Strain Name:
C57BL/6J-MtgxR5244Btlr/Mmmh
Stock Number:
042815-MU
Citation ID:
RRID:MMRRC_042815-MU
Other Names:
R5244 (G1), C57BL/6J-MtgxR5244Btlr
Major Collection:

Strain Information

Zic4
Name: zinc finger protein of the cerebellum 4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22774
Homologene: 32075
Rprd2
Name: regulation of nuclear pre-mRNA domain containing 2
Synonyms: 6720469I21Rik, 2810036A19Rik, 4930535B03Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 75137
Homologene: 19997
Cops4
Name: COP9 signalosome subunit 4
Synonyms: COP9 complex S4, D5Ertd774e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 26891
Homologene: 8067
Srsf11
Name: serine and arginine-rich splicing factor 11
Synonyms: 0610009J05Rik, 2610019N13Rik, Sfrs11
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69207
Homologene: 36164
Slc29a1
Name: solute carrier family 29 (nucleoside transporters), member 1
Synonyms: ENT1, NBMPR-sensitive equilibrative nucleoside transporter, 1200014D21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 63959
Homologene: 37985
Pck1
Name: phosphoenolpyruvate carboxykinase 1, cytosolic
Synonyms: Pck-1, PEPCK
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18534
HGNC: HGNC:8724
Homologene: 1944
Cyfip1
Name: cytoplasmic FMR1 interacting protein 1
Synonyms: P140SRA-1, Shyc, pl-1, l(7)1Rl, Sra-1, E030028J09Rik, l7Rl1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20430
Homologene: 22628
Exoc4
Name: exocyst complex component 4
Synonyms: Sec8, Sec8l1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20336
Homologene: 40654
Kpna6
Name: karyopherin subunit alpha 6
Synonyms: IPOA7, NPI-2, importin alpha 7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16650
HGNC: HGNC:6399
Homologene: 22472
Phc1
Name: polyhomeotic 1
Synonyms: Rae-28, Mph1, rae28, Edr1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13619
HGNC: HGNC:3182
Homologene: 107079
Ttll4
Name: tubulin tyrosine ligase-like family, member 4
Synonyms: 4632407P03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67534
Homologene: 8764
Pirb
Name: paired Ig-like receptor B
Synonyms: Gp91, Lilrb3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18733
Homologene: 134028
Polr2b
Name: polymerase (RNA) II (DNA directed) polypeptide B
Synonyms: RPB2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231329
HGNC: HGNC:9188
Homologene: 722
Zfp219
Name: zinc finger protein 219
Synonyms: 2010302A17Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 69890
VEGA: 14
Homologene: 9504
Cul4a
Name: cullin 4A
Synonyms: 2810470J21Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 99375
HGNC: HGNC:2554
Homologene: 81724
Ttc7b
Name: tetratricopeptide repeat domain 7B
Synonyms: Ttc7l1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104718
VEGA: 12
Homologene: 14675
Trim37
Name: tripartite motif-containing 37
Synonyms: MUL, TEF3, 2810004E07Rik, 1110032A10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68729
HGNC: HGNC:7523
Homologene: 9084
Trhde
Name: TRH-degrading enzyme
Synonyms: 9330155P21Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237553
Homologene: 75007
Pthlh
Name: parathyroid hormone-like peptide
Synonyms: Pthrp, parathyroid hormone-like hormone, PTH-like, PTH-related peptide, parathyroid hormone-related peptide, parathyroid hormone-related protein
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19227
HGNC: HGNC:9607
Homologene: 2113
Abca13
Name: ATP-binding cassette, sub-family A member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268379
Homologene: 27991
Capn11
Name: calpain 11
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268958
HGNC: HGNC:1478
Homologene: 21392
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: hy-3, hy3, 1700034M11Rik, 4930545D19Rik, hyrh
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244653
Homologene: 52118
Adamtsl3
Name: ADAMTS-like 3
Synonyms: punctin-2, 9230119C12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269959
Homologene: 18912
Yif1b
Name: Yip1 interacting factor homolog B (S. cerevisiae)
Synonyms: 9430029K10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77254
Homologene: 60114
Ptprq
Name: protein tyrosine phosphatase receptor type Q
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237523
HGNC: HGNC:9679
Homologene: 83557
Naip5
Name: NLR family, apoptosis inhibitory protein 5
Synonyms: Naip-rs3, Birc1e, Lgn1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17951
HGNC: HGNC:7634
Homologene: 113589
Mbd3l1
Name: methyl-CpG binding domain protein 3-like 1
Synonyms: 1700070G05Rik, Mbd3l, 1700095H13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73503
VEGA: 9
Homologene: 12502
Unc13c
Name: unc-13 homolog C
Synonyms: Munc13-3, Unc13h3, D9Ertd414e, 1500037O19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208898
Homologene: 45443
Slc27a2
Name: solute carrier family 27 (fatty acid transporter), member 2
Synonyms: FATP2, VLCS, Vlacs, Vlac, ACSVL1, FATP2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26458
Homologene: 37830
Or6d13
Name: olfactory receptor family 6 subfamily D member 13
Synonyms: GA_x54KRFPKN04-58174409-58175392, MOR119-3, Olfr213
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 258020
Homologene: 74186
Ifi207
Name: interferon activated gene 207
Synonyms: AI607873, Pyhin-A
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226691
HGNC: HGNC:5395
Homologene: 115929
Or8u10
Name: olfactory receptor family 8 subfamily U member 10
Synonyms: GA_x6K02T2Q125-47560740-47559775, MOR256-34P, MOR171-52, Olfr1037
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259151
Homologene: 66572
Or4k39
Name: olfactory receptor family 4 subfamily K member 39, pseudogene 1
Synonyms: GA_x6K02T2Q125-72459956-72460837, MOR248-17P, MOR248-25_p, Olfr1285
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 545447
Slc4a10
Name: solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
Synonyms: NCBE
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94229
Homologene: 23340
Mfsd6l
Name: major facilitator superfamily domain containing 6-like
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 215723
Homologene: 17128
Stk19
Name: serine/threonine kinase 19
Synonyms: G11, RP1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 54402
Homologene: 10449
Hhipl1
Name: hedgehog interacting protein-like 1
Synonyms: 1600002O04Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 214305
VEGA: 12
Homologene: 81985
Bbof1
Name: basal body orientation factor 1
Synonyms: 2900006K08Rik, Ccdc176
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 72873
Homologene: 75215
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: LOC227058, Dnahc7b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227058
Homologene: 41287
Pnma8a
Name: PNMA family member 8A
Synonyms: 0710005I19Rik, 4930488B01Rik, Pnmal1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71691
Homologene: 10073
Lnpk
Name: lunapark, ER junction formation factor
Synonyms: 2310011O18Rik, 4921514L11Rik, 9530051D01Rik, lunapark, Lnpk1, Lnp
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69605
Homologene: 12319
Or2j6
Name: olfactory receptor family 2 subfamily J member 6
Synonyms: GA_x6K02T2PBJ9-42551260-42550346, MOR251-3, Olfr531
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258955
Or8g20
Name: olfactory receptor family 8 subfamily G member 20
Synonyms: IB3, MOR171-5, GA_x6K02T2PVTD-33181773-33180838, Olfr44
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18343
VEGA: 9
HGNC: HGNC:8484
Homologene: 133633
Plag1
Name: pleiomorphic adenoma gene 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56711
HGNC: HGNC:9045
Homologene: 1993
Kcnh1
Name: potassium voltage-gated channel, subfamily H (eag-related), member 1
Synonyms: ether a go-go, Eag1, Kv10.1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16510
HGNC: HGNC:6250
Homologene: 68242
Or2ag1b
Name: olfactory receptor family 2 subfamily AG member 1B
Synonyms: GA_x6K02T2PBJ9-9067220-9066273, MOR283-9, Olfr694
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258444
Homologene: 79345
4930550C14Rik
Name: RIKEN cDNA 4930550C14 gene
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75311
VEGA: 9
Homologene: 12595
Cbs
Name: cystathionine beta-synthase
Synonyms: HIP4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12411
HGNC: HGNC:1550
Homologene: 37258
Wnt10a
Name: wingless-type MMTV integration site family, member 10A
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22409
Homologene: 22525
Fam13a
Name: family with sequence similarity 13, member A
Synonyms: D430015B01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58909
Homologene: 135847
Ugt2b36
Name: UDP glucuronosyltransferase 2 family, polypeptide B36
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231396
Homologene: 128251
Vmn2r101
Name: vomeronasal 2, receptor 101
Synonyms: EG627576
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627576
Homologene: 115024
Plscr2
Name: phospholipid scramblase 2
Synonyms: PL scramblase
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18828
Homologene: 134152
Chil6
Name: chitinase-like 6
Synonyms: BYm, BC051070
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229688
Homologene: 77638
Slc36a4
Name: solute carrier family 36 (proton/amino acid symporter), member 4
Synonyms: PAT4, 6330573I15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 234967
Homologene: 56300
Zfp82
Name: zinc finger protein 82
Synonyms: KRAB16
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330502
Homologene: 51177
Ehd3
Name: EH-domain containing 3
Synonyms: Ehd2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 57440
HGNC: HGNC:3244
Homologene: 81837
Spa17
Name: sperm autoantigenic protein 17
Synonyms: band 34, Sp17
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20686
VEGA: 9
Homologene: 7951
Pfkfb3
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Synonyms: E330010H22Rik, uPFK-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 170768
HGNC: HGNC:8874
Homologene: 88708
Gulp1
Name: GULP, engulfment adaptor PTB domain containing 1
Synonyms: 5730529O06Rik, GULP, Ced6, 3110030A04Rik, CED-6
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70676
Homologene: 9467
Or7g22
Name: olfactory receptor family 7 subfamily G member 22
Synonyms: GA_x6K02T2PVTD-12873838-12874776, MOR152-2, Olfr837
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258558
HGNC: HGNC:8466
Homologene: 115507
Vmn1r221
Name: vomeronasal 1 receptor 221
Synonyms: Gm11329
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 100312485
Homologene: 110880
Ighv9-4
Name: immunoglobulin heavy variable 9-4
Synonyms: Gm7175
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 636260
Nlrp5-ps
Name: NLR family, pyrin domain containing 5, pseudogene
Synonyms: Gm18756
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100417675
Gm5117
Name: predicted gene 5117
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 330731
Lsm7
Name: LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
Synonyms: 0910001B06Rik, 1110033F18Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66094
VEGA: 10
Homologene: 6781
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 44,788,453 bp
  • T to C, chromosome 1 at 46,233,858 bp
  • T to C, chromosome 1 at 74,696,448 bp
  • T to C, chromosome 1 at 74,803,295 bp
  • C to T, chromosome 1 at 173,729,937 bp
  • A to T, chromosome 1 at 192,224,876 bp
  • T to A, chromosome 2 at 11,484,849 bp
  • T to A, chromosome 2 at 62,288,725 bp
  • C to T, chromosome 2 at 74,531,888 bp
  • C to G, chromosome 2 at 86,084,956 bp
  • T to A, chromosome 2 at 111,408,554 bp
  • T to C, chromosome 2 at 126,578,855 bp
  • T to A, chromosome 2 at 173,154,863 bp
  • T to A, chromosome 3 at 95,790,182 bp
  • A to G, chromosome 3 at 106,389,974 bp
  • C to T, chromosome 3 at 158,023,344 bp
  • A to T, chromosome 4 at 3,903,887 bp
  • A to G, chromosome 4 at 129,655,428 bp
  • A to G, chromosome 5 at 77,343,000 bp
  • T to C, chromosome 5 at 87,091,906 bp
  • C to A, chromosome 5 at 100,533,375 bp
  • T to C, chromosome 6 at 33,332,275 bp
  • G to T, chromosome 6 at 58,953,474 bp
  • T to A, chromosome 6 at 116,541,226 bp
  • A to G, chromosome 6 at 122,321,979 bp
  • T to C, chromosome 6 at 147,257,153 bp
  • G to A, chromosome 7 at 3,716,063 bp
  • G to A, chromosome 7 at 14,580,975 bp
  • A to G, chromosome 7 at 16,961,323 bp
  • G to A, chromosome 7 at 29,244,441 bp
  • A to G, chromosome 7 at 30,056,872 bp
  • C to T, chromosome 7 at 55,925,199 bp
  • C to T, chromosome 7 at 82,598,069 bp
  • T to A, chromosome 7 at 106,689,189 bp
  • A to T, chromosome 7 at 140,400,138 bp
  • T to C, chromosome 8 at 13,146,566 bp
  • A to G, chromosome 8 at 31,738,277 bp
  • A to T, chromosome 8 at 110,532,819 bp
  • A to T, chromosome 9 at 15,734,278 bp
  • T to A, chromosome 9 at 18,484,637 bp
  • A to T, chromosome 9 at 19,137,851 bp
  • T to A, chromosome 9 at 37,611,989 bp
  • T to G, chromosome 9 at 39,484,512 bp
  • G to T, chromosome 9 at 53,411,798 bp
  • C to T, chromosome 9 at 73,525,951 bp
  • T to C, chromosome 9 at 91,384,057 bp
  • C to G, chromosome 9 at 92,291,049 bp
  • T to C, chromosome 10 at 80,853,073 bp
  • A to G, chromosome 10 at 107,586,695 bp
  • T to C, chromosome 10 at 114,801,081 bp
  • C to T, chromosome 11 at 9,275,081 bp
  • T to A, chromosome 11 at 68,557,175 bp
  • C to T, chromosome 11 at 87,218,257 bp
  • A to C, chromosome 12 at 84,430,073 bp
  • A to G, chromosome 12 at 100,348,010 bp
  • T to A, chromosome 12 at 108,312,134 bp
  • T to C, chromosome 12 at 114,300,251 bp
  • T to C, chromosome 13 at 23,217,638 bp
  • C to T, chromosome 13 at 100,245,662 bp
  • C to A, chromosome 14 at 52,008,542 bp
  • T to C, chromosome 17 at 19,611,526 bp
  • C to T, chromosome 17 at 31,617,160 bp
  • A to G, chromosome 17 at 34,832,070 bp
  • T to C, chromosome 17 at 45,588,413 bp
  • T to C, chromosome 17 at 45,633,892 bp
  • A to T, chromosome 17 at 73,830,000 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5244 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042815-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.