Strain Name:
C57BL/6J-MtgxR5485Btlr/Mmmh
Stock Number:
043046-MU
Citation ID:
RRID:MMRRC_043046-MU
Other Names:
R5485 (G1), C57BL/6J-MtgxR5485Btlr
Major Collection:

Gene Information

Stx8
Name: syntaxin 8
Synonyms: 1110002H11Rik, 0610007H08Rik, 4930571E13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 55943
Homologene: 37973
Mrps18b
Name: mitochondrial ribosomal protein S18B
Synonyms: 2400002C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 66973
Homologene: 32205
Clasp1
Name: CLIP associating protein 1
Synonyms: 5730583A19Rik, 1700030C23Rik, mCLASP1, CLASP1alpha, CLASP1, B130045P17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 76707
Homologene: 41024
Mbd4
Name: methyl-CpG binding domain protein 4
Synonyms: Med1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17193
HGNC: HGNC:6919
Homologene: 2916
Senp1
Name: SUMO1/sentrin specific peptidase 1
Synonyms: 2310046A20Rik, E330036L07Rik, D15Ertd528e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223870
Homologene: 8731
Abcb8
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 8
Synonyms: 4833412N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 74610
HGNC: HGNC:49
Homologene: 5203
Zfp318
Name: zinc finger protein 318
Synonyms: TZF, 2610034E08Rik, D530032D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 57908
Homologene: 22808
Sfxn5
Name: sideroflexin 5
Synonyms: C230001H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 94282
Homologene: 16936
Gabbr1
Name: gamma-aminobutyric acid (GABA) B receptor, 1
Synonyms: GABAbR1, GABAB1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 54393
HGNC: HGNC:4070
Homologene: 1132
Crebbp
Name: CREB binding protein
Synonyms: CBP, KAT3A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 12914
HGNC: HGNC:2348
Homologene: 68393
Atp13a5
Name: ATPase type 13A5
Synonyms: C630015F21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 268878
Homologene: 77451
Glt8d2
Name: glycosyltransferase 8 domain containing 2
Synonyms: 1110021D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 74782
Homologene: 41826
Mmp27
Name: matrix metallopeptidase 27
Synonyms: LOC234911
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 234911
Homologene: 23345
Appl1
Name: adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
Synonyms: 7330406P05Rik, 2900057D21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 72993
Homologene: 32143
Gorab
Name: golgin, RAB6-interacting
Synonyms: NTKL-BP1, Scyl1bp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98376
Homologene: 45113
Sbsn
Name: suprabasin
Synonyms: 1110005D19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 282619
Homologene: 17900
Nfkb2
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
Synonyms: p52, NF kappaB2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18034
VEGA: 19
HGNC: HGNC:7795
Homologene: 1873
Peg10
Name: paternally expressed 10
Synonyms: MEF3L, HB-1, MyEF-3, MyEF-3 like, Edr, Mart2, Mar2, Rtl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 170676
Homologene: 116067
Zfhx4
Name: zinc finger homeodomain 4
Synonyms: Zfh-4, C130041O22Rik, Zfh4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80892
Homologene: 23477
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Acz, Pico
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 26875
Homologene: 69111
Hfm1
Name: HFM1, ATP-dependent DNA helicase homolog
Synonyms: LOC381663, A330009G12Rik, Sec63d1, Mer3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 330149
Homologene: 87103
Rims1
Name: regulating synaptic membrane exocytosis 1
Synonyms: RIM1, RIM1a, C030033M19Rik, RIM1alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 116837
Homologene: 128399
Atp2c2
Name: ATPase, Ca++ transporting, type 2C, member 2
Synonyms: 1810010G06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 69047
Homologene: 73463
Wdr64
Name: WD repeat domain 64
Synonyms: 4930415O10Rik, 4930511H01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 75820
Homologene: 51634
Ugt8a
Name: UDP galactosyltransferase 8A
Synonyms: Cgt, mCerGT, Ugt8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 22239
Homologene: 20715
Mogat1
Name: monoacylglycerol O-acyltransferase 1
Synonyms: 0610030A14Rik, mDC2, MGAT1, Dgat2l1, 1110064N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68393
Homologene: 105237
Dgkb
Name: diacylglycerol kinase, beta
Synonyms: DGK-beta, C630029D13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217480
VEGA: 12
HGNC: HGNC:2850
Homologene: 37875
Tpk1
Name: thiamine pyrophosphokinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 29807
Homologene: 6960
Slco6c1
Name: solute carrier organic anion transporter family, member 6c1
Synonyms: 4933404A18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74441
Homologene: 65259
Eqtn
Name: equatorin, sperm acrosome associated
Synonyms: 1700028B15Rik, Afaf, equatorin, 4930579C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67753
HGNC: HGNC:1359
Homologene: 75250
Ctdnep1
Name: CTD nuclear envelope phosphatase 1
Synonyms: 2610507E10Rik, Dullard
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67181
Homologene: 9100
Xkr6
Name: X-linked Kx blood group related 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219149
Homologene: 18287
Tsen54
Name: tRNA splicing endonuclease subunit 54
Synonyms: 0610034P02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76265
Homologene: 35476
Spty2d1
Name: SPT2 chromatin protein domain containing 1
Synonyms: 5830435K17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101685
Homologene: 45499
Slc6a21
Name: solute carrier family 6 member 21
Synonyms: 1700039E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76713
Homologene: 66347
Slc6a13
Name: solute carrier family 6 (neurotransmitter transporter, GABA), member 13
Synonyms: Gabt3, Gat2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14412
Homologene: 9592
Plxnc1
Name: plexin C1
Synonyms: vespr, 2510048K12Rik, CD232
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 54712
HGNC: HGNC:9106
Homologene: 4211
Zfp563
Name: zinc finger protein 563
Synonyms: zinc finger protein, Zfp413
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240068
Homologene: 77346
Spata32
Name: spermatogenesis associated 32
Synonyms: 4933400C05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 328019
Homologene: 17554
Gstm1
Name: glutathione S-transferase, mu 1
Synonyms: Gstb-1, Gstb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14862
HGNC: HGNC:4637
Homologene: 115474
Ecd
Name: ecdysoneless cell cycle regulator
Synonyms: 5730461K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 70601
VEGA: 14
Homologene: 5256
Vmn2r17
Name: vomeronasal 2, receptor 17
Synonyms: EG384221
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 384221
Homologene: 104825
Tmem117
Name: transmembrane protein 117
Synonyms: B930062P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 320709
VEGA: 15
Homologene: 12992
Alox8
Name: arachidonate 8-lipoxygenase
Synonyms: 8S-lipoxygenase, 8-LOX, 8S-LOX, Alox15b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11688
HGNC: HGNC:434
Homologene: 886
Ugt1a2
Name: UDP glucuronosyltransferase 1 family, polypeptide A2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22236
Homologene: 86211
Olfr1513
Name: olfactory receptor 1513
Synonyms: GA_x6K02T2RJGY-644134-645075, MOR223-7P, MOR223-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258008
HGNC: HGNC:8171
Homologene: 79404
Hexim2
Name: hexamethylene bis-acetamide inducible 2
Synonyms: 4933402L21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71059
Homologene: 16946
1700093K21Rik
Name: RIKEN cDNA 1700093K21 gene
Synonyms: b2b3025Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67358
Homologene: 49849
Sytl3
Name: synaptotagmin-like 3
Synonyms: Slp3-a, Slp3-b, Slp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 83672
Homologene: 12855
Endog
Name: endonuclease G
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13804
HGNC: HGNC:3346
Homologene: 55823
Tdrkh
Name: tudor and KH domain containing protein
Synonyms: Tdrd2, 2700091C21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 72634
Homologene: 4999
Duoxa2
Name: dual oxidase maturation factor 2
Synonyms: 9030623N16Rik, Nip2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66811
Homologene: 57037
Gm16686
Name: predicted gene, 16686
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Gm5709
Name: predicted gene 5709
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 435732
Homologene: 33954
Xntrpc
Name: Xndc1-transient receptor potential cation channel, subfamily C, member 2 readthrough
Synonyms: Xndr-trpc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 102443351
Homologene: 134407
Gm7381
Name: predicted gene 7381
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 664870
VEGA: 8
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 22,483,208 bp
  • A to G, chromosome 1 at 78,523,670 bp
  • A to T, chromosome 1 at 88,201,246 bp
  • T to C, chromosome 1 at 97,125,756 bp
  • A to G, chromosome 1 at 118,467,913 bp
  • T to G, chromosome 1 at 163,386,302 bp
  • A to T, chromosome 1 at 175,724,696 bp
  • G to T, chromosome 2 at 30,171,651 bp
  • T to C, chromosome 2 at 122,299,152 bp
  • C to A, chromosome 3 at 5,243,007 bp
  • A to T, chromosome 3 at 59,635,562 bp
  • A to G, chromosome 3 at 94,428,712 bp
  • A to G, chromosome 3 at 108,017,404 bp
  • A to G, chromosome 3 at 125,915,400 bp
  • A to G, chromosome 4 at 88,755,404 bp
  • G to A, chromosome 4 at 94,924,956 bp
  • A to C, chromosome 5 at 14,540,000 bp
  • A to G, chromosome 5 at 24,400,161 bp
  • A to G, chromosome 5 at 106,847,662 bp
  • A to T, chromosome 5 at 109,420,106 bp
  • T to A, chromosome 6 at 4,755,565 bp
  • T to C, chromosome 6 at 43,665,812 bp
  • T to A, chromosome 6 at 85,332,600 bp
  • C to A, chromosome 6 at 115,850,718 bp
  • T to A, chromosome 6 at 121,336,073 bp
  • T to C, chromosome 7 at 30,753,117 bp
  • G to A, chromosome 7 at 45,282,542 bp
  • G to T, chromosome 7 at 46,997,885 bp
  • GTGTCCTA to GTGTCCTATGTCCTA, chromosome 7 at 102,095,213 bp
  • T to C, chromosome 8 at 3,842,161 bp
  • T to A, chromosome 8 at 119,753,062 bp
  • T to A, chromosome 9 at 7,573,362 bp
  • T to A, chromosome 10 at 82,651,448 bp
  • T to A, chromosome 10 at 93,029,117 bp
  • T to G, chromosome 10 at 94,922,742 bp
  • A to T, chromosome 11 at 23,517,378 bp
  • A to G, chromosome 11 at 68,020,966 bp
  • A to C, chromosome 11 at 69,197,420 bp
  • C to T, chromosome 11 at 69,981,490 bp
  • A to G, chromosome 11 at 103,139,058 bp
  • A to G, chromosome 11 at 103,209,296 bp
  • A to G, chromosome 11 at 115,815,222 bp
  • T to C, chromosome 12 at 38,127,364 bp
  • T to C, chromosome 14 at 20,338,205 bp
  • C to A, chromosome 14 at 26,962,866 bp
  • A to T, chromosome 14 at 52,349,319 bp
  • T to C, chromosome 14 at 63,819,384 bp
  • T to C, chromosome 15 at 95,094,830 bp
  • A to G, chromosome 15 at 98,066,496 bp
  • A to C, chromosome 16 at 4,114,913 bp
  • A to G, chromosome 16 at 29,281,942 bp
  • G to A, chromosome 17 at 6,715,480 bp
  • T to C, chromosome 17 at 33,089,566 bp
  • A to T, chromosome 17 at 35,914,344 bp
  • T to A, chromosome 17 at 37,056,875 bp
  • T to A, chromosome 17 at 46,412,254 bp
  • A to T, chromosome 19 at 46,316,089 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
(Deceased) Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5485 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043046-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.