROt, PTP-phi, PTP-BK, PTP-U2, GLEPP1, PTP-oc, Ptpn15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19277
HGNC: HGNC:9678
Homologene: 21564
Rin2
Name: Ras and Rab interactor 2
Synonyms: RASSF4, 4632403N06Rik, 2010003K16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74030
Homologene: 32430
Lrriq1
Name: leucine-rich repeats and IQ motif containing 1
Synonyms: LOC380658, 4930503E15Rik, Gm1557
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 74978
Homologene: 46007
Slc15a2
Name: solute carrier family 15 (H+/peptide transporter), member 2
Synonyms: Pept2, 8430408C16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 57738
Homologene: 56912
Olfr736
Name: olfactory receptor 736
Synonyms: GA_x6K02T2PMLR-6089963-6090901, MOR106-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258660
Homologene: 64902
Nrxn1
Name: neurexin I
Synonyms: alpha-latrotoxin receptor (calcium-dependent), neurexin I beta, neurexin I alpha, neurexin I beta, neurexin I beta, neurexin I alpha, neurexin I alpha, 1700062G21Rik, A230068P09Rik, 9330127H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18189
HGNC: HGNC:8008
Homologene: 21005
Gjc3
Name: gap junction protein, gamma 3
Synonyms: connexin 29, Cx29, Gje1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 118446
Homologene: 15399
Wiz
Name: widely-interspaced zinc finger motifs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22404
Homologene: 7997
Gpc5
Name: glypican 5
Synonyms: A230034F01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 103978
HGNC: HGNC:4453
Homologene: 3285
Steap4
Name: STEAP family member 4
Synonyms: Tiarp, Tnfaip9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 117167
Homologene: 36422
Ccdc85a
Name: coiled-coil domain containing 85A
Synonyms: E030025D05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216613
Homologene: 65605
Cfap221
Name: cilia and flagella associated protein 221
Synonyms: Pcdp1, Gm101
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226356
Homologene: 88578
Ovch2
Name: ovochymase 2
Synonyms: 9230106D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244199
Homologene: 18255
Tmem40
Name: transmembrane protein 40
Synonyms: 9030407H20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 94346
Homologene: 10124
Ak8
Name: adenylate kinase 8
Synonyms: 1190002A17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68870
Homologene: 17622
Vmn2r97
Name: vomeronasal 2, receptor 97
Synonyms: EG627367
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 627367
Homologene: 115024
Gpr150
Name: G protein-coupled receptor 150
Synonyms: PGR11, C030001A19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238725
Homologene: 18457
Foxd2
Name: forkhead box D2
Synonyms: Mf2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 17301
HGNC: HGNC:3803
Homologene: 3292
H2ac8
Name: H2A clustered histone 8
Synonyms: Hist1h2ae
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 319166
HGNC: HGNC:4730
Homologene: 136768
Gm5145
Name: predicted pseudogene 5145
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 381065
VEGA: 17
B930094E09Rik
Name: RIKEN cDNA B930094E09 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
H2ac22
Name: H2A clustered histone 22
Synonyms: Hist1h2an
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 319170
HGNC: HGNC:4737
Homologene: 137349
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 119,954,146 bp
  • G to T, chromosome 1 at 167,372,562 bp
  • G to A, chromosome 2 at 28,733,885 bp
  • C to T, chromosome 2 at 145,860,446 bp
  • T to C, chromosome 4 at 114,908,286 bp
  • C to T, chromosome 4 at 136,771,034 bp
  • G to T, chromosome 5 at 7,980,494 bp
  • T to A, chromosome 5 at 137,957,843 bp
  • A to T, chromosome 5 at 143,884,661 bp
  • T to C, chromosome 6 at 115,733,986 bp
  • T to A, chromosome 6 at 137,443,594 bp
  • A to G, chromosome 7 at 107,796,568 bp
  • T to C, chromosome 8 at 3,532,342 bp
  • A to T, chromosome 10 at 69,899,036 bp
  • T to C, chromosome 10 at 103,216,106 bp
  • T to C, chromosome 11 at 5,910,318 bp
  • T to A, chromosome 11 at 28,576,677 bp
  • G to A, chromosome 11 at 107,074,513 bp
  • T to A, chromosome 12 at 78,881,225 bp
  • A to G, chromosome 13 at 21,786,869 bp
  • G to T, chromosome 13 at 23,570,879 bp
  • G to T, chromosome 13 at 37,893,965 bp
  • T to C, chromosome 13 at 76,056,538 bp
  • A to T, chromosome 13 at 114,869,299 bp
  • A to T, chromosome 14 at 50,392,869 bp
  • T to A, chromosome 14 at 111,679,797 bp
  • T to C, chromosome 14 at 115,370,060 bp
  • A to T, chromosome 15 at 6,759,610 bp
  • A to G, chromosome 16 at 36,782,304 bp
  • T to C, chromosome 16 at 44,487,613 bp
  • A to G, chromosome 16 at 56,186,079 bp
  • C to T, chromosome 17 at 18,928,334 bp
  • A to T, chromosome 17 at 20,571,010 bp
  • G to T, chromosome 17 at 32,357,038 bp
  • T to A, chromosome 17 at 90,623,471 bp
  • G to A, chromosome 18 at 31,609,689 bp
  • T to A, chromosome 18 at 49,878,259 bp
  • T to A, chromosome 19 at 41,558,356 bp
  • C to G, chromosome X at 147,473,007 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3885 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040905-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.