Strain Name:
C57BL/6J-MtgxR4919Btlr/Mmmh
Stock Number:
042521-MU
Citation ID:
RRID:MMRRC_042521-MU
Other Names:
R4919 (G1), C57BL/6J-MtgxR4919Btlr
Major Collection:

Gene Information

Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: Mll3, HALR, E330008K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231051
Homologene: 46480
Pnmt
Name: phenylethanolamine-N-methyltransferase
Synonyms: Pent
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18948
HGNC: HGNC:9160
Homologene: 55673
Traip
Name: TRAF-interacting protein
Synonyms: Trip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22036
Homologene: 31343
Aplf
Name: aprataxin and PNKP like factor
Synonyms: 2010301N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 72103
Homologene: 49753
Mbtd1
Name: mbt domain containing 1
Synonyms: hemp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103537
Homologene: 41185
Dop1a
Name: DOP1 leucine zipper like protein A
Synonyms: Dopey1, D9Ertd809e, B130005I07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 320615
Homologene: 26645
Xpo6
Name: exportin 6
Synonyms: Ranbp20, C230091E20Rik, 2610005L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74204
Homologene: 12544
Tmem39a
Name: transmembrane protein 39a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 67846
Homologene: 9985
Ncapd3
Name: non-SMC condensin II complex, subunit D3
Synonyms: 4632407J06Rik, 2810487N22Rik, B130055D15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 78658
VEGA: 9
Homologene: 41021
Sgo2a
Name: shugoshin 2A
Synonyms: Sgol2a, D1Ertd8e, 5730576N04Rik, 1110007N04Rik, Tripin, Sgol2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68549
Homologene: 51867
Sv2a
Name: synaptic vesicle glycoprotein 2 a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 64051
Homologene: 32237
Grhl3
Name: grainyhead like transcription factor 3
Synonyms: Som, ct, Get1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230824
Homologene: 18864
Tia1
Name: cytotoxic granule-associated RNA binding protein 1
Synonyms: mTIA-1, 2310050N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 21841
Homologene: 20692
Gosr1
Name: golgi SNAP receptor complex member 1
Synonyms: Cis-Golgi SNARE, GS28, GOS-28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 53334
HGNC: HGNC:4430
Homologene: 37977
Ino80
Name: INO80 complex subunit
Synonyms: Inoc1, 2310079N15Rik, INO80, 4632409L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68142
Homologene: 75070
2700049A03Rik
Name: RIKEN cDNA 2700049A03 gene
Synonyms: Ta3, talpid3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 76967
Homologene: 8839
Brd8
Name: bromodomain containing 8
Synonyms: 4432404P07Rik, 2610007E11Rik, SMAP, p120
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 78656
Homologene: 41790
Lnpep
Name: leucyl/cystinyl aminopeptidase
Synonyms: vp165, gp160, 4732490P18Rik, IRAP, 2010309L07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240028
VEGA: 17
HGNC: HGNC:6656
Homologene: 21148
Ssh2
Name: slingshot protein phosphatase 2
Synonyms: SSH-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237860
Homologene: 14116
Enpp1
Name: ectonucleotide pyrophosphatase/phosphodiesterase 1
Synonyms: NPP1, Pca-1, twy, PC-1, Pca, Pdnp1, Npps, E-NPP1, 4833416E15Rik, CD203c, Ly-41
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18605
HGNC: HGNC:3356
Homologene: 38151
Rerg
Name: RAS-like, estrogen-regulated, growth-inhibitor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232441
Homologene: 50026
Sim2
Name: single-minded family bHLH transcription factor 2
Synonyms: bHLHe15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 20465
VEGA: 16
Homologene: 3716
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Vmn2r2
Name: vomeronasal 2, receptor 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 100125586
Homologene: 129753
Olfr1361
Name: olfactory receptor 1361
Synonyms: MOR256-12, GA_x6K02T2QHY8-11577590-11578528
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 258534
Homologene: 88362
Ofcc1
Name: orofacial cleft 1 candidate 1
Synonyms: ojoplano, Opo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218165
VEGA: 13
Homologene: 125376
Coro1b
Name: coronin, actin binding protein 1B
Synonyms: coronin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 23789
HGNC: HGNC:2253
Homologene: 40790
Spata7
Name: spermatogenesis associated 7
Synonyms: B230306G18Rik, HSD3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104871
Homologene: 10189
3425401B19Rik
Name: RIKEN cDNA 3425401B19 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 100504518
VEGA: 14
Homologene: 54908
Fndc7
Name: fibronectin type III domain containing 7
Synonyms: E230011A21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 320181
Homologene: 18551
Olfr525
Name: olfactory receptor 525
Synonyms: GA_x6K02T2PBJ9-42472898-42473827, MOR251-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258958
Homologene: 138321
Musk
Name: muscle, skeletal, receptor tyrosine kinase
Synonyms: Nsk3, Nsk2, Nsk1, MDK4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18198
HGNC: HGNC:7525
Homologene: 4084
Kcnab2
Name: potassium voltage-gated channel, shaker-related subfamily, beta member 2
Synonyms: Kcnb3, F5, I2rf5, I2rf5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 16498
HGNC: HGNC:6229
Homologene: 56492
Klhl17
Name: kelch-like 17
Synonyms: actinfilin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 231003
VEGA: 4
Homologene: 27075
Vwa1
Name: von Willebrand factor A domain containing 1
Synonyms: 4932416A11Rik, WARP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 246228
Homologene: 11270
Gm10923
Name: predicted gene 10923
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 100502582
Olfr1175
Name: olfactory receptor 1175
Synonyms: MOR174-15P, Olfr1175-ps, GA_x6K02T2Q125-49808415-49807477
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 546770
Homologene: 77381
Mydgf
Name: myeloid derived growth factor
Synonyms: D17Wsu104e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 28106
Homologene: 10425
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 57,998,134 bp
  • T to A, chromosome 2 at 40,647,234 bp
  • G to A, chromosome 2 at 41,789,046 bp
  • A to G, chromosome 2 at 88,323,648 bp
  • T to A, chromosome 2 at 119,442,592 bp
  • A to G, chromosome 3 at 64,117,157 bp
  • A to G, chromosome 3 at 96,190,755 bp
  • G to A, chromosome 3 at 108,862,818 bp
  • A to C, chromosome 4 at 58,366,899 bp
  • T to A, chromosome 4 at 135,559,104 bp
  • T to C, chromosome 4 at 152,401,940 bp
  • C to A, chromosome 4 at 155,770,600 bp
  • C to T, chromosome 4 at 156,233,887 bp
  • G to T, chromosome 5 at 25,314,395 bp
  • T to A, chromosome 6 at 86,424,323 bp
  • T to C, chromosome 6 at 87,630,064 bp
  • T to C, chromosome 6 at 137,056,144 bp
  • A to G, chromosome 7 at 126,152,943 bp
  • A to T, chromosome 7 at 140,323,514 bp
  • C to T, chromosome 9 at 27,051,775 bp
  • T to A, chromosome 9 at 86,520,056 bp
  • T to C, chromosome 9 at 107,968,672 bp
  • A to G, chromosome 10 at 24,648,085 bp
  • T to A, chromosome 11 at 76,734,566 bp
  • A to G, chromosome 11 at 77,425,320 bp
  • T to A, chromosome 11 at 93,923,148 bp
  • T to A, chromosome 11 at 98,386,651 bp
  • G to T, chromosome 12 at 71,164,546 bp
  • A to T, chromosome 12 at 71,164,547 bp
  • T to C, chromosome 12 at 98,648,453 bp
  • A to T, chromosome 13 at 21,658,624 bp
  • G to A, chromosome 13 at 40,015,388 bp
  • T to C, chromosome 14 at 32,663,288 bp
  • T to C, chromosome 15 at 85,117,104 bp
  • A to G, chromosome 16 at 38,585,199 bp
  • T to C, chromosome 16 at 94,109,335 bp
  • A to G, chromosome 17 at 17,578,911 bp
  • C to T, chromosome 17 at 56,176,953 bp
  • A to G, chromosome 18 at 34,607,436 bp
  • C to T, chromosome 19 at 4,150,710 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4919 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042521-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.