Strain Name:
C57BL/6J-MtgxR4455Btlr/Mmmh
Stock Number:
041715-MU
Citation ID:
RRID:MMRRC_041715-MU
Other Names:
R4455 (G1), C57BL/6J-MtgxR4455Btlr
Major Collection:

Gene Information

Cdkn2d
Name: cyclin dependent kinase inhibitor 2D
Synonyms: p19, INK4d, p19INK4d, INK4d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12581
VEGA: 9
HGNC: HGNC:1790
Homologene: 36081
Cdh11
Name: cadherin 11
Synonyms: osteoblast-cadherin, OB-cadherin, Cad11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12552
HGNC: HGNC:1750
Homologene: 1361
Eya1
Name: EYA transcriptional coactivator and phosphatase 1
Synonyms: bor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14048
HGNC: HGNC:3519
Homologene: 74943
Resp18
Name: regulated endocrine-specific protein 18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19711
Homologene: 7516
Sntb2
Name: syntrophin, basic 2
Synonyms: Snt2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 20650
Homologene: 4911
Magi1
Name: membrane associated guanylate kinase, WW and PDZ domain containing 1
Synonyms: WWP3, Gukmi1, AIP3, BAP1, Baiap1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14924
HGNC: HGNC:946
Homologene: 31257
Dop1b
Name: DOP1 leucine zipper like protein B
Synonyms: 0610038M01Rik, 2610510B01Rik, Dopey2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 70028
VEGA: 16
HGNC: HGNC:1291
Homologene: 21068
Arfgef2
Name: ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
Synonyms: BIG2, E230011G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99371
Homologene: 111880
Xrn1
Name: 5'-3' exoribonuclease 1
Synonyms: mXrn1, Dhm2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 24127
Homologene: 5894
Mllt1
Name: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1
Synonyms: BAM11, LTG19, ENL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 64144
VEGA: 17
HGNC: HGNC:7134
Homologene: 4339
Hspa4
Name: heat shock protein 4
Synonyms: APG-2, Hsp70RY, Hsp110, 70kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 15525
HGNC: HGNC:5237
Homologene: 1624
Kansl1
Name: KAT8 regulatory NSL complex subunit 1
Synonyms: 1700081L11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76719
Homologene: 9140
Yeats2
Name: YEATS domain containing 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 208146
VEGA: 16
Homologene: 9967
Dctn1
Name: dynactin 1
Synonyms: Glued, p150, p150glued
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 13191
HGNC: HGNC:2711
Homologene: 3011
Grb10
Name: growth factor receptor bound protein 10
Synonyms: Meg1, maternally expressed gene 1, 5730571D09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14783
HGNC: HGNC:4564
Homologene: 3882
Ccdc18
Name: coiled-coil domain containing 18
Synonyms: 1700021E15Rik, 4932411G06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 73254
Homologene: 35455
Utp18
Name: UTP18 small subunit processome component
Synonyms: 6230425C22Rik, Wdr50
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217109
Homologene: 41087
Psmb6
Name: proteasome (prosome, macropain) subunit, beta type 6
Synonyms: subunit 2, Mpnd, Lmp19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 19175
HGNC: HGNC:9543
Homologene: 2092
H3f3a
Name: H3.3 histone A
Synonyms: H3.3A, H3-3a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 15078
HGNC: HGNC:4764
Homologene: 134170
Aktip
Name: AKT interacting protein
Synonyms: Ft1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14339
Homologene: 7721
Mindy1
Name: MINDY lysine 48 deubiquitinase 1
Synonyms: cI-40, 1810005H09Rik, NF-E2 inducible protein, 4930504E06Rik, Fam63a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 75007
Homologene: 32409
Ms4a14
Name: membrane-spanning 4-domains, subfamily A, member 14
Synonyms: LOC383435
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 383435
Homologene: 138453
Baz1a
Name: bromodomain adjacent to zinc finger domain 1A
Synonyms: Gtl5, Wcrf180, Acf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217578
HGNC: HGNC:960
Homologene: 45654
Necap1
Name: NECAP endocytosis associated 1
Synonyms: 1200016B17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 67602
Homologene: 22902
Mslnl
Name: mesothelin-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 328783
VEGA: 17
Homologene: 18633
Calhm6
Name: calcium homeostasis modulator family member 6
Synonyms: A630077B13Rik, Fam26f
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215900
VEGA: 10
Homologene: 25235
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, D830007G01Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Aoc1l3
Name: amine oxidase copper containing 1-like 3
Synonyms: SVS I, Svs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243377
HGNC: HGNC:80
Homologene: 18250
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241516
Homologene: 110349
Ptpro
Name: protein tyrosine phosphatase, receptor type, O
Synonyms: D28, PTPROt, PTP-phi, PTP-BK, PTP-U2, GLEPP1, PTP-oc, Ptpn15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19277
HGNC: HGNC:9678
Homologene: 21564
Camk2d
Name: calcium/calmodulin-dependent protein kinase II, delta
Synonyms: CaMK II, 2810011D23Rik, 8030469K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 108058
HGNC: HGNC:1462
Homologene: 55561
Hfm1
Name: HFM1, ATP-dependent DNA helicase homolog
Synonyms: LOC381663, A330009G12Rik, Sec63d1, Mer3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 330149
Homologene: 87103
Scara5
Name: scavenger receptor class A, member 5
Synonyms: 4932433F15Rik, 4933425F03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 71145
Homologene: 12556
Spata6
Name: spermatogenesis associated 6
Synonyms: 1700062C23Rik, Hash, KRP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67946
Homologene: 10410
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC9, MUC5, 2300002I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Egr2
Name: early growth response 2
Synonyms: Krox20, Egr-2, Krox-20, Zfp-25, NGF1-B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 13654
HGNC: HGNC:3239
Homologene: 20123
Fam227b
Name: family with sequence similarity 227, member B
Synonyms: 4930525F21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 75823
Homologene: 27384
Sspo
Name: SCO-spondin
Synonyms: C79529, Scospondin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243369
Homologene: 45453
Whrn
Name: whirlin
Synonyms: 1110035G07Rik, wi, C430046P22Rik, Dfnb31, Ush2d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 73750
Homologene: 18739
Aoc1
Name: amine oxidase, copper-containing 1
Synonyms: 1600012D06Rik, Abp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 76507
HGNC: HGNC:80
Homologene: 68159
Nsd3
Name: nuclear receptor binding SET domain protein 3
Synonyms: WHISTLE, Whsc1l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234135
Homologene: 56960
Ttc28
Name: tetratricopeptide repeat domain 28
Synonyms: 2310015L07Rik, TPRBK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 209683
Homologene: 41023
Krtap16-1
Name: keratin associated protein 16-1
Synonyms: AI450886
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 100504183
Homologene: 99988
Piwil2
Name: piwi-like RNA-mediated gene silencing 2
Synonyms: Miwi like, mili
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 57746
VEGA: 14
Homologene: 23071
Slc2a4
Name: solute carrier family 2 (facilitated glucose transporter), member 4
Synonyms: Glut-4, Glut4, twgy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20528
Homologene: 74381
Bbs12
Name: Bardet-Biedl syndrome 12 (human)
Synonyms: LOC241950, LOC241950, LOC386537
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 241950
Homologene: 17634
Ankk1
Name: ankyrin repeat and kinase domain containing 1
Synonyms: 9930020N01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244859
VEGA: 9
Homologene: 18258
Rela
Name: v-rel reticuloendotheliosis viral oncogene homolog A (avian)
Synonyms: p65 NF kappaB, p65
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 19697
HGNC: HGNC:9955
Homologene: 32064
Cacnb4
Name: calcium channel, voltage-dependent, beta 4 subunit
Synonyms: Cchb4, 3110038O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12298
HGNC: HGNC:1404
Homologene: 20188
Mettl17
Name: methyltransferase like 17
Synonyms: 2310032K15Rik, D14Ertd209e, Mett11d1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 52535
Homologene: 11226
1700102P08Rik
Name: RIKEN cDNA 1700102P08 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 112418
Homologene: 14230
Tsen34
Name: tRNA splicing endonuclease subunit 34
Synonyms: 0610027F08Rik, Leng5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 66078
Homologene: 44182
Rpl31-ps17
Name: ribosomal protein L31, pseudogene 17
Synonyms: Gm16382
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 673582
D10Bwg1379e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Clca6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 14,183,196 bp
  • A to G, chromosome 1 at 75,274,497 bp
  • G to T, chromosome 1 at 180,803,103 bp
  • A to G, chromosome 2 at 52,465,653 bp
  • T to C, chromosome 2 at 76,946,913 bp
  • G to T, chromosome 2 at 82,990,776 bp
  • T to A, chromosome 2 at 126,146,268 bp
  • T to C, chromosome 2 at 166,894,715 bp
  • T to C, chromosome 3 at 37,320,312 bp
  • G to A, chromosome 3 at 95,281,896 bp
  • T to C, chromosome 3 at 126,780,403 bp
  • G to A, chromosome 3 at 144,957,259 bp
  • T to A, chromosome 4 at 63,416,068 bp
  • T to C, chromosome 4 at 111,805,964 bp
  • T to C, chromosome 5 at 106,886,508 bp
  • C to T, chromosome 5 at 108,161,529 bp
  • AC to A, chromosome 5 at 111,224,058 bp
  • C to T, chromosome 6 at 48,465,516 bp
  • T to A, chromosome 6 at 48,905,467 bp
  • A to T, chromosome 6 at 48,987,460 bp
  • T to C, chromosome 6 at 83,195,049 bp
  • A to G, chromosome 6 at 93,785,457 bp
  • C to T, chromosome 6 at 122,887,369 bp
  • A to G, chromosome 6 at 137,393,659 bp
  • G to A, chromosome 7 at 3,695,098 bp
  • T to C, chromosome 7 at 141,858,818 bp
  • T to C, chromosome 8 at 25,663,169 bp
  • T to C, chromosome 8 at 91,124,851 bp
  • T to C, chromosome 8 at 102,647,823 bp
  • G to A, chromosome 8 at 106,991,607 bp
  • C to G, chromosome 9 at 21,290,889 bp
  • A to G, chromosome 9 at 49,418,066 bp
  • T to A, chromosome 9 at 95,973,645 bp
  • A to G, chromosome 9 at 108,397,196 bp
  • A to T, chromosome 10 at 18,607,675 bp
  • A to T, chromosome 10 at 34,126,535 bp
  • GAA to GA, chromosome 10 at 67,539,903 bp
  • T to G, chromosome 11 at 11,967,665 bp
  • C to A, chromosome 11 at 53,280,659 bp
  • G to A, chromosome 11 at 69,943,322 bp
  • G to T, chromosome 11 at 70,527,525 bp
  • G to A, chromosome 11 at 93,885,447 bp
  • A to T, chromosome 11 at 99,985,733 bp
  • T to C, chromosome 11 at 104,424,358 bp
  • C to T, chromosome 12 at 54,701,612 bp
  • C to A, chromosome 12 at 54,911,368 bp
  • A to G, chromosome 14 at 51,885,455 bp
  • T to A, chromosome 14 at 65,762,747 bp
  • T to C, chromosome 14 at 70,390,565 bp
  • A to G, chromosome 16 at 20,161,993 bp
  • T to C, chromosome 16 at 93,766,215 bp
  • G to A, chromosome 17 at 25,742,934 bp
  • A to G, chromosome 17 at 56,919,965 bp
  • T to A, chromosome 19 at 5,647,262 bp
  • T to A, chromosome 19 at 11,303,626 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4455 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041715-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.