Strain Name:
C57BL/6J-MtgxR5202Btlr/Mmmh
Stock Number:
042777-MU
Citation ID:
RRID:MMRRC_042777-MU
Other Names:
R5202 (G1), C57BL/6J-MtgxR5202Btlr
Major Collection:

Gene Information

Dicer1
Name: dicer 1, ribonuclease type III
Synonyms: Dicer1, D12Ertd7e, 1110006F08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 192119
VEGA: 12
Homologene: 13251
Otx1
Name: orthodenticle homeobox 1
Synonyms: A730044F23Rik, jv
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18423
HGNC: HGNC:8521
Homologene: 7875
Limch1
Name: LIM and calponin homology domains 1
Synonyms: 3732412D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 77569
Homologene: 18953
Frem2
Name: Fras1 related extracellular matrix protein 2
Synonyms: 6030440P17Rik, b2b1562Clo, ne, 8430406N05Rik, my
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242022
Homologene: 18454
Mbd4
Name: methyl-CpG binding domain protein 4
Synonyms: Med1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17193
HGNC: HGNC:6919
Homologene: 2916
Gria4
Name: glutamate receptor, ionotropic, AMPA4 (alpha 4)
Synonyms: Glur-4, Gluralpha4, spkw1, Glur4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 14802
HGNC: HGNC:4574
Homologene: 20227
Rab30
Name: RAB30, member RAS oncogene family
Synonyms: 5033421K01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 75985
HGNC: HGNC:9770
Homologene: 22815
E2f3
Name: E2F transcription factor 3
Synonyms: E2f3a, E2F3b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 13557
HGNC: HGNC:3115
Homologene: 74413
Etaa1
Name: Ewing tumor-associated antigen 1
Synonyms: 5730466H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 68145
Homologene: 10369
Tnks2
Name: tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
Synonyms: 5430432P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 74493
Homologene: 11890
Setd2
Name: SET domain containing 2
Synonyms: 4921524K10Rik, KMT3A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235626
Homologene: 56493
Daam1
Name: dishevelled associated activator of morphogenesis 1
Synonyms: 2310028E21Rik, 1700066F09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 208846
VEGA: 12
Homologene: 36635
Gbf1
Name: golgi-specific brefeldin A-resistance factor 1
Synonyms: 1700083E03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 107338
HGNC: HGNC:4181
Homologene: 37897
Cip2a
Name: cell proliferation regulating inhibitor of protein phosphatase 2A
Synonyms: C330027C09Rik, Cip2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224171
Homologene: 10842
Ttll4
Name: tubulin tyrosine ligase-like family, member 4
Synonyms: 4632407P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67534
Homologene: 8764
Fzd10
Name: frizzled class receptor 10
Synonyms: Fz-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 93897
HGNC: HGNC:4039
Homologene: 21411
Apob
Name: apolipoprotein B
Synonyms: apob-100, apob-48
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Nbeal2
Name: neurobeachin-like 2
Synonyms: 1110014F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235627
Homologene: 86422
Itgb1
Name: integrin beta 1 (fibronectin receptor beta)
Synonyms: Gm9863, Fnrb, 4633401G24Rik, beta1 integrin, CD29
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 16412
HGNC: HGNC:6153
Homologene: 22999
Sorl1
Name: sortilin-related receptor, LDLR class A repeats-containing
Synonyms: Sorla, 2900010L19Rik, mSorLA, LR11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20660
Homologene: 2336
Sptbn2
Name: spectrin beta, non-erythrocytic 2
Synonyms: Spnb3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 20743
VEGA: 19
Homologene: 48482
Dbr1
Name: debranching RNA lariats 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 83703
Homologene: 9428
Chst9
Name: carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
Synonyms: 5430438D01Rik, GalNAc4ST-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 71367
Homologene: 12861
Cyp4f18
Name: cytochrome P450, family 4, subfamily f, polypeptide 18
Synonyms: 1810054N16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 72054
HGNC: HGNC:2646
Homologene: 128623
Foxp2
Name: forkhead box P2
Synonyms: 2810043D05Rik, D0Kist7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 114142
Homologene: 134404
Dmpk
Name: dystrophia myotonica-protein kinase
Synonyms: Dm15, DM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13400
HGNC: HGNC:2933
Homologene: 3247
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: FPC, tigmin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Cyp4a10
Name: cytochrome P450, family 4, subfamily a, polypeptide 10
Synonyms: RP1, D4Rp1, Cyp4a, Msp-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 13117
Homologene: 128044
Sema4f
Name: sema domain, immunoglobulin domain (Ig), TM domain, and short cytoplasmic domain
Synonyms: Sema W
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20355
Homologene: 3147
Tie1
Name: tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Synonyms: TIE, tie-1, D430008P04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 21846
Homologene: 3957
Tdrd12
Name: tudor domain containing 12
Synonyms: 2410070K17Rik, G1-476-14, ecat8, repro23, EG434165, 2410004F06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71981
Homologene: 87053
Cntln
Name: centlein, centrosomal protein
Synonyms: B430108F07Rik, D530005L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 338349
Homologene: 9805
Bfsp1
Name: beaded filament structural protein 1, in lens-CP94
Synonyms: filensin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12075
HGNC: HGNC:1040
Homologene: 922
Nrap
Name: nebulin-related anchoring protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18175
HGNC: HGNC:7988
Homologene: 4499
Csf2rb
Name: colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
Synonyms: common beta chain, Il5rb, Il3rb1, Il3r, AIC2B, beta c, Bc, Csf2rb1, CDw131
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12983
VEGA: 15
HGNC: HGNC:2436
Homologene: 339
Arhgap15
Name: Rho GTPase activating protein 15
Synonyms: 5830480G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76117
Homologene: 41271
Slc48a1
Name: solute carrier family 48 (heme transporter), member 1
Synonyms: 4930570C03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 67739
Homologene: 12184
Gm5581
Name: predicted gene 5581
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 108169183
Nudt14
Name: nudix (nucleoside diphosphate linked moiety X)-type motif 14
Synonyms: 1110030M18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 66174
VEGA: 12
Homologene: 11930
Hspa4l
Name: heat shock protein 4 like
Synonyms: APG-1, 94kDa, Osp94
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18415
Homologene: 22610
Alcam
Name: activated leukocyte cell adhesion molecule
Synonyms: CD166, DM-GRASP, SC1, MuSC, BEN
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 11658
HGNC: HGNC:400
Homologene: 1229
Or14c45
Name: olfactory receptor family 14 subfamily C member 45
Synonyms: GA_x6K02T2NHDJ-9587747-9586815, MOR220-3, Olfr297
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258611
Homologene: 115526
Pcgf5
Name: polycomb group ring finger 5
Synonyms: 5830406C17Rik, 5830443C21Rik, 0610009F02Rik, 9530023M17Rik, 1110054A01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 76073
VEGA: 19
Homologene: 12632
4932414N04Rik
Name: RIKEN cDNA 4932414N04 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 75721
Homologene: 138468
Tmem150c
Name: transmembrane protein 150C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231503
Homologene: 18818
Or2ag2
Name: olfactory receptor family 2 subfamily AG member 2
Synonyms: MOR283-11, Olfr706, GA_x6K02T2PBJ9-9271198-9270248
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258350
Homologene: 133646
Spata1
Name: spermatogenesis associated 1
Synonyms: 4921536I21Rik, SP-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 70951
Homologene: 23356
Nfatc4
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4
Synonyms: 3110041H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 73181
VEGA: 14
HGNC: HGNC:7778
Homologene: 3349
Or7e165
Name: olfactory receptor family 7 subfamily E member 165
Synonyms: Olfr58, MOR146-3, MOR146-7P, GA_x6K02T2PVTD-13523015-13523944, IG6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 18358
Homologene: 134093
Tekt2
Name: tektin 2
Synonyms: tektin-t
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 24084
Homologene: 8043
Bbs2
Name: Bardet-Biedl syndrome 2 (human)
Synonyms: 2410125H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 67378
HGNC: HGNC:967
Homologene: 12122
Paqr9
Name: progestin and adipoQ receptor family member IX
Synonyms: C730029A08Rik, 1700020G04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 75552
Homologene: 18882
Zfp783
Name: zinc finger protein 783
Synonyms: ENSMUSG00000072653, Gm20494, A230106D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232785
Kcnk12
Name: potassium channel, subfamily K, member 12
Synonyms: mntk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 210741
VEGA: 17
HGNC: HGNC:6274
Homologene: 11107
Dhrs7c
Name: dehydrogenase/reductase (SDR family) member 7C
Synonyms: 1110001P11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 68460
Homologene: 19108
Gm17472
Name: predicted gene, 17472
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Igkv4-68
Name: immunoglobulin kappa variable 4-68
Synonyms: LOC232058, LOC384515
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 384515
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 20,547,341 bp
  • G to A, chromosome 1 at 74,687,852 bp
  • A to T, chromosome 2 at 44,063,857 bp
  • A to T, chromosome 2 at 68,731,964 bp
  • T to C, chromosome 2 at 143,826,971 bp
  • T to A, chromosome 3 at 40,781,569 bp
  • A to G, chromosome 3 at 53,551,346 bp
  • T to C, chromosome 3 at 146,493,736 bp
  • A to C, chromosome 4 at 84,971,229 bp
  • T to A, chromosome 4 at 115,532,615 bp
  • C to T, chromosome 4 at 118,480,510 bp
  • T to C, chromosome 4 at 126,324,670 bp
  • C to G, chromosome 5 at 66,993,173 bp
  • G to T, chromosome 5 at 100,079,954 bp
  • T to C, chromosome 5 at 128,602,116 bp
  • A to T, chromosome 6 at 15,394,771 bp
  • T to A, chromosome 6 at 42,981,134 bp
  • A to G, chromosome 6 at 47,951,742 bp
  • G to A, chromosome 6 at 69,304,942 bp
  • A to T, chromosome 6 at 82,917,578 bp
  • A to T, chromosome 6 at 115,849,402 bp
  • G to T, chromosome 6 at 131,166,528 bp
  • C to G, chromosome 7 at 19,088,019 bp
  • A to G, chromosome 7 at 35,490,030 bp
  • C to A, chromosome 7 at 86,527,116 bp
  • T to C, chromosome 7 at 92,835,913 bp
  • T to A, chromosome 7 at 106,886,596 bp
  • C to A, chromosome 8 at 72,009,096 bp
  • G to T, chromosome 8 at 94,092,414 bp
  • A to T, chromosome 8 at 128,720,010 bp
  • T to C, chromosome 9 at 4,424,330 bp
  • T to A, chromosome 9 at 19,783,218 bp
  • A to G, chromosome 9 at 42,033,583 bp
  • A to G, chromosome 9 at 95,560,110 bp
  • T to G, chromosome 9 at 99,583,891 bp
  • A to T, chromosome 9 at 110,551,230 bp
  • T to C, chromosome 9 at 110,644,666 bp
  • A to T, chromosome 11 at 17,947,853 bp
  • C to A, chromosome 11 at 21,997,037 bp
  • A to G, chromosome 11 at 67,815,801 bp
  • A to G, chromosome 12 at 8,013,737 bp
  • G to T, chromosome 12 at 71,944,274 bp
  • A to T, chromosome 12 at 104,694,731 bp
  • A to G, chromosome 12 at 112,935,028 bp
  • G to A, chromosome 13 at 29,918,636 bp
  • A to G, chromosome 14 at 55,826,659 bp
  • T to G, chromosome 15 at 78,349,057 bp
  • A to T, chromosome 15 at 97,790,700 bp
  • A to G, chromosome 16 at 49,010,777 bp
  • T to C, chromosome 16 at 52,274,236 bp
  • T to A, chromosome 17 at 87,746,605 bp
  • A to T, chromosome 18 at 15,453,239 bp
  • G to T, chromosome 19 at 4,724,184 bp
  • T to A, chromosome 19 at 36,437,183 bp
  • G to A, chromosome 19 at 36,888,852 bp
  • A to T, chromosome 19 at 46,268,454 bp
  • G to A, chromosome 19 at 56,335,151 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5202 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042777-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.