Strain Name:
C57BL/6J-MtgxR4293Btlr/Mmmh
Stock Number:
041082-MU
Citation ID:
RRID:MMRRC_041082-MU
Other Names:
R4293 (G1), C57BL/6J-MtgxR4293Btlr
Major Collection:

Gene Information

Myo5a
Name: myosin VA
Synonyms: 9630007J19Rik, MVa, Dbv, MyoVA, Myo5, flail
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 17918
HGNC: HGNC:7602
Homologene: 20100
Lmf1
Name: lipase maturation factor 1
Synonyms: Tmem112, 2400010G15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 76483
Homologene: 23384
Phf14
Name: PHD finger protein 14
Synonyms: 4932409F11Rik, 1110001C23Rik, 5730446A07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 75725
Homologene: 8775
Arfgef2
Name: ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
Synonyms: BIG2, E230011G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99371
Homologene: 111880
Mapkapk3
Name: mitogen-activated protein kinase-activated protein kinase 3
Synonyms: MK3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 102626
HGNC: HGNC:6888
Homologene: 55836
Gmps
Name: guanine monophosphate synthetase
Synonyms: Gm9479
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229363
HGNC: HGNC:4378
Homologene: 68367
Cdca2
Name: cell division cycle associated 2
Synonyms: 2610311M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 108912
Homologene: 18444
Rev1
Name: REV1, DNA directed polymerase
Synonyms: REV1, Rev1l, 1110027I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 56210
Homologene: 32309
Sec16a
Name: SEC16 homolog A, endoplasmic reticulum export factor
Synonyms: C230052J16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227648
Homologene: 10533
Bms1
Name: BMS1, ribosome biogenesis factor
Synonyms: Bms1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 213895
Homologene: 7065
Brwd1
Name: bromodomain and WD repeat domain containing 1
Synonyms: repro5, Wdr9, D530019K20Rik, 5330419I02Rik, G1-403-16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 93871
Homologene: 23130
Kif18a
Name: kinesin family member 18A
Synonyms: B130001M12Rik, gcd2, N-8 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228421
Homologene: 41820
Pik3c3
Name: phosphatidylinositol 3-kinase catalytic subunit type 3
Synonyms: Vps34, 5330434F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225326
HGNC: HGNC:8974
Homologene: 1986
Fnbp1
Name: formin binding protein 1
Synonyms: FBP1, 1110057E06Rik, 2210010H06Rik, FBP17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14269
Homologene: 100983
Tep1
Name: telomerase associated protein 1
Synonyms: Tp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 21745
VEGA: 14
Homologene: 5157
Cip2a
Name: cell proliferation regulating inhibitor of protein phosphatase 2A
Synonyms: Cip2a, C330027C09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224171
Homologene: 10842
C2cd3
Name: C2 calcium-dependent domain containing 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 277939
Homologene: 19524
Ddx18
Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
Synonyms: 2310005B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 66942
HGNC: HGNC:2741
Homologene: 6697
Fbf1
Name: Fas (TNFRSF6) binding factor 1
Synonyms: 1110033G01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217335
Homologene: 16531
Zfp317
Name: zinc finger protein 317
Synonyms: KRAB9, D230022C05Rik, Zfp75, Zfp67
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244713
Homologene: 36389
Tenm3
Name: teneurin transmembrane protein 3
Synonyms: 2610100B16Rik, Ten-m3, Odz3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 23965
Homologene: 22673
Srsf6
Name: serine and arginine-rich splicing factor 6
Synonyms: 1210001E11Rik, Sfrs6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67996
Homologene: 110783
Arid3b
Name: AT rich interactive domain 3B (BRIGHT-like)
Synonyms: Dri2, Bdp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 56380
Homologene: 4721
Lbr
Name: lamin B receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98386
HGNC: HGNC:6518
Homologene: 2455
Dlg3
Name: discs large MAGUK scaffold protein 3
Synonyms: Dlgh3, DLG3, SAP102
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 53310
HGNC: HGNC:2902
Homologene: 41157
Kcnv1
Name: potassium channel, subfamily V, member 1
Synonyms: 2700023A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 67498
VEGA: 15
Homologene: 22811
Fhdc1
Name: FH2 domain containing 1
Synonyms: 6330505N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229474
Homologene: 18920
Ush2a
Name: usherin
Synonyms: MUSH2A, A930011D15Rik, Ushrn, Ush2a, LOC269160, LOC381317, A930037M10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22283
Homologene: 66151
Ralgps1
Name: Ral GEF with PH domain and SH3 binding motif 1
Synonyms: RALGPS1A, 5830418G11Rik, RALGEF2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241308
Homologene: 65163
Celsr2
Name: cadherin, EGF LAG seven-pass G-type receptor 2
Synonyms: EGFL2, Adgrc2, mfmi1, flamingo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 53883
HGNC: HGNC:3231
Homologene: 1078
Plpp4
Name: phospholipid phosphatase 4
Synonyms: LOC381925, Ppapdc1a, C030048B12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381925
Homologene: 38751
Xpr1
Name: xenotropic and polytropic retrovirus receptor 1
Synonyms: Rmc-1, Rmc1, suppressor of yeast Ga deletion, Syg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19775
Homologene: 134226
Slc4a5
Name: solute carrier family 4, sodium bicarbonate cotransporter, member 5
Synonyms: C330016K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232156
Homologene: 31125
Pcdhb5
Name: protocadherin beta 5
Synonyms: PcdhbE, Pcdhb4A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93876
HGNC: HGNC:8689
Homologene: 75103
Vwce
Name: von Willebrand factor C and EGF domains
Synonyms: 1300015B04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 71768
VEGA: 19
Homologene: 17651
Slfn10-ps
Name: schlafen 10, pseudogene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237887
Dpy19l1
Name: dpy-19-like 1 (C. elegans)
Synonyms: 1100001I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244745
Homologene: 14762
Atf6b
Name: activating transcription factor 6 beta
Synonyms: ATF6beta, Crebl1, Creb-rp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12915
HGNC: HGNC:2349
Homologene: 31238
Actn3
Name: actinin alpha 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 11474
HGNC: HGNC:165
Homologene: 862
Mettl18
Name: methyltransferase like 18
Synonyms: 2810422O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 69962
Homologene: 32680
Spata13
Name: spermatogenesis associated 13
Synonyms: ESTM11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219140
Homologene: 19482
Cyp2c55
Name: cytochrome P450, family 2, subfamily c, polypeptide 55
Synonyms: 2010318C06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 72082
HGNC: HGNC:2620
Homologene: 133567
Olfr926
Name: olfactory receptor 926
Synonyms: MOR171-8, GA_x6K02T2PVTD-32573036-32573962
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258811
VEGA: 9
HGNC: HGNC:8482
Homologene: 128215
Vmn2r101
Name: vomeronasal 2, receptor 101
Synonyms: EG627576
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 627576
Homologene: 115024
Atpaf1
Name: ATP synthase mitochondrial F1 complex assembly factor 1
Synonyms: ATP11p, 6330547J17Rik, ATP11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230649
Homologene: 41492
Bivm
Name: basic, immunoglobulin-like variable motif containing
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 246229
Homologene: 9783
Usp36
Name: ubiquitin specific peptidase 36
Synonyms: 2700002L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 72344
Homologene: 11828
Stk32c
Name: serine/threonine kinase 32C
Synonyms: Pkek, YANK3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57740
Homologene: 75157
Olfr1378
Name: olfactory receptor 1378
Synonyms: MOR129-2, GA_x6K02T2QP88-4469162-4468215
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258912
Homologene: 133679
Asgr2
Name: asialoglycoprotein receptor 2
Synonyms: ASGPR2, Asgr-2, Asgr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11890
HGNC: HGNC:743
Homologene: 912
Igdcc4
Name: immunoglobulin superfamily, DCC subclass, member 4
Synonyms: WI-18508, WI-16786, 9330155G14Rik, Nope
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 56741
VEGA: 9
Homologene: 10570
Slfn9
Name: schlafen 9
Synonyms: 9830137M10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237886
Homologene: 45432
G730003C15Rik
Name: RIKEN cDNA G730003C15 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Gm16686
Name: predicted gene, 16686
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 38,108,419 bp
  • A to T, chromosome 1 at 44,138,633 bp
  • A to G, chromosome 1 at 59,119,836 bp
  • T to C, chromosome 1 at 121,561,392 bp
  • A to G, chromosome 1 at 155,312,796 bp
  • A to G, chromosome 1 at 163,996,602 bp
  • C to T, chromosome 1 at 181,820,702 bp
  • C to T, chromosome 1 at 188,576,251 bp
  • A to G, chromosome 2 at 26,422,155 bp
  • A to G, chromosome 2 at 31,105,350 bp
  • T to C, chromosome 2 at 33,273,642 bp
  • T to C, chromosome 2 at 109,293,053 bp
  • T to C, chromosome 2 at 162,934,716 bp
  • T to C, chromosome 2 at 166,890,291 bp
  • A to G, chromosome 3 at 63,990,619 bp
  • C to A, chromosome 3 at 84,444,826 bp
  • T to C, chromosome 3 at 108,393,677 bp
  • A to T, chromosome 4 at 88,755,473 bp
  • A to T, chromosome 4 at 115,788,359 bp
  • C to T, chromosome 6 at 11,987,097 bp
  • C to T, chromosome 6 at 83,260,529 bp
  • T to C, chromosome 6 at 118,405,347 bp
  • G to A, chromosome 7 at 100,390,297 bp
  • A to G, chromosome 7 at 129,307,632 bp
  • T to C, chromosome 7 at 139,120,788 bp
  • T to C, chromosome 8 at 48,395,658 bp
  • A to G, chromosome 9 at 19,646,694 bp
  • G to A, chromosome 9 at 24,414,354 bp
  • A to G, chromosome 9 at 38,877,313 bp
  • A to T, chromosome 9 at 57,790,430 bp
  • A to G, chromosome 9 at 65,124,610 bp
  • A to T, chromosome 9 at 75,144,171 bp
  • T to C, chromosome 9 at 107,258,932 bp
  • T to C, chromosome 11 at 50,969,426 bp
  • C to A, chromosome 11 at 70,098,231 bp
  • T to C, chromosome 11 at 82,982,508 bp
  • T to C, chromosome 11 at 83,035,434 bp
  • A to G, chromosome 11 at 116,148,894 bp
  • G to A, chromosome 11 at 118,263,647 bp
  • T to C, chromosome 14 at 50,846,861 bp
  • T to A, chromosome 14 at 60,709,555 bp
  • T to C, chromosome 14 at 67,714,850 bp
  • G to A, chromosome 15 at 45,114,444 bp
  • T to A, chromosome 16 at 49,013,249 bp
  • G to A, chromosome 16 at 96,017,604 bp
  • A to T, chromosome 17 at 19,612,041 bp
  • T to C, chromosome 17 at 25,654,481 bp
  • T to A, chromosome 17 at 34,652,674 bp
  • G to A, chromosome 18 at 30,343,990 bp
  • T to A, chromosome 18 at 37,322,681 bp
  • T to C, chromosome 19 at 4,865,440 bp
  • A to G, chromosome 19 at 10,659,632 bp
  • A to T, chromosome 19 at 39,011,791 bp
  • A to T, chromosome X at 100,796,682 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4293 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041082-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.