Strain Name:
C57BL/6J-MtgxR5939Btlr/Mmmh
Stock Number:
043243-MU
Citation ID:
RRID:MMRRC_043243-MU
Other Names:
R5939 (G1), C57BL/6J-MtgxR5939Btlr
Major Collection:

Gene Information

Slc6a6
Name: solute carrier family 6 (neurotransmitter transporter, taurine), member 6
Synonyms: Taut
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 21366
Homologene: 2291
Penk
Name: preproenkephalin
Synonyms: Penk1, ENK, Penk, PPA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18619
HGNC: HGNC:8831
Homologene: 4528
D630045J12Rik
Name: RIKEN cDNA D630045J12 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330286
Homologene: 19782
Srsf11
Name: serine and arginine-rich splicing factor 11
Synonyms: Sfrs11, 2610019N13Rik, 0610009J05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 69207
Homologene: 36164
Psmb1
Name: proteasome (prosome, macropain) subunit, beta type 1
Synonyms: Lmpc5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 19170
VEGA: 17
HGNC: HGNC:9537
Homologene: 2087
Xpo1
Name: exportin 1
Synonyms: Crm1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103573
Homologene: 2554
Cep170
Name: centrosomal protein 170
Synonyms: A330004A13Rik, 4933426L22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 545389
Homologene: 22844
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Arel1
Name: apoptosis resistant E3 ubiquitin protein ligase 1
Synonyms: 1110018G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 68497
Homologene: 8885
Mcm3ap
Name: minichromosome maintenance complex component 3 associated protein
Synonyms: GANP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 54387
VEGA: 10
HGNC: HGNC:6946
Homologene: 2902
Nr3c1
Name: nuclear receptor subfamily 3, group C, member 1
Synonyms: glucocorticoid receptor, Grl-1, Grl1, GR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 14815
HGNC: HGNC:7978
Homologene: 30960
Nrip1
Name: nuclear receptor interacting protein 1
Synonyms: 6030458L20Rik, RIP140, 8430438I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 268903
HGNC: HGNC:8001
Homologene: 2606
Adam32
Name: a disintegrin and metallopeptidase domain 32
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 353188
Homologene: 17021
Nrros
Name: negative regulator of reactive oxygen species
Synonyms: Lrrc33, E430025L02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224109
Homologene: 17134
Rab23
Name: RAB23, member RAS oncogene family
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19335
Homologene: 7503
Dync2h1
Name: dynein cytoplasmic 2 heavy chain 1
Synonyms: 4432416O06Rik, b2b414Clo, DHC1b, DHC2, m407Asp, D330044F14Rik, D030010H02Rik, Dnchc2, m152Asp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 110350
HGNC: HGNC:2962
Homologene: 14468
Tpcn1
Name: two pore channel 1
Synonyms: 5730403B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 252972
Homologene: 9905
Rnf214
Name: ring finger protein 214
Synonyms: D130054N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235315
Homologene: 109357
Pcdhb16
Name: protocadherin beta 16
Synonyms: PcdhbP, Pcdhb8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93887
HGNC: HGNC:8693
Homologene: 99843
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: calcium release channel isoform 1, skrr, Ryr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20190
Homologene: 68069
Nek10
Name: NIMA (never in mitosis gene a)- related kinase 10
Synonyms: LOC238944
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 674895
Homologene: 130947
Slc9c1
Name: solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1
Synonyms: spermNHE, Slc9a10, LOC208169
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 208169
Homologene: 19505
Col7a1
Name: collagen, type VII, alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12836
HGNC: HGNC:2214
Homologene: 73
Intu
Name: inturned planar cell polarity protein
Synonyms: Pdzd6, Pdzk6, 9230116I04Rik, 9430087H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 380614
Homologene: 41059
Neb
Name: nebulin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Cabp2
Name: calcium binding protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 29866
HGNC: HGNC:1385
Homologene: 8487
Lrguk
Name: leucine-rich repeats and guanylate kinase domain containing
Synonyms: 4921528H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 74354
Homologene: 34923
Duox1
Name: dual oxidase 1
Synonyms: THOX1, 9930101G15Rik, NOXEF1, LNOX1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99439
HGNC: HGNC:3062
Homologene: 68136
Inpp4b
Name: inositol polyphosphate-4-phosphatase, type II
Synonyms: E130107I17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234515
HGNC: HGNC:6075
Homologene: 20832
Top2b
Name: topoisomerase (DNA) II beta
Synonyms: Top-2, D230016L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 21974
Homologene: 134711
Spef2
Name: sperm flagellar 2
Synonyms: C230086A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 320277
Homologene: 23371
Erlin2
Name: ER lipid raft associated 2
Synonyms: Spfh2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244373
HGNC: HGNC:1356
Homologene: 5193
Man1c1
Name: mannosidase, alpha, class 1C, member 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230815
Homologene: 69303
Zfp286
Name: zinc finger protein 286
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 192651
Homologene: 56892
Ppp2r3a
Name: protein phosphatase 2, regulatory subunit B'', alpha
Synonyms: 3222402P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235542
HGNC: HGNC:9307
Homologene: 20595
Thoc2l
Name: THO complex subunit 2-like
Synonyms: Gm3179, BC005561
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100042165
Xirp1
Name: xin actin-binding repeat containing 1
Synonyms: mXin alpha, Xin, Cmya1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22437
VEGA: 9
Homologene: 7998
Tmem246
Name: transmembrane protein 246
Synonyms: 2810432L12Rik, 9330170P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67063
Homologene: 12080
Armh1
Name: armadillo-like helical domain containing 1
Synonyms: LOC381544, LOC381543, Gm1661, Ncrna00082
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 381544
Homologene: 28727
Gnal
Name: guanine nucleotide binding protein, alpha stimulating, olfactory type
Synonyms: 9630020G10Rik, Golf, Gna10, Galphaolf, G alpha 10, 2610011C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 14680
VEGA: 18
HGNC: HGNC:4388
Homologene: 68222
Olfr1120
Name: olfactory receptor 1120
Synonyms: GA_x6K02T2Q125-48849180-48850100, MOR264-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 259031
Homologene: 72054
Tmc7
Name: transmembrane channel-like gene family 7
Synonyms: C630024K23Rik, 1700030H01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 209760
Homologene: 36424
Ager
Name: advanced glycosylation end product-specific receptor
Synonyms: RAGE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 11596
HGNC: HGNC:320
Homologene: 883
Cenps
Name: centromere protein S
Synonyms: Apitd1, 2810407L01Rik, 2610040C18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69928
Homologene: 66004
Tmem70
Name: transmembrane protein 70
Synonyms: 2210416J16Rik, 1110020A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 70397
Homologene: 9890
Olfr1167
Name: olfactory receptor 1167
Synonyms: MOR174-16, GA_x6K02T2Q125-49641892-49640942
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258291
Homologene: 138307
Cxcl3
Name: chemokine (C-X-C motif) ligand 3
Synonyms: Dcip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 330122
Homologene: 138183
Gm26513
Name: predicted gene, 26513
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 108168225
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 16,677,391 bp
  • T to C, chromosome 1 at 33,723,909 bp
  • C to T, chromosome 1 at 176,793,643 bp
  • T to C, chromosome 2 at 52,257,594 bp
  • A to C, chromosome 2 at 87,357,704 bp
  • T to C, chromosome 2 at 88,149,509 bp
  • A to T, chromosome 2 at 122,346,351 bp
  • T to C, chromosome 3 at 40,692,584 bp
  • C to T, chromosome 3 at 158,023,344 bp
  • A to G, chromosome 4 at 4,138,010 bp
  • T to A, chromosome 4 at 49,586,412 bp
  • T to C, chromosome 4 at 117,229,922 bp
  • C to T, chromosome 4 at 134,565,836 bp
  • C to A, chromosome 4 at 149,130,201 bp
  • C to T, chromosome 5 at 90,786,316 bp
  • T to C, chromosome 5 at 104,519,207 bp
  • A to T, chromosome 5 at 120,539,827 bp
  • G to T, chromosome 6 at 34,078,753 bp
  • A to C, chromosome 6 at 38,194,969 bp
  • A to G, chromosome 6 at 91,754,948 bp
  • C to T, chromosome 7 at 29,116,127 bp
  • C to T, chromosome 7 at 118,545,727 bp
  • A to T, chromosome 8 at 24,914,122 bp
  • T to C, chromosome 8 at 27,036,526 bp
  • T to A, chromosome 8 at 81,844,447 bp
  • A to G, chromosome 9 at 7,037,801 bp
  • T to A, chromosome 9 at 45,869,541 bp
  • A to T, chromosome 9 at 101,212,625 bp
  • A to G, chromosome 9 at 108,975,927 bp
  • T to C, chromosome 9 at 108,984,145 bp
  • T to G, chromosome 9 at 120,018,509 bp
  • A to G, chromosome 10 at 76,508,361 bp
  • T to C, chromosome 11 at 23,282,718 bp
  • A to C, chromosome 11 at 62,753,462 bp
  • C to A, chromosome 12 at 84,926,292 bp
  • C to T, chromosome 13 at 11,790,332 bp
  • A to T, chromosome 14 at 14,931,290 bp
  • T to C, chromosome 14 at 16,422,786 bp
  • G to A, chromosome 15 at 9,614,215 bp
  • G to A, chromosome 15 at 98,094,397 bp
  • A to G, chromosome 16 at 32,143,454 bp
  • A to G, chromosome 16 at 45,547,668 bp
  • T to C, chromosome 16 at 76,292,122 bp
  • A to G, chromosome 17 at 15,498,178 bp
  • G to T, chromosome 17 at 34,598,201 bp
  • A to G, chromosome 18 at 37,478,064 bp
  • A to G, chromosome 18 at 39,420,653 bp
  • G to A, chromosome 18 at 67,191,385 bp
  • G to T, chromosome 19 at 4,086,470 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5939 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043243-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.