Strain Name:
C57BL/6J-MtgxR4260Btlr/Mmmh
Stock Number:
041073-MU
Citation ID:
RRID:MMRRC_041073-MU
Other Names:
R4260 (G1), C57BL/6J-MtgxR4260Btlr
Major Collection:

Gene Information

Ide
Name: insulin degrading enzyme
Synonyms: 1300012G03Rik, 4833415K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 15925
HGNC: HGNC:5381
Homologene: 3645
Ptprf
Name: protein tyrosine phosphatase, receptor type, F
Synonyms: RPTP-LAR, LAR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 19268
HGNC: HGNC:9670
Homologene: 20623
Luc7l3
Name: LUC7-like 3 (S. cerevisiae)
Synonyms: 3300001P08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 67684
Homologene: 75056
Scg3
Name: secretogranin III
Synonyms: 1B1075, Chgd, SgIII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 20255
VEGA: 9
Homologene: 7526
Kifap3
Name: kinesin-associated protein 3
Synonyms: KAP3, Smg GDS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 16579
Homologene: 7799
Csnk2a2
Name: casein kinase 2, alpha prime polypeptide
Synonyms: 1110035J23Rik, CK2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 13000
HGNC: HGNC:2459
Homologene: 20444
Cep290
Name: centrosomal protein 290
Synonyms: Nphp6, b2b1752Clo, Kiaa, b2b1454Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 216274
VEGA: 10
Homologene: 77213
Tcf7l2
Name: transcription factor 7 like 2, T cell specific, HMG box
Synonyms: Tcf4, Tcf-4, mTcf-4B, mTcf-4E, TCF4B, TCF4E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 21416
Homologene: 7564
Setdb1
Name: SET domain, bifurcated 1
Synonyms: ESET, KMT1E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 84505
Homologene: 32157
Ccnf
Name: cyclin F
Synonyms: CycF, Fbxo1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 12449
VEGA: 17
HGNC: HGNC:1591
Homologene: 1335
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: D130015N03Rik, 2810449H11Rik, tbl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Zfp985
Name: zinc finger protein 985
Synonyms: Gm13154
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 433804
Homologene: 133076
Grb2
Name: growth factor receptor bound protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 14784
HGNC: HGNC:4566
Homologene: 1576
Gm11189
Name: predicted gene 11189
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 623205
Epg5
Name: ectopic P-granules autophagy protein 5 homolog (C. elegans)
Synonyms: 5430411K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 100502841
VEGA: 18
Homologene: 14575
Adnp2
Name: ADNP homeobox 2
Synonyms: Zfp508, 8430420L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 240442
Homologene: 8945
Zap70
Name: zeta-chain (TCR) associated protein kinase
Synonyms: ZAP-70, TZK, Srk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 22637
Homologene: 839
Mettl7a1
Name: methyltransferase like 7A1
Synonyms: 2210414H16Rik, 3300001H21Rik, Mettl7a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 70152
VEGA: 15
Homologene: 86842
Degs1
Name: delta(4)-desaturase, sphingolipid 1
Synonyms: Des1, Mdes
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 13244
Homologene: 55770
Eif2ak3
Name: eukaryotic translation initiation factor 2 alpha kinase 3
Synonyms: PERK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 13666
HGNC: HGNC:3255
Homologene: 3557
Raph1
Name: Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
Synonyms: Lpd, C730009O10Rik, lamellipodin, 9430025M21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 77300
Homologene: 71030
Rprd1a
Name: regulation of nuclear pre-mRNA domain containing 1A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 225283
VEGA: 18
Homologene: 124432
Gemin5
Name: gem nuclear organelle associated protein 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 216766
Homologene: 9155
Kel
Name: Kell blood group
Synonyms: CD238
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 23925
HGNC: HGNC:6308
Homologene: 362
Dnah12
Name: dynein, axonemal, heavy chain 12
Synonyms: Dnahc12, HL-19, DLP12, HL19, DHC3, 4921531P07Rik, Hdhc3, Dnahc7l, LOC380889
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 110083
HGNC: HGNC:2943
Homologene: 56821
Slc38a4
Name: solute carrier family 38, member 4
Synonyms: Ata3, 1110012E16Rik, 1700012A18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 69354
VEGA: 15
Homologene: 75077
Ptpdc1
Name: protein tyrosine phosphatase domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 218232
VEGA: 13
Homologene: 17576
Cd109
Name: CD109 antigen
Synonyms: Gov platelet alloantigens, 9930012E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235505
Homologene: 25183
Mrpl4
Name: mitochondrial ribosomal protein L4
Synonyms: 1110017G11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 66163
VEGA: 9
Homologene: 32286
Olfr1285
Name: olfactory receptor 1285
Synonyms: MOR248-17P, GA_x6K02T2Q125-72459956-72460837, MOR248-25_p
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 545447
Cyld
Name: CYLD lysine 63 deubiquitinase
Synonyms: CYLD1, 2900009M21Rik, C130039D01Rik, 2010013M14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 74256
HGNC: HGNC:2584
Homologene: 9069
Pld2
Name: phospholipase D2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 18806
HGNC: HGNC:9068
Homologene: 55672
Pbld1
Name: phenazine biosynthesis-like protein domain containing 1
Synonyms: Pbld, 0610038K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 68371
VEGA: 10
Homologene: 41470
Spata17
Name: spermatogenesis associated 17
Synonyms: 4930504I07Rik, 1700065F16Rik, 4930513F16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 74717
Homologene: 12551
Ccdc83
Name: coiled-coil domain containing 83
Synonyms: 4930549K11Rik, 4932423M01Rik, 4930554C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 75338
Homologene: 32709
Gm5581
Name: predicted gene 5581
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
Slc5a4b
Name: solute carrier family 5 (neutral amino acid transporters, system A), member 4b
Synonyms: SGLT3b, 2010104G07Rik, SAAT1, pSGLT2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 64454
Homologene: 56968
Cntnap5a
Name: contactin associated protein-like 5A
Synonyms: Caspr5-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 636808
Homologene: 43974
Klra10
Name: killer cell lectin-like receptor subfamily A, member 10
Synonyms: Ly49i2, Ly49J
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 16628
Homologene: 110821
Olfr669
Name: olfactory receptor 669
Synonyms: GA_x6K02T2PBJ9-7567376-7568329, MOR34-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 259045
Homologene: 72057
Zhx3
Name: zinc fingers and homeoboxes 3
Synonyms: Tix1, 1810059C13Rik, 4932418O04Rik, 9530010N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 320799
Homologene: 9000
Best3
Name: bestrophin 3
Synonyms: mBest4, Vmd2l3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 382427
VEGA: 10
Homologene: 33850
Ppcs
Name: phosphopantothenoylcysteine synthetase
Synonyms: 6330579B17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 106564
Homologene: 6173
Fam220a
Name: family with sequence similarity 220, member A
Synonyms: 2810453I06Rik, 1500026F15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 67238
Homologene: 57041
Gm4975
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 36,779,108 bp
  • A to T, chromosome 1 at 60,502,965 bp
  • G to T, chromosome 1 at 116,446,595 bp
  • C to A, chromosome 1 at 163,862,028 bp
  • A to T, chromosome 1 at 182,279,241 bp
  • T to A, chromosome 1 at 187,048,480 bp
  • T to A, chromosome 2 at 111,408,505 bp
  • T to C, chromosome 2 at 160,751,707 bp
  • G to A, chromosome 3 at 95,327,497 bp
  • A to G, chromosome 4 at 118,226,083 bp
  • A to G, chromosome 4 at 119,421,909 bp
  • G to A, chromosome 4 at 147,583,572 bp
  • G to C, chromosome 5 at 143,563,007 bp
  • A to T, chromosome 6 at 41,686,423 bp
  • G to A, chromosome 6 at 70,889,513 bp
  • A to G, chromosome 6 at 130,272,681 bp
  • T to A, chromosome 6 at 131,168,079 bp
  • T to G, chromosome 7 at 90,228,391 bp
  • A to C, chromosome 7 at 104,938,596 bp
  • A to T, chromosome 8 at 63,928,296 bp
  • T to C, chromosome 8 at 88,741,391 bp
  • A to T, chromosome 8 at 95,457,399 bp
  • A to G, chromosome 9 at 21,007,692 bp
  • CTGAGGACTCTTTG to CTG, chromosome 9 at 66,448,348 bp
  • A to G, chromosome 9 at 75,651,697 bp
  • T to A, chromosome 9 at 78,636,463 bp
  • T to C, chromosome 10 at 63,024,407 bp
  • A to G, chromosome 10 at 76,103,852 bp
  • A to C, chromosome 10 at 100,514,492 bp
  • A to T, chromosome 10 at 117,024,226 bp
  • A to C, chromosome 11 at 53,200,876 bp
  • G to A, chromosome 11 at 58,168,359 bp
  • A to G, chromosome 11 at 70,554,894 bp
  • A to T, chromosome 11 at 94,296,050 bp
  • A to G, chromosome 11 at 115,649,816 bp
  • A to G, chromosome 13 at 48,579,758 bp
  • A to G, chromosome 14 at 26,798,926 bp
  • A to G, chromosome 15 at 96,998,493 bp
  • A to G, chromosome 15 at 100,313,070 bp
  • G to A, chromosome 17 at 24,226,767 bp
  • G to A, chromosome 18 at 24,488,295 bp
  • A to T, chromosome 18 at 77,959,121 bp
  • G to C, chromosome 18 at 78,015,699 bp
  • G to A, chromosome 18 at 80,137,527 bp
  • A to C, chromosome 19 at 37,329,186 bp
  • A to G, chromosome 19 at 55,817,805 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4260 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041073-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.