Strain Name:
C57BL/6J-MtgxR5388Btlr/Mmmh
Stock Number:
042960-MU
Citation ID:
RRID:MMRRC_042960-MU
Other Names:
R5388 (G1), C57BL/6J-MtgxR5388Btlr
Major Collection:

Gene Information

Adamts20
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20
Synonyms: bt, ADAMTS-20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 223838
Homologene: 11808
Chd7
Name: chromodomain helicase DNA binding protein 7
Synonyms: Lda, A730019I05Rik, Edy, Mt, Cyn, WBE1, Dz, Gena 52, GENA 47, Obt, Cycn, GENA 60, Todo, Flo, Whi
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 320790
Homologene: 19067
Ep400
Name: E1A binding protein p400
Synonyms: 1700020J09Rik, p400, mDomino
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 75560
Homologene: 38779
Cfdp1
Name: craniofacial development protein 1
Synonyms: cp27, Bcnt, Bucentaur
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 23837
HGNC: HGNC:1873
Homologene: 4611
Kdm5b
Name: lysine (K)-specific demethylase 5B
Synonyms: 2010009J12Rik, 2210016I17Rik, D1Ertd202e, Plu1, PLU-1, Rb-Bp2, Jarid1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 75605
Homologene: 48448
Camsap3
Name: calmodulin regulated spectrin-associated protein family, member 3
Synonyms: Nezha, 2310057J16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 69697
Homologene: 18966
Fgr
Name: FGR proto-oncogene, Src family tyrosine kinase
Synonyms: Ali18, Mhdaali18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 14191
HGNC: HGNC:3697
Homologene: 3842
Usp1
Name: ubiquitin specific peptidase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230484
Homologene: 2528
Acap2
Name: ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
Synonyms: Centb2, 9530039J15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 78618
VEGA: 16
Homologene: 8182
Usp14
Name: ubiquitin specific peptidase 14
Synonyms: 2610005K12Rik, dUB-type TGT, 2610037B11Rik, NMF375, ataxia, nmf375, ax
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 59025
Homologene: 3780
Zfhx3
Name: zinc finger homeobox 3
Synonyms: Sci, A230102L03Rik, WBP9, Atbf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 11906
HGNC: HGNC:777
Homologene: 21366
Polr3a
Name: polymerase (RNA) III (DNA directed) polypeptide A
Synonyms: RPC1, 9330175N20Rik, RPC155
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 218832
VEGA: 14
Homologene: 5124
Zfp622
Name: zinc finger protein 622
Synonyms: D15Ertd806e, 1110033B05Rik, ZPR9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 52521
VEGA: 15
Homologene: 74377
Atp6v1b2
Name: ATPase, H+ transporting, lysosomal V1 subunit B2
Synonyms: HO57, Atp6b2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 11966
HGNC: HGNC:854
Homologene: 1279
Trhr
Name: thyrotropin releasing hormone receptor
Synonyms: TRH-R1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 22045
VEGA: 15
Homologene: 20707
Ppp1r7
Name: protein phosphatase 1, regulatory subunit 7
Synonyms: SDS22, 2310014J01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 66385
HGNC: HGNC:9295
Homologene: 2032
Camta1
Name: calmodulin binding transcription activator 1
Synonyms: 1810059M14Rik, 2310058O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 100072
Homologene: 18942
Lama5
Name: laminin, alpha 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 16776
HGNC: HGNC:6485
Homologene: 4060
Ncam1
Name: neural cell adhesion molecule 1
Synonyms: NCAM-1, CD56, E-NCAM, NCAM-180, NCAM-140, NCAM-120, NCAM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 17967
HGNC: HGNC:7656
Homologene: 40754
Yme1l1
Name: YME1-like 1 (S. cerevisiae)
Synonyms: Ftsh, ATP-dependent metalloprotease FtsH1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 27377
Homologene: 31996
Paxip1
Name: PAX interacting (with transcription-activation domain) protein 1
Synonyms: D5Ertd149e, PTIP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 55982
HGNC: HGNC:8624
Exosc7
Name: exosome component 7
Synonyms: 2610002K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 66446
Homologene: 8994
Ythdc2
Name: YTH domain containing 2
Synonyms: 3010002F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 240255
Homologene: 11265
Epp13
Name: epididymal protein 13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 627821
Abca16
Name: ATP-binding cassette, sub-family A (ABC1), member 16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233810
Homologene: 132942
Col4a4
Name: collagen, type IV, alpha 4
Synonyms: E130010M05Rik, [a]4(IV)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 12829
HGNC: HGNC:2206
Homologene: 20071
Cybrd1
Name: cytochrome b reductase 1
Synonyms: 2210407P13Rik, Dcytb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 73649
Homologene: 69387
Celsr1
Name: cadherin, EGF LAG seven-pass G-type receptor 1
Synonyms: Crsh, crash, Adgrc1, Scy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 12614
VEGA: 15
HGNC: HGNC:1850
Homologene: 7665
Pramel1
Name: preferentially expressed antigen in melanoma-like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 83491
Homologene: 87078
Nlrp1b
Name: NLR family, pyrin domain containing 1B
Synonyms: Nalp1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 637515
Homologene: 19080
Prdm1
Name: PR domain containing 1, with ZNF domain
Synonyms: PRDI-BF1, Blimp1, b2b1765Clo, Blimp-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 12142
HGNC: HGNC:9346
Homologene: 925
Antxr2
Name: anthrax toxin receptor 2
Synonyms: CMG2, cI-35, CMG-2, 2310046B19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 71914
Homologene: 43236
Rnf225
Name: ring finger protein 225
Synonyms: 2310014L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 381845
Homologene: 78604
Pign
Name: phosphatidylinositol glycan anchor biosynthesis, class N
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 27392
HGNC: HGNC:8967
Homologene: 6330
Topaz1
Name: testis and ovary specific PAZ domain containing 1
Synonyms: Gm9524
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 671232
VEGA: 9
Homologene: 19835
Mtus2
Name: microtubule associated tumor suppressor candidate 2
Synonyms: 5730592G18Rik, C130038G02Rik, A730013O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 77521
Homologene: 78141
4932415D10Rik
Name: RIKEN cDNA 4932415D10 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 102635990
VEGA: 10
Homologene: 82476
Ppfibp1
Name: PTPRF interacting protein, binding protein 1 (liprin beta 1)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 67533
HGNC: HGNC:9249
Homologene: 2685
Cacna1e
Name: calcium channel, voltage-dependent, R type, alpha 1E subunit
Synonyms: Cchra1, alpha1E, Cav2.3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 12290
HGNC: HGNC:1392
Homologene: 20185
Kcna5
Name: potassium voltage-gated channel, shaker-related subfamily, member 5
Synonyms: Kv1.5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 16493
HGNC: HGNC:6224
Homologene: 1683
Npc1l1
Name: NPC1 like intracellular cholesterol transporter 1
Synonyms: Niemann-Pick disease, type C1, 9130221N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 237636
HGNC: HGNC:7898
Homologene: 56585
Zbbx
Name: zinc finger, B-box domain containing
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 213234
Homologene: 11661
Rad21l
Name: RAD21-like (S. pombe)
Synonyms: Gm14160
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 668929
Homologene: 82650
Tmem38b
Name: transmembrane protein 38B
Synonyms: 1600017F22Rik, TRIC-B, D4Ertd89e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 52076
Homologene: 10010
Pkn3
Name: protein kinase N3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 263803
Homologene: 50980
Cfd
Name: complement factor D (adipsin)
Synonyms: factor D, Adn, DF, D component (adipsin) of complement
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 11537
VEGA: 10
HGNC: HGNC:2771
Homologene: 20453
Ace
Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
Synonyms: CD143
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 11421
HGNC: HGNC:2707
Homologene: 37351
Ripply1
Name: ripply transcriptional repressor 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 622473
Homologene: 134609
Cntn6
Name: contactin 6
Synonyms: NB-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 53870
HGNC: HGNC:2176
Homologene: 8702
Nkapl
Name: NFKB activating protein-like
Synonyms: 4921504I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 66707
Homologene: 57034
Smpd2
Name: sphingomyelin phosphodiesterase 2, neutral
Synonyms: nSMase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 20598
Homologene: 31129
Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Synonyms: Cyp2e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 13106
HGNC: HGNC:2631
Homologene: 68089
Gm15922
Name: predicted gene 15922
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
Grxcr1
Name: glutaredoxin, cysteine rich 1
Synonyms: tde, pi
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 433899
Homologene: 42423
Gm12367
Name: predicted gene 12367
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
Gm10100
Name: predicted gene 10100
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 100502953
VEGA: 10
Homologene: 135713
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 82,493,591 bp
  • T to C, chromosome 1 at 93,352,590 bp
  • A to T, chromosome 1 at 105,655,970 bp
  • T to A, chromosome 1 at 134,608,897 bp
  • G to A, chromosome 1 at 154,477,796 bp
  • T to G, chromosome 2 at 23,162,557 bp
  • T to A, chromosome 2 at 30,081,074 bp
  • T to C, chromosome 2 at 71,137,645 bp
  • C to T, chromosome 2 at 151,653,483 bp
  • T to A, chromosome 2 at 180,190,746 bp
  • G to T, chromosome 3 at 75,083,670 bp
  • T to C, chromosome 4 at 8,752,509 bp
  • T to C, chromosome 4 at 35,235,690 bp
  • C to T, chromosome 4 at 53,859,945 bp
  • A to G, chromosome 4 at 98,931,057 bp
  • T to C, chromosome 4 at 132,995,031 bp
  • T to C, chromosome 4 at 143,397,384 bp
  • G to T, chromosome 4 at 151,075,238 bp
  • C to G, chromosome 5 at 27,781,455 bp
  • C to A, chromosome 5 at 68,166,195 bp
  • A to G, chromosome 5 at 97,977,599 bp
  • G to A, chromosome 5 at 110,701,728 bp
  • C to T, chromosome 5 at 148,306,708 bp
  • A to T, chromosome 6 at 104,832,562 bp
  • C to T, chromosome 6 at 126,534,896 bp
  • T to A, chromosome 6 at 146,996,840 bp
  • T to G, chromosome 6 at 147,016,330 bp
  • T to C, chromosome 7 at 3,738,857 bp
  • T to C, chromosome 7 at 6,266,347 bp
  • A to G, chromosome 7 at 12,928,005 bp
  • T to C, chromosome 7 at 120,540,746 bp
  • T to C, chromosome 7 at 140,763,993 bp
  • A to T, chromosome 8 at 3,604,276 bp
  • G to A, chromosome 8 at 69,101,437 bp
  • G to A, chromosome 8 at 108,946,814 bp
  • T to C, chromosome 8 at 111,768,752 bp
  • A to C, chromosome 9 at 49,544,754 bp
  • A to T, chromosome 9 at 122,774,093 bp
  • A to T, chromosome 9 at 123,118,907 bp
  • A to G, chromosome 10 at 41,487,971 bp
  • G to A, chromosome 10 at 44,446,907 bp
  • G to A, chromosome 10 at 77,726,726 bp
  • A to T, chromosome 10 at 79,892,125 bp
  • T to C, chromosome 10 at 82,283,727 bp
  • T to A, chromosome 11 at 6,214,733 bp
  • T to G, chromosome 11 at 71,172,141 bp
  • C to A, chromosome 11 at 105,988,458 bp
  • T to C, chromosome 13 at 21,467,570 bp
  • T to C, chromosome 14 at 24,454,941 bp
  • T to C, chromosome 15 at 25,996,199 bp
  • T to C, chromosome 15 at 44,197,477 bp
  • A to G, chromosome 15 at 85,925,518 bp
  • C to G, chromosome 15 at 94,345,778 bp
  • C to A, chromosome 16 at 31,109,725 bp
  • C to T, chromosome 18 at 10,018,023 bp
  • T to A, chromosome 18 at 44,857,025 bp
  • TTCCTCCTCCTCCTCCTCCTCCTCCTCCTCCT to TTCCTCCTCCTCCTCCTCCTCCTCCTCCT, chromosome X at 139,779,850 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5388 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042960-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.