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Strain Name:
C57BL/6J-MtgxR5890Btlr/Mmmh
Stock Number:
044091-MU
Citation ID:
RRID:MMRRC_044091-MU
Other Names:
R5890 (G1)
Major Collection:

Strain Information

Mecp2
Name: methyl CpG binding protein 2
Synonyms: WBP10, Mbd5, 1500041B07Rik, D630021H01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 17257
HGNC: HGNC:6990
Homologene: 3657
Sufu
Name: SUFU negative regulator of hedgehog signaling
Synonyms: Su(Fu), 2810026F04Rik, b2b273Clo
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 24069
Homologene: 9262
Nrcam
Name: neuronal cell adhesion molecule
Synonyms: Bravo, C030017F07Rik, C130076O07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319504
VEGA: 12
HGNC: HGNC:7994
Homologene: 21041
Defb3
Name: defensin beta 3
Synonyms: mBD-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 27358
Ptprf
Name: protein tyrosine phosphatase receptor type F
Synonyms: LAR, RPTP-LAR
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19268
HGNC: HGNC:9670
Homologene: 20623
Mif4gd
Name: MIF4G domain containing
Synonyms: 1110014L05Rik, 2310075G12Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69674
Homologene: 41389
Wdr47
Name: WD repeat domain 47
Synonyms: 1810073M12Rik, nemitin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99512
Homologene: 8984
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 53,318,167 bp
  • G to A, chromosome 1 at 75,493,859 bp
  • T to C, chromosome 1 at 132,038,928 bp
  • T to A, chromosome 2 at 18,046,003 bp
  • A to T, chromosome 2 at 26,986,591 bp
  • T to C, chromosome 2 at 35,715,402 bp
  • C to A, chromosome 2 at 76,709,899 bp
  • A to G, chromosome 2 at 153,129,076 bp
  • A to G, chromosome 3 at 28,915,395 bp
  • C to A, chromosome 3 at 103,090,075 bp
  • G to T, chromosome 3 at 108,610,012 bp
  • A to G, chromosome 3 at 125,875,553 bp
  • A to T, chromosome 3 at 148,859,175 bp
  • T to C, chromosome 4 at 43,454,475 bp
  • A to T, chromosome 4 at 118,224,735 bp
  • A to C, chromosome 4 at 133,294,362 bp
  • T to C, chromosome 4 at 152,547,079 bp
  • A to G, chromosome 5 at 29,658,292 bp
  • A to G, chromosome 5 at 32,064,807 bp
  • A to G, chromosome 5 at 36,229,191 bp
  • T to A, chromosome 5 at 41,820,578 bp
  • A to T, chromosome 5 at 96,645,948 bp
  • A to T, chromosome 6 at 31,490,547 bp
  • T to A, chromosome 6 at 117,845,086 bp
  • C to T, chromosome 6 at 126,534,736 bp
  • A to G, chromosome 6 at 142,604,828 bp
  • T to C, chromosome 7 at 30,753,267 bp
  • A to G, chromosome 7 at 35,429,162 bp
  • T to A, chromosome 7 at 45,144,545 bp
  • T to A, chromosome 7 at 48,551,959 bp
  • T to A, chromosome 7 at 59,272,028 bp
  • T to C, chromosome 7 at 96,902,860 bp
  • T to G, chromosome 7 at 109,934,221 bp
  • T to A, chromosome 7 at 118,190,586 bp
  • C to A, chromosome 7 at 119,775,234 bp
  • T to C, chromosome 7 at 123,286,758 bp
  • G to A, chromosome 8 at 19,295,184 bp
  • T to A, chromosome 9 at 40,922,662 bp
  • T to C, chromosome 9 at 82,906,952 bp
  • G to T, chromosome 9 at 111,228,495 bp
  • A to T, chromosome 9 at 123,061,638 bp
  • C to A, chromosome 10 at 80,259,907 bp
  • A to T, chromosome 10 at 127,298,045 bp
  • T to A, chromosome 11 at 69,792,729 bp
  • C to T, chromosome 11 at 78,273,270 bp
  • A to G, chromosome 11 at 85,326,908 bp
  • G to T, chromosome 11 at 114,789,438 bp
  • G to T, chromosome 11 at 115,609,362 bp
  • A to T, chromosome 12 at 4,867,651 bp
  • A to T, chromosome 12 at 16,733,421 bp
  • G to T, chromosome 12 at 44,576,771 bp
  • C to T, chromosome 12 at 75,415,822 bp
  • T to C, chromosome 12 at 101,885,972 bp
  • T to C, chromosome 14 at 26,706,884 bp
  • T to A, chromosome 14 at 33,102,577 bp
  • A to C, chromosome 14 at 121,668,408 bp
  • T to A, chromosome 15 at 64,815,417 bp
  • C to T, chromosome 15 at 76,593,585 bp
  • G to A, chromosome 17 at 12,271,416 bp
  • A to T, chromosome 17 at 24,185,526 bp
  • C to T, chromosome 17 at 31,613,219 bp
  • C to A, chromosome 18 at 36,969,068 bp
  • A to T, chromosome 18 at 37,505,233 bp
  • T to A, chromosome 18 at 74,221,166 bp
  • A to G, chromosome 18 at 82,640,151 bp
  • A to G, chromosome 19 at 12,763,993 bp
  • A to T, chromosome 19 at 39,712,492 bp
  • A to T, chromosome 19 at 46,454,733 bp
  • C to T, chromosome X at 74,035,437 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5890 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044091-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.