Strain Name:
C57BL/6J-MtgxR4175Btlr/Mmmh
Stock Number:
041013-MU
Citation ID:
RRID:MMRRC_041013-MU
Other Names:
R4175 (G1), C57BL/6J-MtgxR4175Btlr
Major Collection:

Gene Information

Apobec3
Name: apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3
Synonyms: CEM15, Gm20117, Rfv3, Rfv-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 80287
Homologene: 105420
Pik3r1
Name: phosphoinositide-3-kinase regulatory subunit 1
Synonyms: p85alpha, p50alpha, PI3K, p55alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 18708
HGNC: HGNC:8979
Homologene: 7889
Mindy3
Name: MINDY lysine 48 deubiquitinase 3
Synonyms: 1810041E18Rik, Fam188a, 5830410F13Rik, 2310047O13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 66960
Homologene: 11478
Prrc2b
Name: proline-rich coiled-coil 2B
Synonyms: 5830434P21Rik, Bat2l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 227723
Homologene: 106649
Ano6
Name: anoctamin 6
Synonyms: F730003B03Rik, 2900059G15Rik, Tmem16f
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 105722
VEGA: 15
Homologene: 27888
Trip11
Name: thyroid hormone receptor interactor 11
Synonyms: 3110031G15Rik, GMAP-210, TRIP230, 6030460N08Rik, 2610511G22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 109181
Homologene: 20897
Ctbp1
Name: C-terminal binding protein 1
Synonyms: D4S115h, D5H4S115E, CtBP1-L, CtBP1-S, CtBP3/BARS, D5H4S115, BARS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 13016
HGNC: HGNC:2494
Homologene: 1015
Arfgef1
Name: ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)
Synonyms: D130059B05Rik, BIG1, ARFGEP1, P200, D730028O18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 211673
Homologene: 4687
Ncor2
Name: nuclear receptor co-repressor 2
Synonyms: SMRT, SMRTe
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 20602
HGNC: HGNC:7673
Homologene: 31370
Usp24
Name: ubiquitin specific peptidase 24
Synonyms: 2810030C21Rik, 2700066K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 329908
Homologene: 35420
Rasa2
Name: RAS p21 protein activator 2
Synonyms: 5430433H21Rik, GAP1m
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 114713
HGNC: HGNC:9872
Homologene: 4745
Clmp
Name: CXADR-like membrane protein
Synonyms: 9030425E11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 71566
Homologene: 11705
Kcnip2
Name: Kv channel-interacting protein 2
Synonyms: KChIP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 80906
Homologene: 23710
Creb3l1
Name: cAMP responsive element binding protein 3-like 1
Synonyms: Oasis, BBF-2 (drosophila) homolog
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 26427
Homologene: 8058
D230025D16Rik
Name: RIKEN cDNA D230025D16 gene
Synonyms: Lin10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234678
Homologene: 11864
Tapt1
Name: transmembrane anterior posterior transformation 1
Synonyms: 4932414K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231225
Homologene: 80206
Fhdc1
Name: FH2 domain containing 1
Synonyms: 6330505N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229474
Homologene: 18920
Kat2a
Name: K(lysine) acetyltransferase 2A
Synonyms: Gcn5, Gcn5l2, PCAF-B/GCN5, 1110051E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 14534
HGNC: HGNC:4201
Homologene: 41343
Pcdh15
Name: protocadherin 15
Synonyms: roda, nmf19, Ush1f, Gm9815
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 11994
Homologene: 23401
Epb41l4b
Name: erythrocyte membrane protein band 4.1 like 4b
Synonyms: Lulu2, 6430543G08Rik, Epb4.1l4b, Ehm2, D4Ertd346e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 54357
Homologene: 69270
Med17
Name: mediator complex subunit 17
Synonyms: Crsp6, C330002H14Rik, Trap80
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 234959
VEGA: 9
HGNC: HGNC:2375
Homologene: 3151
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Acz, Pico
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 26875
Homologene: 69111
Ptprq
Name: protein tyrosine phosphatase, receptor type, Q
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 237523
HGNC: HGNC:9679
Homologene: 83557
Olfr994
Name: olfactory receptor 994
Synonyms: GA_x6K02T2Q125-46907515-46906571, MOR203-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258425
Homologene: 17245
Slc26a6
Name: solute carrier family 26, member 6
Synonyms: Pat1, CFEX, B930010B04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 171429
Homologene: 99903
Ifi208
Name: interferon activated gene 208
Synonyms: Pydc3, Pyr-rv1, E430029J22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 100033459
HGNC: HGNC:5395
Homologene: 115929
Slco3a1
Name: solute carrier organic anion transporter family, member 3a1
Synonyms: MJAM, 5830414C08Rik, OATP-D, Anr1, Slc21a11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 108116
Homologene: 40862
Unc13a
Name: unc-13 homolog A
Synonyms: Munc13-1, 2410078G03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 382018
Homologene: 11279
Dus1l
Name: dihydrouridine synthase 1-like (S. cerevisiae)
Synonyms: 1110032N12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 68730
Homologene: 6569
Tmem145
Name: transmembrane protein 145
Synonyms: B930076A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 330485
Homologene: 18333
Mmp1a
Name: matrix metallopeptidase 1a (interstitial collagenase)
Synonyms: Mcol-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 83995
VEGA: 9
HGNC: HGNC:7155
Homologene: 20544
Col11a1
Name: collagen, type XI, alpha 1
Synonyms: C530001D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 12814
HGNC: HGNC:2186
Homologene: 56389
Slc7a13
Name: solute carrier family 7, (cationic amino acid transporter, y+ system) member 13
Synonyms: AGT-1, 0610009O04Rik, XAT2, AGT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 74087
Homologene: 23656
Osmr
Name: oncostatin M receptor
Synonyms: OSMRB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 18414
HGNC: HGNC:8507
Homologene: 2972
Cbfa2t3
Name: CBFA2/RUNX1 translocation partner 3
Synonyms: MTGR2, Eto2, ETO-2, A630044F12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 12398
HGNC: HGNC:1537
Homologene: 74543
Inpp5e
Name: inositol polyphosphate-5-phosphatase E
Synonyms: 1200002L24Rik, 72kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 64436
Homologene: 56863
Elp5
Name: elongator acetyltransferase complex subunit 5
Synonyms: Clone 13u, Rai12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 54351
Homologene: 10291
Cd200r3
Name: CD200 receptor 3
Synonyms: 4833409J19Rik, 4733401I18Rik, mCD200RLb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 74603
Ankrd63
Name: ankyrin repeat domain 63
Synonyms: Gm1337, LOC383787
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 383787
Homologene: 19774
Six4
Name: sine oculis-related homeobox 4
Synonyms: TrexBF, AREC3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 20474
Homologene: 69089
Gm26919
Name: predicted gene, 26919
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
Homologene: 134227
Gm11131
Name: predicted gene 11131
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
Zfp36l3
Name: zinc finger protein 36, C3H type-like 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 333473
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 10,159,636 bp
  • A to T, chromosome 1 at 173,682,701 bp
  • C to T, chromosome 2 at 12,405,865 bp
  • A to G, chromosome 2 at 26,400,925 bp
  • G to GCT, chromosome 2 at 32,218,808 bp
  • A to T, chromosome 2 at 85,430,618 bp
  • A to G, chromosome 2 at 91,983,175 bp
  • T to C, chromosome 2 at 118,702,619 bp
  • T to C, chromosome 3 at 84,456,987 bp
  • A to C, chromosome 3 at 114,208,223 bp
  • G to A, chromosome 4 at 19,819,492 bp
  • A to G, chromosome 4 at 57,076,556 bp
  • T to C, chromosome 4 at 106,316,773 bp
  • A to G, chromosome 5 at 14,713,875 bp
  • A to G, chromosome 5 at 33,266,906 bp
  • G to A, chromosome 5 at 44,177,105 bp
  • A to T, chromosome 5 at 125,050,956 bp
  • T to A, chromosome 6 at 130,677,147 bp
  • T to C, chromosome 7 at 25,308,793 bp
  • T to A, chromosome 7 at 74,318,554 bp
  • A to G, chromosome 8 at 71,667,724 bp
  • T to C, chromosome 8 at 105,241,131 bp
  • C to T, chromosome 8 at 122,643,318 bp
  • A to G, chromosome 9 at 7,467,235 bp
  • A to G, chromosome 9 at 15,267,469 bp
  • A to T, chromosome 9 at 40,771,136 bp
  • G to T, chromosome 9 at 96,560,777 bp
  • G to A, chromosome 9 at 108,854,217 bp
  • G to A, chromosome 10 at 74,631,997 bp
  • T to G, chromosome 10 at 107,711,917 bp
  • T to C, chromosome 11 at 69,970,562 bp
  • A to G, chromosome 11 at 100,705,266 bp
  • G to A, chromosome 11 at 120,795,680 bp
  • G to A, chromosome 12 at 73,108,831 bp
  • G to A, chromosome 12 at 101,895,698 bp
  • A to T, chromosome 13 at 101,701,732 bp
  • G to A, chromosome 13 at 101,701,733 bp
  • A to T, chromosome 15 at 6,852,546 bp
  • A to G, chromosome 15 at 79,895,452 bp
  • A to T, chromosome 15 at 95,962,169 bp
  • T to A, chromosome 16 at 44,954,189 bp
  • A to T, chromosome 17 at 35,379,908 bp
  • G to C, chromosome 19 at 45,812,215 bp
  • T to C, chromosome X at 53,775,873 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4175 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041013-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.