Strain Name:
C57BL/6J-MtgxR4345Btlr/Mmmh
Stock Number:
041666-MU
Citation ID:
RRID:MMRRC_041666-MU
Other Names:
R4345 (G1), C57BL/6J-MtgxR4345Btlr
Major Collection:

Gene Information

Foxp4
Name: forkhead box P4
Synonyms: 1200010K03Rik, 2310007G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 74123
Homologene: 12536
Lactb2
Name: lactamase, beta 2
Synonyms: E430032H21Rik, Cgi-83
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 212442
Homologene: 9349
Mier3
Name: MIER family member 3
Synonyms: D130064H19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218613
Homologene: 18196
Usp10
Name: ubiquitin specific peptidase 10
Synonyms: Uchrp, 2610014N07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 22224
Homologene: 31294
Pno1
Name: partner of NOB1 homolog
Synonyms: 1810003N24Rik, Emi3, Imi3, expressed during mesenchymal induction 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 66249
Homologene: 6961
Lepr
Name: leptin receptor
Synonyms: obese-like, leptin receptor gene-related protein, OB-RGRP, Modb1, LEPROT, Leprb, Obr, obl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 16847
HGNC: HGNC:6554
Homologene: 1731
Prr14l
Name: proline rich 14-like
Synonyms: C330019G07Rik, 6030436E02Rik, Prl14l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 215476
Homologene: 65866
Zswim6
Name: zinc finger SWIM-type containing 6
Synonyms: 2900036G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 67263
VEGA: 13
Homologene: 83517
Fbf1
Name: Fas (TNFRSF6) binding factor 1
Synonyms: 1110033G01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217335
Homologene: 16531
Igf2r
Name: insulin-like growth factor 2 receptor
Synonyms: M6P/IGF2R, IGF-II/CI-MPR, CI-MPR, mannose-6-phosphate receptor, cation independent, Mpr300, CD222
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 16004
HGNC: HGNC:5467
Homologene: 676
Map4k3
Name: mitogen-activated protein kinase kinase kinase kinase 3
Synonyms: 9530052P13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 225028
VEGA: 17
HGNC: HGNC:6865
Homologene: 2683
Heatr5b
Name: HEAT repeat containing 5B
Synonyms: A230048G03Rik, 2010013B10Rik, D330050P16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 320473
VEGA: 17
Homologene: 25536
Kcnv1
Name: potassium channel, subfamily V, member 1
Synonyms: 2700023A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 67498
VEGA: 15
Homologene: 22811
Ttn
Name: titin
Synonyms: D830007G01Rik, connectin, 1100001C23Rik, 2310036G12Rik, mdm, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru, L56
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Slc9a5
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 5
Synonyms: LOC277973
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 277973
Homologene: 31247
Trpm3
Name: transient receptor potential cation channel, subfamily M, member 3
Synonyms: 6330504P12Rik, LTRPC3, melastatin 2, MLSN2, B930001P07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226025
VEGA: 19
Homologene: 62287
Loxhd1
Name: lipoxygenase homology domains 1
Synonyms: sba, 1700096C21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240411
C3ar1
Name: complement component 3a receptor 1
Synonyms: C3aR, anaphylatoxin C3a receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12267
HGNC: HGNC:1319
Homologene: 2992
Pdzd8
Name: PDZ domain containing 8
Synonyms: A630041P07Rik, Pdzk8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 107368
VEGA: 19
Homologene: 14879
Astn1
Name: astrotactin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11899
HGNC: HGNC:773
Homologene: 7233
Stard9
Name: START domain containing 9
Synonyms: 4831403C07Rik, Kif16a, E230025N21Rik, N-3 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 668880
Homologene: 130712
Gramd4
Name: GRAM domain containing 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223752
Homologene: 18199
Olfr320
Name: olfactory receptor 320
Synonyms: Olfr321-ps1, MOR285-5, GA_x6K02T2NKPP-730312-729392, GA_x6K02T2NKPP-733777-732813, Olfr320, MOR285-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216783
Homologene: 133825
Them4
Name: thioesterase superfamily member 4
Synonyms: 2700077M13Rik, 4921507I02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 75778
Homologene: 14208
Nsd3
Name: nuclear receptor binding SET domain protein 3
Synonyms: Whsc1l1, WHISTLE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234135
Homologene: 56960
Usp4
Name: ubiquitin specific peptidase 4 (proto-oncogene)
Synonyms: F730026I20Rik, Unp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22258
Homologene: 20716
Asap2
Name: ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
Synonyms: Ddef2, LOC385250, 6530401G17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 211914
HGNC: HGNC:2721
Homologene: 2888
Nfasc
Name: neurofascin
Synonyms: D430023G06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 269116
Homologene: 24945
Tgfbrap1
Name: transforming growth factor, beta receptor associated protein 1
Synonyms: 3110018K12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 73122
Homologene: 3141
Olfr1065
Name: olfactory receptor 1065
Synonyms: GA_x6K02T2Q125-47915274-47914333, MOR190-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258403
Homologene: 74195
Thoc2l
Name: THO complex subunit 2-like
Synonyms: BC005561, Gm3179
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100042165
Vmn1r72
Name: vomeronasal 1 receptor 72
Synonyms: V1rg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 252905
Homologene: 74318
Ttl
Name: tubulin tyrosine ligase
Synonyms: 2410003M22Rik, 2700049H19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 69737
Homologene: 32678
Zmym5
Name: zinc finger, MYM-type 5
Synonyms: 9830124H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219105
Homologene: 16997
Plod3
Name: procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
Synonyms: LH3, lysyl hydroxylase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 26433
HGNC: HGNC:9083
Homologene: 843
Mrpl43
Name: mitochondrial ribosomal protein L43
Synonyms: bMRP36a, 4930442D21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 94067
VEGA: 19
Homologene: 41847
Il1r1
Name: interleukin 1 receptor, type I
Synonyms: CD121a, IL-iR, IL-1R1, Il1r-1, IL-1 receptor alpha chain
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16177
HGNC: HGNC:5993
Homologene: 677
Sri
Name: sorcin
Synonyms: 2900070H08Rik, 2210417O06Rik, Sor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 109552
Homologene: 37736
Setbp1
Name: SET binding protein 1
Synonyms: Seb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240427
Homologene: 9192
Mcee
Name: methylmalonyl CoA epimerase
Synonyms: 1110007A04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 73724
Homologene: 13078
Gm5878
Name: predicted gene 5878
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 545861
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 13,660,350 bp
  • A to G, chromosome 1 at 40,297,924 bp
  • T to C, chromosome 1 at 43,056,706 bp
  • A to G, chromosome 1 at 132,631,705 bp
  • T to A, chromosome 1 at 158,502,032 bp
  • G to T, chromosome 2 at 76,756,316 bp
  • T to A, chromosome 2 at 86,445,845 bp
  • G to A, chromosome 2 at 120,701,946 bp
  • T to C, chromosome 2 at 129,075,858 bp
  • A to G, chromosome 3 at 94,329,865 bp
  • G to A, chromosome 4 at 101,765,152 bp
  • G to T, chromosome 5 at 8,059,427 bp
  • A to G, chromosome 5 at 32,828,576 bp
  • A to G, chromosome 5 at 104,521,449 bp
  • G to C, chromosome 5 at 136,988,146 bp
  • G to A, chromosome 6 at 85,125,651 bp
  • T to C, chromosome 6 at 122,850,700 bp
  • T to A, chromosome 7 at 11,670,036 bp
  • T to C, chromosome 7 at 64,411,938 bp
  • G to C, chromosome 8 at 25,641,317 bp
  • T to C, chromosome 8 at 105,349,455 bp
  • T to A, chromosome 8 at 119,954,814 bp
  • T to A, chromosome 9 at 108,368,023 bp
  • A to G, chromosome 11 at 17,209,095 bp
  • A to G, chromosome 11 at 58,683,945 bp
  • A to G, chromosome 11 at 116,147,742 bp
  • T to C, chromosome 12 at 21,230,831 bp
  • G to T, chromosome 13 at 107,726,931 bp
  • A to G, chromosome 13 at 111,705,283 bp
  • T to C, chromosome 14 at 56,796,626 bp
  • G to A, chromosome 15 at 45,114,444 bp
  • T to C, chromosome 15 at 86,134,893 bp
  • C to T, chromosome 17 at 12,709,511 bp
  • G to A, chromosome 17 at 47,874,648 bp
  • A to T, chromosome 17 at 78,760,511 bp
  • A to G, chromosome 17 at 80,597,551 bp
  • A to G, chromosome 18 at 77,399,001 bp
  • T to A, chromosome 18 at 79,086,579 bp
  • A to T, chromosome 19 at 22,897,697 bp
  • T to C, chromosome 19 at 45,006,110 bp
  • T to C, chromosome 19 at 59,300,128 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4345 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041666-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.