Strain Name:
C57BL/6J-MtgxR6049Btlr
Stock Number:
044217-MU
Citation ID:
RRID:MMRRC_044217-MU
Other Names:
R6049 (G1)
Major Collection:

Gene Information

Pdpk1
Name: 3-phosphoinositide dependent protein kinase 1
Synonyms: Pkb kinase, Pdk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18607
HGNC: HGNC:8816
Homologene: 37643
Limch1
Name: LIM and calponin homology domains 1
Synonyms: 3732412D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 77569
Homologene: 18953
Slc1a3
Name: solute carrier family 1 (glial high affinity glutamate transporter), member 3
Synonyms: Eaat1, GLAST, Gmt1, B430115D02Rik, MGluT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 20512
Homologene: 20882
Ank2
Name: ankyrin 2, brain
Synonyms: ankyrin B, Ank-2, Ankyrin-2, Gm4392, Ankyrin-B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Prkcd
Name: protein kinase C, delta
Synonyms: Pkcd, PKCdelta, D14Ertd420e, PKC[d]
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 18753
HGNC: HGNC:9399
Homologene: 55963
Rfx3
Name: regulatory factor X, 3 (influences HLA class II expression)
Synonyms: C230093O12Rik, MRFX3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 19726
HGNC: HGNC:9984
Homologene: 7917
Cemip2
Name: cell migration inducing hyaluronidase 2
Synonyms: Tmem2, 3110012M15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 83921
VEGA: 19
Homologene: 75008
Phf12
Name: PHD finger protein 12
Synonyms: PF1, 2410142K10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268448
Homologene: 10841
Crybg3
Name: beta-gamma crystallin domain containing 3
Synonyms: Gm9581
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224273
Homologene: 28544
Arhgap39
Name: Rho GTPase activating protein 39
Synonyms: D15Wsu169e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223666
Homologene: 27825
Kif15
Name: kinesin family member 15
Synonyms: N-10 kinesin, Knsl7, 3930402I10Rik, 3110023M17Rik, HKLP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 209737
VEGA: 9
Homologene: 23210
Supt5
Name: suppressor of Ty 5, DSIF elongation factor subunit
Synonyms: Spt5, Supt5h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20924
Homologene: 2384
Cux1
Name: cut-like homeobox 1
Synonyms: CDP, Cux, Cux-1, Cutl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13047
HGNC: HGNC:2557
Tanc2
Name: tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
Synonyms: 3526402J09Rik, 5730590C14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 77097
Homologene: 64680
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: enaptin165, nesprin-1, SYNE-1, C130039F11Rik, A330049M09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Rbck1
Name: RanBP-type and C3HC4-type zinc finger containing 1
Synonyms: HOIL-1, HOIL-1L, Ubce7ip3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 24105
Homologene: 32448
St7
Name: suppression of tumorigenicity 7
Synonyms: TSG7, 9430001H04Rik, RAY1, SEN4, HELG, Fam4a2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 64213
Homologene: 10185
C6
Name: complement component 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12274
HGNC: HGNC:1339
Homologene: 47
Rmdn3
Name: regulator of microtubule dynamics 3
Synonyms: Fam82a2, 1200015F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67809
Homologene: 34926
Dnajc1
Name: DnaJ heat shock protein family (Hsp40) member C1
Synonyms: ERdj1, MTJ1, D230036H06Rik, Dnajl1, 4733401K02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13418
Homologene: 7293
Med18
Name: mediator complex subunit 18
Synonyms: 2810046C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67219
Homologene: 9756
Med6
Name: mediator complex subunit 6
Synonyms: 1500012F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 69792
Homologene: 3990
Cd2bp2
Name: CD2 cytoplasmic tail binding protein 2
Synonyms: 2410024K20Rik, 1500011B02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 70233
HGNC: HGNC:1656
Homologene: 4455
Kat6a
Name: K(lysine) acetyltransferase 6A
Synonyms: MOZ, Zfp220, Myst3, 9930021N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244349
Homologene: 4924
Szt2
Name: SZT2 subunit of KICSTOR complex
Synonyms: seaizure threshold 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230676
Homologene: 49413
Cngb1
Name: cyclic nucleotide gated channel beta 1
Synonyms: Cngb1b, BC016201, Cngb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 333329
HGNC: HGNC:2151
Homologene: 136420
Pde4d
Name: phosphodiesterase 4D, cAMP specific
Synonyms: 9630011N22Rik, dunce, Dpde3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238871
HGNC: HGNC:8783
Cacna1a
Name: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Synonyms: Ccha1a, smrl, nmf352, alpha1A, SCA6, Cacnl1a4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12286
HGNC: HGNC:1388
Homologene: 56383
Ttn
Name: titin
Synonyms: L56, 2310074I15Rik, 2310036G12Rik, 1100001C23Rik, connectin, shru, D830007G01Rik, mdm, D330041I19Rik, 2310057K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: A730004I20Rik, Dnahc6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Tnr
Name: tenascin R
Synonyms: TN-R, J1-tenascin, janusin, restrictin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 21960
Homologene: 124416
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: Mgr1, Gpr98, Mass1, VLGR1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 110789
Homologene: 19815
Deup1
Name: deuterosome assembly protein 1
Synonyms: 4933401K09Rik, Ccdc67
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 234964
Homologene: 18760
Ctsq
Name: cathepsin Q
Synonyms: 1600010J02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 104002
Homologene: 122226
Nlrp4b
Name: NLR family, pyrin domain containing 4B
Synonyms: Nalp-gamma, Nalp4b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 210045
Homologene: 65242
Fscb
Name: fibrous sheath CABYR binding protein
Synonyms: EG623046
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 623046
VEGA: 12
Homologene: 136275
Irs2
Name: insulin receptor substrate 2
Synonyms: Irs-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 384783
HGNC: HGNC:6126
Homologene: 2778
Adgb
Name: androglobin
Synonyms: 9130014G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215772
Homologene: 100289
Greb1
Name: gene regulated by estrogen in breast cancer protein
Synonyms: 5730583K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 268527
Homologene: 8780
Smc1b
Name: structural maintenance of chromosomes 1B
Synonyms: Smc1l2, SMC1beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 140557
VEGA: 15
Homologene: 13786
Slc27a6
Name: solute carrier family 27 (fatty acid transporter), member 6
Synonyms: 4732438L20Rik, FATP6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225579
Homologene: 38385
Aadacl2fm2
Name: AADACL2 family member 2
Synonyms: Gm5538
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 433597
Homologene: 79018
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: Dnahc7b, LOC227058
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227058
Homologene: 41287
Tgfbr3
Name: transforming growth factor, beta receptor III
Synonyms: betaglycan, TBRIII, 1110036H20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 21814
Homologene: 2436
Krt42
Name: keratin 42
Synonyms: ecat6, K17n, Ka22, 2410039E07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 68239
Homologene: 107091
Crat
Name: carnitine acetyltransferase
Synonyms: CARAT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12908
HGNC: HGNC:2342
Homologene: 598
Pnliprp2
Name: pancreatic lipase-related protein 2
Synonyms: PLRP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18947
VEGA: 19
HGNC: HGNC:9157
Homologene: 3936
Tbc1d7
Name: TBC1 domain family, member 7
Synonyms: 2610009C09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 67046
VEGA: 13
Homologene: 9538
Rpusd3
Name: RNA pseudouridylate synthase domain containing 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 101122
Homologene: 18342
Gabbr2
Name: gamma-aminobutyric acid (GABA) B receptor, 2
Synonyms: GB2, Gababr2, Gpr51, LOC242425
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242425
HGNC: HGNC:4507
Homologene: 55902
Olfr191
Name: olfactory receptor 191
Synonyms: GA_x54KRFPKG5P-55314632-55313703, MOR183-5P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 258035
Homologene: 128162
Tbpl2
Name: TATA box binding protein like 2
Synonyms: Trf3, LOC227606
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227606
Homologene: 133152
D7Ertd443e
Name: DNA segment, Chr 7, ERATO Doi 443, expressed
Synonyms: 4933400E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71007
Homologene: 18998
4921539E11Rik
Name: RIKEN cDNA 4921539E11 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 70941
Homologene: 52843
Abcd2
Name: ATP-binding cassette, sub-family D (ALD), member 2
Synonyms: ABC39, ALDR, ALDL1, adrenoleukodystrophy related
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 26874
VEGA: 15
HGNC: HGNC:66
Homologene: 55873
Olfr846
Name: olfactory receptor 846
Synonyms: MOR149-3, GA_x6K02T2PVTD-13098546-13097608
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258279
Olfr823
Name: olfactory receptor 823
Synonyms: MOR210-4, GA_x6K02T2PULF-11783479-11782532
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258668
Homologene: 45026
Cplane2
Name: ciliogenesis and planar polarity effector 2
Synonyms: b2b2804Clo, 6330545A04Rik, Rsg1, b2b2827Clo, LOC279260
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 76166
Homologene: 12793
Hace1
Name: HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
Synonyms: A730034A22Rik, 1700042J16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 209462
Homologene: 10807
Ska1
Name: spindle and kinetochore associated complex subunit 1
Synonyms: 2810433K01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 66468
VEGA: 18
Homologene: 11975
Pdzk1
Name: PDZ domain containing 1
Synonyms: 1700023D20Rik, mPDZK1, 4921513F16Rik, D3Ertd537e, 2610507N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 59020
HGNC: HGNC:8821
Homologene: 1964
Prl7b1
Name: prolactin family 7, subfamily b, member 1
Synonyms: PLP-N, 1600014J19Rik, Prlpn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 75596
Homologene: 17809
Mup13
Name: major urinary protein 13
Synonyms: Gm13513
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100039089
Homologene: 74304
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 46,085,602 bp
  • T to C, chromosome 1 at 159,912,754 bp
  • T to C, chromosome 2 at 18,231,700 bp
  • T to C, chromosome 2 at 24,094,992 bp
  • A to G, chromosome 2 at 30,403,541 bp
  • G to A, chromosome 2 at 76,846,310 bp
  • A to G, chromosome 2 at 119,153,425 bp
  • G to T, chromosome 2 at 152,323,174 bp
  • A to C, chromosome 3 at 59,752,149 bp
  • A to G, chromosome 3 at 96,851,663 bp
  • T to A, chromosome 3 at 126,943,020 bp
  • A to G, chromosome 4 at 46,787,641 bp
  • T to C, chromosome 4 at 61,227,597 bp
  • G to A, chromosome 4 at 103,231,323 bp
  • A to G, chromosome 4 at 118,402,988 bp
  • G to T, chromosome 4 at 132,459,713 bp
  • T to A, chromosome 4 at 141,218,162 bp
  • A to T, chromosome 5 at 67,030,860 bp
  • C to T, chromosome 5 at 107,118,485 bp
  • T to C, chromosome 5 at 136,332,710 bp
  • A to G, chromosome 6 at 17,694,348 bp
  • T to C, chromosome 6 at 73,086,166 bp
  • A to C, chromosome 6 at 113,417,841 bp
  • T to A, chromosome 7 at 10,714,713 bp
  • A to G, chromosome 7 at 28,315,197 bp
  • A to T, chromosome 7 at 127,193,835 bp
  • T to C, chromosome 7 at 134,298,232 bp
  • A to C, chromosome 8 at 11,006,805 bp
  • T to A, chromosome 8 at 22,939,037 bp
  • A to G, chromosome 8 at 84,638,846 bp
  • T to C, chromosome 8 at 95,270,842 bp
  • A to G, chromosome 9 at 15,561,256 bp
  • C to A, chromosome 9 at 19,361,344 bp
  • G to A, chromosome 9 at 123,011,622 bp
  • A to T, chromosome 10 at 5,347,926 bp
  • A to G, chromosome 10 at 10,378,026 bp
  • A to T, chromosome 10 at 45,686,662 bp
  • A to T, chromosome 10 at 130,112,612 bp
  • A to G, chromosome 11 at 78,028,170 bp
  • C to T, chromosome 11 at 100,267,060 bp
  • G to A, chromosome 11 at 105,867,717 bp
  • T to A, chromosome 12 at 16,681,394 bp
  • T to C, chromosome 12 at 64,474,320 bp
  • T to C, chromosome 12 at 81,591,323 bp
  • G to T, chromosome 13 at 27,606,178 bp
  • A to C, chromosome 13 at 43,159,360 bp
  • A to G, chromosome 13 at 61,038,758 bp
  • A to G, chromosome 13 at 81,397,354 bp
  • A to T, chromosome 13 at 109,032,585 bp
  • T to C, chromosome 14 at 30,607,297 bp
  • T to C, chromosome 15 at 4,735,172 bp
  • T to C, chromosome 15 at 8,645,693 bp
  • A to G, chromosome 15 at 76,727,401 bp
  • A to G, chromosome 15 at 85,121,695 bp
  • A to G, chromosome 15 at 91,178,236 bp
  • A to T, chromosome 16 at 59,086,146 bp
  • T to C, chromosome 16 at 59,544,054 bp
  • A to T, chromosome 17 at 24,098,135 bp
  • T to A, chromosome 18 at 58,598,660 bp
  • T to C, chromosome 18 at 74,202,600 bp
  • A to T, chromosome 19 at 21,826,126 bp
  • A to T, chromosome 19 at 27,802,395 bp
  • A to G, chromosome 19 at 58,760,452 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6049 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044217-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.