Strain Name:
C57BL/6J-MtgxR5380Btlr/Mmmh
Stock Number:
042955-MU
Citation ID:
RRID:MMRRC_042955-MU
Other Names:
R5380 (G1), C57BL/6J-MtgxR5380Btlr
Major Collection:

Gene Information

Prkar2a
Name: protein kinase, cAMP dependent regulatory, type II alpha
Synonyms: RII(alpha), 1110061A24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 19087
HGNC: HGNC:9391
Homologene: 3064
Gga3
Name: golgi associated, gamma adaptin ear containing, ARF binding protein 3
Synonyms: C230037M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 260302
Homologene: 121703
Tnrc6b
Name: trinucleotide repeat containing 6b
Synonyms: A730065C02Rik, D230019K20Rik, 2700090M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 213988
VEGA: 15
Homologene: 66194
Otx1
Name: orthodenticle homeobox 1
Synonyms: A730044F23Rik, jv
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18423
HGNC: HGNC:8521
Homologene: 7875
Dop1b
Name: DOP1 leucine zipper like protein B
Synonyms: 0610038M01Rik, 2610510B01Rik, Dopey2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 70028
VEGA: 16
HGNC: HGNC:1291
Homologene: 21068
Prpf6
Name: pre-mRNA splicing factor 6
Synonyms: 1190003A07Rik, U5-102K, ANT-1, 2610031L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68879
Homologene: 5368
Lims1
Name: LIM and senescent cell antigen-like domains 1
Synonyms: 2310016J22Rik, 4921524A02Rik, Lims1l, PINCH1, C430041B13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 110829
HGNC: HGNC:6616
Homologene: 68428
Rabif
Name: RAB interacting factor
Synonyms: RASGFR3, MSS4, E130318E12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98710
HGNC: HGNC:9797
Homologene: 37702
Atr
Name: ataxia telangiectasia and Rad3 related
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 245000
HGNC: HGNC:882
Homologene: 96916
R3hdm2
Name: R3H domain containing 2
Synonyms: 1300003K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71750
Homologene: 8954
Zfp281
Name: zinc finger protein 281
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226442
Homologene: 8270
Aco1
Name: aconitase 1
Synonyms: Irp1, Irebp, Aco-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11428
HGNC: HGNC:117
Homologene: 1657
Tsg101
Name: tumor susceptibility gene 101
Synonyms: CC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22088
Homologene: 4584
Ms4a6b
Name: membrane-spanning 4-domains, subfamily A, member 6B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 69774
Homologene: 128306
Pfkl
Name: phosphofructokinase, liver, B-type
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18641
HGNC: HGNC:8876
Homologene: 55668
Tomm40
Name: translocase of outer mitochondrial membrane 40
Synonyms: Tom40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 53333
Homologene: 101105
Foxo1
Name: forkhead box O1
Synonyms: FKHR, Fkhr1, Afxh, Foxo1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56458
HGNC: HGNC:3819
Homologene: 1527
Cmip
Name: c-Maf inducing protein
Synonyms: 5830471E12Rik, 4933407C03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74440
Homologene: 18869
Ssh2
Name: slingshot protein phosphatase 2
Synonyms: SSH-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237860
Homologene: 14116
Fgfr4
Name: fibroblast growth factor receptor 4
Synonyms: Fgfr-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 14186
HGNC: HGNC:3691
Homologene: 20461
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: A730004I20Rik, Dnahc6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Enpep
Name: glutamyl aminopeptidase
Synonyms: Bp-1/6C3, APA, Ly51, Ly-51, 6030431M22Rik, aminopeptidase-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 13809
HGNC: HGNC:3355
Homologene: 68216
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 329628
Homologene: 14377
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241516
Homologene: 110349
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22635
Homologene: 124417
Dgkb
Name: diacylglycerol kinase, beta
Synonyms: DGK-beta, C630029D13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217480
VEGA: 12
HGNC: HGNC:2850
Homologene: 37875
Ror2
Name: receptor tyrosine kinase-like orphan receptor 2
Synonyms: Ntrkr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 26564
Homologene: 55831
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: LOC227058, Dnahc7b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227058
Homologene: 41287
Dusp18
Name: dual specificity phosphatase 18
Synonyms: LMWDSP20, DUSP20, 4930527G07Rik, DSP18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 75219
Homologene: 34984
Igfn1
Name: immunoglobulin-like and fibronectin type III domain containing 1
Synonyms: 9830123M21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226438
Homologene: 130054
Cyba
Name: cytochrome b-245, alpha polypeptide
Synonyms: b558, cytochrome beta-558, p22 phox
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 13057
HGNC: HGNC:2577
Homologene: 80
Notum
Name: notum palmitoleoyl-protein carboxylesterase
Synonyms: 5730593N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 77583
Homologene: 45335
Zdhhc1
Name: zinc finger, DHHC domain containing 1
Synonyms: 4432412D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 70796
Homologene: 36891
Msl3l2
Name: MSL3 like 2
Synonyms: 1700060H10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 73390
VEGA: 10
Homologene: 128448
V1ra8
Name: vomeronasal 1 receptor, A8
Synonyms: Vmn1r-ps33
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 113850
Tspo2
Name: translocator protein 2
Synonyms: 2510027D20Rik, Bzrpl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 70026
Homologene: 12344
Pkd2l1
Name: polycystic kidney disease 2-like 1
Synonyms: polycystin-L, Pkdl, PCL, TRPP3, PKD2L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 329064
HGNC: HGNC:9011
Homologene: 22946
1700012P22Rik
Name: RIKEN cDNA 1700012P22 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69364
Homologene: 17541
Rab27b
Name: RAB27B, member RAS oncogene family
Synonyms: 2310021G14Rik, B130064M09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 80718
HGNC: HGNC:9767
Homologene: 20879
Spata21
Name: spermatogenesis associated 21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329972
Homologene: 18639
Gm11077
Name: predicted gene 11077
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Haus4
Name: HAUS augmin-like complex, subunit 4
Synonyms: 9430093H08Rik, D14Ertd500e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219072
VEGA: 14
Homologene: 9854
Gemin6-ps
Name: gem nuclear organelle associated protein 6, pseudogene
Synonyms: Gm6253
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 621705
Homologene: 11711
Igkv4-80
Name: immunoglobulin kappa variable 4-80
Synonyms: Gm16729
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 545848
Mir6930
Name: microRNA 6930
Synonyms: mmu-mir-6930
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 102465561
VEGA: 11
4930512B01Rik
Name: RIKEN cDNA 4930512B01 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 74724
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 46,217,191 bp
  • A to G, chromosome 1 at 134,506,242 bp
  • G to A, chromosome 1 at 135,966,087 bp
  • A to G, chromosome 1 at 136,625,938 bp
  • T to C, chromosome 2 at 82,975,398 bp
  • T to A, chromosome 2 at 181,608,266 bp
  • T to A, chromosome 3 at 38,888,864 bp
  • T to A, chromosome 3 at 52,269,025 bp
  • A to G, chromosome 3 at 129,305,446 bp
  • A to T, chromosome 4 at 40,177,848 bp
  • A to G, chromosome 4 at 141,107,185 bp
  • A to T, chromosome 4 at 144,423,802 bp
  • T to C, chromosome 5 at 137,457,840 bp
  • A to C, chromosome 6 at 69,016,665 bp
  • T to C, chromosome 6 at 73,037,615 bp
  • T to A, chromosome 6 at 90,203,022 bp
  • A to G, chromosome 6 at 117,809,009 bp
  • A to T, chromosome 6 at 140,729,322 bp
  • A to G, chromosome 7 at 19,701,750 bp
  • A to T, chromosome 7 at 46,891,120 bp
  • CGGGGG to CGGGGGG, chromosome 8 at 105,483,744 bp
  • T to A, chromosome 8 at 117,422,890 bp
  • G to T, chromosome 8 at 122,426,979 bp
  • T to C, chromosome 9 at 95,857,656 bp
  • T to C, chromosome 9 at 108,740,685 bp
  • A to G, chromosome 10 at 56,115,572 bp
  • A to T, chromosome 10 at 58,416,670 bp
  • T to G, chromosome 10 at 77,997,589 bp
  • T to C, chromosome 10 at 127,485,447 bp
  • C to A, chromosome 11 at 3,897,037 bp
  • C to A, chromosome 11 at 21,997,037 bp
  • A to G, chromosome 11 at 77,453,945 bp
  • A to G, chromosome 11 at 102,404,975 bp
  • G to T, chromosome 11 at 115,588,431 bp
  • G to T, chromosome 11 at 120,656,715 bp
  • C to T, chromosome 12 at 38,127,300 bp
  • C to T, chromosome 12 at 69,792,299 bp
  • T to C, chromosome 13 at 53,117,149 bp
  • T to A, chromosome 13 at 55,167,417 bp
  • T to A, chromosome 14 at 54,549,775 bp
  • C to G, chromosome 15 at 80,879,565 bp
  • A to G, chromosome 16 at 93,763,410 bp
  • A to G, chromosome 17 at 48,448,752 bp
  • T to C, chromosome 18 at 69,996,155 bp
  • A to T, chromosome 19 at 11,521,680 bp
  • A to G, chromosome 19 at 44,157,732 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5380 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042955-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.