Strain Name:
C57BL/6J-MtgxR5529Btlr/Mmmh
Stock Number:
043087-MU
Citation ID:
RRID:MMRRC_043087-MU
Other Names:
R5529 (G1), C57BL/6J-MtgxR5529Btlr
Major Collection:

Gene Information

Cadps
Name: Ca2+-dependent secretion activator
Synonyms: CAPS1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 27062
VEGA: 14
HGNC: HGNC:1426
Homologene: 2755
Kdm5b
Name: lysine (K)-specific demethylase 5B
Synonyms: PLU-1, Jarid1b, 2010009J12Rik, Rb-Bp2, D1Ertd202e, Plu1, 2210016I17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 75605
Homologene: 48448
Fgf1
Name: fibroblast growth factor 1
Synonyms: Fgfa, fibroblast growth factor 1 (acidic), Fgf-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 14164
HGNC: HGNC:3665
Homologene: 625
Usp48
Name: ubiquitin specific peptidase 48
Synonyms: Usp31, 2810449C13Rik, D330022K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 170707
Homologene: 12988
Katnb1
Name: katanin p80 (WD40-containing) subunit B 1
Synonyms: 2410003J24Rik, KAT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 74187
HGNC: HGNC:6217
Homologene: 4302
Spred2
Name: sprouty-related EVH1 domain containing 2
Synonyms: Spred-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 114716
Homologene: 24918
Tbc1d8
Name: TBC1 domain family, member 8
Synonyms: AD3, GRAM domain, BUB2-like protein 1, HBLP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 54610
Homologene: 31421
Prom1
Name: prominin 1
Synonyms: Prom-1, 4932416E19Rik, AC133, Prom, CD133
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 19126
HGNC: HGNC:9454
Homologene: 4390
Zfp472
Name: zinc finger protein 472
Synonyms: Krim-1, Krim-1B, Krim-1A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 224691
Homologene: 77422
Zbtb40
Name: zinc finger and BTB domain containing 40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230848
Homologene: 8912
Son
Name: Son DNA binding protein
Synonyms: 2900011L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 20658
Homologene: 10551
Pole
Name: polymerase (DNA directed), epsilon
Synonyms: pol-epsilon
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 18973
HGNC: HGNC:9177
Homologene: 4539
Tdp2
Name: tyrosyl-DNA phosphodiesterase 2
Synonyms: Ttrap, D13Ertd656e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 56196
Homologene: 9591
Alg2
Name: asparagine-linked glycosylation 2 (alpha-1,3-mannosyltransferase)
Synonyms: ALPG2, 1110018A23Rik, CDGIi, 1300013N08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 56737
Homologene: 5930
Hspg2
Name: perlecan (heparan sulfate proteoglycan 2)
Synonyms: Pcn, Plc, perlecan, per
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 15530
HGNC: HGNC:5273
Homologene: 68473
Paxbp1
Name: PAX3 and PAX7 binding protein 1
Synonyms: Gcfc1, 1810007M14Rik, Pax3/7bp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 67367
Homologene: 9604
Ndufa11
Name: NADH:ubiquinone oxidoreductase subunit A11
Synonyms: 11, 14.7kDa, B14.7, 2010012C24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 69875
VEGA: 17
Homologene: 17926
Ddhd2
Name: DDHD domain containing 2
Synonyms: 2010305K11Rik, SAMWD1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 72108
Homologene: 66646
Zfp655
Name: zinc finger protein 655
Synonyms: 2700038I16Rik, 9030409O18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 72611
Homologene: 12473
Zfp266
Name: zinc finger protein 266
Synonyms: 5330440G10Rik, 5730601F06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 77519
Homologene: 105676
Dnhd1
Name: dynein heavy chain domain 1
Synonyms: 8030491N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 77505
Homologene: 131117
Vhl
Name: von Hippel-Lindau tumor suppressor
Synonyms: Vhlh, pVHL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 22346
Homologene: 465
Reln
Name: reelin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 19699
HGNC: HGNC:9957
Homologene: 3699
Fbn1
Name: fibrillin 1
Synonyms: Fib-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 14118
HGNC: HGNC:3603
Homologene: 30958
Anxa3
Name: annexin A3
Synonyms: Anx3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 11745
HGNC: HGNC:541
Homologene: 68445
Rp1
Name: retinitis pigmentosa 1 (human)
Synonyms: mG145, Rp1h, oxygen-regulated protein 1, Orp1, Dcdc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 19888
Homologene: 4564
Gm10036
Name: predicted gene 10036
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 100040551
VEGA: 18
F12
Name: coagulation factor XII (Hageman factor)
Synonyms: FXII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 58992
HGNC: HGNC:3530
Homologene: 425
Nlrp4b
Name: NLR family, pyrin domain containing 4B
Synonyms: Nalp-gamma, Nalp4b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 210045
Homologene: 65242
Tmem89
Name: transmembrane protein 89
Synonyms: 1700024B07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 69384
Homologene: 52857
Hivep1
Name: human immunodeficiency virus type I enhancer binding protein 1
Synonyms: Cryabp1, alphaA-CRYBP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 110521
VEGA: 13
HGNC: HGNC:4920
Homologene: 1596
Shroom1
Name: shroom family member 1
Synonyms: Apx, 1300007L22Rik, Shrm1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 71774
Homologene: 12411
Eml6
Name: echinoderm microtubule associated protein like 6
Synonyms: 2900083P10Rik, C230094A16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 237711
Homologene: 104282
Vrk2
Name: vaccinia related kinase 2
Synonyms: 2810003O05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 69922
Homologene: 55966
Daam2
Name: dishevelled associated activator of morphogenesis 2
Synonyms: 2310016D11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 76441
VEGA: 17
Homologene: 69186
Olfr558
Name: olfactory receptor 558
Synonyms: GA_x6K02T2PBJ9-5425951-5426904, MOR18-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 259097
Homologene: 17503
Psg28
Name: pregnancy-specific glycoprotein 28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 114871
Homologene: 110989
Atp8a2
Name: ATPase, aminophospholipid transporter-like, class I, type 8A, member 2
Synonyms: agil, wl, Ib
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 50769
Homologene: 4443
Ccn5
Name: cellular communication network factor 5
Synonyms: CCN5, Crgr4, Wisp2, rCop1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22403
Homologene: 2882
Ky
Name: kyphoscoliosis peptidase
Synonyms: D9Mgc44e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 16716
Homologene: 11506
Fgf14
Name: fibroblast growth factor 14
Synonyms: Fhf4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 14169
HGNC: HGNC:3671
Homologene: 3037
Birc7
Name: baculoviral IAP repeat-containing 7 (livin)
Synonyms: ML-IAP, Livin, KIAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 329581
Homologene: 51405
Olfr361
Name: olfactory receptor 361
Synonyms: GA_x6K02T2NLDC-33777519-33776551, MOR159-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258365
Homologene: 27142
Ces2e
Name: carboxylesterase 2E
Synonyms: Ces5, 9030624L02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234673
HGNC: HGNC:1864
Homologene: 86210
Vmn2r23
Name: vomeronasal 2, receptor 23
Synonyms: EG435916
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 435916
Homologene: 135826
Lrwd1
Name: leucine-rich repeats and WD repeat domain containing 1
Synonyms: Orca, 1200011O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 71735
Homologene: 17678
Setbp1
Name: SET binding protein 1
Synonyms: Seb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 240427
Homologene: 9192
Dcstamp
Name: dendrocyte expressed seven transmembrane protein
Synonyms: 4833414I07Rik, DC-STAMP, Tm7sf4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 75766
VEGA: 15
Homologene: 12769
Med9
Name: mediator complex subunit 9
Synonyms: Med25, MED25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 192191
Homologene: 32385
Mtx1
Name: metaxin 1
Synonyms: Gcap6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 17827
HGNC: HGNC:7504
Homologene: 37623
Gm5117
Name: predicted gene 5117
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 330731
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 4,345,832 bp
  • T to G, chromosome 1 at 39,372,755 bp
  • C to T, chromosome 1 at 134,588,003 bp
  • T to A, chromosome 2 at 37,084,909 bp
  • G to A, chromosome 2 at 125,373,950 bp
  • T to C, chromosome 2 at 163,825,359 bp
  • A to G, chromosome 2 at 180,932,974 bp
  • T to C, chromosome 3 at 89,212,920 bp
  • T to C, chromosome 4 at 47,472,101 bp
  • A to G, chromosome 4 at 136,983,163 bp
  • C to A, chromosome 4 at 137,551,828 bp
  • C to T, chromosome 4 at 137,625,268 bp
  • A to C, chromosome 5 at 21,932,715 bp
  • G to T, chromosome 5 at 44,026,768 bp
  • A to G, chromosome 5 at 96,828,379 bp
  • G to A, chromosome 5 at 110,332,466 bp
  • A to T, chromosome 5 at 136,133,299 bp
  • A to G, chromosome 5 at 145,244,736 bp
  • T to C, chromosome 6 at 113,629,463 bp
  • C to T, chromosome 6 at 123,713,451 bp
  • T to A, chromosome 7 at 10,714,946 bp
  • G to A, chromosome 7 at 18,430,448 bp
  • A to T, chromosome 7 at 102,709,693 bp
  • G to A, chromosome 7 at 105,703,209 bp
  • C to T, chromosome 8 at 25,739,560 bp
  • T to A, chromosome 8 at 31,737,835 bp
  • C to T, chromosome 8 at 95,097,672 bp
  • G to T, chromosome 8 at 104,929,911 bp
  • A to G, chromosome 9 at 20,506,734 bp
  • C to T, chromosome 9 at 102,542,075 bp
  • T to C, chromosome 9 at 108,915,477 bp
  • G to T, chromosome 11 at 20,021,301 bp
  • T to C, chromosome 11 at 26,499,036 bp
  • T to A, chromosome 11 at 29,764,126 bp
  • T to C, chromosome 11 at 53,463,922 bp
  • T to G, chromosome 11 at 59,960,660 bp
  • A to T, chromosome 13 at 24,838,236 bp
  • T to C, chromosome 13 at 42,156,650 bp
  • T to C, chromosome 13 at 55,422,059 bp
  • T to C, chromosome 14 at 12,454,285 bp
  • A to G, chromosome 14 at 59,793,865 bp
  • T to A, chromosome 14 at 123,980,455 bp
  • A to G, chromosome 15 at 39,754,536 bp
  • T to A, chromosome 16 at 91,030,513 bp
  • T to A, chromosome 16 at 91,655,466 bp
  • T to A, chromosome 17 at 32,978,433 bp
  • A to G, chromosome 17 at 49,459,057 bp
  • T to A, chromosome 17 at 56,721,059 bp
  • A to T, chromosome 18 at 15,832,801 bp
  • G to T, chromosome 18 at 38,858,604 bp
  • T to C, chromosome 18 at 79,086,652 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5529 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043087-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.