Strain Name:
C57BL/6J-MtgxR4287Btlr/Mmmh
Stock Number:
041652-MU
Citation ID:
RRID:MMRRC_041652-MU
Other Names:
R4287 (G1), C57BL/6J-MtgxR4287Btlr
Major Collection:

Gene Information

Glrb
Name: glycine receptor, beta subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 14658
HGNC: HGNC:4329
Homologene: 20224
Pnn
Name: pinin
Synonyms: D12Ertd512e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 18949
VEGA: 12
HGNC: HGNC:9162
Homologene: 37656
Anapc5
Name: anaphase-promoting complex subunit 5
Synonyms: 2510006G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 59008
Homologene: 41118
Sec23ip
Name: Sec23 interacting protein
Synonyms: p125, D7Ertd373e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 207352
Homologene: 38288
4932438A13Rik
Name: RIKEN cDNA 4932438A13 gene
Synonyms: FSA, Tweek
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229227
Homologene: 52105
Smurf1
Name: SMAD specific E3 ubiquitin protein ligase 1
Synonyms: 4930431E10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 75788
Homologene: 10712
Ash1l
Name: ASH1 like histone lysine methyltransferase
Synonyms: E430018P19Rik, 8030453L17Rik, KMT2H, chromatin remodeling factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 192195
Homologene: 10225
Tomm70a
Name: translocase of outer mitochondrial membrane 70A
Synonyms: D16Wsu109e, 2610044B22Rik, D16Ium22e, D16Ium22, Tomm70a, Tom70
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 28185
VEGA: 16
Homologene: 40112
Slc41a3
Name: solute carrier family 41, member 3
Synonyms: 1010001P06Rik, SLC41A1-L2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 71699
Homologene: 23052
Rreb1
Name: ras responsive element binding protein 1
Synonyms: 1110037N09Rik, B930013M22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 68750
Homologene: 2218
Ripor2
Name: RHO family interacting cell polarization regulator 2
Synonyms: Fam65b, 1700108N18Rik, 6330500D04Rik, E430013J17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 193385
Homologene: 9284
Mpp3
Name: membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
Synonyms: Dlgh3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 13384
HGNC: HGNC:7221
Homologene: 31065
Tln1
Name: talin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 21894
Homologene: 21267
Cog1
Name: component of oligomeric golgi complex 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 16834
HGNC: HGNC:6545
Homologene: 8411
Memo1
Name: mediator of cell motility 1
Synonyms: 0610016J10Rik, D930048L02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 76890
VEGA: 17
Homologene: 6272
Kidins220
Name: kinase D-interacting substrate 220
Synonyms: 3110039L19Rik, C330002I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 77480
VEGA: 12
Homologene: 14254
Klra3
Name: killer cell lectin-like receptor, subfamily A, member 3
Synonyms: Nk-2, Ly49c, NK-2.1, 5E6, Nk2, Nk2.1, Ly49C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 16634
Homologene: 110821
Zfp629
Name: zinc finger protein 629
Synonyms: 9330199A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 320683
Homologene: 65318
Olfr186
Name: olfactory receptor 186
Synonyms: MOR183-9, GA_x54KRFPKG5P-55257214-55256285
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 258318
Homologene: 133671
Umodl1
Name: uromodulin-like 1
Synonyms: D17Ertd488e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 52020
VEGA: 17
Homologene: 45466
Unc5d
Name: unc-5 netrin receptor D
Synonyms: D930029E11Rik, Unc5h4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 210801
Homologene: 15450
Mug2
Name: murinoglobulin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 17837
Homologene: 136663
Zfp986
Name: zinc finger protein 986
Synonyms: Gm13235
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
Itgav
Name: integrin alpha V
Synonyms: D430040G12Rik, 1110004F14Rik, 2610028E01Rik, vitronectin receptor alpha polypeptide (VNRA), alphav-integrin, CD51
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 16410
HGNC: HGNC:6150
Homologene: 20510
Unc5c
Name: unc-5 netrin receptor C
Synonyms: Unc5h3, B130051O18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 22253
Homologene: 2765
Rrs1
Name: ribosome biogenesis regulator 1
Synonyms: 5730466A07Rik, D1Ertd701e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 59014
Homologene: 41014
Ric8a
Name: RIC8 guanine nucleotide exchange factor A
Synonyms: synembryn, RIC-8, Ric8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 101489
Homologene: 23331
Klk14
Name: kallikrein related-peptidase 14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 317653
HGNC: HGNC:6362
Homologene: 69348
Tmed3
Name: transmembrane p24 trafficking protein 3
Synonyms: 1200002G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 66111
Homologene: 7213
Ndufb8
Name: NADH:ubiquinone oxidoreductase subunit B8
Synonyms: 2900010I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 67264
HGNC: HGNC:7703
Homologene: 3668
Vmn2r97
Name: vomeronasal 2, receptor 97
Synonyms: EG627367
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 627367
Homologene: 115024
Setbp1
Name: SET binding protein 1
Synonyms: Seb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 240427
Homologene: 9192
Il1rn
Name: interleukin 1 receptor antagonist
Synonyms: F630041P17Rik, IL-1ra
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 16181
HGNC: HGNC:6000
Homologene: 11163
Ccdc82
Name: coiled-coil domain containing 82
Synonyms: 2310043N13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 66396
VEGA: 9
Homologene: 11678
Lce1i
Name: late cornified envelope 1I
Synonyms: 2310069N01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 76585
Fpgt
Name: fucose-1-phosphate guanylyltransferase
Synonyms: 1700016E03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 75540
HGNC: HGNC:3825
Homologene: 2847
Gm7135
Name: predicted gene 7135
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 634346
Homologene: 86643
Slc25a51
Name: solute carrier family 25, member 51
Synonyms: 9130208E07Rik, Mcart1, D130005A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230125
Homologene: 88487
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 9,546,215 bp
  • C to T, chromosome 1 at 9,546,223 bp
  • A to G, chromosome 1 at 97,400,398 bp
  • T to C, chromosome 2 at 24,349,545 bp
  • G to T, chromosome 2 at 83,724,840 bp
  • T to C, chromosome 3 at 36,917,757 bp
  • A to T, chromosome 3 at 80,845,232 bp
  • T to A, chromosome 3 at 89,066,415 bp
  • A to G, chromosome 3 at 92,777,435 bp
  • T to C, chromosome 3 at 141,714,674 bp
  • T to C, chromosome 3 at 155,091,360 bp
  • C to T, chromosome 4 at 43,543,509 bp
  • C to T, chromosome 4 at 45,399,768 bp
  • T to C, chromosome 4 at 145,892,518 bp
  • A to G, chromosome 5 at 122,800,601 bp
  • A to G, chromosome 5 at 144,891,458 bp
  • A to T, chromosome 6 at 90,640,922 bp
  • T to A, chromosome 6 at 122,063,673 bp
  • A to G, chromosome 6 at 130,334,302 bp
  • G to A, chromosome 7 at 43,692,077 bp
  • T to C, chromosome 7 at 127,611,938 bp
  • A to G, chromosome 7 at 128,777,333 bp
  • A to G, chromosome 7 at 140,861,422 bp
  • T to A, chromosome 8 at 28,719,796 bp
  • C to A, chromosome 9 at 13,253,418 bp
  • A to G, chromosome 9 at 89,704,898 bp
  • G to A, chromosome 11 at 102,023,463 bp
  • A to G, chromosome 11 at 113,654,027 bp
  • G to A, chromosome 12 at 25,056,846 bp
  • C to T, chromosome 12 at 59,072,170 bp
  • G to A, chromosome 13 at 24,725,009 bp
  • A to T, chromosome 13 at 37,931,931 bp
  • T to G, chromosome 16 at 57,140,622 bp
  • A to T, chromosome 16 at 59,027,613 bp
  • A to T, chromosome 17 at 18,948,075 bp
  • A to G, chromosome 17 at 30,988,065 bp
  • T to C, chromosome 17 at 74,255,298 bp
  • T to C, chromosome 18 at 78,859,061 bp
  • T to C, chromosome 19 at 44,552,691 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4287 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041652-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.