Strain Name:
C57BL/6J-MtgxR4168Btlr/Mmmh
Stock Number:
041009-MU
Citation ID:
RRID:MMRRC_041009-MU
Other Names:
R4168 (G1), C57BL/6J-MtgxR4168Btlr
Major Collection:

Gene Information

Snx17
Name: sorting nexin 17
Synonyms: b2b1625.1Clo, D5Ertd260e, 5830447M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 266781
Homologene: 8838
Clasrp
Name: CLK4-associating serine/arginine rich protein
Synonyms: Srsf16, SWAP2, Sfrs16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 53609
Homologene: 134306
Nop14
Name: NOP14 nucleolar protein
Synonyms: Nol14, 2610033H07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 75416
Homologene: 41773
Dmap1
Name: DNA methyltransferase 1-associated protein 1
Synonyms: 1500016M21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66233
Homologene: 41311
C3
Name: complement component 3
Synonyms: Plp, complement factor 3, acylation stimulating protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12266
HGNC: HGNC:1318
Homologene: 68031
Chpf2
Name: chondroitin polymerizing factor 2
Synonyms: 2010209O12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100910
Homologene: 14763
Znrf2
Name: zinc and ring finger 2
Synonyms: 1190002C14Rik, D6Ertd365e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 387524
Homologene: 15668
Zc2hc1a
Name: zinc finger, C2HC-type containing 1A
Synonyms: 3110050N22Rik, Fam164a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 67306
Homologene: 9338
Cmip
Name: c-Maf inducing protein
Synonyms: 4933407C03Rik, 5830471E12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74440
Homologene: 18869
Tmem119
Name: transmembrane protein 119
Synonyms: obif
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231633
Homologene: 17145
Pde4d
Name: phosphodiesterase 4D, cAMP specific
Synonyms: 9630011N22Rik, Dpde3, dunce
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238871
HGNC: HGNC:8783
Kif27
Name: kinesin family member 27
Synonyms: 4930517I18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 75050
VEGA: 13
Homologene: 69235
Intu
Name: inturned planar cell polarity protein
Synonyms: Pdzd6, 9230116I04Rik, 9430087H23Rik, Pdzk6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 380614
Homologene: 41059
Rb1cc1
Name: RB1-inducible coiled-coil 1
Synonyms: LaXp180, Cc1, Fip200, 5930404L04Rik, 2900055E04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12421
Homologene: 7659
9530053A07Rik
Name: RIKEN cDNA 9530053A07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 319482
Homologene: 130055
Haspin
Name: histone H3 associated protein kinase
Synonyms: Gsg2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14841
Homologene: 49236
Gabrb2
Name: gamma-aminobutyric acid (GABA) A receptor, subunit beta 2
Synonyms: C030002O17Rik, C030021G16Rik, Gabrb-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14401
HGNC: HGNC:4082
Homologene: 7327
Mogat1
Name: monoacylglycerol O-acyltransferase 1
Synonyms: mDC2, Dgat2l1, 1110064N14Rik, 0610030A14Rik, MGAT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68393
Homologene: 105237
Olfr195
Name: olfactory receptor 195
Synonyms: GA_x54KRFPKG5P-55369823-55370749, MOR184-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 259000
Homologene: 128109
Padi6
Name: peptidyl arginine deiminase, type VI
Synonyms: Pad6, ePAD, Padi5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242726
Homologene: 17695
Pla2r1
Name: phospholipase A2 receptor 1
Synonyms: M-type receptor, PLA2-I receptor, Pla2g1br
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18779
HGNC: HGNC:9042
Homologene: 32016
Gm12789
Name: predicted gene 12789
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 381536
Hddc2
Name: HD domain containing 2
Synonyms: 2310057G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 69692
Homologene: 5431
Vmn2r112
Name: vomeronasal 2, receptor 112
Synonyms: EG628185
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 628185
Homologene: 86604
Ctif
Name: CBP80/20-dependent translation initiation factor
Synonyms: Gm672, LOC269037
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 269037
VEGA: 18
Homologene: 56682
Elk3
Name: ELK3, member of ETS oncogene family
Synonyms: Erp, D430049E23Rik, Net, Sap-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 13713
HGNC: HGNC:3325
Homologene: 3833
Rexo5
Name: RNA exonuclease 5
Synonyms: 2610020H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434234
Homologene: 12803
Flt4
Name: FMS-like tyrosine kinase 4
Synonyms: VEGFR-3, Flt-4, VEGFR3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14257
HGNC: HGNC:3767
Homologene: 7321
Olfr1040
Name: olfactory receptor 1040
Synonyms: GA_x6K02T2Q125-47615732-47614791, MOR185-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 404323
Homologene: 79382
Cbr4
Name: carbonyl reductase 4
Synonyms: A730083J17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234309
Homologene: 57181
Oxct2b
Name: 3-oxoacid CoA transferase 2B
Synonyms: Scot-t2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 353371
Homologene: 137359
Cd200r3
Name: CD200 receptor 3
Synonyms: 4733401I18Rik, 4833409J19Rik, mCD200RLb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 74603
Gm5724
Name: predicted gene 5724
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 435927
Zfp128
Name: zinc finger protein 128
Synonyms: 9630016P15Rik, mZnf8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243833
Homologene: 10889
Olfr1167
Name: olfactory receptor 1167
Synonyms: MOR174-16, GA_x6K02T2Q125-49641892-49640942
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258291
Homologene: 138307
Cltb
Name: clathrin, light polypeptide (Lcb)
Synonyms: 2310046E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 74325
HGNC: HGNC:2091
Homologene: 37532
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 6,230,024 bp
  • T to C, chromosome 1 at 78,512,035 bp
  • A to T, chromosome 2 at 60,497,614 bp
  • A to G, chromosome 2 at 86,146,179 bp
  • T to C, chromosome 2 at 88,149,845 bp
  • A to G, chromosome 3 at 7,518,391 bp
  • C to T, chromosome 3 at 40,672,623 bp
  • A to G, chromosome 4 at 101,989,962 bp
  • T to A, chromosome 4 at 117,681,310 bp
  • T to C, chromosome 4 at 123,117,685 bp
  • A to G, chromosome 4 at 140,741,934 bp
  • T to C, chromosome 5 at 24,591,790 bp
  • T to C, chromosome 5 at 31,195,971 bp
  • A to G, chromosome 5 at 34,656,744 bp
  • T to C, chromosome 5 at 113,794,987 bp
  • T to C, chromosome 6 at 54,863,960 bp
  • T to C, chromosome 6 at 141,738,947 bp
  • A to G, chromosome 7 at 12,890,362 bp
  • A to G, chromosome 7 at 19,581,154 bp
  • T to C, chromosome 7 at 28,137,109 bp
  • A to G, chromosome 7 at 119,827,398 bp
  • T to A, chromosome 8 at 61,491,521 bp
  • A to T, chromosome 8 at 117,456,917 bp
  • G to T, chromosome 10 at 31,316,311 bp
  • A to G, chromosome 10 at 93,265,335 bp
  • A to T, chromosome 11 at 42,421,328 bp
  • G to A, chromosome 11 at 49,630,573 bp
  • A to G, chromosome 11 at 73,136,022 bp
  • G to A, chromosome 13 at 54,598,727 bp
  • A to G, chromosome 13 at 58,345,748 bp
  • T to C, chromosome 13 at 109,740,423 bp
  • T to A, chromosome 16 at 44,954,189 bp
  • A to T, chromosome 16 at 59,149,000 bp
  • T to A, chromosome 17 at 22,603,088 bp
  • A to T, chromosome 17 at 57,218,608 bp
  • A to C, chromosome 18 at 75,637,215 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4168 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041009-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.