Strain Name:
C57BL/6J-MtgxR5614Btlr
Stock Number:
043275-MU
Citation ID:
RRID:MMRRC_043275-MU
Other Names:
R5614 (G1)
Major Collection:

Gene Information

Ylpm1
Name: YLP motif containing 1
Synonyms: ZAP, A930013E17Rik, Zap3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 56531
Homologene: 87707
Dtx4
Name: deltex 4, E3 ubiquitin ligase
Synonyms: RNF155
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 207521
VEGA: 19
Homologene: 27781
Zfp638
Name: zinc finger protein 638
Synonyms: Zfml, Np220
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 18139
Homologene: 7447
Odf2
Name: outer dense fiber of sperm tails 2
Synonyms: MMTEST29, cenexin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 18286
HGNC: HGNC:8114
Homologene: 1907
Fus
Name: fused in sarcoma
Synonyms: D930039C12Rik, pigpen, Tls, translocated in liposarcoma, D430004D17Rik, hnRNP P2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233908
HGNC: HGNC:4010
Homologene: 134091
Zmym4
Name: zinc finger, MYM-type 4
Synonyms: 6330503C17Rik, Zfp262
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 67785
Homologene: 35470
Fasn
Name: fatty acid synthase
Synonyms: A630082H08Rik, FAS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 14104
HGNC: HGNC:3594
Homologene: 55800
Abca1
Name: ATP-binding cassette, sub-family A (ABC1), member 1
Synonyms: ABC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 11303
HGNC: HGNC:29
Homologene: 21130
Iars2
Name: isoleucine-tRNA synthetase 2, mitochondrial
Synonyms: 2010002H18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 381314
Homologene: 7118
Fam171b
Name: family with sequence similarity 171, member B
Synonyms: D430039N05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241520
Homologene: 18462
Nxpe2
Name: neurexophilin and PC-esterase domain family, member 2
Synonyms: 4432416J03Rik, Fam55b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 78252
Homologene: 87072
Nelfa
Name: negative elongation factor complex member A, Whsc2
Synonyms: Nelf-A, Whsc2, Whsc2h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 24116
Homologene: 68478
Rnf6
Name: ring finger protein (C3H2C3 type) 6
Synonyms: 5730419H05Rik, 1200013I08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 74132
Homologene: 14036
Chrne
Name: cholinergic receptor, nicotinic, epsilon polypeptide
Synonyms: AChrepsilon, Acre
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 11448
HGNC: HGNC:1966
Homologene: 60
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 665700
Homologene: 90772
Hmgcll1
Name: 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 208982
Homologene: 27863
Ttn
Name: titin
Synonyms: shru, connectin, mdm, 2310057K23Rik, D330041I19Rik, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, L56, 2310074I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22138
Homologene: 130650
Fig4
Name: FIG4 phosphoinositide 5-phosphatase
Synonyms: A530089I17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 103199
VEGA: 10
Homologene: 6713
Rtp1
Name: receptor transporter protein 1
Synonyms: LOC239766, LOC385871
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 239766
VEGA: 16
Homologene: 17806
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: FPC, tigmin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Col5a3
Name: collagen, type V, alpha 3
Synonyms: Pro-alpha3(V)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 53867
Homologene: 9253
Tecta
Name: tectorin alpha
Synonyms: Tctna, [a]-tectorin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 21683
Homologene: 3955
Sec24c
Name: Sec24 related gene family, member C (S. cerevisiae)
Synonyms: 2610204K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 218811
VEGA: 14
Homologene: 3615
Clspn
Name: claspin
Synonyms: E130314M08Rik, C85083
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 269582
Homologene: 11138
Stxbp5
Name: syntaxin binding protein 5 (tomosyn)
Synonyms: LGL3, 0710001E20Rik, 4930565N16Rik, tomosyn 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 78808
Homologene: 16402
Osbpl6
Name: oxysterol binding protein-like 6
Synonyms: 1110062M20Rik, ORP-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 99031
Homologene: 101447
Rgs1
Name: regulator of G-protein signaling 1
Synonyms: BL34
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 50778
HGNC: HGNC:9991
Homologene: 2191
Ces1d
Name: carboxylesterase 1D
Synonyms: Ces3, TGH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 104158
HGNC: HGNC:1863
Homologene: 35606
Ankmy2
Name: ankyrin repeat and MYND domain containing 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 217473
VEGA: 12
Homologene: 10662
Npbwr1
Name: neuropeptides B/W receptor 1
Synonyms: Gpr7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226304
HGNC: HGNC:4522
Homologene: 21096
Zfp800
Name: zinc finger protein 800
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 627049
Homologene: 18529
Lrit1
Name: leucine-rich repeat, immunoglobulin-like and transmembrane domains 1
Synonyms: Lrrc21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 239037
Homologene: 9215
Wfdc8
Name: WAP four-disulfide core domain 8
Synonyms: LOC277343
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 277343
Homologene: 33799
Serpini2
Name: serine (or cysteine) peptidase inhibitor, clade I, member 2
Synonyms: 1810006A24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 67931
HGNC: HGNC:8945
Homologene: 21248
Tmem67
Name: transmembrane protein 67
Synonyms: 5330408M12Rik, b2b1163.1Clo, b2b1291.1Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 329795
Homologene: 71886
Nod2
Name: nucleotide-binding oligomerization domain containing 2
Synonyms: Card15, F830032C23Rik, Nlrc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 257632
HGNC: HGNC:5331
Homologene: 11156
Zfp326
Name: zinc finger protein 326
Synonyms: ZAN75, 5730470H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 54367
Homologene: 10297
Iqca1l
Name: IQ motif containing with AAA domain 1 like
Synonyms: 4931409K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231045
Homologene: 18602
Ces1b
Name: carboxylesterase 1B
Synonyms: Gm5158
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 382044
HGNC: HGNC:1863
Homologene: 117484
Hook2
Name: hook microtubule tethering protein 2
Synonyms: A630054I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 170833
Homologene: 8332
Cant1
Name: calcium activated nucleotidase 1
Synonyms: SCAN-1, D11Bwg0554e, Apy1h, 5830420C20Rik, Shapy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 76025
Homologene: 69460
Fam43a
Name: family with sequence similarity 43, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 224093
Homologene: 17800
Thg1l
Name: tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
Synonyms: 1700121M19Rik, 5730409G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 66628
Homologene: 5959
Atp13a2
Name: ATPase type 13A2
Synonyms: 1110012E06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 74772
Homologene: 56940
Arfrp1
Name: ADP-ribosylation factor related protein 1
Synonyms: 1500006I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 76688
HGNC: HGNC:662
Homologene: 2425
Tollip
Name: toll interacting protein
Synonyms: 4931428G15Rik, 4930403G24Rik, Toll interacting protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 54473
Homologene: 10375
Tgfb2
Name: transforming growth factor, beta 2
Synonyms: Tgfb-2, Tgf-beta2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 21808
Homologene: 2432
Vgll2
Name: vestigial like family member 2
Synonyms: VITO-1, Vgl-2, Vito1, C130057C21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 215031
Homologene: 35066
Myl9
Name: myosin, light polypeptide 9, regulatory
Synonyms: RLC-C, MLC20, Mylc2c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 98932
Homologene: 21230
Cfap54
Name: cilia and flagella associated protein 54
Synonyms: Gm872, LOC380653, 4930485B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 380654
Homologene: 133438
Wbscr22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 5,916,811 bp
  • A to G, chromosome 1 at 20,073,526 bp
  • G to T, chromosome 1 at 144,246,257 bp
  • T to C, chromosome 1 at 185,289,508 bp
  • T to A, chromosome 1 at 186,625,513 bp
  • A to G, chromosome 2 at 29,920,867 bp
  • G to T, chromosome 2 at 31,428,303 bp
  • T to A, chromosome 2 at 76,568,109 bp
  • A to G, chromosome 2 at 76,712,107 bp
  • T to A, chromosome 2 at 83,812,873 bp
  • G to A, chromosome 2 at 156,781,163 bp
  • G to T, chromosome 2 at 164,603,203 bp
  • A to G, chromosome 2 at 181,359,443 bp
  • T to C, chromosome 3 at 75,257,707 bp
  • C to A, chromosome 4 at 12,061,755 bp
  • A to G, chromosome 4 at 53,046,132 bp
  • A to G, chromosome 4 at 126,580,962 bp
  • A to G, chromosome 4 at 126,910,936 bp
  • A to G, chromosome 4 at 140,992,182 bp
  • G to A, chromosome 5 at 24,550,142 bp
  • A to T, chromosome 5 at 33,920,500 bp
  • T to A, chromosome 5 at 105,888,495 bp
  • C to A, chromosome 5 at 135,059,112 bp
  • T to C, chromosome 5 at 146,218,100 bp
  • G to A, chromosome 6 at 28,243,136 bp
  • T to C, chromosome 6 at 83,929,641 bp
  • T to C, chromosome 7 at 127,974,371 bp
  • T to C, chromosome 7 at 141,892,088 bp
  • T to A, chromosome 8 at 85,002,508 bp
  • A to T, chromosome 8 at 88,664,196 bp
  • T to C, chromosome 8 at 93,068,208 bp
  • T to C, chromosome 8 at 93,176,204 bp
  • A to G, chromosome 9 at 20,783,476 bp
  • A to G, chromosome 9 at 42,339,055 bp
  • A to T, chromosome 9 at 48,323,101 bp
  • A to G, chromosome 9 at 76,081,393 bp
  • A to T, chromosome 10 at 9,760,894 bp
  • A to T, chromosome 10 at 41,272,985 bp
  • A to T, chromosome 10 at 52,025,222 bp
  • A to G, chromosome 10 at 93,045,049 bp
  • T to C, chromosome 11 at 45,950,227 bp
  • C to T, chromosome 11 at 70,615,053 bp
  • T to C, chromosome 11 at 118,408,743 bp
  • T to C, chromosome 11 at 120,813,328 bp
  • T to C, chromosome 12 at 36,193,784 bp
  • T to C, chromosome 12 at 85,064,944 bp
  • T to A, chromosome 14 at 20,682,738 bp
  • T to A, chromosome 14 at 37,061,954 bp
  • C to A, chromosome 16 at 23,431,190 bp
  • T to C, chromosome 16 at 30,601,672 bp
  • T to C, chromosome 19 at 12,482,183 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5614 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043275-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.