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Availability & Fees Order this Strain
Homozygous: Non-lethal. No abnormal physiology detected
Hetero/Hemizygous: No abnormal physiology detected. Induces T and B cell tolerance to epitopes from the HA
Caton AJ, Swartzentruber JR, Kuhl AL, Carding SR, Stark SE. Activation andnegative selection of functionally distinct subsets of antibody-secreting cellsby influenza hemagglutinin as a viral and a neo-self antigen. J Exp Med. 1996 Jan1;183(1):13-26. (Medline PMID: 8551216)
Reed AJ, Riley MP, Caton AJ. Virus-induced maturation and activation of autoreactive memory B cells. J Exp Med. 2000 Dec 18;192(12):1763-74. (Medline PMID: 11120773)
Picca CC, Oh S, Panarey L, Aitken M, Basehoar A, Caton AJ. Thymocyte deletion can bias Treg formation toward low-abundance self-peptide. Eur J Immunol. 2009 Dec;39(12):3301-6. doi: 10.1002/eji.200939709. (Medline PMID: 19768697)
Kim JI, O'connor MR, Duff PE, Zhao G, Lee KM, Eliades P, Deng S, Yeh H, Caton AJ, Markmann JF. Generation of adaptive regulatory T cells by alloantigen is required for some but not all transplant tolerance protocols. Transplantation. 2011 Apr 15;91(7):707-13. doi: 10.1097/TP.0b013e31820e50b3. (Medline PMID: 21386770)
Juchem KW, Anderson BE, Zhang C, McNiff JM, Demetris AJ, Farber DL, Caton AJ, Shlomchik WD, Shlomchik MJ. A repertoire-independent and cell-intrinsic defect inmurine GVHD induction by effector memory T cells. Blood. 2011 Dec1;118(23):6209-19. doi: 10.1182/blood-2011-01-330035. Epub 2011 Jul 18. (Medline PMID: 21768295)
Related strains: HA28 (MMRRC:43825) and HACII mice (MMRRC:43832)
Cryo-recovered strains distributed by the MMRRC at JAX are shipped to the customer from the Pathogen & Opportunistic-Free Animal Room G200 - see https://www.jax.org/jax-mice-and-services/customer-support/customer-service/animal-health/health-status-reports.
Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.
Cryopreserved material may be available upon request, please inquire to csmmrrc@jax.org for more information.
Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.
The donor or their institution limits the distribution to non-profit institutions only.
Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.
1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.
2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.
3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.
4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.