Strain Name:
C57BL/6J-MtgxR5993Btlr
Stock Number:
044172-MU
Citation ID:
RRID:MMRRC_044172-MU
Other Names:
R5993 (G1)
Major Collection:

Gene Information

Adamts20
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20
Synonyms: ADAMTS-20, bt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 223838
Homologene: 11808
Sema3e
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
Synonyms: Semah
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 20349
Homologene: 8247
Kcnc1
Name: potassium voltage gated channel, Shaw-related subfamily, member 1
Synonyms: KShIIIB, KV4, Kv3.1, C230009H10Rik, Kcr2-1, Shaw, NGK2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 16502
HGNC: HGNC:6233
Homologene: 68134
Bpifb3
Name: BPI fold containing family B, member 3
Synonyms: Rya3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 378700
Homologene: 18807
Anks3
Name: ankyrin repeat and sterile alpha motif domain containing 3
Synonyms: 2700067D09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 72615
VEGA: 16
Homologene: 12475
Add1
Name: adducin 1 (alpha)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 11518
HGNC: HGNC:243
Homologene: 22758
Shroom3
Name: shroom family member 3
Synonyms: Shrm3, Shrm, D5Ertd287e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 27428
Homologene: 9263
Ankrd17
Name: ankyrin repeat domain 17
Synonyms: Gtar, A130069E23Rik, 4933425K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 81702
Homologene: 82403
Thrap3
Name: thyroid hormone receptor associated protein 3
Synonyms: 9330151F09Rik, B230333E16Rik, Trap150
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230753
Homologene: 31289
Aspm
Name: abnormal spindle microtubule assembly
Synonyms: Sha1, D330028K02Rik, Calmbp1, Aspm, MCPH5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 12316
Homologene: 7650
Smg1
Name: SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
Synonyms: 5430435M13Rik, C130002K18Rik, 2610207I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233789
Homologene: 56697
Cux1
Name: cut-like homeobox 1
Synonyms: Cux-1, Cux, Cutl1, CDP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 13047
HGNC: HGNC:2557
Supt16
Name: SPT16, facilitates chromatin remodeling subunit
Synonyms: Fact140, Supt16h, Spt16, Cdc68
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 114741
VEGA: 14
Homologene: 5207
Wwc1
Name: WW, C2 and coiled-coil domain containing 1
Synonyms: Kibra
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 211652
Homologene: 69180
Ptk7
Name: PTK7 protein tyrosine kinase 7
Synonyms: chz, mPTK7/CCK4, 8430404F20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 71461
VEGA: 17
HGNC: HGNC:9618
Homologene: 43672
Prox1
Name: prospero homeobox 1
Synonyms: A230003G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 19130
HGNC: HGNC:9459
Homologene: 2069
Alas1
Name: aminolevulinic acid synthase 1
Synonyms: succinyl-CoA: glycine C-succinyl transferase, 5-aminolevulinate synthase, ALAS-N, Alas-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 11655
HGNC: HGNC:396
Homologene: 55478
Nop2
Name: NOP2 nucleolar protein
Synonyms: Nol1, 120kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 110109
HGNC: HGNC:7867
Homologene: 135865
Mphosph9
Name: M-phase phosphoprotein 9
Synonyms: MPP9, MPP-9, B930097C17Rik, 9630025B04Rik, 4930548D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 269702
HGNC: HGNC:7215
Homologene: 11256
Akap2
Name: A kinase (PRKA) anchor protein 2
Synonyms: B230340M18Rik, AKAP-KL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
Dppa4
Name: developmental pluripotency associated 4
Synonyms: 2410091M23Rik, ECAT15-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 73693
VEGA: 16
Homologene: 130462
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: b2b1537Clo, b2b1565Clo, b2b3491Clo, b2b1154Clo, Mdnah5, Dnahc5, b2b1134Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Ttn
Name: titin
Synonyms: shru, connectin, mdm, 2310057K23Rik, D330041I19Rik, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, L56, 2310074I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22138
Homologene: 130650
Mrc1
Name: mannose receptor, C type 1
Synonyms: CD206, MR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 17533
HGNC: HGNC:7228
Homologene: 37622
Drc7
Name: dynein regulatory complex subunit 7
Synonyms: Ccdc135, SRG-L, LOC330830
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 330830
Homologene: 12996
D430041D05Rik
Name: RIKEN cDNA D430041D05 gene
Synonyms: G2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241589
Homologene: 115928
Serpina3j
Name: serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3J
Synonyms: Gm4931, alpha-1 antiproteinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 238395
HGNC: HGNC:16
Homologene: 120222
Gcc1
Name: golgi coiled coil 1
Synonyms: 4932417P04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 74375
Homologene: 11567
Skint6
Name: selection and upkeep of intraepithelial T cells 6
Synonyms: OTTMUSG00000008519
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230622
Homologene: 135888
Zc3h7a
Name: zinc finger CCCH type containing 7 A
Synonyms: Zc3h7, A430104C18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 106205
Homologene: 8563
Mroh1
Name: maestro heat-like repeat family member 1
Synonyms: Heatr7a, D330001F17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 223658
Homologene: 44882
Dclre1a
Name: DNA cross-link repair 1A
Synonyms: 2810043H12Rik, mSNM1, SMN1a, SNM1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 55947
Homologene: 8920
Topaz1
Name: testis and ovary specific PAZ domain containing 1
Synonyms: Gm9524
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 671232
VEGA: 9
Homologene: 19835
Krt78
Name: keratin 78
Synonyms: 2310030B04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 332131
VEGA: 15
Homologene: 65261
Greb1l
Name: growth regulation by estrogen in breast cancer-like
Synonyms: mKIAA4095, AK220484
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 381157
Homologene: 73393
Sema5b
Name: sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B
Synonyms: Semag, SemG, SemG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 20357
Homologene: 8427
Nlrp10
Name: NLR family, pyrin domain containing 10
Synonyms: Nalp10, 6430548I20Rik, Pynod
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 244202
Homologene: 18468
Ccdc149
Name: coiled-coil domain containing 149
Synonyms: Gm447, LOC242997
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 100503884
Homologene: 65264
Ccdc57
Name: coiled-coil domain containing 57
Synonyms: 4933434G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 71276
Homologene: 52351
Atp8b4
Name: ATPase, class I, type 8B, member 4
Synonyms: Im
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241633
Homologene: 133162
Ttll3
Name: tubulin tyrosine ligase-like family, member 3
Synonyms: 4833441J24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 101100
Homologene: 134361
Man2b2
Name: mannosidase 2, alpha B2
Synonyms: 135 kDa alpha-D-mannosidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 17160
Homologene: 7411
Rhot2
Name: ras homolog family member T2
Synonyms: Arht2, Miro2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 214952
Homologene: 56038
Rhov
Name: ras homolog family member V
Synonyms: Arhv, A030005A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228543
Homologene: 26426
Fam71d
Name: family with sequence similarity 71, member D
Synonyms: 4930516C23Rik, 4921509E07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 70897
Homologene: 49887
Runx1t1
Name: RUNX1 translocation partner 1
Synonyms: Cbfa2t1h, MTG8, ETO
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 12395
HGNC: HGNC:1535
Homologene: 3801
Oxld1
Name: oxidoreductase like domain containing 1
Synonyms: 1810049H13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 66431
Homologene: 49831
Bin2
Name: bridging integrator 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 668218
HGNC: HGNC:1053
Homologene: 22965
Cyp2c44
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 139,479,531 bp
  • T to A, chromosome 1 at 190,162,239 bp
  • A to G, chromosome 2 at 14,305,327 bp
  • T to G, chromosome 2 at 76,795,907 bp
  • A to G, chromosome 2 at 104,168,067 bp
  • A to G, chromosome 2 at 119,270,052 bp
  • C to T, chromosome 2 at 126,403,234 bp
  • T to A, chromosome 2 at 153,929,314 bp
  • A to T, chromosome 4 at 13,841,863 bp
  • A to T, chromosome 4 at 13,875,490 bp
  • A to G, chromosome 4 at 57,855,273 bp
  • A to T, chromosome 4 at 112,809,079 bp
  • A to T, chromosome 4 at 126,175,460 bp
  • A to G, chromosome 5 at 14,224,293 bp
  • A to C, chromosome 5 at 34,601,533 bp
  • A to G, chromosome 5 at 36,820,980 bp
  • C to T, chromosome 5 at 52,402,775 bp
  • A to T, chromosome 5 at 90,339,672 bp
  • A to T, chromosome 5 at 92,940,188 bp
  • A to T, chromosome 5 at 124,316,098 bp
  • T to C, chromosome 5 at 136,363,271 bp
  • G to A, chromosome 6 at 28,424,852 bp
  • T to A, chromosome 6 at 113,398,031 bp
  • C to T, chromosome 6 at 125,144,019 bp
  • G to A, chromosome 7 at 46,427,532 bp
  • A to T, chromosome 7 at 108,927,013 bp
  • A to G, chromosome 7 at 118,140,509 bp
  • T to A, chromosome 8 at 95,074,192 bp
  • A to G, chromosome 9 at 106,234,129 bp
  • T to C, chromosome 9 at 122,749,039 bp
  • T to C, chromosome 11 at 35,852,336 bp
  • A to G, chromosome 11 at 120,457,009 bp
  • T to C, chromosome 11 at 120,894,724 bp
  • C to A, chromosome 12 at 78,715,436 bp
  • A to G, chromosome 12 at 104,314,687 bp
  • C to A, chromosome 14 at 52,178,334 bp
  • T to C, chromosome 15 at 28,299,226 bp
  • C to A, chromosome 15 at 76,446,680 bp
  • G to T, chromosome 15 at 94,338,723 bp
  • CGGAGCTGA to C, chromosome 15 at 100,645,020 bp
  • T to A, chromosome 15 at 101,950,449 bp
  • C to T, chromosome 16 at 4,958,137 bp
  • T to A, chromosome 16 at 11,150,662 bp
  • T to A, chromosome 16 at 35,646,202 bp
  • C to T, chromosome 16 at 48,289,346 bp
  • T to A, chromosome 17 at 25,841,111 bp
  • T to C, chromosome 17 at 46,565,370 bp
  • G to A, chromosome 18 at 10,544,455 bp
  • A to G, chromosome 19 at 44,012,360 bp
  • A to C, chromosome 19 at 56,542,737 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5993 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044172-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.