Strain Name:
C57BL/6J-MtgxR5923Btlr/Mmmh
Stock Number:
043241-MU
Citation ID:
RRID:MMRRC_043241-MU
Other Names:
R5923 (G1), C57BL/6J-MtgxR5923Btlr
Major Collection:

Gene Information

Ntrk3
Name: neurotrophic tyrosine kinase, receptor, type 3
Synonyms: TrkC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18213
HGNC: HGNC:8033
Homologene: 49183
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Nup188
Name: nucleoporin 188
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227699
Homologene: 45683
Map1b
Name: microtubule-associated protein 1B
Synonyms: MAP5, Mtap-5, Mtap5, LC1, Mtap1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17755
VEGA: 13
HGNC: HGNC:6836
Homologene: 38111
Plcb4
Name: phospholipase C, beta 4
Synonyms: C230058B11Rik, A930039J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18798
HGNC: HGNC:9059
Homologene: 8471
Cdr2
Name: cerebellar degeneration-related 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12585
HGNC: HGNC:1799
Homologene: 7262
Brpf3
Name: bromodomain and PHD finger containing, 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268936
Homologene: 16092
Polk
Name: polymerase (DNA directed), kappa
Synonyms: Dinb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 27015
VEGA: 13
HGNC: HGNC:9183
Homologene: 32140
Usp19
Name: ubiquitin specific peptidase 19
Synonyms: 8430421I07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 71472
Homologene: 41730
Tbcd
Name: tubulin-specific chaperone d
Synonyms: A030005L14Rik, 2310057L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 108903
Homologene: 4368
Zc3h3
Name: zinc finger CCCH type containing 3
Synonyms: Smicl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223642
VEGA: 15
Homologene: 9029
Bod1l
Name: biorientation of chromosomes in cell division 1-like
Synonyms: A230054D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 665775
Homologene: 45109
Spg11
Name: SPG11, spatacsin vesicle trafficking associated
Synonyms: C530005A01Rik, 6030465E24Rik, spastic paraplegia 11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 214585
Homologene: 41614
Hgfac
Name: hepatocyte growth factor activator
Synonyms: HGFA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 54426
HGNC: HGNC:4894
Homologene: 1170
Kat6a
Name: K(lysine) acetyltransferase 6A
Synonyms: MOZ, Zfp220, 9930021N24Rik, Myst3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244349
Homologene: 4924
Nbeal1
Name: neurobeachin like 1
Synonyms: A530050O19Rik, ALS2CR17, A530083I02Rik, 2310076G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 269198
Homologene: 16453
Samd12
Name: sterile alpha motif domain containing 12
Synonyms: A830094I09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 320679
Homologene: 35979
Tatdn3
Name: TatD DNase domain containing 3
Synonyms: 1500010M24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68972
Homologene: 45949
Itga2
Name: integrin alpha 2
Synonyms: VLA-2 receptor, alpha 2 subunit, CD49B, DX5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 16398
VEGA: 13
HGNC: HGNC:6137
Homologene: 1662
Cubn
Name: cubilin (intrinsic factor-cobalamin receptor)
Synonyms: D2Wsu88e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 65969
HGNC: HGNC:2548
Homologene: 37434
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Cacna1d
Name: calcium channel, voltage-dependent, L type, alpha 1D subunit
Synonyms: D-LTCC, Cchl1a, Cchl1a2, Cacnl1a2, 8430418G19Rik, Cav1.3alpha1, C79217
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12289
VEGA: 14
HGNC: HGNC:1391
Homologene: 578
Arnt2
Name: aryl hydrocarbon receptor nuclear translocator 2
Synonyms: bHLHe1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11864
Homologene: 7230
Scap
Name: SREBF chaperone
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235623
Homologene: 8160
Prl6a1
Name: prolactin family 6, subfamily a, member 1
Synonyms: PLP-B, Prlpb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 19111
Homologene: 49261
Cacna1s
Name: calcium channel, voltage-dependent, L type, alpha 1S subunit
Synonyms: Cchl1a3, fmd, mdg, sj, muscle dysgenesis, Cav1.1, DHPR alpha1s
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12292
HGNC: HGNC:1397
Homologene: 37257
Unc79
Name: unc-79 homolog
Synonyms: 9030205A07Rik, Mlca3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217843
Homologene: 41397
Abca9
Name: ATP-binding cassette, sub-family A (ABC1), member 9
Synonyms: D630040K07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217262
HGNC: HGNC:39
Homologene: 33332
4921513I03Rik
Name: RIKEN cDNA 4921513I03 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 70874
VEGA: 10
Tmc8
Name: transmembrane channel-like gene family 8
Synonyms: EVIN2, Ever2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217356
Homologene: 45126
Cilp2
Name: cartilage intermediate layer protein 2
Synonyms: CLIP-2, 1110031K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 68709
Homologene: 17713
Zfp598
Name: zinc finger protein 598
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 213753
VEGA: 17
Homologene: 5672
Hivep3
Name: human immunodeficiency virus type I enhancer binding protein 3
Synonyms: Krc, E030045D18Rik, 2900056N03Rik, Shn3, Schnurri-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 16656
Homologene: 7803
Vmn2r24
Name: vomeronasal 2, receptor 24
Synonyms: EG243628
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243628
Homologene: 135915
Tial1
Name: Tia1 cytotoxic granule-associated RNA binding protein-like 1
Synonyms: mTIAR, 5330433G13Rik, TIAR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 21843
Homologene: 87796
Echdc3
Name: enoyl Coenzyme A hydratase domain containing 3
Synonyms: 2310005D12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67856
Homologene: 11484
Olfr885
Name: olfactory receptor 885
Synonyms: GA_x6K02T2PVTD-31740639-31741568, MOR162-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 257885
Homologene: 79400
Vmn1r12
Name: vomeronasal 1 receptor 12
Synonyms: Gm6674
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 626397
Homologene: 74373
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 34,181,759 bp
  • T to C, chromosome 1 at 60,248,395 bp
  • T to A, chromosome 1 at 136,076,822 bp
  • T to C, chromosome 1 at 191,049,310 bp
  • A to G, chromosome 2 at 6,189,572 bp
  • A to T, chromosome 2 at 13,486,078 bp
  • A to G, chromosome 2 at 30,304,090 bp
  • T to A, chromosome 2 at 76,812,557 bp
  • A to T, chromosome 2 at 122,093,478 bp
  • A to T, chromosome 2 at 135,961,814 bp
  • G to T, chromosome 4 at 120,096,293 bp
  • C to T, chromosome 5 at 35,045,188 bp
  • G to A, chromosome 5 at 41,817,419 bp
  • G to A, chromosome 6 at 57,159,035 bp
  • A to G, chromosome 6 at 123,815,792 bp
  • A to T, chromosome 7 at 78,451,928 bp
  • G to T, chromosome 7 at 84,262,533 bp
  • A to G, chromosome 7 at 120,982,001 bp
  • A to G, chromosome 7 at 128,448,207 bp
  • A to G, chromosome 8 at 22,939,479 bp
  • A to G, chromosome 8 at 69,882,875 bp
  • T to A, chromosome 9 at 38,061,858 bp
  • C to A, chromosome 9 at 108,493,779 bp
  • G to T, chromosome 9 at 110,383,580 bp
  • T to G, chromosome 10 at 120,778,770 bp
  • A to G, chromosome 11 at 110,160,552 bp
  • C to T, chromosome 11 at 117,783,812 bp
  • G to A, chromosome 11 at 121,580,152 bp
  • T to C, chromosome 12 at 103,112,468 bp
  • A to T, chromosome 13 at 27,316,363 bp
  • A to T, chromosome 13 at 96,495,415 bp
  • T to C, chromosome 13 at 99,433,153 bp
  • T to C, chromosome 13 at 114,884,519 bp
  • T to C, chromosome 14 at 30,111,148 bp
  • A to G, chromosome 15 at 53,860,254 bp
  • G to T, chromosome 15 at 75,785,564 bp
  • T to C, chromosome 17 at 24,677,549 bp
  • G to A, chromosome 17 at 28,806,636 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5923 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043241-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.