Strain Name:
Stock Number:
Citation ID:
Other Names:

Gene Information

Allele Symbol: Bbs1Gt1Nk (Mus musculus (mouse))
Name: Bardet-Biedl syndrome 1 (human); gene trap 1, Nicholas Katsanis
Synonyms: Bbs1<->
Chromosome: 19
Alteration at locus: Gene Trap
Monarch Initiative (Disease and Phenotype Associations): MGI:3055491
Gene Symbol: Bbs1 (Mus musculus (mouse))
Name: Bardet-Biedl syndrome 1 (human)
Synonyms: D19Ertd609e
Chromosome: 19
Alteration at locus: Gene Trap
Monarch Initiative (Disease and Phenotype Associations): MGI:1277215
Genetic Alterations
Genetrap in Bbs1.
Genotype Determination
ES Cell Line
AB2.2 derived from 129S7/SvEvBrd-Hprtb-m2

Homozygous: Mice display retinal degeneration, obesity, and infertility. Phenotype is less severe than for Bbs4 gene-trap mice (MMRRC:42278).

Heterozygous: No major phenotypes observed.

Mammalian Phenotype Terms
Allelic Composition: (Genetic Background: )

MeSH Terms
  • Animals
  • Bardet-Biedl Syndrome/genetics
  • Cilia/ultrastructure
  • Humans
  • Mice
  • Microtubule-Associated Proteins
  • Microtubules/ultrastructure
  • Mutagenesis, Site-Directed
  • Mutation
  • Nasal Mucosa/ultrastructure
  • Nose/metabolism
  • Olfaction Disorders/genetics
  • Proteins/genetics
  • Proteins/metabolism
Strain Development
129SvEvAB2.2 embryonic stem cell lines were targeted for Bbs1. 20 mouse embryonic stem cells were microinjected into host blastocysts. Chimeras were  bred to C57BL/6J mice, which were then bred to homozygosity. The strain was maintained by backcrossing to C57BL/6J mice.
Suggested Control Mice
Wild-type littermates
  • Cell Biology
  • Developmental Biology
  • Diabetes
  • Endocrine Deficiency
  • Metabolism
  • Models for Human Disease
    • ciliopathies
  • Neurobiology
  • Obesity
  • Reproduction
  • Sensorineural
Nicholas Katsanis, Ph.D., Duke University.
Primary Reference

Kulaga HM, Leitch CC, Eichers ER, Badano JL, Lesemann A, Hoskins BE, Lupski JR, Beales PL, Reed RR, Katsanis N. Loss of BBS proteins causes anosmia in humans and defects in olfactory cilia structure and function in the mouse. Nat Genet. 2004 Sep;36(9):994-8. Epub 2004 Aug 22. (Medline PMID:15322545)

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email .
Coat Color
MMRRC Breeding System
Breeding Scheme(s)

Wild-type (C57BL/6J) female x Heterozygous male or reciprocal mating

Overall Breeding Performance
Viability and Fertility: Female Male Comments
Homozygotes are viable: Yes Yes
Homozygotes are fertile: No No
Heterozygotes are fertile: Yes Yes
Age Reproductive Decline: Undetermined Undetermined
Average litter size
Recommended wean age
3-4 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041470-MU-RESUS Litter recovered from cryo-archive $2,624.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials and based on the transfer success rate of the MMRRC facility) to transfer to at least two recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.