Strain Name:
C.Cg-Tg(SV40-HA)HA104Ajca/Mmjax
Stock Number:
043831-JAX
Citation ID:
RRID:MMRRC_043831-JAX
Other Names:
HA104

Gene Information

Promoter: SV40 (Simian virus 40 (SV40))
Name: simian virus 40 early region promoter/enhancer
Alteration at locus: Transgenic
Monarch Initiative (Disease and Phenotype Associations):
Transgene: HA (Influenza virus)
Name: haemagglutinin, Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Alteration at locus: Transgenic
Monarch Initiative (Disease and Phenotype Associations):
Transgene: Tg(SV40-HA)HA104Ajca (Influenza virus)
Name: transgene insertion 104, Andrew Caton
Chromosome: random insertion
Alteration at locus: Transgenic
Monarch Initiative (Disease and Phenotype Associations):
Genetic Alterations
Full-length influenza virus A/PR/8/34 hemagglutinin under control of SV40 early region promoter/enhancer
Genotype Determination
ES Cell Line
N/A
Phenotype

Homozygous: Non-lethal. No abnormal physiology detected

Hetero/Hemizygous: No abnormal physiology detected. Induces T and B cell tolerance to epitopes from the HA

MeSH Terms
    Strain Development
    Backcrossed 13 generations with BALB/cAnNCrl (Charles River Strain 028), then intermated to homozygosity. Maintained as homozygotes. Upon arrival at the MMRRC: backcrossing to BALB/cByJ (Jackson Strain #001026).
    Suggested Control Mice
    Wild-type littermates
    • Diabetes
    • Immunology and Inflammation
    • Models for Human Disease
    Donor
    Andrew Caton, Ph.D., The Wistar Institute.

    Colony and Husbandry Informationon

    Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email csmmrrc@jax.org .
    Coat Color
    albino
    MMRRC Breeding System
    Sib-mating
    Generation
    N13F10-15
    Overall Breeding Performance
    Good
    NOTE: "Hemizygote" as used here refers to males carrying a mutation on the X Chromosome or mice of either sex carrying an inserted transgene with no homologous allele on the other chromosome.
    Viability and Fertility: Female Male Comments
    Homozygotes are viable: Yes Yes
    Homozygotes are fertile: Yes Yes
    Hetero/Hemizygotes are fertile: Yes Yes
    Age Reproductive Decline: 8 to 12 months 8 to 12 months
    Bred to Homozygosity
    No
    Average litter size
    4-6
    Recommended wean age
    3-4 weeks
    Average Pups Weaned
    4-6

    Order Request Information

    Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

    Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

    The donor or their institution limits the distribution to non-profit institutions only.

    Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

    Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
    MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
    043831-JAX-SPERM Cryo-preserved spermatozoa $437.00 / Non-Profit Aliquot Approximate quantity2
    043831-JAX-RESUS Litter recovered from cryo-archive $2,022.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.

    1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

    2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

    3 An aliquot contains a sufficient number of embryos (in one or more vials and based on the transfer success rate of the MMRRC facility) to transfer to at least two recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

    To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.