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Strain Name:
C57BL/6J-MtgxR6120Btlr
Stock Number:
044268-MU
Citation ID:
RRID:MMRRC_044268-MU
Other Names:
R6120 (G1)
Major Collection:

Strain Information

Sema3c
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
Synonyms: Semae, 1110036B02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20348
Homologene: 36201
Chrna4
Name: cholinergic receptor, nicotinic, alpha polypeptide 4
Synonyms: alpha4 nAChR, Acra-4, Acra4, a4 nicotinic receptor, alpha4-nAChR
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11438
HGNC: HGNC:1958
Homologene: 592
Bpifb3
Name: BPI fold containing family B, member 3
Synonyms: Rya3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 378700
Homologene: 18807
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: DNA-PKcs, slip, DNAPDcs, XRCC7, DNA-PK, DOXNPH, dxnph
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Pam, C130061D10Rik, Phr1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105689
Homologene: 9005
Kif13b
Name: kinesin family member 13B
Synonyms: GAKIN, N-3 kinesin, C130021D12Rik, 5330429L19Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16554
VEGA: 14
Homologene: 9073
Rrm1
Name: ribonucleotide reductase M1
Synonyms: RnrM1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20133
Homologene: 806
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 93,024,574 bp
  • T to C, chromosome 1 at 188,358,603 bp
  • T to A, chromosome 2 at 25,399,466 bp
  • T to C, chromosome 2 at 85,786,341 bp
  • A to G, chromosome 2 at 136,550,376 bp
  • A to G, chromosome 2 at 143,801,111 bp
  • G to T, chromosome 2 at 153,931,443 bp
  • A to G, chromosome 2 at 181,024,806 bp
  • A to T, chromosome 3 at 36,554,672 bp
  • C to T, chromosome 3 at 67,594,385 bp
  • T to A, chromosome 3 at 107,753,854 bp
  • C to T, chromosome 3 at 109,664,365 bp
  • A to G, chromosome 3 at 116,124,400 bp
  • T to C, chromosome 4 at 129,293,751 bp
  • A to T, chromosome 5 at 4,894,029 bp
  • A to G, chromosome 5 at 17,727,632 bp
  • T to C, chromosome 5 at 73,640,810 bp
  • T to A, chromosome 6 at 48,465,576 bp
  • T to A, chromosome 7 at 3,645,336 bp
  • A to G, chromosome 7 at 3,841,554 bp
  • A to G, chromosome 7 at 62,419,534 bp
  • T to C, chromosome 7 at 80,380,867 bp
  • G to A, chromosome 7 at 102,460,856 bp
  • A to T, chromosome 7 at 108,104,133 bp
  • A to G, chromosome 7 at 129,624,791 bp
  • G to T, chromosome 7 at 130,228,690 bp
  • T to G, chromosome 8 at 3,621,764 bp
  • G to T, chromosome 8 at 80,711,743 bp
  • A to G, chromosome 8 at 84,998,125 bp
  • G to A, chromosome 9 at 58,086,600 bp
  • T to A, chromosome 10 at 56,388,505 bp
  • A to G, chromosome 10 at 76,209,446 bp
  • G to T, chromosome 10 at 110,939,279 bp
  • G to A, chromosome 10 at 129,801,820 bp
  • C to A, chromosome 10 at 129,801,821 bp
  • A to G, chromosome 11 at 48,894,781 bp
  • A to G, chromosome 11 at 54,510,000 bp
  • T to C, chromosome 11 at 66,147,399 bp
  • T to G, chromosome 12 at 16,708,621 bp
  • C to T, chromosome 12 at 108,527,724 bp
  • G to A, chromosome 14 at 31,641,108 bp
  • A to G, chromosome 14 at 45,348,673 bp
  • A to T, chromosome 14 at 64,751,558 bp
  • A to T, chromosome 14 at 103,275,887 bp
  • C to T, chromosome 15 at 73,696,004 bp
  • T to C, chromosome 15 at 99,940,363 bp
  • C to A, chromosome 16 at 15,739,471 bp
  • T to C, chromosome 16 at 32,756,795 bp
  • T to A, chromosome 17 at 23,346,029 bp
  • T to A, chromosome 17 at 57,525,973 bp
  • T to C, chromosome 17 at 67,780,617 bp
  • T to A, chromosome 18 at 6,638,795 bp
  • A to G, chromosome 18 at 22,097,728 bp
  • A to G, chromosome 18 at 61,199,417 bp
  • A to G, chromosome 19 at 11,521,695 bp
  • A to G, chromosome 19 at 46,279,321 bp
  • A to G, chromosome 19 at 47,267,409 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6120 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044268-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.