Strain Name:
C57BL/6J-MtgxR5010Btlr/Mmmh
Stock Number:
042601-MU
Citation ID:
RRID:MMRRC_042601-MU
Other Names:
R5010 (G1), C57BL/6J-MtgxR5010Btlr
Major Collection:

Gene Information

Ext1
Name: exostosin glycosyltransferase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 14042
HGNC: HGNC:3512
Homologene: 30957
Slc1a3
Name: solute carrier family 1 (glial high affinity glutamate transporter), member 3
Synonyms: Gmt1, Eaat1, B430115D02Rik, GLAST, MGluT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 20512
Homologene: 20882
Egr1
Name: early growth response 1
Synonyms: ETR103, NGFI-A, Egr-1, NGF1-A, Krox-24, Zfp-6, Krox24, Zenk, Zif268, A530045N19Rik, Krox-1, TIS8, NGFIA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13653
HGNC: HGNC:3238
Homologene: 56394
Lrrfip2
Name: leucine rich repeat (in FLII) interacting protein 2
Synonyms: 5133400F20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 71268
HGNC: HGNC:6703
Homologene: 22476
Vps13c
Name: vacuolar protein sorting 13C
Synonyms: C230055H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 320528
VEGA: 9
Homologene: 41188
Med13l
Name: mediator complex subunit 13-like
Synonyms: Trap240L, Thrap2, 6330591G05Rik, 2210413I17Rik, 9030618F05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 76199
Homologene: 25256
Rpap1
Name: RNA polymerase II associated protein 1
Synonyms: A730023M06Rik, 1190005L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68925
Homologene: 32269
Msh2
Name: mutS homolog 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 17685
HGNC: HGNC:7325
Homologene: 210
Dis3l2
Name: DIS3 like 3'-5' exoribonuclease 2
Synonyms: 8030493P09Rik, 4930429A22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 208718
Homologene: 62417
Iqgap2
Name: IQ motif containing GTPase activating protein 2
Synonyms: 4933417J23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 544963
VEGA: 13
HGNC: HGNC:6111
Homologene: 101543
Tanc2
Name: tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
Synonyms: 3526402J09Rik, 5730590C14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 77097
Homologene: 64680
Gja8
Name: gap junction protein, alpha 8
Synonyms: Aey5, connexin 50, Cx50, alpha 8 connexin, dcm, Lop10, Cnx50
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14616
HGNC: HGNC:4281
Homologene: 3857
Exosc8
Name: exosome component 8
Synonyms: 2310032N20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 69639
Homologene: 12323
Echdc2
Name: enoyl Coenzyme A hydratase domain containing 2
Synonyms: 1300017C12Rik, 2610009M20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 52430
Homologene: 23088
Klhl28
Name: kelch-like 28
Synonyms: Btbd5, 4122402F11Rik, 2810440N09Rik, 4931401E10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 66689
VEGA: 12
Homologene: 23036
Notch1
Name: notch 1
Synonyms: N1, lin-12, 9930111A19Rik, Tan1, Motch A, Mis6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18128
HGNC: HGNC:7881
Homologene: 32049
Nop2
Name: NOP2 nucleolar protein
Synonyms: 120kDa, Nol1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 110109
HGNC: HGNC:7867
Homologene: 135865
Drg1
Name: developmentally regulated GTP binding protein 1
Synonyms: Nedd3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 13494
HGNC: HGNC:3029
Homologene: 3060
Timm50
Name: translocase of inner mitochondrial membrane 50
Synonyms: TIM50L, 2810403L02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 66525
Homologene: 57031
Scpep1
Name: serine carboxypeptidase 1
Synonyms: 2410018F01Rik, Risc, 4833411K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 74617
Homologene: 41443
Qser1
Name: glutamine and serine rich 1
Synonyms: 4732486I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99003
Homologene: 11710
Zfp445
Name: zinc finger protein 445
Synonyms: ZNF168
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235682
VEGA: 9
Homologene: 27832
Taf4b
Name: TATA-box binding protein associated factor 4b
Synonyms: 105kDa, 4932409F03Rik, 2610524B04Rik, Taf2c2, TAFII105
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 72504
VEGA: 18
Homologene: 28266
Ddx11
Name: DEAD/H box helicase 11
Synonyms: KRG2, CHL1, CHLR1, essa15a, 4732462I11Rik, DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 320209
VEGA: 17
HGNC: HGNC:2736
Homologene: 68973
Slamf9
Name: SLAM family member 9
Synonyms: Cd2f10, CD84-H1, SF2001, CD2F-10, 2310026I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98365
Homologene: 12642
Mfsd14a
Name: major facilitator superfamily domain containing 14A
Synonyms: Hiat1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 15247
Homologene: 22456
Smad6
Name: SMAD family member 6
Synonyms: Madh6, Smad 6, b2b390Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 17130
HGNC: HGNC:6772
Homologene: 4079
Ttn
Name: titin
Synonyms: D830007G01Rik, connectin, 1100001C23Rik, 2310036G12Rik, mdm, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru, L56
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Hgsnat
Name: heparan-alpha-glucosaminide N-acetyltransferase
Synonyms: Tmem76, D8Ertd354e, 9430010M12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 52120
Homologene: 15586
Mccc1
Name: methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)
Synonyms: MCCalpha, 2310058B18Rik, 1810045E08Rik, MCCA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 72039
HGNC: HGNC:6936
Homologene: 10603
Rusc2
Name: RUN and SH3 domain containing 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100213
Homologene: 18967
Tbc1d20
Name: TBC1 domain family, member 20
Synonyms: bs, 2810442O16Rik, 1110028I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67231
Homologene: 32574
Vwf
Name: Von Willebrand factor
Synonyms: 6820430P06Rik, B130011O06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 22371
Homologene: 466
Skint5
Name: selection and upkeep of intraepithelial T cells 5
Synonyms: OTTMUSG00000008560
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242627
Homologene: 135888
Serpinb6d
Name: serine (or cysteine) peptidase inhibitor, clade B, member 6d
Synonyms: SPI3D, Gm11390
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238568
HGNC: HGNC:8950
Atg9a
Name: autophagy related 9A
Synonyms: Apg9l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 245860
Homologene: 34495
1810065E05Rik
Name: RIKEN cDNA 1810065E05 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69864
Homologene: 87042
Skint10
Name: selection and upkeep of intraepithelial T cells 10
Synonyms: A030001H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230613
Homologene: 136292
Myom2
Name: myomesin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17930
HGNC: HGNC:7614
Homologene: 2953
Gpr87
Name: G protein-coupled receptor 87
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 84111
HGNC: HGNC:4538
Homologene: 13021
Tas2r110
Name: taste receptor, type 2, member 110
Synonyms: T2R10, STC 9-1, Tas2r10, mt2r57
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 387344
Homologene: 130069
Mertk
Name: MER proto-oncogene tyrosine kinase
Synonyms: Eyk, nmf12, Tyro 12, Nyk, Mer
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17289
HGNC: HGNC:7027
Homologene: 4626
Serpinb11
Name: serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 11
Synonyms: 2310046M08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 66957
Homologene: 41653
Rxfp2
Name: relaxin/insulin-like family peptide receptor 2
Synonyms: Gpr106, LGR8, Great
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 140498
Homologene: 15402
Dctd
Name: dCMP deaminase
Synonyms: 6030466N05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 320685
HGNC: HGNC:2710
Homologene: 55618
Kcnb2
Name: potassium voltage gated channel, Shab-related subfamily, member 2
Synonyms: 9630047L19Rik, Kv2.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98741
HGNC: HGNC:6232
Homologene: 31263
Psg28
Name: pregnancy-specific glycoprotein 28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 114871
Homologene: 110989
Olfr292
Name: olfactory receptor 292
Synonyms: GA_x6K02T2NHDJ-9425121-9424195, MOR220-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258613
Homologene: 115526
Kcnk3
Name: potassium channel, subfamily K, member 3
Synonyms: Task-1, cTBAK-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 16527
HGNC: HGNC:6278
Homologene: 1692
Gm597
Name: predicted gene 597
Synonyms: LOC210962
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 210962
Psg18
Name: pregnancy specific glycoprotein 18
Synonyms: Cea3, mmCGM6, Cea-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 26438
Homologene: 110989
9430097D07Rik
Name: RIKEN cDNA 9430097D07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 319245
VEGA: 2
Fbxw22
Name: F-box and WD-40 domain protein 22
Synonyms: Gm5164
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 382156
Homologene: 110776
Jchain
Name: immunoglobulin joining chain
Synonyms: Igj, 9530090F24Rik, J chain, Jch
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 16069
HGNC: HGNC:5713
Homologene: 16958
Exosc3
Name: exosome component 3
Synonyms: 2310005D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66362
Homologene: 6867
Ang5
Name: angiogenin, ribonuclease A family, member 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 503844
Homologene: 134083
Actr5
Name: ARP5 actin-related protein 5
Synonyms: B430109J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 109275
Homologene: 6818
Snx31
Name: sorting nexin 31
Synonyms: 4631426E05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 66696
Homologene: 23551
Cracd
Name: capping protein inhibiting regulator of actin
Synonyms: C530008M17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 320827
Homologene: 136278
Nme5
Name: NME/NM23 family member 5
Synonyms: 1700019D05Rik, Nm23-M5, non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 75533
HGNC: HGNC:7853
Homologene: 2628
2310040G07Rik
Name: RIKEN cDNA 2310040G07 gene
Synonyms: Gm16528
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Prss23os
Name: protease, serine 23, opposite strand
Synonyms: 1700019G06Rik, 4930479H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 108167445
Gm21814
Name: predicted gene, 21814
Synonyms: 6620401J10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 436100
Gm21915
Name: predicted gene, 21915
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 15,312,962 bp
  • A to G, chromosome 1 at 28,777,862 bp
  • A to T, chromosome 1 at 75,186,060 bp
  • G to A, chromosome 1 at 86,760,321 bp
  • A to G, chromosome 1 at 107,379,649 bp
  • A to T, chromosome 1 at 172,476,213 bp
  • A to T, chromosome 2 at 26,476,114 bp
  • A to G, chromosome 2 at 32,574,428 bp
  • T to G, chromosome 2 at 76,900,511 bp
  • T to C, chromosome 2 at 104,787,831 bp
  • T to C, chromosome 2 at 119,770,041 bp
  • C to A, chromosome 2 at 128,784,000 bp
  • G to A, chromosome 2 at 152,293,936 bp
  • T to A, chromosome 2 at 158,635,363 bp
  • T to C, chromosome 3 at 35,979,017 bp
  • T to C, chromosome 3 at 54,729,223 bp
  • T to C, chromosome 3 at 59,178,958 bp
  • T to C, chromosome 3 at 96,919,849 bp
  • T to C, chromosome 3 at 116,636,427 bp
  • T to C, chromosome 4 at 43,415,926 bp
  • T to C, chromosome 4 at 45,317,702 bp
  • T to C, chromosome 4 at 108,172,131 bp
  • T to G, chromosome 4 at 112,727,672 bp
  • T to C, chromosome 4 at 113,546,537 bp
  • C to A, chromosome 5 at 30,622,805 bp
  • G to C, chromosome 5 at 76,657,834 bp
  • C to T, chromosome 5 at 76,928,678 bp
  • T to C, chromosome 5 at 88,522,505 bp
  • T to C, chromosome 5 at 118,593,550 bp
  • T to A, chromosome 5 at 150,067,360 bp
  • T to C, chromosome 6 at 125,133,763 bp
  • T to C, chromosome 6 at 125,566,257 bp
  • T to A, chromosome 6 at 132,868,475 bp
  • T to A, chromosome 6 at 149,583,618 bp
  • A to T, chromosome 7 at 18,349,354 bp
  • A to G, chromosome 7 at 18,427,891 bp
  • A to T, chromosome 7 at 28,306,859 bp
  • T to C, chromosome 7 at 86,694,585 bp
  • T to A, chromosome 7 at 89,510,214 bp
  • G to A, chromosome 8 at 15,083,310 bp
  • G to A, chromosome 8 at 25,947,960 bp
  • C to T, chromosome 8 at 48,137,414 bp
  • T to A, chromosome 9 at 40,670,648 bp
  • T to A, chromosome 9 at 63,953,900 bp
  • T to A, chromosome 9 at 67,916,379 bp
  • T to C, chromosome 9 at 109,403,424 bp
  • T to C, chromosome 9 at 111,223,972 bp
  • T to C, chromosome 9 at 122,852,345 bp
  • A to G, chromosome 10 at 93,065,118 bp
  • G to A, chromosome 11 at 3,252,249 bp
  • C to T, chromosome 11 at 58,422,804 bp
  • T to A, chromosome 11 at 88,941,349 bp
  • T to C, chromosome 11 at 105,780,092 bp
  • C to T, chromosome 12 at 64,957,227 bp
  • T to A, chromosome 13 at 33,671,444 bp
  • A to G, chromosome 13 at 95,673,743 bp
  • A to G, chromosome 14 at 43,962,845 bp
  • T to C, chromosome 15 at 8,650,846 bp
  • A to T, chromosome 15 at 36,555,324 bp
  • T to A, chromosome 15 at 53,092,412 bp
  • G to A, chromosome 17 at 66,147,722 bp
  • C to A, chromosome 17 at 87,723,413 bp
  • A to G, chromosome 18 at 14,822,172 bp
  • A to C, chromosome 18 at 34,578,685 bp
  • A to G, chromosome 18 at 34,863,658 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5010 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042601-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.