Strain Name:
C57BL/6J-MtgxR4874Btlr/Mmmh
Stock Number:
042484-MU
Citation ID:
RRID:MMRRC_042484-MU
Other Names:
R4874 (G1), C57BL/6J-MtgxR4874Btlr
Major Collection:

Gene Information

Glrb
Name: glycine receptor, beta subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 14658
HGNC: HGNC:4329
Homologene: 20224
Slit1
Name: slit guidance ligand 1
Synonyms: Slil1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 20562
Homologene: 2302
Pibf1
Name: progesterone immunomodulatory binding factor 1
Synonyms: 4933438D16Rik, 4930513H15Rik, D14Ertd581e, 1700017E21Rik, 4933439E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 52023
VEGA: 14
Homologene: 4628
Mki67
Name: antigen identified by monoclonal antibody Ki 67
Synonyms: D630048A14Rik, Ki67, Ki-67
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 17345
HGNC: HGNC:7107
Homologene: 1814
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: Dnec1, dynein heavy chain, retrograde transport, MAP1C, 9930018I23Rik, Swl, Loa, Dnchc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Bcam
Name: basal cell adhesion molecule
Synonyms: 1200005K12Rik, Lu, B-CAM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 57278
HGNC: HGNC:6722
Homologene: 21149
Hpgd
Name: hydroxyprostaglandin dehydrogenase 15 (NAD)
Synonyms: 15-PGDH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 15446
HGNC: HGNC:5154
Homologene: 68095
Adamtsl1
Name: ADAMTS-like 1
Synonyms: 6720426B09Rik, 5930437A14Rik, punctin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 77739
Homologene: 64642
Sorl1
Name: sortilin-related receptor, LDLR class A repeats-containing
Synonyms: LR11, 2900010L19Rik, Sorla, mSorLA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 20660
Homologene: 2336
Zfp644
Name: zinc finger protein 644
Synonyms: BM-005, D5Ertd689e, 1110068L01Rik, Zep-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 52397
Homologene: 12971
Prkaa1
Name: protein kinase, AMP-activated, alpha 1 catalytic subunit
Synonyms: AMPKalpha1, C130083N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 105787
VEGA: 15
HGNC: HGNC:9376
Homologene: 49590
Rufy1
Name: RUN and FYVE domain containing 1
Synonyms: 3000002E04Rik, ZFYVE12, Rabip4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 216724
Homologene: 23522
Papln
Name: papilin, proteoglycan-like sulfated glycoprotein
Synonyms: E030033C16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 170721
Homologene: 71541
Pgap1
Name: post-GPI attachment to proteins 1
Synonyms: PGAP1, oto, 9030223K07Rik, 5033403E17Rik, D230012E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 241062
Homologene: 41605
Mfng
Name: MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Synonyms: manic fringe
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 17305
HGNC: HGNC:7038
Homologene: 1803
Haus3
Name: HAUS augmin-like complex, subunit 3
Synonyms: D5H4S43, D4S43h, D5H4S43E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231123
Homologene: 75209
Nbas
Name: neuroblastoma amplified sequence
Synonyms: 4933425L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 71169
VEGA: 12
Homologene: 41073
Il16
Name: interleukin 16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 16170
HGNC: HGNC:5980
Homologene: 18157
Pitpnm1
Name: phosphatidylinositol transfer protein, membrane-associated 1
Synonyms: RdgB, DRES9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 18739
HGNC: HGNC:9003
Homologene: 3608
Ern2
Name: endoplasmic reticulum (ER) to nucleus signalling 2
Synonyms: Ire1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 26918
Homologene: 22687
Sall3
Name: spalt like transcription factor 3
Synonyms: Salt, Spalt, Msal-1, B130022O04Rik, Msal
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 20689
VEGA: 18
Homologene: 18142
4932431P20Rik
Name: RIKEN cDNA 4932431P20 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 114675
Aadat
Name: aminoadipate aminotransferase
Synonyms: mKat-2, Kyat2, Kat2, KATII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 23923
Homologene: 56540
Dcdc5
Name: doublecortin domain containing 5
Synonyms: 4732421G10Rik, EG436559
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 329482
Homologene: 79722
Reg3b
Name: regenerating islet-derived 3 beta
Synonyms: REG-III, Pap, RegIII (beta), PAP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 18489
HGNC: HGNC:8601
Homologene: 130506
Megf10
Name: multiple EGF-like-domains 10
Synonyms: LOC240312, 3000002B06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 70417
Homologene: 23771
Vmn2r115
Name: vomeronasal 2, receptor 115
Synonyms: V2Rp4, EG638102
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 638102
Homologene: 86604
Dll1
Name: delta like canonical Notch ligand 1
Synonyms: Delta1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 13388
HGNC: HGNC:2908
Homologene: 4104
Opn5
Name: opsin 5
Synonyms: TMEM13, PGR12, Gpr136, Neuropsin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 353344
VEGA: 17
Homologene: 72341
Shank1
Name: SH3 and multiple ankyrin repeat domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 243961
Homologene: 22949
Mertk
Name: MER proto-oncogene tyrosine kinase
Synonyms: Mer, Nyk, nmf12, Eyk, Tyro 12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 17289
HGNC: HGNC:7027
Homologene: 4626
B4galnt3
Name: beta-1,4-N-acetyl-galactosaminyl transferase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 330406
Homologene: 18328
Spata20
Name: spermatogenesis associated 20
Synonyms: Tisp78
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217116
Homologene: 11264
Emilin1
Name: elastin microfibril interfacer 1
Synonyms: gp115, EMILIN-1, 5830419M17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 100952
Homologene: 5117
Rpusd2
Name: RNA pseudouridylate synthase domain containing 2
Synonyms: 4921503C21Rik, BB231107
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 271842
Homologene: 5588
Lamc2
Name: laminin, gamma 2
Synonyms: nicein, 100kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 16782
HGNC: HGNC:6493
Homologene: 4062
Cr2
Name: complement receptor 2
Synonyms: Cr1, CD21, Cr-1, CD35, Cr-2, C3DR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 12902
HGNC: HGNC:2336
Homologene: 55611
Olfr16
Name: olfactory receptor 16
Synonyms: MOR267-13, MOR23, GA_x6K02T2R7CC-893157-892228
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 18313
Homologene: 7460
Negr1
Name: neuronal growth regulator 1
Synonyms: 5330422G01Rik, Ntra
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 320840
Homologene: 41447
Aph1b
Name: aph1 homolog B, gamma secretase subunit
Synonyms: 2310057K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 208117
Homologene: 12844
Olfr1094
Name: olfactory receptor 1094
Synonyms: GA_x6K02T2Q125-48321457-48322449, MOR179-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258362
Homologene: 133609
Esp36
Name: exocrine gland secreted peptide 36
Synonyms: Gm20408
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 100126765
Foxd2
Name: forkhead box D2
Synonyms: Mf2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 17301
HGNC: HGNC:3803
Homologene: 3292
Olfr707
Name: olfactory receptor 707
Synonyms: MOR260-8P, GA_x6K02T2PBJ9-9276470-9275547
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 194433
Homologene: 133899
Prcd
Name: photoreceptor disc component
Synonyms: Gm11744
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 100038570
Ighv1-22
Name: immunoglobulin heavy variable 1-22
Synonyms: Gm16860
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 780883
Gm13608
Name: predicted gene 13608
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 100417346
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 54,530,137 bp
  • T to C, chromosome 1 at 153,154,395 bp
  • A to G, chromosome 1 at 172,957,599 bp
  • A to T, chromosome 1 at 195,176,570 bp
  • A to G, chromosome 2 at 31,980,584 bp
  • T to A, chromosome 2 at 86,829,254 bp
  • T to C, chromosome 2 at 106,368,106 bp
  • T to C, chromosome 2 at 119,034,879 bp
  • T to C, chromosome 2 at 128,750,159 bp
  • T to C, chromosome 3 at 80,851,042 bp
  • T to C, chromosome 3 at 156,859,445 bp
  • A to G, chromosome 4 at 86,342,492 bp
  • G to T, chromosome 4 at 114,907,571 bp
  • A to T, chromosome 5 at 30,918,564 bp
  • A to G, chromosome 5 at 34,167,628 bp
  • A to G, chromosome 5 at 106,635,413 bp
  • T to A, chromosome 6 at 78,372,826 bp
  • C to A, chromosome 6 at 120,207,206 bp
  • T to C, chromosome 7 at 19,769,322 bp
  • A to G, chromosome 7 at 29,536,183 bp
  • C to T, chromosome 7 at 44,316,073 bp
  • A to T, chromosome 7 at 83,660,945 bp
  • C to T, chromosome 7 at 106,891,435 bp
  • T to C, chromosome 7 at 122,176,587 bp
  • T to C, chromosome 7 at 135,708,771 bp
  • A to T, chromosome 8 at 56,317,803 bp
  • G to A, chromosome 8 at 60,516,113 bp
  • A to T, chromosome 9 at 42,063,752 bp
  • A to T, chromosome 9 at 66,790,596 bp
  • T to C, chromosome 11 at 50,406,450 bp
  • C to T, chromosome 11 at 94,482,685 bp
  • T to A, chromosome 11 at 116,659,771 bp
  • A to G, chromosome 12 at 13,321,755 bp
  • G to T, chromosome 12 at 83,777,143 bp
  • C to A, chromosome 12 at 110,658,126 bp
  • T to A, chromosome 12 at 114,746,416 bp
  • T to C, chromosome 14 at 99,140,556 bp
  • A to G, chromosome 15 at 5,174,357 bp
  • C to T, chromosome 15 at 78,764,388 bp
  • A to T, chromosome 17 at 15,370,239 bp
  • T to A, chromosome 17 at 23,359,851 bp
  • A to T, chromosome 17 at 38,417,096 bp
  • C to G, chromosome 17 at 42,580,719 bp
  • G to A, chromosome 18 at 57,293,858 bp
  • T to C, chromosome 18 at 80,973,973 bp
  • T to C, chromosome 19 at 4,112,252 bp
  • C to T, chromosome 19 at 41,729,054 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4874 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042484-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.