Strain Name:
C57BL/6J-MtgxR5714Btlr/Mmmh
Stock Number:
043186-MU
Citation ID:
RRID:MMRRC_043186-MU
Other Names:
R5714 (G1), C57BL/6J-MtgxR5714Btlr
Major Collection:

Strain Information

Vps33a
Name: VPS33A CORVET/HOPS core subunit
Synonyms: bf, 3830421M04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 77573
Homologene: 11294
Srd5a3
Name: steroid 5 alpha-reductase 3
Synonyms: 1110025P14Rik, D730040M03Rik, Srd5a2l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 57357
Homologene: 41385
Zfp97
Name: zinc finger protein 97
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22759
Homologene: 133884
Bcar3
Name: breast cancer anti-estrogen resistance 3
Synonyms: AND-34
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 29815
HGNC: HGNC:973
Homologene: 31181
Zfp532
Name: zinc finger protein 532
Synonyms: C530030I18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 328977
Homologene: 138627
Flnb
Name: filamin, beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 286940
HGNC: HGNC:3755
Homologene: 37480
Pcnt
Name: pericentrin (kendrin)
Synonyms: m239Asp, m275Asp, Pcnt2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18541
VEGA: 10
Helz
Name: helicase with zinc finger domain
Synonyms: 3110078M01Rik, 9430093I07Rik, 9630002H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 78455
Homologene: 8918
Mcm5
Name: minichromosome maintenance complex component 5
Synonyms: mCD46, Mcmd5, Cdc46
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17218
HGNC: HGNC:6948
Homologene: 4904
Polg
Name: polymerase (DNA directed), gamma
Synonyms: Pol gamma, mitochondrial DNA polymerase gamma, polymerase gamma, mitochondrial DNA polymerase-gamma, Polga
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18975
HGNC: HGNC:9179
Homologene: 2016
Cemip
Name: cell migration inducing protein, hyaluronan binding
Synonyms: 9930013L23Rik, 12H19.01.T7, Hybid, 6330404C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 80982
Homologene: 10268
Glul
Name: glutamate-ammonia ligase
Synonyms: GS, Glns
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14645
HGNC: HGNC:4341
Homologene: 37567
Yy1
Name: YY1 transcription factor
Synonyms: delta transcription factor, UCRBP transcription factor, NF-E1, Yin Yang 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 22632
Homologene: 2556
Dpys
Name: dihydropyrimidinase
Synonyms: DHPase, 1200017I10Rik, 1300004I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 64705
HGNC: HGNC:3013
Homologene: 20359
Wscd1
Name: WSC domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216881
Homologene: 18590
Pdgfra
Name: platelet derived growth factor receptor, alpha polypeptide
Synonyms: Pdgfr-2, CD140a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18595
HGNC: HGNC:8803
Homologene: 31361
Slc35e2
Name: solute carrier family 35, member E2
Synonyms: A530082C11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 320541
Homologene: 84987
Ttn
Name: titin
Synonyms: D330041I19Rik, 2310057K23Rik, connectin, shru, 1100001C23Rik, L56, mdm, D830007G01Rik, 2310074I15Rik, 2310036G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Ush2a
Name: usherin
Synonyms: Ush2a, Ushrn, MUSH2A, LOC381317, LOC269160, A930037M10Rik, A930011D15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22283
Homologene: 66151
Garre1
Name: granule associated Rac and RHOG effector 1
Synonyms: 4931406P16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233103
Homologene: 8795
Cacna1s
Name: calcium channel, voltage-dependent, L type, alpha 1S subunit
Synonyms: mdg, sj, Cchl1a3, DHPR alpha1s, muscle dysgenesis, Cav1.1, fmd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12292
HGNC: HGNC:1397
Homologene: 37257
Pard3b
Name: par-3 family cell polarity regulator beta
Synonyms: 1810008K04Rik, PAR3B, 2010002N16Rik, Als2cr19, PAR3beta, PAR3L, 2810455B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 72823
Homologene: 35389
Nat8f2
Name: N-acetyltransferase 8 (GCN5-related) family member 2
Synonyms: Cml2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 93673
Tmem94
Name: transmembrane protein 94
Synonyms: 2310067B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71947
Homologene: 8831
Slc27a6
Name: solute carrier family 27 (fatty acid transporter), member 6
Synonyms: FATP6, 4732438L20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225579
Homologene: 38385
Alpk2
Name: alpha-kinase 2
Synonyms: Hak
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225638
Homologene: 50475
Rtl1
Name: retrotransposon Gaglike 1
Synonyms: Mar, Mor1, Mart1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 353326
VEGA: 12
Homologene: 120261
Cyp4f39
Name: cytochrome P450, family 4, subfamily f, polypeptide 39
Synonyms: 4732474A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 320997
VEGA: 17
Homologene: 69814
Lypd3
Name: Ly6/Plaur domain containing 3
Synonyms: 2310061G07Rik, C4.4A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 72434
Homologene: 8672
Rars2
Name: arginyl-tRNA synthetase 2, mitochondrial
Synonyms: Rarsl, PRO1992, 1500002I10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 109093
Homologene: 5707
Slc22a19
Name: solute carrier family 22 (organic anion transporter), member 19
Synonyms: Slc22a9, Oat5, D630043A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 207151
Homologene: 133125
Phyhd1
Name: phytanoyl-CoA dioxygenase domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227696
Homologene: 14939
Kcnh8
Name: potassium voltage-gated channel, subfamily H (eag-related), member 8
Synonyms: ELK1, C130090D05Rik, Kv12.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 211468
Homologene: 14332
Kptn
Name: kaptin
Synonyms: C030013F01Rik, 2310042D10Rik, 2E4, actin-binding protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 70394
HGNC: HGNC:6404
Homologene: 5127
Vmn2r109
Name: vomeronasal 2, receptor 109
Synonyms: EG627814
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 627814
Homologene: 129678
Slc18b1
Name: solute carrier family 18, subfamily B, member 1
Synonyms: 1110021L09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 76306
Homologene: 33473
Mios
Name: meiosis regulator for oocyte development
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 252875
Homologene: 10371
Ankub1
Name: ankyrin repeat and ubiquitin domain containing 1
Synonyms: Gm410, LOC242037
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242037
Homologene: 54680
Prl7c1
Name: prolactin family 7, subfamily c, member 1
Synonyms: Prlpo, PLP-O, 1600017N11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 67505
HGNC: HGNC:9445
Homologene: 137377
Tgfbr2
Name: transforming growth factor, beta receptor II
Synonyms: TbetaRII, TBR-II, 1110020H15Rik, TbetaR-II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 21813
VEGA: 9
Homologene: 2435
Kap
Name: kidney androgen regulated protein
Synonyms: kidney androgen-regulated protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16483
Homologene: 49244
Or1e16
Name: olfactory receptor family 1 subfamily E member 16
Synonyms: I54, GA_x6K02T2P1NL-3556334-3555390, MOR135-13, Olfr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258923
Homologene: 115482
Vgll4
Name: vestigial like family member 4
Synonyms: VGL-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232334
Homologene: 18603
Fbxl21
Name: F-box and leucine-rich repeat protein 21
Synonyms: FBXL3B, Psttm, D630045D17Rik, FBL3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 213311
Homologene: 78724
Cdc42ep1
Name: CDC42 effector protein 1
Synonyms: CEP1, Borg5, MSE55, 1810058K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 104445
VEGA: 15
Homologene: 5128
Fgf9
Name: fibroblast growth factor 9
Synonyms: Eks, glia activating factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 14180
HGNC: HGNC:3687
Homologene: 1523
Fkbp14
Name: FK506 binding protein 14
Synonyms: FKBP22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 231997
Homologene: 23059
9430002A10Rik
Name: RIKEN cDNA 9430002A10 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 62,637,916 bp
  • A to G, chromosome 1 at 136,112,066 bp
  • T to C, chromosome 1 at 153,906,497 bp
  • A to T, chromosome 1 at 188,400,257 bp
  • T to A, chromosome 2 at 30,279,982 bp
  • G to A, chromosome 2 at 76,822,493 bp
  • G to A, chromosome 3 at 57,672,837 bp
  • G to A, chromosome 3 at 122,455,087 bp
  • T to A, chromosome 4 at 34,645,779 bp
  • C to T, chromosome 4 at 155,610,026 bp
  • T to C, chromosome 5 at 75,186,012 bp
  • T to A, chromosome 5 at 76,153,566 bp
  • T to C, chromosome 5 at 123,569,500 bp
  • T to A, chromosome 6 at 8,215,434 bp
  • A to G, chromosome 6 at 54,585,850 bp
  • A to G, chromosome 6 at 85,867,909 bp
  • A to T, chromosome 6 at 114,890,776 bp
  • A to G, chromosome 6 at 133,851,993 bp
  • A to G, chromosome 7 at 16,120,758 bp
  • A to G, chromosome 7 at 24,639,069 bp
  • G to A, chromosome 7 at 34,240,516 bp
  • C to A, chromosome 7 at 79,451,991 bp
  • T to A, chromosome 7 at 83,975,179 bp
  • A to C, chromosome 8 at 75,120,910 bp
  • T to A, chromosome 8 at 88,174,981 bp
  • A to T, chromosome 9 at 116,175,024 bp
  • A to T, chromosome 10 at 23,798,766 bp
  • A to T, chromosome 10 at 76,420,491 bp
  • T to C, chromosome 11 at 71,784,435 bp
  • T to A, chromosome 11 at 73,395,361 bp
  • T to A, chromosome 11 at 107,626,521 bp
  • C to A, chromosome 11 at 115,793,190 bp
  • C to A, chromosome 12 at 108,814,668 bp
  • A to G, chromosome 12 at 109,593,680 bp
  • A to T, chromosome 13 at 27,778,966 bp
  • A to G, chromosome 13 at 56,527,072 bp
  • C to A, chromosome 13 at 67,296,426 bp
  • A to C, chromosome 14 at 7,929,073 bp
  • T to C, chromosome 14 at 58,109,565 bp
  • T to A, chromosome 15 at 39,857,157 bp
  • C to A, chromosome 15 at 78,849,777 bp
  • A to G, chromosome 17 at 17,145,609 bp
  • A to G, chromosome 17 at 20,552,859 bp
  • G to A, chromosome 17 at 32,481,825 bp
  • T to C, chromosome 17 at 52,978,122 bp
  • A to T, chromosome 18 at 58,598,553 bp
  • G to T, chromosome 18 at 65,305,461 bp
  • G to A, chromosome 18 at 65,623,535 bp
  • T to C, chromosome 19 at 7,711,022 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5714 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043186-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.